Regular Fish Intake Supports Cognitive Health in Aging
Fish consumption and cognitive function in aging: a systematic review of observational studies "In conclusion, the evidence suggests that regular fish intake (typically ≥1–2 servings per week) is linked to preserved cognitive performance, although some inconsistent findings require further investigations." https://t.co/1axIS85WGf @GeroScienceAGE
Fuel Your Mitochondria, Unlock Peak Performance
I don’t take 150 pills a day to feel average. I take them because your biology responds to inputs, and most people never give their cells what they need to perform. Your mitochondria run the entire energy economy of your...
ART Reverses HIV‑Induced Aging, Cutting Years Off Biological Clock
Great news for HIV positive patients. A study presented at ESCMID Global 2026 found that untreated HIV can accelerate biological aging by up to a decade, but antiretroviral therapy can reverse this effect by nearly four years within about 18...
Only Proven Sleep Hacks Actually Improve Your Rest
I Tested Every Sleep Hack on the Planet — Here's What Actually Works https://t.co/13yp3N9anK via @YouTube
AI Reads Retina to Diagnose Multiple Metabolic Diseases
In 2014 I predicted we'd diagnose metabolic disease just by looking into your eyes. Nature Medicine just published the proof. Researchers built an AI called Reti-Pioneer. You look into a camera. It scans your retina. No blood draw. No needles. No lab. What it can...
Athletes Over
In the last 20 athlete profiles we have done there has been 1-athlete whose perceived stress, and actual stress markers were aligned. Most people are dealing with some sort of autonomic imbalance as sympathetic dominance, while simultaneously thinking they manage stress...
High Protein Enables Recomp Whether in Deficit or Maintenance
Interesting finding that kind of defies physics, but it is what it is, proving there’s still more we need to learn… Muscle maintenance/body recomp strategy #1: eat adequate calories (isocaloric) Muscle maintenance/body recomp strategy #2: eat a calorie deficit, but include adequate...
Clarify Healthspan: When Does Quality Living End?
Lifespan stops at death, but when does healthspan stop? "...Greater conceptual clarity is essential..." https://t.co/ybrK3kkQCS
GLP Success, Injection Comfort, and Broad Curiosity Fuel Peptide Boom
3 things set the stage for peptides to become a WAY bigger than “supplements”: 1) GLPs (with RCT support) inadvertently made the “peptide” label seem generally approachable 2) GLPs made people less wary of injecting themselves 3) Women & men of many ages...
10 Simple Habits Linked to Healthy Aging
I’m a bioscientist studying aging 🧬 Here are 10 simple habits most strongly associated with healthy aging ↓
Endurance Performance: Beyond Mileage, Intervals, and Carbs
Traditional endurance advice has often focused on mileage, intervals, and carbohydrate. But is that the full picture? Join Dr Mike Ormsbee for Endurance Reimagined, an expert lecture on the latest science in endurance performance. https://t.co/5Zy1jrLXXW
Mild Sleep Loss Alters Blood DNA Methylation Patterns
Prolonged Mild Sleep Restriction Changes Epigenome-Wide DNA Methylation in Peripheral Blood Cells: A Randomized Crossover Trial https://t.co/nb9s0AP9O1
SGLT2 Inhibitors Cut Cardiovascular Death by 14%
As a medical school professor: when I trained, "diabetes drugs" meant blood-sugar drugs. That ceiling has been broken. Meta-analysis in Am J Med (Jaiswal et al, U Chicago, Mar 26 2026) pooled 18 RCTs, n=95,913 patients with diabetes, heart failure, or...
10‑Marker Bioage Score Outperforms Chronological Age
As a medical school professor: chronological age is a tax bracket. Biological age is the actual bill. Aging Cell paper from MARK-AGE (Moreno-Villanueva, Burkle et al, U Konstanz, 2026) screened 362 biomarkers in ~3,300 adults across 8 European countries, then distilled...
Maintain Strong Paraspinal Muscles Into Your 60s
Train. This is what your paraspinal muscles should look like in your 60s and beyond. https://t.co/XR59But4a9
High Hs‑CRP, Not LDL, Drives Statin Benefit
"But my cholesterol is normal." JUPITER trial (NEJM): 18,000 people, normal LDL, high hs-CRP. Statin → cardiac events ↓44%, heart attacks ↓54%, strokes ↓48%. 322,000-person UK Biobank: hs-CRP outranked LDL. Full episode 🎙 https://youtu.be/FBLB1CQGBPM
Longevity Genes Can Switch From Benefit to Harm
As a medical school professor, I tell students: be careful with "longevity gene." Prof. Nikolai Slavov (Northeastern) just argued that single "longevity genes" are oversimplified. The same gene's effect on lifespan can flip sign with age -- helpful early, harmful later....
Invasive Nanowire BCIs Needed, Non‑Invasive for Biomarkers
I love brain-to-computer interfaces and one of my first papers and granted patents was in AI/ML for BCI. And I was very much impressed with BrainCo's non-invasive BCIs and artificial limbs and sensing fingers (that they sell to Tesla btw)....
Extracellular Vesicles Deliver SASP, Fuel Aging, Offer Therapies
Extracellular Vesicles as Key SASP Carriers Driving Cellular Senescence, Inflammaging, and Therapeutic Opportunities in Aging and Age-Related Diseases https://t.co/SURS5ZbTD9 https://t.co/IXM2BkdurZ
True Fitness Lies in Metabolic Flexibility, Not Looks
What is fitness, and what is the concept of being metabolically fit? We use the word 'fitness' constantly... but I hear so many different definitions of it. If you asked ten people at a gym what it means to be...
Science and Gadgets Extend Athletes' Careers Beyond Age
The Longevity Secrets Helping Athletes Blow Past the Limits of Age With cutting-edge sports medicine and sci-fi gadgetry, more and more athletes are figuring out how to extend their careers. https://t.co/RsXENoJYgj
New Liver Replacement: Prime Strategy for Aging Liver
The best treatment for aging liver is the new liver. Replacement is a viable long-term therapeutic and longevity strategy. Great insights from the replacement workshop organized by Sierra Lore and team as part of @ARDD_Meeting https://t.co/xYFQ9Fy2Jc https://t.co/ipQfpxcRNq
Sympathetic Overdrive Caps Peak Power, Breath Tests Reveal
Peak neuromuscular output is one of the most autonomically-sensitive measurements you can test. A sympathetic-dominant system—of which is the most prominent problem—will frequently underexpress alactic power (peak power) because the recruitment ceiling is being protectively capped. The athletes that can...
Supplements Boost Cellular Health, FDA Finally Acknowledges
When the FDA finally admits what biohackers have known for years... 😏💊 And check out @suppgradelabs for my go-to supplements (ie: DAKE + Organs 101 = Daily Multi-Vitamin...comment DAKE for my discount code). Supplements support cellular function, mitochondrial health, and metabolic...
Obesity Requires More Than Lifestyle Changes, Biology Matters
Why Lifestyle Alone Is Insufficient in Obesity: Biological Evidence, Conceptual Analogies and a Legacy of Missed Opportunities in Patient Care https://t.co/MOXZrDVWZD
Skipping Recovery Slashes Fat Burning, Forces Carb Dependence
How much does the nervous and aerobic systems change when not recovered? Rested, and ready I’ve tested at >10 kcal/min fat max. HR 120 Not ready, while I’m still trying to recover that fat max reached 4.4 kcal/min today. HR max was...
SIRT6 Shields Aorta by Cutting Inflammation and Aging
SIRT6 appears protective in aortic disease, as higher levels reduce vascular inflammation and smooth muscle cell aging, thereby helping prevent both aortic aneurysm and dissection progression. https://t.co/eXuKrR7oNF
Socioeconomic, Lifestyle, and Genetic Factors Jointly Shape Intrinsic Capacity
Associations and interaction effects of socioeconomic, lifestyle, and genetic factors on intrinsic capacity https://t.co/crOBp21bRN https://t.co/LgbFdA0GEe
Breathwork + Sauna: Free Biohack Boosts Brain and Body
The ultimate biohack is free: Your breath. 🫁 I’ve been stacking SOMA breathwork with dry sauna sessions and the physiological shifts are insane. Here is why this combo is a powerhouse for your brain and body:
Bulk‑and‑cut Offers No Edge over Recomping
You don’t have to bulk and cut. The current evidence has yet to show an advantage for it compared to recomping. Been saying this for over a decade now.
Ground Sitting Boosts Lifelong Mobility and Joint Health
Sitting on the ground more is one of the simplest things you can do for long-term mobility. It sounds almost too basic, but getting down to the floor and back up is a real marker of independence. If you lose that...
Meta‑analysis Finds No Benefit to Extra DHA
I am sometimes asked why @getkion fish oil does NOT have “extra” DHA…fact is, a recent meta-analysis of 96 randomized controlled trials at https://t.co/YZMb5dar8P showed no clear advantage of decreasing the EPA:DHA ratio…learn more about the formula here: https://t.co/8REbBJKoBJ
Young‑Adult Work Activity May Shield Against Dementia
Physical activity across the life course and neural biomarkers 💡"PA done as part of one's job or schooling during young adulthood, such as standing and walking, may be protective against dementia later in life." https://t.co/tGarY3gUA2
Gut Microbiome Resilience: Key to Longevity
Gut Microbiota Resilience and Environmental Stressors: A Hidden Key to Lifespan Optimization? "...The review also outlines practical ways to bolster resilience: fiber-rich, plant-based and fermented foods; targeted probiotics, prebiotics/synbiotics, and (in special cases) fecal microbiota transplantation; regular physical activity; good sleep...
Peptides Boost Hormones, Yet Trigger Serious Metabolic Side Effects
People mistakenly believe peptides are only good. Peptides can be bad, too. They can cause adverse effects. Some dangerous. I did a peptide experiment and measured its effects in my body. The results are complicated. I tried a peptide called CJC-1295....
30 Years of Coaching Reveal High‑Performance Essentials
The 123 of High Performance: What 30 years as a coach and exercise physiologist has taught me... 👇🧵
5 Foods That Fuel Cellular Renewal and Longevity
You’re not just getting older, your body is constantly renewing itself. 🧬 These 5 foods deliver nutrients your body actually uses to protect your brain, reduce inflammation, and support long-term energy. Small shifts. Big impact. Which one are you already eating regularly? #Longevity...
Visceral and Muscle Fat Dramatically Boost Disease Risk
Excess visceral fat around organs is associated with 2.3 higher diabetes risk High muscle fat raises cardiovascular event risk by 54% Low muscle predicts 44% higher risk of death from any cause Eat less. Move. Work out https://t.co/ZLhRXdu1H6
AI MRI Links Body Composition to Longevity
As a medical school professor and radiologist, this is one of the most important imaging-meets-longevity studies of the year. AI-driven whole-body MRI body composition in 66,608 adults (UK Biobank + German National Cohort, mean age 57.7, mean BMI 26.2), published in...
Caffeine Boosts Carb Absorption, Enhances Endurance Performance
Carbohydrates and caffeine are often consumed to improve endurance performance. Can caffeine increase the absorption of carbohydrates during exercise? If so, what does this mean for performance? Read the blog for more: https://t.co/tI4zx8NQXp https://t.co/gqJ47oCKaM
Two‑Thirds of Americans Suffer Chronic Magnesium Deficiency
More than two-thirds of U.S. adults are deficient in magnesium, according to the most recent data. ~66% of men and ~70% of women have serum magnesium levels below 2.06 mg/dL (known as chronic latent magnesium deficiency). Importantly, magnesium levels are lower in...
More Steps Can Counteract Sedentary Disease Risk
As a medical school professor, the most actionable longevity finding of April 2026 came from 15,327 adults in the All of Us Research Program, published in Nature Communications. Researchers tracked Fitbit data over years (millions of person-days). They asked: can extra...
Training Framework: Variables, Not Prescribed Workouts
The Modules... Not specific workouts... but the variables you need to consider as you build your plan. Basically, the science behind the planning. A thread... Again... This is not a training program. It is a framework for understanding how...
India's Deep-Tech Startup Crafts Next-Gen Sleep System
This is wild. Look at how seriously the Indian deep-tech scene is taking sleep now: > bed senses your sleep stage in real time > auto-cools when you hit deep sleep > auto-elevates when it detects snoring > tracks HRV, RHR, breathing without a wearable >...
Choosing the Right Weight Boosts Training Effectiveness
The question of what weight to use in a resistance training program comes up commonly not only among beginners, but also experienced lifters. Here are some thoughts on making good weight selections: https://t.co/sc72FmZc57
Klotho Deficiency Heightens Stroke Risk in Aging
The antiaging protein Klotho is a key factor in susceptibility to cerebral ischemia Highlights: • Klotho deficiency links aging to higher vulnerability to ischemic stroke • Klotho deficiency increases inflammation and disrupts the blood–brain barrier. • Loss of Klotho intensifies ischemia-induced oxidative and ER...
New Framework Separates True Aging Effects From Study Bias
Mitigating the Hawthorne effect in aging “This Comment proposes a methodological framework to distinguish true biological aging modulation from the confounding effects of study participation.” https://t.co/h9Z2qiFzwv https://t.co/KdnJfSJzhe
Young Gut Microbes Fail
Gut microbiota transplantation from young adult mice fails to restore low bone and muscle mass in old mice https://t.co/BXKJo3Ovi6 https://t.co/JZ3O4BqXd6
GLP‑1 Drugs Boost Weight Loss and Health, Not Replace Lifestyle
Yes, GLP-1 meds help reduce your weight though a calorie deficit Yes, they have metabolic effects beyond this that help with various health conditions (CVD, psoriasis, alcohol abuse, etc). No, they don’t replace lifestyle changes. Yes, they help you make...
Longevity Experts Reveal How to Live to 100
How to Live to 100, According to Longevity Experts In his new book, ‘Longevity Nation,’ Michael Clinton shares insights from experts about how to make the most of the second half of your life. @ROARforward | @goodhousemag https://t.co/hwABZaPQ49