New Delivery Bypasses Diet, Fuels Cells with Urolithin A
Only 30% of people can actually produce Urolithin A from food. And even if you are one of them, you would need six cups of pomegranate juice a day to hit the minimum effective dose. Scientists have found a way to skip that entirely and get Urolithin A straight to your cells. There it clears out dying mitochondria, and revitalizes your immune cells.
Blood Test Identifies Molecules Predicting Short‑term Survival
New Blood Test Signals Who is Most Likely to Live Longer, Study Finds Research finds tiny molecules in blood strongly predict short‑term survival in older adults https://t.co/8bv3I5CCXE https://t.co/IdZ5eYOmwe
Wheat Bran Plus Resistant Starch Improves Fecal Health Markers
Combining wheat bran with resistant starch has more beneficial effects on fecal indexes than does wheat bran alone https://t.co/c5q4PlNB2l
Two-Day Oatmeal Diet Cuts LDL by 10%
Cholesterol: 2-day oatmeal diet may help reduce LDL levels by 10% https://t.co/R0WWUUxAKN via @mnt #CardioTwitter #hearthealth #MedTwitter #health #nutrition
Rejecting Life Extension = Costly, Intentional Aging Choice
"If you have access to life extension therapies and decline them, you’re making a deliberate choice to age and die on an old biological timeline." -- the additional medical cost associated with NOT choosing these therapies, may make it an...
Prioritize Healthspan over Chasing Immortality
As a longevity scientist, I’m not interested in helping people live forever. I’m interested in helping people avoid the long period of decline and chronic disease that has become normal in the final 10–20 years of life. Extend healthspan - and a...
Interferon Pathway Drives Inflammaging, Offers Epigenetic Target
We've known inflammaging is a big part of why the human aging process accelerates. Now the interferon pathway is invoked as having a causal role (via epigenetics) and potential for targeting https://t.co/0Di0xiLGyy
Ultra-Processed Foods Boost Death Risk for Cancer Survivors
As a medical school professor, this study should be front-page news. Researchers tracked cancer survivors and found those eating the most ultra-processed food had: -- 48% higher risk of death from any cause -- 57% higher risk of... https://www.youtube.com/@RobertLufkinMD https://www.aacr.org/about-the-aacr/newsroom/news-releases/high-consumption-of-ultraprocessed-foods-may-be-linked-to-cancer-survivors-risk-of-death/ CancerPrevention #UltraProcessedFood #MetabolicHealth #Nutrition #Longevity
Movement‑Informed Breathwork May Boost HRV More Than Traditional Techniques
Could it be that movement-informed breathwork (MiB) can have more profound effects on HRV than coherent/resonance breathing?
Stable Weight Maintenance Predicts Longer Lifespan in Mice
Longitudinal analysis of body weight reveals homeostatic and adaptive traits linked to lifespan in diversity outbred mice "We observed that the ability to maintain stable body weight, despite fluctuations in energy intake and expenditure, was positively associated with lifespan in an...
Super‑agers Defy Aging: Brains Stay 25‑year‑old Sharp
‘Harvard Thinking’: How super-agers keep their brains young Experts break down ‘biological contradiction’ of a 65-year-old with the memory of a 25-year-old — and what that means for the rest of us https://t.co/29qpNudp1J https://t.co/X951FiSfiS
High SHBG Increases Sarcopenia Risk; Free Hormones Protect
Endogenous sex hormones, sex hormone-binding globulin, and muscle health: insights into sarcopenia and sarcopenic obesity from the Women’s Health Initiative "Among postmenopausal women, higher SHBG concentrations at baseline were associated with lower lean body mass and a higher odds of sarcopenia,...
Perceived Sleep Quality Beats Objective Data in Reducing Worry
Better Sleep Can Reduce Worry and Rumination in Older Adults People’s perceptions of their sleep also proves to have stronger associations with their worry and rumination than objective sleep quality monitored with a device. https://t.co/rgAxrILC6E https://t.co/JpHwzEczjH
7‑8 Hours Nightly Cuts Type 2 Diabetes Risk
This Is How Much Sleep You Need to Lower Your Type 2 Diabetes Risk https://t.co/UI9VyQiv3a https://t.co/ac9eBXPIBu
Certain Fibers Boost Colonic Sugar Fermentation in Obesity
Ha, it may seem like an esoteric subject, but I'm hot on the trail of something Specific dietary fibers steer toward distal colonic saccharolytic fermentation using the microbiota of individuals with overweight/obesity https://t.co/6b8y6du2On
GLP‑1 Drugs Show Promise for Treating All Addictions
GLP-1 medications get at the heart of addiction: study Diabetes and obesity drugs show promise in treating and preventing all substance use disorders https://t.co/buHywnw9Wk https://t.co/0lunbQbjsb
AI Creates Orexin Activator to Boost Focus, Reduce Sleep
Two researchers just used AI to design a selective orexin activator. If you care about focus, steady energy, or needing less sleep, this is worth paying attention to. https://t.co/3qbzB6J7X3
Mitochondrial Transplantation Reverses Cell Degeneration
In terms of my top bets for rejuvenation-based therapies, mitochondrial transplanation has entered the chat Cell-type-targeted mitochondrial transplantation rescues cell degeneration https://t.co/izvDaRk7kz
Cellular Stress Drives Stem Cell Aging, Revealing Therapy Targets
Beyond Cell Death: The Hidden Drivers of Stem Cell Aging “The findings shed light on how cellular stress shapes stem cell aging and highlight potential pathways for developing therapies to counter age-related decline...” https://t.co/hBUchsNtQ4 https://t.co/6HyOSZZ6ZS
Reversing Aging Could Halt Chronic Disease Progression
Aging is the primary driver of most chronic diseases. But what if aspects of aging can be reversed? I join @TomBilyeu on Impact Theory to discuss the latest about what we’re learning in the lab and in human clinical trials Full conversation:...
Stress‑induced Mitochondrial Condensate Fusion Drives Aging
It works by phase separation, where mitochondrial DNA and proteins cluster into droplet-like biomolecular condensates that organize gene activity, but under stress these droplets fuse and grow abnormally, disrupting function and contributing to aging. https://t.co/dRzhFVzxQQ
Better Health Can Shrink Your Sleep Needs
Some people actually live longer while sleeping less than eight hours a night. Improve your health, and your sleep requirement often drops. https://t.co/hkfVvcsD4t
P21⁺TREM2⁺ Macrophages Drive Inflammaging and Liver Disease
Delighted to be part of this study identifying p21⁺TREM2⁺ senescent macrophages as drivers of inflammaging and metabolic liver disease. A fantastic collaboration led by @ACovarrubiasPhD 👏
Sauna Benefits Require 31 Minutes to Trigger HSPs
Most people might miss the biggest benefit of sauna You need to get really really hot… Your core body temperature needs to hit 102.4°F (39°C). For reference, a fever is anything above 100.4°F (38°C) So I swallowed a temperature monitoring pill. It goes through...
Ancient Pomegranate Remedy Validated by Modern Science
Pomegranates have been used by Persian and Greek doctors for thousands of years to improve vitality, and modern science is finally catching up to why. https://t.co/6Ei5AXfk1Y
Exercise and Modest Protein Mimic Rapamycin’s Benefits,
is the point as which Dr Pfleger wants to chime in on the expected longer term outcomes of protein maxing in humans?
Racket Sports Boost Cerebellum Activity and Longevity
lots of articles currently circulating about how racket sports activate the cerebellum as well as improving longevity. https://t.co/kK7TwJIeya
High‑Resolution TORC2 Structure Opens Path to Age‑Related Therapies
Activating TORC2 holds potential in medicine for treating age-related memory & hearing loss. New study out today @MolecularCell reveals the structure of TORC2 in highest-ever resolution - which is good news for drug developers & all of us who age...
DNA Circles in Cancers Show Accelerated Epigenetic Aging
30 years ago, we discovered circular DNA molecules 1. pinch off yeast chromosomes 2. multiply 3. sequester epigenetic regulators (eg sirtuins) 5. cause aging New review today @CellCellPress about DNA circles in human cancers - which are epigenetically older than normal cells https://t.co/VlkBWCFnPi
First Large Rapamycin Trial Aims to Boost Human Healthspan
Finally—this is the kind of study the field has been waiting for. A 720-person randomized clinical trial testing low-dose rapamycin in adults 65+ is about to get underway at @UAZPharmacy , with the goal of answering a simple but critical question:...
Your 40s‑50s: Crucial Years for Lifelong Health
As a longevity researcher, I can’t stress this enough: Your 40s and 50s are one of the most influential periods for shaping long-term health and age-related disease risk. The key is simply finding your version of the basics you can sustain -...
Human Enhancement Is a Fundamental Right, Not Luxury
The United States Declaration of Independence enshrines the idea that every individual has the fundamental right to pursue a fulfilling and meaningful life. The government’s role is to protect that freedom - not to define happiness itself. I believe that one...
Build Muscle to Beat Insulin Resistance
The principle mechanism to overcome insulin resistance in this setting is to increase your onboard glucose management system — AKA skeletal muscle mass 👏🔥👊💪
Infrared Light Essential for Health, Modern Life Deprives It
Infrared light is critical to health and longevity It penetrates through clothes deep into the tissue to: - support energy production - stimulate neurons - improve vascular function - help with skin rejuvenation - stimulate stem cells - support wound healing - lowers inflammation Unfortunately, modern living conditions are...
Three-Day Fast Triggers Free Longevity Boost via Autophagy
The best longevity drug in history is totally free. It's called autophagy. Several things happen when you do a 3 day fast: - your body cannibalizes bad cells / pre-cancer cells / heart plaque - gene expression changes at the 72 hour mark and...
Hip Flexor Power Drives Sprint Performance
Sprint running is heavily dependent upon the power output that can be generated by the hip flexors and extensors. Read more in the weekly free Patreon article. https://t.co/sbu6sERoiD
Accelerated Biological Aging Raises Dementia Risk in Women
Epigenetic Clocks of Biological Aging and Risk of Incident Mild Cognitive Impairment and Dementia: The Women's Health Initiative Memory Study "In this cohort study of older women, accelerated biological aging measured by AgeAccelGrim2 was associated with higher risk of incident MCI/probable...
Testing Tirzepatide‑CJC1295 Combo to Balance Side Effects
Just spent over an hour with my clinical team debating which growth hormone peptide protocol to run. Still torn. Wanted to share the thinking and get your take. The goal: Increase GH and IGF-1 to support anabolism, recovery, and sleep, but...
Massive Health Gains: Weight Loss, Hormones, Labs Improve
Fitness progress: - 29+ lbs down, 11 more to go this phase - Testosterone +20% YoY - A1c 5.7 → 5.2 (out of pre-diabetes) - Insulin -71% YoY - Triglycerides -60% YoY - Liver enzymes normal, reversed early fatty liver disease - HRV +300% & RHR -21%...
Scientists Explore Possibility of Slowing Human Aging
Can aging be slowed? Some academic scientists think so with @NirBarzilaiMD, @mkaeberlein, and @sessi73 https://t.co/1EoZ7evdDF @AAMC https://t.co/StDgRGSRqr
Strength Training Boosts Mental Resilience and Stress Tolerance
One of the biggest benefits I noticed after starting to strength train seriously was the "mental fitness" I gained. Doing tough lifts is challenging enough that it changes how the rest of my day feels. I handle stress better, things don't...
Cut MSG, Seed Oils, Colors to Eliminate Brain Fog
Unlabeled MSG in your food is why you crash after lunch, why you crave sugar, and why your brain feels like static by 3pm. Cut MSG, seed oils, and artificial colorings and watch your brain fog disappear. https://t.co/MUpFZfSEbO
Sleep Under 7 Hours Cuts Life Expectancy Like Smoking
Sleep isn't a nice-to-have. It's a survival requirement. A major new study from OHSU found that getting less than seven hours a night was more strongly linked to decreased life expectancy than pretty much everything but smoking. Fix your sleep...
Free Blood Biomarker Testing Empowers Early Health Intervention
You can now get your blood work at cost. We launched a biomarkers testing platform. I make $0 on it. Blood testing needs to be more accessible. Instead, we wait until we get sick. And in the meantime, companies...
Engineered Brain Cells Erase Alzheimer’s Proteins in Mice
Enhanced brain cells clear away dementia-related proteins New cellular immunotherapy approach for Alzheimer’s disease shows promise in mice https://t.co/YBoqUZLvJo https://t.co/FjG699Etga
Boosted Ritt Hammer’s CHS by 11 Mph in 12 Weeks
Earlier this year I helped for @DPWorldTour player @Ritt_Hammer gain 11mph CHS in just 12 weeks. Here’s how ⬇️ https://t.co/3SO3bHodQq
15 Bioscientist Habits to Tame Silent Inflammation
Chronic inflammation is silent — but it’s a key driver of many age-related diseases. 🧬 Here are 15 habits I prioritise as a bioscientist to keep it in check ↓
Discover Cutting‑Edge Stem Cell Advances at BEYOND 2026
The best place to learn about the latest stem cell research is at BEYOND, Austin, TX, May 27-29, 2026. Learn all the new ways stem cell research is growing and becoming more available from @stemcellchristian at the BEYOND Biohacking Conference. https://t.co/e04Xnfyjwa
Science-Backed Toughness Guide for Action‑Driven Procrastinators
A practical, science based guide to toughening up — for those who can only “just do it” when conditions are right. @DrAndyGalpin PERFORM podcast hits another grand slam:
Dietary Restriction Extends Lifespan via Conserved Molecular Pathways
Molecular mechanisms underlying the lifespan and healthspan benefits of dietary restriction across species https://t.co/JodR3q7w2z https://t.co/46npim9J0m