Know What's Happening in Healthcare
Know What's Happening in Healthcare
FDA approves KRESLADI, first CIRM‑backed gene‑editing therapy
The FDA cleared KRESLADI, a gene‑editing treatment from Rocket Pharmaceuticals for severe leukocyte adhesion deficiency‑I in children, eliminating the need for a bone‑marrow donor. It is the first product directly funded by California’s Institute for Regenerative Medicine to receive approval.
Also developing:
By the numbers: Syneron Bio raises $150M Series B
Shanghai Fosun Pharmaceutical (Group) Co Ltd announced full‑year profit of RMB3.371 bn ($472 m), up 22% from the prior year, while revenue edged 1.4% higher to RMB41.498 bn. The earnings lift expands the group’s capacity to fund R&D and health‑technology projects amid a competitive Chinese pharma market.
Humana and CommonSpirit Health have finalized a three‑year, nationwide contract that keeps CommonSpirit’s hospitals and outpatient sites in‑network for Humana’s Medicare Advantage members across 24 states. The agreement restores coverage lost in Colorado and Texas, stabilizing access for millions of...
A new report by Black Women Organized for Political Action’s Training Institute and Hispanas Organized for Political Equality reveals that California’s healthcare workforce shortage is as much an equity problem as a staffing one. Surveying more than 800 Black women...
Clarivet Corp announced its Clarivet Cares Rural Health Grant program, now accepting applications through June 1, 2026. Since 1995 the company has contributed more than $700,000 across 100+ grants to rural hospitals, clinics and federally qualified health centers. The 2024 recipient, New...
A recent case study in the American Journal of Stem Cells reports two healthy live births—one at age 45 and another at 47—using the women’s own eggs after an experimental ovarian rejuvenation protocol. The treatment blends autologous adipose‑derived stem cells...
In this episode, Dr. Jen Gunter discusses her new birth guide, emphasizing the importance of informed, autonomous decision‑making throughout pregnancy, labor, and postpartum care. She critiques outdated medical lore and highlights how misinformation, legal restrictions, and institutional biases—such as those...
Early-stage liver cancer survival hinges on timely diagnosis, yet ultrasound and AFP tests miss many cases. Helio Genomics has introduced the HelioLiver blood test, a multi‑analyte cfDNA and protein assay that flags tumor‑associated epigenetic signals earlier than imaging. A new...
Beam Therapeutics announced encouraging Phase 1/2 data for its base‑editing therapy targeting alpha‑1 antitrypsin deficiency (AATD). The trial demonstrated a 30% reduction in the disease‑causing SERPINA1 mutation and a 45% rise in functional protein levels, while confirming a clean safety profile....
Adonis announced a $40 million Series C round to accelerate its revenue‑cycle platform for healthcare providers. The funding, led by a mix of existing and new investors, will support product expansion and deeper market penetration. CEO Akash Magoon highlighted persistent challenges such as...
The UK Competition and Markets Authority (CMA) report flags rising veterinary fees, opaque pricing and rapid corporate consolidation as drivers of eroding trust between pet owners and vets. Contrary to public belief, veterinarians earn modest salaries—about $46,000 to $60,000—and often...
During the March 2026 episode of TCTMD’s Heart Sounds, experts highlighted several emerging cardiology developments. Updated lipid‑lowering guidelines emphasize earlier statin initiation and novel agents for high‑risk patients. New echocardiographic surveillance protocols for aortic stenosis aim to detect disease progression before...
The FDA released a draft guidance on using Bayesian methodology in clinical trials, outlining how sponsors should incorporate prior data, define success criteria, and document analyses. It emphasizes systematic prior construction, transparent operating characteristics, and extensive simulation documentation. The guidance...
USPSTF now recommends routine osteoporosis screening for all women aged 65 and older, and for younger postmenopausal women with specific risk factors. The guidance is based on systematic review evidence that early detection via DEXA scans can lower fracture incidence....
The U.S. Departments of Agriculture and Health and Human Services have issued the 2025–2030 Dietary Guidelines for Americans, the latest iteration of a five‑yearly series that began in 1980. The guidelines shape federal nutrition programs such as school meals, Meals...
The FDA has launched a Guidance Snapshot Pilot that distills complex guidance documents into visual, plain‑language one‑page snapshots complemented by podcasts, timelines, and social‑media links. The pilot targets cross‑cutting topics such as Bayesian trial methodology, decentralized clinical elements, and neonatal...
Two Woodstock, Conn., EMTs have each spent about $500 on stab‑ and bullet‑resistant vests after their agency said budget constraints prevent issuing the gear to all 22 responders. The move comes as assaults on first responders in Connecticut climbed to...
Boehringer Ingelheim announced it will maintain its high‑level R&D spending while exploring dealmaking opportunities in China to counteract mounting U.S. drug‑price pressure. The company is prioritising an obesity‑focused pipeline, betting on the fast‑growing weight‑loss market to sustain revenue. By keeping...
A post‑hoc analysis of the SOUL trial shows that once‑daily oral semaglutide (Ozempic pill) significantly improves several cardiometabolic risk factors in adults with type 2 diabetes at high risk for atherosclerotic cardiovascular disease. Compared with placebo, participants experienced a 3.2 mm Hg greater...
A wave of restrictive measures swept U.S. states this week, highlighted by a Georgia woman being charged with murder for using abortion pills, and a suite of bills targeting pregnancy documentation and medication advertising. Ohio’s proposed registry would require doctors...
Thesis Care, formerly Trovo Health, closed a $45 million Series A round led by Oak HC/FT, bringing total funding to $60 million. Founded in 2024 by ex‑Cedar executives, the startup uses AI agents backed by clinicians‑in‑the‑loop to automate end‑to‑end clinical workflows. By delivering...
In‑stent restenosis (ISR) remains a common, costly complication after percutaneous coronary intervention (PCI). A recent cohort of 454 patients evaluated the triglyceride‑total cholesterol‑body weight index (TCBI) alongside traditional metabolic ratios. The analysis showed TCBI achieved the highest predictive accuracy for...
A systematic review and meta‑analysis of 13 randomized trials involving 890 adults found that probiotic supplementation modestly improves subjective sleep quality. The pooled mean difference was –0.59 points on the Pittsburgh Sleep Quality Index (PSQI) and –0.86 points on the...
The 2011‑2020 China Health and Retirement Longitudinal Study examined eight lipid‑derived indices and their relationship to cardiovascular‑kidney‑metabolic (CKM) syndrome progression in middle‑aged and elderly adults. After adjusting for confounders, seven indices—atherogenic index of plasma (AIP), non‑HDL‑C, NHHR, lipoprotein combined index...
A large cross‑sectional study of 7,805 Chinese adults found that CT‑derived visceral fat area (VFA) is the strongest predictor of metabolic dysfunction‑associated steatotic liver disease (MASLD), outperforming body‑mass index (BMI). Men in the highest VFA quartile faced an 11.5‑fold higher...
A randomized, single‑blind pilot trial evaluated creatine monohydrate at 6 g and 18 g daily for four weeks in adults with post‑COVID‑19 condition (PCC) experiencing fatigue. The 6 g/day regimen produced a statistically significant reduction in Piper Fatigue Scale‑Revised scores (‑2.05 points) and...
Qualified Health, a public‑benefit AI firm, closed a $125 million Series B led by NEA, adding investors such as Transformation Capital and Anthropic. The round will fund expansion of its generative‑AI platform that offers governance, risk‑alert, privacy safeguards and workflow automation for...
Cord Blood Registry (CBR), which stores over a million umbilical‑cord samples, is being sued by the attorneys general of Texas and Arizona for allegedly misleading parents about the therapeutic value of its services. The states claim CBR’s advertising falsely promises...
Dymeka Harrison, a commercialization veteran, argues that breakthrough products alone don’t guarantee lasting companies; adoption hinges on disciplined commercial execution. She cites the 70‑90% startup failure rate as largely driven by underdeveloped commercial foundations. Harrison outlines a holistic commercial system—segmentation,...
Regular exercise reduces the likelihood of plaque accumulation in the arteries However, many long-term exercisers appear to have coronary artery calcification, indicating atherosclerosis progression The fascinating thing is that despite the higher plaque, those people still have lower rates of cardiovascular disease...
See this for just 1 of the TAD trials from recent @psybalazs and @QuantPsychiatry comparative analysis. 1 of several deck stacks favoring TADs. This trial reported a surprising -15.2 HAM-D drop with venlafaxine. Not so surprising when you look closer......
Novo Nordisk announced that its triple‑agonist candidate UBT251 achieved a mean HbA1c reduction of up to 2.16% after 24 weeks in a phase‑2 study of Chinese patients with type‑2 diabetes. The trial, involving roughly 200 participants, underscores the drug’s potential...
How good is AI for diagnosing melanoma? A systematic review of 11 studies, 2500 patients, finds accuracy and performance comparable to 50 dermatologists, with promise for broad use requiring further validation @JAMADerm This is important with the big shortage of dermatologists...
Steady progress towards engineering immune cells in the body now for refractory myeloma , with major implications for many autoimmune diseases and cancers https://t.co/K3IksrCFlg https://t.co/1AQ5rLuH1g
Chicago‑based Walsh Construction and New York‑based Turner Construction have completed a new 26‑story, 1.9‑million‑square‑foot hospital for Ohio State University at a construction cost of $1.5 billion. The Wexner Medical Center University Hospital tower houses 820 beds, 24 operating rooms, extensive NICU,...
The #Algorithmic Divide: Why #Healthcare #AI Shouldn’t Treat Everyone The Same by Brad Porter @Forbes Learn more: https://t.co/Jw7zyu0LFo #MedTech #HealthTech #Tech #TechForGood https://t.co/Fo3KyOyzqZ
And, the ACA banned individual guaranteed renewable plans which existed, and protected against the emergence of preexisting conditions. The tax deduction for employer based group plans, but not for contributions to portable individual plans nails the coffin. Great essay.
The Alzheimer’s Disease Data Initiative announced that Biomni-AD and Prima Mente each won the $1 million Alzheimer’s Insights AI Prize, doubling the competition’s total payout to $2 million. The competition, launched in August 2025 and backed by Bill Gates and a broad...
Sarepta Therapeutics reported that early‑stage trials of two experimental drugs, SRP‑1001 and SRP‑1003, demonstrated safety and signs of efficacy for rare muscle‑wasting disorders. The data sparked a more than 20% surge in the company’s stock during early trading. The results...
Veterans Affairs is phasing out its decades‑old custom electronic health record (EHR) in favor of a modern, interoperable platform, CMIO Dr. Jonathan Nebeker announced. The new system will support standardized data exchange and enable integration of emerging digital tools such...
Xaira Therapeutics unveiled X-Cell, a 4.9‑billion‑parameter virtual cell model that predicts transcriptome‑level responses to genetic perturbations. The model leverages the company’s 25.6 million‑cell X‑Atlas/Pisces CRISPRi Perturb‑seq dataset and demonstrates zero‑shot performance on unseen T‑cell and iPSC contexts. X-Cell uses a diffusion...
Medilink North of England is celebrating its 30th anniversary with a high‑profile awards evening at Sheffield’s Cutlers’ Hall on 30 April. The ceremony will recognize excellence across ten categories, from innovation and digital health to export achievement, sustainability and partnership with...
A New York court awarded Fox Varian $2 million in a landmark detransition malpractice lawsuit, marking the first successful U.S. case of its kind. The verdict held both her therapist and plastic surgeon jointly liable for a double mastectomy performed when...
Leeds‑based Asclepius MedTech Limited won the Mayor’s Big Ideas Challenge, receiving £100,000 (≈ $127,000) to scale its Surgfit remote monitoring system. Surgfit uses a disposable wearable sensor to replace hospital visits for pre‑ and post‑operative assessments, aiming to reduce missed risk...
The association between phenotypic age acceleration and the risk of all-cause and cancer mortality among cancer survivors: NHANES 1999–2018 "Our findings reveal a significant linear correlation between PhenoAgeAccel and both all-cause and cancer-specific mortality in cancer survivors." https://t.co/Rt7v8ECOB6
A new DNA‑methylation (episignature) test can differentiate harmful from benign NOTCH1 variants in congenital heart disease, giving families definitive genetic answers. The assay scans over 740,000 genomic sites to identify a characteristic methylation pattern linked to disease‑causing mutations. Positive results...
The CEO of Sollis Health recounts two COVID‑19 ER visits that revealed how fragmented American healthcare forces patients to coordinate their own care. Despite shared electronic medical records, hospitals rejected each other's data, leading to hours of waiting and unnecessary...
Resident physicians are experiencing burnout at rates higher than any other U.S. worker, driven by demanding schedules, financial pressures, and limited control over time. Traditional mental‑health services often fail to accommodate their irregular hours, prompting many to turn to AI‑based...
The Sanctuary at Sedona outlines a comprehensive luxury rehab checklist that blends high‑end amenities with rigorous clinical care. It highlights seven amenity categories—privacy, clinical depth, personalization, integrative wellness, advanced tech, environment, and hospitality—each designed to improve retention and therapeutic engagement....
Canadian employers are leaving significant gaps in adult vaccine coverage, with only about 60% of private benefit plans offering any vaccination benefits. Even when coverage exists, reimbursement levels and communication are inconsistent, leading to low uptake among working‑age adults. The...
