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Daily
Every morning
Weekly
Tuesday recap
Gilead to acquire Germany’s Tubulis for up to $5B, bolstering oncology pipeline
Gilead Sciences announced it will buy Tubulis GmbH for up to $5 billion, adding the biotech’s antibody‑drug conjugate platform to its portfolio. The deal follows Gilead’s recent $7.8 billion purchase of Arcellx and a $2 billion acquisition of Ouro Medicines as it pivots toward cancer therapies. Tubulis’ lead ADC candidate will join Gilead’s expanding oncology roster.
Also developing:
By the numbers: Neurocrine Biosciences acquires Soleno Therapeutics for $2.9B
Researchers published in Nature Communications have identified a dual‑fragment protein system, SLIT3‑N and SLIT3‑C, that constructs the vascular and neural scaffolding essential for brown adipose tissue to burn calories. The discovery, based on analysis of more than 1,500 human samples, links reduced SLIT3 infrastructure to obesity and suggests a new therapeutic angle beyond appetite suppression.
The European Union‑funded PsyPal project kicked off its first psychedelic‑assisted therapy trials for psychological distress in palliative care on 13 April 2026 in Brussels. The launch, hosted by the Directorate‑General for Health and Food Safety, signals a coordinated effort to...
Developers of next‑generation mindfulness platforms are rolling out AI‑powered tools that read heart‑rate variability, skin conductance and sleep data to deliver instant stress‑relief interventions. A University of Bern study of 830 users showed sustained reductions in stress after eight weeks,...
Catalyst Precision Health, founded by Dr. Westley Spiro and Matt Renart, introduced the first at‑home, subscription‑based longevity platform for men, bundling in‑home lab draws, physician house calls and ongoing personalized treatment. The launch targets a $600 billion global longevity market and...
Interventional radiologists at Mount Sinai performed the world’s first TheraSphere Y‑90 Any Day Dosing procedure for hepatocellular carcinoma, following the FDA’s March 2026 clearance. The treatment uses microspheres to deliver targeted radiation directly to liver tumors while sparing healthy tissue. The...
Palantir Technologies faces a fresh political onslaught in the United Kingdom as MPs question its £330 million NHS data platform and defense contracts. Executive Vice President Louis Mosley defended the firm’s role in a BBC interview, but lawmakers warned the company...
After a 2024 appearance on Andrew Huberman’s podcast, Dr. Koniver’s peptide‑focused clinic added 800 new patients in a month, now serving about 1,000 and maintaining a 6,000‑person waitlist. Memberships cost $15,000 a year, generating tens of millions in revenue, while...
CMS has launched the MAHA ELEVATE $100 million cooperative agreement, inviting up to 30 organizations to run randomized, evidence‑generating lifestyle and functional‑medicine trials in the Original Medicare population. A non‑binding Letter of Intent is due by April 10 5 pm ET, with full applications required by...
The article warns that GLP‑1 drugs such as Ozempic, Wegovy and Mounjaro, while effective for weight loss, may blunt dopamine‑driven pleasure centers, leading to apathy and altered behavior. It draws a parallel between these modern injectables and the historic side...
Fake surgery is just as good as actual surgery. For these conditions. Degenerative Rotator Cuff Tear Degenerative Meniscal Tears Subacromial Decompression for Shoulder Pain Whenever surgery is recommended make sure to FIRST ask what happens if you load it instead.
I look forward to giving talks and lectures this coming weekend @uiowa for their Darwin Day celebrations, speaking on climate health, global vaccines, and the dangers of rising antivaccine activism https://t.co/qjv3pnN3oB https://t.co/ISy1vMm9hG
The U.S. Office of Personnel Management released its annual call letter in late March 2026, setting 2027 policy goals that brand the next year’s federal health benefits as “well‑care.” The guidance expands preventive services, obesity treatment, and fertility support while...
AI x Drug Discovery meetup next Tues (14) in NYC ! @ginkgo excited to host with @AAlphaBio — sign up here : https://t.co/GG5c7F4ogO
University College London scientists have released the Diet‑Nutrition Misinformation Risk Assessment Tool (Diet‑MisRAT), a rule‑based platform that rates the potential health harm of online nutrition claims. Calibrated with input from nearly 60 public‑health and dietetics experts, the tool moves beyond...
A new JAMA Internal Medicine study reports that 88% of participants accurately judged their eligibility for an over‑the‑counter medication abortion kit, suggesting self‑assessment could be safe. The findings arrive amid state bans and a lack of FDA applications, intensifying calls...
In this episode, host Chad Bowne and guest Tom Boyke dissect the Trump administration’s new pharmaceutical tariffs and the U.S.-U.K. pricing arrangement, explaining how they aim to address two distinct challenges: low‑margin generic drug shortages tied to China and India,...
Researchers leveraged a large health‑system biobank to combine genomic polygenic risk scores with electronic health‑record phenotypes, creating a scalable pipeline for PTSD biomarker discovery. The analysis identified immune‑related and metabolic signatures that correlate with PTSD risk, and highlighted sex‑specific genetic...
In the inaugural episode of "The Heart of It All," host Terri Hart shares her personal journey transitioning from caring for her father to supporting her mother, highlighting the emotional rollercoaster of caregiving. She discusses the challenges of shifting family...
The first quarter of 2026 NEJM featured several disruptive studies, including a Canadian‑Australian dialysis trial where fish‑oil supplementation halved myocardial infarctions and cut strokes by two‑thirds. Merck’s oral PCSK9 inhibitor enlicitide achieved a 57% LDL reduction, positioning it for a...
ImmunityBio (NASDAQ: IBRX) saw its stock dip after the FDA sent a warning letter accusing the company of false or misleading promotion of its bladder‑cancer drug Anktiva. The regulator flagged a TV advertisement and a provocative podcast episode, prompting ImmunityBio...
3D-printed spanlastics, microscopic carriers for cancer drugs, show potential to target tumors directly and reduce side effects by concentrating therapy at the tumor site rather than throughout the body. nanotechnology
University of Mississippi researchers unveiled a FRESH 3D‑printing technique that fabricates hydrogel‑based spanlastic nanocarriers, 200–300 nm in size, loaded with anticancer drugs such as doxorubicin. The printed implants can be placed directly onto tumor sites, delivering high‑dose therapy locally while shielding...
Scientists from the University of Concepción and the University of Maryland identified a previously unknown appetite‑regulating circuit in the hypothalamus. The study, published in PNAS on April 6, 2026, shows that tanycytes release lactate, which activates astrocytic HCAR1 receptors, prompting glutamate release...
The on‑demand webinar hosted by CAP TODAY on January 28, 2026, featured Dr. Josef Rüschoff, a leading authority on HER2 testing, to explain the newest ASCO/CAP guidelines for HER2 assessment in gastric cancer. It highlighted why HER2 is a critical therapeutic target beyond breast...
Researchers at Oregon State University have engineered lipid nanoparticles that carry follistatin messenger RNA to lung tumors, simultaneously attacking the cancer and the muscle‑wasting cachexia that often accompanies it. In mouse models the nanocarriers bind circulating vitronectin, home to integrin‑rich...
Experts at the Antoni van Leeuwenhoek Hospital in Amsterdam have integrated AI‑driven synthetic imaging software into their MRI scanner, cutting abdominal exam times from roughly 23 minutes to nine minutes. The AI fills in missing slices, allowing technologists to acquire...
The Centers for Medicare & Medicaid Services opened applications for its new Long‑Term Enhanced ACO Design (LEAD) model, with a May 17 deadline and a Jan 1 2027 start date. LEAD replaces the outgoing ACO REACH program and promises broader inclusion of high‑needs...
Astera Health CEO Joel Beiswenger announced his retirement effective July 1, ending an 18‑year tenure that began as CFO in 1998 and as CEO since 2008. Under his leadership, the system completed a merger to form Astera Health, partnered with Wadena...
The U.S. Drug Enforcement Administration issued an Immediate Suspension Order against A+ Pharmacy in Chattanooga, Tennessee, revoking its authority to handle controlled substances. The action resulted from a joint investigation with the Tennessee Board of Pharmacy that uncovered violations of...
Epic is hosting its second annual Open@Epic conference in Verona, Wisconsin, in October, inviting app developers to expand its connected health data ecosystem. Since the inaugural event, monthly patient‑directed data exchanges via Epic APIs have climbed from roughly 3.1 billion to...
The Centers for Medicare & Medicaid Services (CMS) finalized a 2.48% average increase in Medicare Advantage payments for 2027, translating to roughly $13 billion more than the agency’s modest 0.09% proposal earlier this year. When adjusted for risk‑score trends, the effective...
Utah’s state auditor found that hospital‑affiliated entities retained roughly $472 million of the $922 million collected through the Skilled Nursing Facility Upper Payment Limit program, leaving only about $450.5 million for nursing homes. The audit, covering 2016‑2024, says 51 percent of supplemental Medicaid funds...
Premier Health, a five‑hospital system in Dayton, Ohio, is deploying two AI‑driven clinical decision‑support tools across its network. The first, UpToDate Expert AI, merges evidence‑based medical content with advanced artificial intelligence and has received approval from the system’s AI governance...
The Trump administration announced a 2.48% increase in Medicare Advantage payments for 2027, adding roughly $13 billion to the CMS budget—far above the 0.09% proposal and the market’s 1% expectation. The surprise boost sent UnitedHealth Group up 7.7%, Humana up 11.1%,...
A randomized trial at Cedars‑Sinai evaluated pharmacist‑led transition‑of‑care programs for adults 55 and older on multiple or high‑risk medications. Across 6,478 hospitalizations, the intervention did not significantly lower 30‑day overall or same‑hospital utilization compared with usual care. However, among patients...
Children’s Minnesota, the only pediatric‑only health system in the state, has resumed all services in its Gender Health program after a temporary pause that began on Feb. 27. The pause was lifted following a March federal court ruling that invalidated...
The National Labor Relations Board dismissed a petition to decertify SEIU Healthcare Pennsylvania as the bargaining representative for roughly 290 service and maintenance workers at UPMC Washington Hospital. The board ruled that a collective bargaining agreement ratified on February 10 2025, and...
Researchers at Penn State have created bio‑hybrid cell spheroids that self‑assemble like a snowball, rapidly increasing in size while preserving oxygen and nutrient flow. By embedding living cells in microgel particles, the new spheroids overcome diffusion barriers that traditionally limit...
When I lost my period at 14, the first thing my doctor did was put me on birth control. No questions about what I was eating. No questions about how much I was exercising. No investigation into why a 14-year-old...
Shameful and moronic: "Trump’s Immigration Policy Sidelines Foreign Doctors Amid Shortage: Physicians from 39 countries are being pushed out of U.S. hospitals as a policy blocks their ability to work." https://t.co/H5bNHlIhrz https://t.co/b1jQU4oIDU
Kansas Senate Bill 334, now law without Governor Laura Kelly's signature, eliminates the requirement that nursing faculty hold a credential one level higher than the program they teach. The change targets the chronic shortage of nursing educators by allowing instructors...
“The link between lack of sleep and cancer is now so strong that the World Health Organization has classified any form of nighttime shift work as a probable carcinogen." https://t.co/179qEbvyZe
Policy polarization is rewriting the American geography of longevity "...because where you live is increasingly tied to how you live, as state policy contexts within the country pull father apart, so too do the patterns of American longevity..." https://t.co/vofUi8dN3S https://t.co/c68k3lJ7gb
CAR‑T cell therapy, a personalized immunotherapy that re‑programs a patient’s T cells, has transformed treatment for certain leukemias and lymphomas but remains prohibitively expensive in Canada, with commercial products costing roughly $325‑$466 k USD per patient and requiring 4‑6 weeks for manufacturing....
Single dose of a psychedelic drug can rapidly reduce depressive symptoms, clinical trial suggests https://t.co/c72qpfwQPm https://t.co/xR7hbj4v8e
Great reporting from @Philanthropy on our grantee @CuresWReach, which runs small trials testing whether existing, approved drugs might work for entirely different diseases.
The Trump administration approved a 2.48% increase in Medicare Advantage payments for 2027, adding roughly $13 billion to insurer reimbursements. This figure far exceeds the 0.09% hike originally floated in January. The larger rate boost lifted UnitedHealth, CVS Health and Humana...
Yes, among people who refused Covid vaccines during the delta and BA.1 omicron waves in 2021-22, that resulted in 200,000-300,000 needless deaths. They were victims of antivaccine activism driven by politics and the corrupt wellness/influencer industry pushing ivermectin, which did...
Michigan’s youth mental‑health system is collapsing, forcing an increasing number of children to be placed in out‑of‑state treatment facilities as local beds close. Placements rose from 74 in 2023 to 152 by September 2025, with some families traveling to Missouri,...
Dr. Mehmet Oz highlighted that 221 hospice providers have been suspended in the Los Angeles area, underscoring an unprecedented scale of abuse. Federal and state officials, including the California Attorney General, announced arrests and a coordinated crackdown on the alleged...
