What's happening: FDA places Regeneron's anti‑activin A antibody garetosmab under priority review
The FDA has granted priority review to Regeneron's garetosmab for the rare disease fibrodysplasia ossificans progressiva, with a decision expected by August. Phase 3 OPTIMA results showed a 94% reduction in new heterotopic ossification lesions at the lower dose and a 90% reduction at the higher dose, alongside a >99% drop in lesion volume.
Also developing:

Carroll County, Maryland launched a Whole Blood Program in May, enabling paramedics to carry and transfuse 500‑ml Type O‑positive units on scene. The initiative has saved 14 lives and been used 17 times, with 100% survival for internal hemorrhage cases and roughly 50% survival for crash‑related injuries. A federal Rural Health Transformation grant of $911,000 now funds the program for the next five years. Carroll became the 350th EMS system nationwide and the fourth county in Maryland to adopt the practice.

"Immune Reset" Rebooting the immune system by depletion of B cells, like a reboot of a computer, to achieve cures vs autoimmune diseases https://t.co/253NtyFmCN

Researchers at Vrije Universiteit Amsterdam built an 80‑compound, three‑dimensional fragment library and screened it against the histamine H1 receptor. Only one fragment (1a) showed activity, but iterative optimization yielded the low‑nanomolar antagonist VUF26691 with picomolar cellular potency. The campaign required...
Prime Healthcare conducted a nine‑month, 13‑hospital trial of two virtual sitter models—an integrated turnkey vendor and a split‑component approach—to enhance patient safety in Phase 2 of its virtual care strategy. The integrated model, which supplies hardware, software, and remote observers, outperformed...

p-tau217 is a breakthrough blood test for risk of developing Alzheimer's disease. Important to know there are sex differences for this biomarker, with women having higher values at baseline and more tau deposition. @JAMANeuro https://t.co/Xrr8SjsiVY https://t.co/eyDt6mgSqR

A psychedelic quickly reduced depression (in patients with major depression disorder) in a small, double-blind placebo randomized trial @NatureMedicine https://t.co/vvug72VGBi https://t.co/Tn58rP0ufS

The fourth quarter of 2025 marked the first quarter‑over‑quarter rise in biopharma job postings, with a 10% increase and a 4% uptick in average listings, despite a 14% year‑over‑year decline. Science/research and development roles grew 14% while clinical positions surged...
The article traces the shifting terminology of digital health records, noting that the "electronic health record" (EHR) label gained popularity during the Bush 43 era while earlier versions were called CPR and later EMR. It argues the rebranding served vendor pricing...

A new Science #Robotics study describes a #bionic eye that can simulate irregular pupils such as a cat’s vertical pupil for precise focus while hunting and a toad's heart-shaped pupil for improved depth perception. https://t.co/p1uZy6rbky https://t.co/X4pzdrnoIi

Direct‑to‑consumer advertising for prescription drugs is resurging, highlighted by Novo Nordisk’s $180 million spend on Ozempic TV spots in 2022 and $189 million in 2023. The ads use upbeat jingles and lifestyle imagery to present the GLP‑1 medication as a gateway to...

The lipid serine hydrolase PNPLA3, especially its I148M mutant, has emerged as a genetically validated driver of MASLD/MASH, prompting a wave of genotype‑focused drug programs. RNA‑based modalities—Arrowhead’s GalNAc‑siRNA ARO‑PNPLA3 and AstraZeneca/Ionis’ GalNAc‑ASO AZD2693—are in clinical trials aiming to lower mutant...
A pragmatic randomized trial in the southeastern US tested a 12‑month produce‑prescription program that gave diabetes patients at risk of food insecurity an $80 monthly debit card for fruits and vegetables. After enrolling 2,155 participants, the intervention showed no significant...
Medicare announced a sweeping transition to value‑based care, extending bundled‑payment and quality‑adjusted reimbursement models to virtually all Medicare‑eligible services. The initiative introduces new performance metrics that link payments directly to patient outcomes, with quarterly reporting requirements for participating providers. Early...

When the LLM rewrites the radiology report, patient understanding is increased and clinical accuracy is maintained. @LancetDigitalH @curtlanglotz @smrabd https://t.co/q2UHebBQG7 https://t.co/IwZAx59brY

Precision treatment with artificial intelligence assisted subtyping enhances therapeutic efficacy in HR+/HER2− breast cancer: The LINUXtrial https://t.co/UF4Lt3g5QK https://t.co/LWuJYD2qGh

On Jan 2026 the FDA issued updated guidance that relaxes oversight for low‑risk digital health products, including many AI‑enabled clinical decision support tools and consumer wellness wearables. The guidance clarifies which software falls outside the medical device definition, allowing these tools...

Virtual reality (VR) therapy shows rapid clinical effects but remains confined to pilot studies due to a lack of standardized dosage protocols. Researchers highlight wide variation in session length, frequency, and content across studies, preventing reliable comparison and scaling. The...

The article examines a proposed federal framework that would shift health‑affordability dollars into individual‑controlled accounts, highlighting that ownership of the payment infrastructure will decide market winners. It points to the rapid growth of high‑deductible plans, Health Savings Accounts exceeding $100 billion,...

The article contends that an over‑emphasis on formal assessment in residency programs suppresses residents' natural curiosity and deep reasoning. When attendings prioritize grading over dialogue, trainees like June learn to memorize correct answers rather than explore underlying mechanisms. This performance‑driven...

Researchers at the University of Tokyo applied a machine‑learning tool, AI‑IR, to estimate insulin resistance in half a million UK Biobank participants. The analysis revealed insulin resistance as a significant risk factor for twelve distinct cancer types, providing the first...

University of California, Irvine researchers have created the first cell-type-specific gene regulatory network (GRN) map for Alzheimer’s disease using a new machine‑learning framework called SIGNET. By integrating single‑nucleus RNA‑seq and whole‑genome sequencing data from 272 AD patients, SIGNET identified causal...
Roche announced that its anti‑CD20 antibody Gazyva (obinutuzumab) met the primary endpoint in the phase 3 MAJESTY trial for primary membranous nephropathy (pMN). The study showed significantly higher complete remission rates at two years compared with the immunosuppressant tacrolimus, while maintaining...

Cardiovascular disease remains the top U.S. killer, driven by the intertwined cardiovascular‑kidney‑metabolic (CKM) syndrome that links obesity, diabetes, and chronic kidney disease. About one‑third of adults carry three or more CKM risk factors, and 90% meet early‑stage criteria. Monogram Health’s...

Richard Pazdur, longtime FDA oncology leader, resigned after being pressured to endorse a controversial policy that would reduce required drug approval trials from two to one. He said Commissioner Marty Makary breached the traditional independence between the commissioner’s office and...

The MHRA has opened a public consultation proposing that CE‑marked medical devices be recognised indefinitely in Great Britain. Around 90% of devices used in the GB market currently carry a CE mark, and the agency aims to align transition timelines...

The article highlights a persistent gender gap in medical care for menstrual health, noting that up to 75% of menstruating individuals experience PMS and 3‑8% suffer from PMDD, yet these conditions remain underdiagnosed and underfunded. A survey of 3,000 Japanese...

In this episode, a16z partner Jorge Conde interviews Novartis CEO Vasant Narasimhan about reshaping the 250‑year‑old conglomerate into a focused medicines company, a move he estimates will unlock $180 billion of value. Narasimhan outlines Novartis’s three platform pillars—cell and gene therapies,...

The episode examines Epic Systems' recent courtroom setback in the CureIS litigation, focusing on the court's denial of a motion to stay discovery and the nuanced protective order regarding "Highly Confidential – Attorneys' Eyes Only" information. It highlights how Epic's...

César de la Fuente’s Penn team is using artificial intelligence to scour genomes for antimicrobial peptides, creating a library of over one million candidate sequences. The AI has uncovered promising molecules hidden in archaea, venomous species, and even extinct organisms...

A recent national study of 2,300 women aged 21‑65 found that 60.8% still prefer clinician‑collected cervical cancer screening over FDA‑approved at‑home self‑collection kits. While 20.4% expressed interest in home testing, the majority’s preference signals that traditional Pap and HPV specimens...
Medtronic has secured FDA clearance for its Stealth AXiS spine‑surgery robotics platform, an integrated solution that combines robotics, planning and navigation in a single workflow. The system features LiveAlign segmental tracking, delivering real‑time visualization of anatomical movement and reducing the need...
Researchers at the AITHYRA Institute introduced a high‑throughput chemical diversification platform that systematically creates molecular‑glue candidates and screens them directly in living cells. Applying the workflow to the leukemia‑associated protein ENL, they identified a small molecule that selectively induces ENL...

Brainomix unveiled its next‑generation Brainomix 360 Stroke platform at the International Stroke Conference, featuring an industry‑first net water uptake (NWU) metric derived from routine non‑contrast CT scans. The platform earned the Red Dot Design Award, highlighting its superior usability and innovative...

VISIE Inc. announced the launch of its Partner APIs, a robot‑agnostic interface that brings the company’s spatial computing and real‑time scanning capabilities to surgical robotics platforms. Built on gRPC and supporting multiple programming languages, the APIs deliver scanner control, object...

TechRadar’s Graham reviews Sentai, a UK‑made AI voice companion built for seniors living independently. The speaker delivers reminders, medication prompts, and conversational companionship while deliberately avoiding constant listening or surveillance. In testing, Sentri handled emotional cues, emergency alerts, and privacy...
Researchers introduced a microneedle patch (MN‑Mg) that simultaneously delivers hydrogen gas and magnesium ions directly into the injured spinal cord. The hydrogen component rapidly scavenges reactive oxygen species, cutting oxidative stress by roughly 55%, while the magnesium release sustains microglial...

Google’s AI Overviews, which appear atop search results, provide health answers without an upfront safety disclaimer. The only warning—"For informational purposes only"—shows after users click the “Show more” button and is rendered in a smaller, lighter font. Experts say this...
Researchers at KRIBB demonstrated that the pharmaceutical excipient n‑dodecyl‑β‑D‑maltoside (DDM) can pre‑activate innate immunity, delivering complete survival in mice challenged with multidrug‑resistant bacteria and lethal influenza. The protection stems from selective neutrophil mobilization that activates only upon pathogen detection, avoiding...

Everdrone and the Ambulance Services Administration in Region Stockholm have signed an agreement to roll out an autonomous emergency‑response drone system. The drones will transport defibrillators to suspected cardiac arrests and deliver early situational awareness at accident scenes. Placement of...

Artificial intelligence projects in pharma face a steep attrition rate, with roughly 80% of pilots never reaching production. The primary barrier is not algorithmic sophistication but fragmented data silos and delayed governance that hinder scalable deployment. Experts argue that interoperable,...

Sword Intelligence has launched its AI‑driven care‑operations platform in the UK, aiming to automate triage, coordination and scheduling to ease NHS waiting‑list pressures. The company is also building one of Europe’s first AI‑powered healthcare “front doors” in Greece for a...
The United States faces a potential decline in biotech leadership as recent Supreme Court decisions blur patent eligibility and congressional price‑control measures under the Inflation Reduction Act force program cancellations. Proposals to seize university licensing revenue further strain tech‑transfer offices,...

Medical clinics face chronic cash‑flow volatility due to delayed reimbursements, labor costs, and fragmented financial systems. The article argues that the structure of a clinic’s checking account is a core revenue‑cycle asset, not merely a passive fund holder. By integrating...
Siemens Healthineers and the Mayo Clinic announced an expanded partnership aimed at accelerating imaging and interventional care across several high‑impact disease areas. The collaboration will integrate Siemens’ AI‑enhanced imaging platforms with Mayo’s clinical expertise to develop new diagnostics for neurodegenerative...

Yuanhua Tech’s HX Orthopaedic‑specific Robotic Arm has been clinically validated at West China Hospital of Sichuan University, marking the first domestically developed orthopaedic surgical robot in China. The system demonstrated zero‑lag, zero‑error performance and incorporates high‑precision zero‑gravity compensation, compliant control,...

South Korean AI firm Neurophet secured FDA 510(k) clearance for its AQUA AD Plus software, enabling quantitative MRI and PET analysis for Alzheimer’s treatment planning. Japanese health‑tech startup Ubie partnered with Mayo Clinic to roll out a unified digital front‑door...

DailyRounds posted a Rs 363 crore profit on Rs 641 crore operating revenue for FY25, marking a 13% rise in both profit and revenue from FY24. The company’s flagship subscription platform Marrow contributed 88% of revenue, while non‑operating income added Rs 132 crore....