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Daily
Every morning
Weekly
Tuesday recap
Gilead to acquire Germany’s Tubulis for up to $5B, bolstering oncology pipeline
Gilead Sciences announced it will buy Tubulis GmbH for up to $5 billion, adding the biotech’s antibody‑drug conjugate platform to its portfolio. The deal follows Gilead’s recent $7.8 billion purchase of Arcellx and a $2 billion acquisition of Ouro Medicines as it pivots toward cancer therapies. Tubulis’ lead ADC candidate will join Gilead’s expanding oncology roster.
Also developing:
By the numbers: Neurocrine Biosciences acquires Soleno Therapeutics for $2.9B
In February, Kezar Life Sciences secured an FDA agreement for a clinical trial on autoimmune hepatitis, but the meeting was cancelled four months late, prompting the biotech to begin winding down. Meanwhile, U.S. physicians are increasingly prescribing oral GLP‑1 weight‑loss drugs, with Novo Nordisk’s Wegovy pill already in use and Eli Lilly’s newly approved Foundayo entering the market. The oral obesity‑treatment segment is projected to exceed $100 billion annually within a decade. These developments highlight regulatory risk for small biotechs and a shifting preference toward convenient, lower‑cost weight‑loss therapies.
The MOMENTUM study of 1,086 patients with resistant hypertension found that 27.3% had endogenous hypercortisolism. Nearly a quarter of those positive cases displayed adrenal nodules, and 21.5% also had primary hyperaldosteronism, with 5.9% harboring both disorders. Hypercortisolism was associated with...
American Association of Clinical Endocrinology (AACE) released its 2026 consensus algorithm for managing adult type 2 diabetes, the first revision since 2023. The update introduces a diagnostic classification chart to confirm type 2 diabetes and adds metabolic dysfunction‑associated steatotic liver disease (MASLD)...
Researchers have engineered a bifunctional antibody fragment that simultaneously blocks Marburg virus attachment and neutralizes the exposed receptor‑binding site after the virus undergoes its conformational change. By mimicking the host cell receptor, the antibody tightly binds the viral protein, shutting...
Microsoft’s new low‑code AI platform lets healthcare staff build custom agents without programming expertise, enabling rapid solutions for clinical and back‑office challenges. By offering drag‑and‑drop interfaces and pre‑built connectors to electronic health records and billing systems, the tool democratizes agentic...
Neurocrine Biosciences agreed to acquire Soleno Therapeutics for $2.9 billion, securing the rare‑disease drug Vykat XR. Vykat generated $190 million in 2025 sales, including $92 million in the fourth quarter, but recent safety concerns and a slowdown in new patient starts have clouded its...
CuraTeQ Biologics, a subsidiary of Aurobindo Pharma, announced positive top‑line results from its Phase 3 trial of BP11, a biosimilar to omalizumab (Xolair). The study enrolled 608 patients across 80 sites in seven European countries and India, meeting all primary endpoints...
The European MedTech sector is entering a phase of industrial maturity, with the global market projected to grow from $549.5 billion in 2025 to $853.4 billion by 2035 at a 4.5% CAGR. Investment is concentrating in three emerging hubs—Ghent, Porto, and Wroclaw—each...
WELL Health announced a partnership with AliveCor to bring the Kardia mobile ECG platform to Canadian patients. The collaboration enables remote cardiac monitoring and real‑time cardiologist review through WELL Health’s telehealth network. By integrating AliveCor’s FDA‑cleared devices, the service aims...
Steven Kheloussi, PharmD, argues that smarter clinical decision‑support tools and multidisciplinary teams are essential for effective multiple sclerosis (MS) management. He highlights how integrated EHR‑embedded tools can consolidate relapse history, MRI data, and patient preferences to guide personalized therapy, while...
The article reviews current intraocular lens (IOL) fixation methods for complex cataract surgery, focusing on scleral‑sutured, Yamane‑type sutureless intrascleral, iris‑claw, and piggyback lenses. It highlights the Yamane technique’s advantages in reducing inflammation, eliminating suture‑related complications, and delivering stable centration. Iris‑claw...
Ben Beckley, CEO of RevHealth, warns that AI is now the primary gateway to pharmaceutical information, turning search into zero‑click answer delivery. Pharma must move from traditional content publishing to engineering discoverability with machine‑readable, citation‑dense data that AI can surface...
Healthcare brands are shifting toward direct‑to‑consumer (DTC) engagement, expanding patient portals and digital front doors. Traditional commercialization stacks—data providers, manual intelligence, and media execution—remain siloed, limiting how quickly insights can be applied. While enterprises build internal data lakes and proprietary...
Getting an education is important for a lot of reasons, but there might be one reason you haven’t heard — it could lower your risk of dementia later in life. Decades of research have supported this claim, with one study...
Researchers at Vanderbilt have leveraged a protein‑observed NMR fragment screen to revive interest in SARS‑CoV‑2 papain‑like protease (PLPro), an essential viral enzyme with few existing inhibitors. From 13,824 fragments, 77 hits were confirmed, leading to a non‑covalent series that progressed...
Rural and children’s hospitals in the United States face severe financial strain, with 45% operating at a loss and more than 300 at risk of closing. The Centers for Medicare & Medicaid Services has launched the Rural Health Transformation program,...
Stealth biotech Stipple is quietly advancing secretive antibody‑drug conjugates (ADCs) as the market races toward targeted cancer therapies. A recent four‑month FDA review delay forced a cash‑strapped small biotech to shut down, underscoring the existential risk of regulatory setbacks for...
Quemliclustat (AB680) is a highly potent (5 pM) selective CD73 inhibitor that completed a Phase I trial in healthy volunteers, demonstrating a pharmacokinetic profile suitable for biweekly intravenous dosing. Early clinical data showed promising activity, prompting a successful Phase II study in pancreatic...
U.S. non‑farm payrolls rose by 178,000 in March, far exceeding expectations, while the unemployment rate held at 4.3%. The healthcare sector drove much of the gain, adding 76,000 jobs, with ambulatory services and physicians’ offices leading the surge. Healthcare stocks...
Pharmaceutical companies face a hidden operational crisis: managing thousands of post‑approval changes across hundreds of markets using outdated, spreadsheet‑based processes. A typical large firm evaluates about 6,000 changes annually, generating roughly 90,000 country‑level regulatory filings that can take three to...
Cartography Bio secured FDA approval of an investigational new drug application and fast‑track designation for its T‑cell engager CBI‑1214, aimed at colorectal cancer. The clearance lets the company launch a Phase 1 study, marking a milestone for cellular immunotherapy in a...
A rare mitochondrial DNA point mutation (mtND4 m.11232T>C) has been linked to catastrophic neurologic injury in children exposed to the volatile anesthetic sevoflurane. The mutation, maternally inherited and prevalent among people of Venezuelan ancestry, was identified after decades of isolated...
A Workers’ Compensation Research Institute study of over seven thousand lost‑time claims across 34 states finds that provider networks lower total claim costs by 26%, saving roughly $11,820 per claim at 36 months. Medical payments drop 27%, about $3,500 per...
Family caregiving in the United States has surged to 63 million adults, a 45% increase since 2015, placing unprecedented strain on hospice providers. End‑of‑life caregivers average 20 hours of support per week, juggling medical, logistical, and emotional duties. Hospices are responding by...
As a medical school professor, I teach that sleep matters for metabolism. But now we have the precise number. A study of 23,475 adults published in BMJ Open Diabetes Research & Care found the optimal sleep duration for preventing insulin resistance:...
Centene announced creation of two senior executive roles, naming Daniel Finke as group president of markets and commercial and Michael Carson as group president of Medicare and specialty. The moves come as the insurer grapples with a $1 billion fourth‑quarter loss...
As a medical school professor, I never imagined a single mineral could be this important to gut health. But the data is staggering. A new study in Aging Cell found that magnesium levels decline specifically in the gut as we age...
The U.S. Food and Drug Administration issued a closeout letter to Media Networks Sydney Pty Ltd confirming that the company has discontinued its U.S. listings for Mylanta 2go Antacid Double Strength and Microlax Enema after corrective actions. The agency noted that...
Better than drugs and injections for low back pain: -Exercise -Physical Therapy -Chiropractic -Acupuncture -Yoga -Tai Chi -Cognitive Behavior Therapy Prioritizing your MENTAL and PHYSICAL health is the best form of medicine.
Recent commentary warns against the allure of one‑drug cancer cures, arguing that such reductionist approaches echo past failures in oncology. While repurposed agents like ivermectin and fenbendazole demonstrate laboratory activity, the author cites severe side effects, including a patient death,...
Great tables from Wedbush listing small molecule oncology and hemonc drugs ordered by approval date. I counted ~20 different classes for solid tumors and ~6 for liquid, most revenues are driven by a handful of classes that reached multi...
What happens when you give engineered cells their own wireless oxygen supply inside a thumb-drive-sized implant? https://spectrum.ieee.org/biologic-drugs-implant-bioelectronics-medicine?share_id=9322774
Researchers have identified a novel method to boost the brain’s waste‑disposal system by targeting the DDR2 receptor, a protein previously studied for lung health. In mouse models, blocking DDR2 lowered amyloid‑beta production and enhanced clearance of toxic protein aggregates, leading...
MedTech Innovator is debuting the Radar Forum, a single, invite‑only event held April 7‑9, 2026 in Manhattan Beach that replaces its previous multi‑city road‑tour pitches. The three‑day forum will host roughly 500 attendees, including 300 top experts who will evaluate the top...
Affinia Therapeutics has secured Health Canada approval to launch the UPBEAT© Phase 1/2 trial of its gene‑therapy candidate AFTX‑201 for BAG3‑associated dilated cardiomyopathy. The investigational product delivers a full‑length BAG3 transgene via a proprietary low‑dose AAV capsid, aiming for a one‑time...
The White House Office of Management and Budget’s FY 2027 budget proposal slashes health‑care spending, cutting the Department of Health and Human Services by $15 billion (12% less than FY 2026) and proposing a $911 billion reduction in Medicaid over ten years. At the...
Neurocrine BioSciences announced a $2.9 billion acquisition of Soleno Therapeutics, paying $53 per share for the rare‑disease specialist. The deal brings Soleno’s late‑stage Prader‑Willi syndrome therapy into Neurocrine’s growing portfolio. Soleno, a profitable company, adds a commercial platform and additional rare‑disease...
Capitol Imaging Services, a 60‑location outpatient imaging network in the Gulf South and Southeast, is piloting an AI‑enabled radiology information system (RIS) to automate front‑office tasks. Partnering with AbbaDox, the group uses an AI voice agent named Abby to parse...
On April 4, 2026, attorney Rick Jaffe filed a massive 903‑page appeal challenging Judge Brian Murphy’s injunction that freezes all CDC childhood vaccine schedule changes. The judge ruled that only the agency’s advisory committee could originate policy, effectively paralyzing the CDC’s...
Neurocrine Biosciences announced a $2.9 billion cash acquisition of Soleno Therapeutics, marking its first foray into metabolic diseases. The deal secures Vykat XR, the inaugural FDA‑approved treatment for hyperphagia in Prader‑Willi syndrome, expanding Neurocrine’s rare‑disease portfolio. Soleno shareholders receive $53 per share,...
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Long‑term care costs in U.S. nursing homes have risen to an average of about $10,000 per month in 2026, with prices ranging from $5,800 in low‑cost states to over $32,000 in high‑cost markets like Alaska. Medicare only pays for the...
Stipple Bio, founded by cancer biologists Aaron Ring and colleagues, announced its launch with a $100 million Series A round. The company’s mission is to pinpoint highly precise binding sites on cancer‑related proteins, steering clear of oversaturated targets like PD‑1×VEGF or HER2....
During Parkinson’s Awareness Month 2026, GlobalData reports a clear shift in the drug development landscape toward alpha‑synuclein as the top therapeutic target. While 53% of the 64 approved Parkinson’s drugs still focus on dopamine receptors, the pipeline now includes 62...
If you prescribe GLP-1s, you are not just starting a medication. You are setting expectations for a chronic disease. That is the tension at the center of this episode of The Podcast by KevinMD with obesity medicine physician Jessica Duncan. One of...
I remember interviewing Bill Dalton in 2005 about new developments in myeloma and how he wished for new regimens to take OS out beyond 3-4 yrs. Two decades on we've hit jackpot...
Chinese biotech Syneron Bio announced a $150 million Series B financing round, bringing its total capital raised to $250 million after a $100 million round last year. The funds will be allocated to advance its peptide therapeutic platform, a drug...
The big issue here surely is the lack of true empathy and therapeutic relationship. Care is not just diagnosis and treatment-it involves emotional support, motivation, and reassurance that AI cannot fully replicate. #AI #health #healthcare #aichatbot https://t.co/ImuiD51Vna
FDA calls to permanently re-authorize the rare pediatric disease PRV program in Friday's 2027 budget plan -- far cry from the FDA that complained to the GAO about PRVs as distracting from their public health priorities https://t.co/i79F7X1ECw
How a four-month FDA delay forced a small biotech company to close its doors https://t.co/6vMGJM5SjH
Late-life disability following the action for health in diabetes (Look AHEAD) trial 😷Regardless of age, those with higher BMI had increased late-life mobility and IADL disability. https://t.co/QeU9TJhf9y https://t.co/zeCNrGcO7x
