Know What's Happening in Healthcare
Know What's Happening in Healthcare
FDA approves KRESLADI, first CIRM‑backed gene‑editing therapy
The FDA cleared KRESLADI, a gene‑editing treatment from Rocket Pharmaceuticals for severe leukocyte adhesion deficiency‑I in children, eliminating the need for a bone‑marrow donor. It is the first product directly funded by California’s Institute for Regenerative Medicine to receive approval.
Also developing:
By the numbers: Syneron Bio raises $150M Series B
Researchers at Penn Vet used lipid nanoparticles (LNPs) to deliver FAP‑CAR mRNA directly to patients' T cells, enabling in‑vivo engineering of CAR T cells that attack cancer‑associated fibroblasts in pancreatic ductal adenocarcinoma. In a preclinical mouse model, a single dose of targeted LNPs achieved 40‑60% CAR expression on T cells and markedly reduced the desmoplastic matrix, slowing tumor growth more effectively than conventional ex‑vivo CAR T therapy. The technique simplifies manufacturing, cuts costs, and opens the door for combination regimens. The findings suggest a scalable path to bring CAR T therapy to solid tumors.
A retrospective cohort of 118,740 Israeli adults found that serum IgE levels below 25 IU/mL were associated with almost double the hazard of developing chronic lymphocytic leukemia (CLL) over a seven‑year follow‑up. The multivariable Cox model adjusted for age, sex, obesity,...
A new longitudinal study of 83 healthy military personnel tracked cardiac biomarkers after two mRNA COVID‑19 vaccine doses. Within two weeks of the second shot, 49% of participants exhibited a rise in NT‑proBNP exceeding 1.5 times their baseline, indicating subclinical...
Researchers at Tongji Hospital in Wuhan built a closed‑loop digital intelligence platform that integrates scheduling and report dispatch into the electronic health record. Post‑implementation, exam volume rose 66.4% while CT appointment times fell 72.4% and MRI times dropped 33.8%. However,...
Soficabtagene geleucel (WU‑CART‑007), an off‑the‑shelf CRISPR‑engineered CAR‑T therapy, received FDA Breakthrough Therapy Designation for relapsed or refractory T‑cell leukemia and lymphoma. In a phase 1/2 trial of 28 patients, the drug achieved a 91% overall response rate and a 73% complete...
New data from the PRO‑TAVI trial, presented at ACC.26 and published in The Lancet, show that deferring percutaneous coronary intervention (PCI) in elderly patients undergoing transcatheter aortic valve replacement (TAVR) yields outcomes comparable to performing PCI beforehand. The trial enrolled...
Orthopedic surgeons from the American Association of Hip and Knee Surgeons spent a day lobbying in Washington, D.C., highlighting steep Medicare reimbursement cuts and advocating for continued support of alternative payment models (APMs). The group met with congressional staff, testified...
A newly introduced bill in Congress would grant workers up to 12 days of paid reproductive health leave each year, covering period pain, menopause, IVF, miscarriage, and endometriosis. The legislation responds to the fact that roughly half of women experience...
Stanford researcher Shebani Sethi’s metabolic psychiatry framework is drawing unprecedented attention after health secretary Robert F. Kennedy Jr.’s diet‑cure claim sparked debate, and a landmark Nature Mental Health review consolidates evidence that metabolic dysfunction fuels psychiatric illness. The emerging field...
Kobe University researchers engineered a synthetic right‑handed (D) peptide that binds amyloid‑beta, the disordered protein driving Alzheimer’s plaques, and blocks its aggregation. In mouse brain cell cultures the mirror peptide restored cell viability to 100%, compared with 50% survival when...
The Fourth Circuit affirmed a preliminary injunction that blocks West Virginia’s Senate Bill 325, which would have forced drug manufacturers to extend 340B discounts to prescriptions filled by contract pharmacies. The injunction, originally issued by a West Virginia district court,...
Researchers led by Dr. Bedoyan, Dr. Morgan and Dr. Sun completed a phase 1/2 trial that used nuclease‑free homologous recombination to edit the genes of children with methylmalonic acidemia. The therapy lowered toxic metabolite levels and showed durable engraftment without...
In this episode, senior fellow Jessica Rose discusses her forthcoming paper on the shortcomings of the U.S. Vaccine Adverse Event Reporting System (VAERS) and proposes a modernization framework. She highlights structural issues such as poor data quality, under‑reporting, lack of...
GoHealth reported full‑year 2025 results showing a sharp decline in revenue and profitability as it intentionally scaled back Medicare Advantage activity. Net revenues dropped 55% to $361.8 million, and Adjusted EBITDA swung to a $35.1 million loss. The company emphasized a consumer‑first...
The Food and Drug Administration is preparing to reverse its 2023 restriction on dozens of experimental peptides, permitting licensed compounding pharmacies to produce them again. The move follows Health Secretary Robert F. Kennedy Jr.’s public promise on the Joe Rogan...
Company owner announced that the former chief financial officer has agreed to repay the $21 million he owes to the firm. The statement, reportedly supported by a video, aims to reassure stakeholders about the company’s financial stability. This repayment pledge follows...
I was interviewed about a study of GH001, vaporized 5-MeO-DMT, for treatment-resistant depression. I commented that, while promising and encouraging, the thing that popped out to me was the almost complete lack of placebo response in the placebo group. Even...
Samantha Jacques, senior leader at McLaren Health Care, is spearheading a public‑private partnership through the Health Sector Coordinating Council to safeguard connected clinical environments. Her team delivers unified guidance that addresses the rising tide of cyber threats targeting hospitals and...
A coalition of 17 public‑health researchers and advocates from North America and Europe issued a joint statement calling for stricter regulation of glyphosate after a University of Washington symposium. They cite compelling evidence linking the herbicide to cancer, particularly non‑Hodgkin...
CareCloud, a publicly traded healthcare‑technology firm, disclosed a cyberattack that knocked out one of its six electronic health‑record environments for eight hours on March 16, 2026. The breach may have allowed attackers to view or copy patient information, prompting a...
Biogen announced a definitive agreement to buy Apellis Pharmaceuticals for $41 a share in cash, valuing the transaction at roughly $5.6 billion. The deal lifts Apellis shares 135.7% to $40.28 and adds two marketed complement‑inhibitor drugs, EMPAVELI and SYFOVRE, to Biogen’s...
Joseph Mikhael, MD, highlights a dramatic shift in multiple myeloma care for older adults, driven by refined frailty assessments and the rise of targeted immunotherapies such as CAR‑T cells and bispecific antibodies. These advances have translated into higher survival rates...
Over the past two years, the HFMA Oklahoma Chapter partnered with the University of Oklahoma Hudson College of Public Health to embed HFMA certifications into the MHA curriculum. The collaboration has led 54 students to earn the Certified Specialist in...
Pennsylvania enacted Act 57 of 2025, creating an ENDS directory that limits market access to products with FDA PMTA approval before September 9, 2020. The law imposes a $50,000 surety bond, $2,000 per brand‑family and $200 per brand‑style certification fees, plus annual renewals, and...
Medical devices are becoming increasingly sophisticated, blurring the lines between engineering and information technology responsibilities, says McLaren Health Care’s Samantha Jacques, a HIMSS26 Changemaker Award winner. She argues that effective device management now demands close collaboration between clinical engineers and...
A new animal study suggests that erythritol, a zero‑calorie sugar alcohol popular in low‑carb foods, may promote blood clot formation in the brain, raising concerns about stroke risk. Researchers observed increased cerebral clotting in mice fed typical dietary levels of...
Pharmaceutical companies launched an eight‑day acquisition blitz, with six firms announcing deals worth about $25.5 billion. Two of those transactions involve upfront payments exceeding $5 billion each, underscoring the aggressive pace. The deals focus on securing biotech pipelines and specialty drug assets...
The phase 2 ACCESS trial demonstrated that post‑transplant cyclophosphamide (PTCy) combined with tacrolimus and MMF enables high‑survival outcomes for patients receiving mismatched unrelated donor peripheral blood stem cell transplants. One‑year overall survival reached 86% for donors mismatched at less than 7/8...
I'd like to draw your attention to my fantastic @statnews colleague @elaineywchen. She led the way our obesity drug coverage, is a host on our podcast, and writes our biotech newsletter most days. Today has two big examples of the...
The Centers for Medicare & Medicaid Services issued a Quality and Safety Special Alert urging hospitals to redesign patient meals in line with the updated Dietary Guidelines for Americans, which prioritize fruits, vegetables, whole grains, and minimally processed proteins while...
The British Columbia Human Rights Tribunal dismissed a registered nurse's challenge to a COVID‑19 vaccine mandate, ruling that a vague medical note does not constitute a protected disability and that a genuinely held political belief does not exempt compliance with...
The U.S. Supreme Court issued an 8‑1 decision that treats gay conversion therapy for minors as protected speech, sharply limiting states' ability to ban the practice. Author Garrick Conley, whose memoir *Boy Erased* chronicled his own abusive experience, described the...
Haag‑Streit has launched its Metis 3D Digital Heads‑Up Module worldwide, extending the Metis 900 microscope line with a 4K, 3‑D visualization platform. The system places a high‑resolution screen in the surgeon’s line of sight, allowing a more upright posture and reducing neck...
March has been colorectal cancer awareness month. A reminder of the work of Bert Vogelstein, one of the most cited cancer researchers in history. He showed that colorectal cancer is a slow, stepwise process (often over 20–25 years): normal tissue ➡️...
MIT researchers unveiled a myoneural actuator (MNA) that rewires sensory nerves to transform existing muscle into a fatigue‑resistant, computer‑controlled motor for paralyzed organs. In rodent models the MNA restored intestinal squeezing and mimicked residual calf muscle function while sending sensory...
Researchers at Brown University analyzed over 75,000 low‑dose CT scans from the National Lung Screening Trial, covering more than 26,000 participants. They found that about 7% of exams contained significant incidental findings (SIFs) that were cancerous, and roughly 3% of...
Around 60 blood banks, including 29 charitable ones, operate in Lucknow despite repeated Food Safety and Drug Administration (FSDA) inspections that uncovered critical safety lapses. Inspections have repeatedly flagged missing testing equipment, absent qualified doctors, and poor record‑keeping, yet many...
Canadian psychiatrists testified before a parliamentary committee that expanding Medical Assistance in Dying (MAiD) to include mental illness alone is premature. They highlighted unreliable data, inadequate screening for suicide risk, and a surge in Track 2 MAiD use among vulnerable groups....
CMS‑0057‑F, a new regulatory mandate, is prompting health plans to shift from viewing it as a compliance burden to a strategic advantage. Payers are aligning the rule’s four required APIs with business goals, automating prior‑authorization, and improving data sharing. By...
A six‑year, single‑center study of 1,001 eyes shows the PreserFlo MicroShunt dramatically lowers intraocular pressure (IOP) and medication use in glaucoma patients. IOP fell from a baseline 24.8 mmHg to 9.6 mmHg one day after surgery and remained around 13.7 mmHg through four...
Tenpoint Therapeutics announced that Yuvezzi, the first FDA‑approved eye‑drop for presbyopia, is now commercially available in the United States. The formulation combines carbachol 2.75 % and brimonidine tartrate 0.1 % to induce pupil constriction within 30 minutes, providing up to ten hours...
HFMA’s FastFinance newsletter has launched a podcast, offering finance leaders a new audio format for industry updates. A recent HFMA analysis reveals that non‑patient‑care services now generate the majority of hospital revenue, with patient‑care share varying widely by hospital type....
Researchers at Lund University have unveiled a deep joint‑learning AI model that can simultaneously identify five neurodegenerative conditions—including Alzheimer’s, Parkinson’s, ALS, frontotemporal dementia, and prior stroke—from a single blood sample. Trained on the Global Neurodegenerative Proteomics Consortium’s database of over...
It’s not even April fools yet and people are still making posts against vaccines and GLP-1 meds.
Whatever marketer came up with the reframe of closing down newborn baby nurseries to shave hospital costs and then declaring that “baby friendly” should get an award. Meanwhile mothers recovering from surgeries, third degree tears & other childbirth outcomes get...
The Nursing and Artificial Intelligence Innovation Consortium, led by FSU Dean Jing Wang, is tackling the gap between laboratory‑tested AI tools and real‑world nursing workflows. It aims to create national standards that embed nurses in AI‑enhanced clinical processes, ensuring predictions...
Study finds stroke can make undamaged parts of the brain appear younger as it rewires to aid recovery https://t.co/r39ZMz5AGU
Forget Antibiotics: These Killer Cells Wipe Out Deadly Superbugs in a Day by @ShellyFan https://t.co/KVAaK61555 https://t.co/cXP8loNRHn
Irregular Bedtime Doubles Cardiac Risk - https://t.co/zh3GeyBz0n via @neurosciencenew #sleep #lifestylemedicine #health #pavingwellness #CardioTwitter #hearthealth
Healthcare is adopting AI at 2x the rate of other industries. Lenovo’s Healthcare CTO calls it “assistive intelligence.” What that means for the hospital of the future. 👉 https://t.co/eGplzkBn4T @Lenovo @DukeHealth #CES2026 #HITSM
