One Year of Training at 63 Reveals Surprising Aging Insights
Interesting post today. I’ve written about how and why I trained at 62. Now I’m turning 63 and I always look back… But this post is different. It isn’t a rehash of the same program with a new number at the top. It’s what a year of actually living that program taught me — what held, what changed, what surprised me, and what my aging biology had in store for me. If the first post was the plan, this one is the honest accounting of the previous year. https://t.co/SwQBeeXEIU
Neural Computers Turn AI Into Integrated Computing Substrate
🚨 NEW paper from Meta What if the model wasn’t just using the computer… but actually became the computer? A new paper from Meta AI + KAUST makes a compelling case for Neural Computers (NCs) — a paradigm where computation, memory, and...
Hyatt Pretends Free Toiletries, Then Charges Guests
Hyatt Hotel Puts Bathroom Soap And Lotion On The Counter Like They’re Free — Then Charges Guests For Using Them - View from the Wing https://t.co/1pEpTaNr12
Obsession, Not Accident, Drives Wealth and Fitness
If you want to achieve anything great, it needs to become your one true priority. The only thing on your mind. Nobody accidentally got rich from business. Nobody accidentally built a great physique. They were obsessed with it for multiple...
Inside My Trader Mind: Schwab’s Brain Scan Reveals
Charles Schwab scanned my brain for their Mind of a Trader series and here's what they found👇 https://t.co/rK220rqekN
Beyond Behavior Management: Building a Nervous System
Say it with me: I am not just managing behavior. I am building a nervous system.
Neocognitron: 1980 Japanese Breakthrough that Birthed CNNs
#otd in 1980 a Japanese computer scientist published a paper proposing the “Neocognitron,” the neural net that directly inspired CNNs: https://t.co/v7TCOMPN6x Kunihiko Fukushima’s paper explained back in 1986: https://t.co/vaIJlc5GdV https://t.co/SgyWzAorUX
Cut Phone Distractions to Unlock 10x ARR Growth
The path to 10x ARR growth starts with being less distracted. The average founder picks up their phone over 150 times per day.
Rom‑com “You Me And
Issues for #YouMeAndTuscany with just $3.1M Friday, weekend in $8M range Rom-coms just don’t sell like they used to
Open‑minded Apprenticeship Accelerates Personal and Organizational Growth
Trainees must be open-minded; the process requires them to suspend their egos while they discover what they are doing well and what they are doing poorly and decide what to do about it. The trainer must be open-minded as well,...
Threats Won’t Stop Kids, They Cost Money
Told my 10yo and my 5yo to stop hitting each other or I'd destroy their entire civilization. Now they are still fighting but I have to put a twenty dollar bill in a machine on their door to go into their...
B12‑producing Gut Microbes Linked to Colorectal Cancer Progression
Some interesting nuggets in this study which found microbiome subspecies prevalence associated with colorectal cancer (CRC). And one highly associated subspecies makes Vitamin B12. "Interestingly, higher concentrations of B12 are measured in the serum of CRC patients, and these B12 levels...
Solidarity Struggles When You Have Cool Things
“Solidarity can be difficult if you’ve got cool stuff to lose” I can’t tell if that’s a great line or a terrible one, but either way, I love the new Strokes single https://t.co/DqwWUdXYNP
Invisible Parenting Patterns Can Cause Childhood Trauma
Not all childhood trauma comes from abuse. Sometimes it grows quietly in everyday parenting patterns. When children feel unseen, constantly compared, or emotionally responsible for adults, it shapes how they see themselves and the world. Healthy parenting doesn’t mean perfection. It means awareness, connection,...
Epigenetic Clock Detects Aging and Cancer via Blood Test
This is the future: An epigenetic clock for the simultaneous assessment of biological aging and cancer from a simple, cheap blood test 👏 https://t.co/uzGoZWos9C
Luke's Moto Quest: Uncharted Gravel Roads and Mystery Camping
This weekend we have a Moto adventure to go on https://t.co/DjXeGbQIwi This time Luke is out with his motorcycle for an adventure in a remote national forest With hundreds of miles of gravel roads to explore, where will he ended up camping at,...
1917 Artists Declare Greenwich Village Independent Republic
1917, WITH WWI RAGING IN EUROPE, Marcel Duchamp, John Sloan & others broke into NYC’s Washington Square Arch, climbed to top, & declared Greenwich Village an independent republic— as memorialized in Sloan’s “Arch Conspirators.” Second image is Duchamp. From mlobelart
Spinoza Meets Boltzmann Brain in Keating
The Book Spinoza Would Have Written If He Had Boltzmann’s Brain (Review of The Mattering Instinct by physicist Brian Keating) @platobooktour https://t.co/Ji8gHpQFeD
HTRAB: The Essential Book for Understanding Reality
My single most recommended book to read, to literally everyone, assuming they're going to read more than one. HTRAB is 100% my brain's foundational system for understanding reality, much less text. (1/5)
Your N=1 Outweighs Any Randomized Controlled Trial
Your N = 1 is more relevant to you than any RCT will ever be.
Spatial Biology, Single‑cell Profiling, and AI Map T‑cell Immunity
Towards Spatial Medicine for individualized cancer immunotherapy @SciImmunology "The convergence of spatial biology platforms, single-cell immune profiling, and machine learning is positioning the community to decode how T cell immunity is spatially organized in human tissues and to exploit that organization...
Aorta Ages First, Driving Heart Disease
13 major organs age at different rates. - Aorta: onset ~30, peak ~55 - Adrenal gland: onset ~30, peak 45-55 - Spleen: onset ~30, peak 45-55 - Pancreas: onset ~35, peak 45-60 - Liver: onset ~40, peak 50-60 - Muscle: onset ~40, peak 55-68 - Heart: onset...
PPIs May Deplete Fertility‑Critical Nutrients—Get Tested
If you have been on a proton pump inhibitor for reflux or heartburn for more than a few months, it is worth noting that it can deplete you of certain nutrients. PPIs suppress stomach acid, which your body needs to...
Mindful Cooking Transforms Chores Into Purposeful Self‑care
Mindful cooking connects me to my senses and brings me back to myself. It turns a chore into a sense of purpose. One where I get to give love to myself and others.
Progerin Bridges Premature and Natural Aging, Biomarker Potential
Progerin expression in humans: implications for natural ageing "These insights may collectively position progerin as a mechanistic link between premature ageing and physiological ageing, positioning it as a potential component of biomarker strategies." https://t.co/KZuV0c7TOK
Extreme 3x20s Workouts Leave You Exhausted, Nauseous
I just saw someone recommend 3x20sec all out, max effort with 2min rest 3 day a week as a time saver for exercise.. Sure…until you realize you’ll be lying on the ground for 20min after with a headache, unable to function,...
Playful Parenting: Singing Fugazi About My Chunky Baby
Singing Fugazi to my chunky 5-month-old: “You are a heavy boy; you weigh, you weigh, you weigh, you weigh.”
Cell‑free DNA Manufacturing Eliminates Cloning Bottlenecks
Your DNA synthesis workflow is probably slowing you down more than you think. Cloning introduces delays, contamination risk, and hard limits on what you can build. Most of the field is still living with these constraints — even as mRNA therapeutics,...
Fossil Firms Favor GWP100 to Dodge Real Climate Action
Fossil companies support GWP100 over GWP20 because GWP100 allows them to do nothing about air pollution or global warming-to continue spewing BC, CH4 & O3 precursors & proposing fake solutions to CO2 (carbon capture, direct air capture, blue H2, electro...
Even Well‑supported Employees May Need to Be Let Go
“If an employee has been managed effectively, given support, encouragement & feedback, and adequate time & opportunity to prove themself, all to no avail, then you must take further action—even dismissal. Yet many mgrs. shy away from this.” https://t.co/gNw3MlEKqF #leadership https://t.co/eRy2hJISjb
10,000 Rare Live Recordings From Nirvana to Phish Released Online
Amazing. From Early Nirvana To Phish, A Chicago Fan's Secret Recordings Of 10,000 Shows Are Now Online https://t.co/0ToFE4VRlI
Inflammation: Essential Defense, Harmful When Dysregulated
Inflammation is often portrayed as harmful and linked to chronic disease, but is it always bad? This blog explores how inflammation is a vital, tightly regulated part of immune defence, and why problems arise when it becomes dysregulated. Click here:...
Uncomfortable Conversations Drive Higher Income
I'm convinced your income is directly proportional to: The number of uncomfortable conversations you're willing to have. • Turn people away • Raise your prices • Ask for the sale • Fire bad clients Comfort keeps you broke
Lost Lambs: My Sole 5‑star Read of 2024
The only novel I’ve rated 5 stars so far this year, of the 38 I’ve read 📚 Here’s why I think you should read Lost Lambs by Madeline Cash 🐑
Vince Gill's 50 Years From Home Delivers 37 Fresh Hits
Vince Gill's 50 Years From Home project is amazing. We've gotten 37 new songs over the course of half a year with more on the way. He still sounds, plays, and writes with the skill of an artist in their...
Insulin‑Lowering Diets Show Promise for Metastatic Cancer
Insulin lowering diets and metastatic disease. The results are promising but we need more studies that are adequately powered to evaluate whether insulin-lowering diets improve cancer outcomes. On the other hand, there appears to be little downside. https://pubmed.ncbi.nlm.nih.gov/36079800/
Midday Pilates Reset Boosts Afternoon Creativity and Energy
Every day at 1pm I leave the studio for Pilates. I drive 10 minutes, I take a call on the way, and then I'm there. It's what I call my "afternoon delight". But it's not your typical indulgence. That mid-day break is...
Bioinformatics Isn’t a One‑Click, Push‑Button Process
🧵 The Myth of Push-Button Bioinformatics 1/ Some think bioinformatics is just pressing a button: 🔘 RNA-seq Analysis 🔘 Make Fancy Figures 🔘 Submit to GenBank If only it were that easy... but reality is very different. https://t.co/HrPErqRzBV
Trace Logic Unveils Recursive Theory of Collective Agency
Pioneering research by the Levin Lab is exploring multi-scale collective intelligence in biological systems. Here I discuss the potential of a newly discovered “trace logic” to model their findings and to offer a recursive theory of agency. https://t.co/EGFgjSy27V
One Question Unlocks Kids' Unique Family Perspectives
There are certain questions that really unlock your kid. I asked each of mine this: “What’s something that makes our family different from other families?” Three kids. Three different answers. Three really connecting conversations.
Better Prompts Save Founders Ten Hours Weekly
Most founders are one great prompt away from 10 hours back per week. Learn to ask better questions.
Make Chocolate Marshmallows with My New Book
[New video and recipe] How to make chocolate marshmallows, from my new book The Great Book of Chocolate https://t.co/sUXFaCc79v
Learn Happiness by Inviting Constantly Joyful People
Some people seem to be genuinely happy all the time. Invite these people into your life and then learn from them.
Traveling with Kids: Airport Chaos Beats Flight Comfort
No one warns you that the airport is harder than the actual flight when you're traveling with kids. Or that jet lag will last way longer than you expect. Or that you will absolutely overpack and regret every single extra item. We moved...
Stool Test Detects 90% of Colorectal Cancers
As a medical school professor, I've watched colorectal cancer screening rely on colonoscopies for decades. That era may be ending. Researchers at the University of Geneva just published a breakthrough in Cell Host & Microbe: a simple stool test that detects...
Real‑time Biological Data Is the Missing Link for AI
🧵 Unlocking the true potential of AI and bioinformatics hinges on one missing link: real-time biological data. I saw that Prof. Nikolai Slavov posted this, and that reminds me of how complicated a single cell is. https://t.co/UCUeL2Bdge
2026 Tax Bill Lets Charitable Donations Yield Deductions
Most people donate to charity and get $0 of tax benefit. In 2026, that finally changes because of the new tax bill. Here’s how to take advantage:
Teen Procrastination Stems From Emotional, Not Time, Issues
Your teen’s procrastination isn’t just about poor time management... They're likely struggling with poor emotion management.
Clear Nutrition Plans Boost Student-Athlete Strength and Recovery
Student-athletes often struggle to build muscle, increase strength, and recover effectively not because they lack effort, but because they lack clarity around what to eat, how much to eat, and when to eat. My Elite Athlete Program removes the guesswork providing...
Choose Automation over Burnout, Not Manual Grind
You'd rather spend 40 hours a week doing tasks manually than 4 hours building systems that do them for you? Cool. You just don't get to complain about burnout.