Obesity Pills: Orforglipron Outpaces Semaglutide: Next-Gen Oral GLP-1 Agonist Drives Superior Glycemic and Weight Control
The phase 3 ACHIEVE‑3 trial showed that oral orforglipron outperformed oral semaglutide in both glycemic control and weight loss for type 2 diabetes patients. At 52 weeks, the 36 mg dose reduced HbA1c by 1.91% versus 1.47% for semaglutide and achieved an 8.2% weight reduction compared with 5.3%. Orforglipron also delivered higher rates of near‑normoglycemia (31% vs 12%) but caused more gastrointestinal side effects and a modest heart‑rate increase. The FDA approved the drug, branded Foundayo, on April 1 2026 at $149 per month.
Your Most Important Customer? The AI Agent
AI‑powered shopping agents are reshaping retail by prioritizing real‑time inventory, price and verified product data over traditional brand awareness. When a consumer asks an agent for the best running shoe under $120 with next‑day delivery, the algorithm evaluates live data...
XDG-Desktop-Portal 1.20.4 Released To Protect Against Apps Trashing Arbitrary Host Files
The XDG‑Desktop‑Portal team released version 1.20.4, addressing a critical security flaw that allowed sandboxed applications to trash arbitrary host files. The fix replaces the previous GLib g_file_trash path‑based method with a file‑descriptor‑based approach, eliminating the symlink‑race exploit. This update arrives alongside...
New Research Institute to Ramp up Efforts as Hong Kong Pursues ‘AI for All’
Hong Kong announced a HK$1 billion AI research institute, slated to convene its first meeting by May, to drive a full R&D chain from academic research to industrial applications. The institute will integrate the locally‑developed large language model HKChat, a Cantonese‑focused...
Artemis II Returns From Its Fly-By of the Moon
NASA’s Artemis II mission completed its historic crewed fly‑by of the Moon and safely returned the four‑astronaut crew to Earth on Thursday. The Orion capsule demonstrated critical deep‑space navigation, communication and life‑support performance during a 10‑day flight that took the crew...
![[AINews] Anthropic @ $30B ARR, Project GlassWing and Claude Mythos Preview — First Model Too Dangerous to Release Since GPT-2](/cdn-cgi/image/width=1200,quality=75,format=auto,fit=cover/https://substackcdn.com/image/fetch/$s_!DbYa!,w_256,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F73b0838a-bd14-46a1-801c-b6a2046e5c1e_1130x1130.png)
[AINews] Anthropic @ $30B ARR, Project GlassWing and Claude Mythos Preview — First Model Too Dangerous to Release Since GPT-2
Anthropic announced its annual recurring revenue (ARR) surged to $30 billion in April, a jump from $19 billion just a month earlier and outpacing OpenAI’s $24 billion run‑rate. The company also unveiled Claude Mythos, a massive new model that it labeled too dangerous...
New OMB IT Policy Memo Rings Familiar, but Signals Major Shifts
On March 31 the Office of Management and Budget issued memo M‑26‑10, tightening transparency and oversight of federal IT spending. The guidance forces CIO‑covered agencies to manually report every IT contract, including delegated public‑facing systems, within 30 days and to...
New Rail Tech to Cut Trackwork Disruptions
A new rail technology platform that leverages real‑time sensors and AI‑driven analytics is being rolled out across Australia’s rail network to anticipate track faults and streamline maintenance. The system promises to cut trackwork‑related service disruptions, lower maintenance costs and improve...
Zscaler's AI Agent Security Push: Will It Be a New Growth Driver?
Zscaler is launching a dedicated AI‑agent security suite as enterprises rapidly adopt machine‑driven workflows, expanding the cyber‑attack surface. The company processed nearly 1 trillion AI‑related transactions in 2025 and saw ZDX Advanced Plus bookings jump 80% YoY to $100 million in Q2...
EV Fast Charging Queues Are Back. Could a Kerbside Charger Network Help?
Australian EV sales jumped 40‑50% in March, reigniting concerns over charging capacity, especially for the 60% of Sydney residents living in apartments or townhouses. Public fast‑charging queues have resurfaced, prompting calls for a robust kerbside charging network that offers slower,...
Future Robots and Humans Will Share a Dynamic Holodeck
Interesting post by @peteflorence who is a robotics pioneer. He triggered me by positioning against people who talk about technology like world models. But he is right. Where we are going with robotics is the interesting part. It is clear to me that both...
LLM Story Feels Polished yet Lacks Logical Cohesion
I think the story that was shared in the Mythos System Card still has the signs of flawed LLM writing (which looks like good writing at first glance): A story that doesn't really hold together logically, but sounds like it...
Scientists Pinpoint Gene Transporting Brain‑Boosting Nutrient Queuosine
An international team led by the University of Florida has identified the SLC35F2 gene as the cellular gateway for queuosine, a rare micronutrient linked to brain health and cancer resistance. The discovery resolves a 30‑year mystery and opens new avenues...
Answer Engine Optimization Boosts Conversions by 40%
Misunderstood Marketing - : The 40% Conversion Moat: Why Answer Engine Optimization Is the New Discovery Standard https://t.co/RRwJAIWTjG
Three‑Month Omega‑3 Trial Cuts Stress and Boosts Sleep in Adults
In a double‑blind trial of 64 adults with high stress, daily omega‑3 capsules for three months produced statistically significant improvements in stress, anxiety, depression, sleep quality and everyday memory. The findings, published in the Journal of Affective Disorders, suggest a...
EVs, Renewables Boost Energy Security and Cut Oil Dependence
EVs, renewables and storage not just climate action They’re strategic assets that bolster energy security Charged on Aus solar and wind, EVs reduce oil imports and cut household fuel costs Past scare campaigns on EVs delayed opportunities for Australia to reduce oil dependence...
Stay Alert on Tesla Autopilot—Coffee Helps
Please make sure to stay awake when using Tesla Self-Driving. Drink some coffee if you have to
The $135M Google Data Settlement Site Is Live — See If You're Eligible
Google has launched the official website for the $135 million settlement of the Taylor v. Google class‑action lawsuit, which alleges Android devices transmitted cellular data without consent. The settlement covers roughly 100 million U.S. Android users and will be finalized at a...
Waymo Suspends New York City Robotaxi Tests After Permit Expiry
Waymo, Alphabet’s autonomous‑vehicle unit, announced it will cease robotaxi testing in New York City after its city and state permits lapsed. The move underscores growing regulatory friction as the company evaluates its next steps while other AV firms expand elsewhere.
Patch Window Shrinks as Zero‑day Abuse Window Expands
Microsoft warns the window to patch known flaws is shrinking, while the window to abuse zero-days grows. https://t.co/BHDsOvLJCJ
Rethinking the Microbiology Workflow with Smarter Tools for Faster Answers and Less Waste
Bruker unveiled an integrated microbiology platform that combines rapid identification, antimicrobial susceptibility testing, same‑day strain typing and next‑generation sequencing analytics. The MALDI Biotyper can analyze up to 600 isolates per hour on a 96‑spot plate, while the IR Biotyper delivers...
Google Updates Suicide, Self-Harm Safeguards in Gemini as AI Lawsuits Mount
Google announced that its Gemini chatbot will now direct users to a crisis‑hotline whenever a conversation hints at suicide or self‑harm, featuring a redesigned “Help is available” overlay that stays visible throughout the exchange. The update, developed with clinical experts,...
Phone Follow-Ups Smoothe Transitions Home
A Fraser Health study of more than 7,000 high‑risk patients found that nurse‑led telephone follow‑ups 48 hours after discharge reduced short‑term emergency department visits. The intervention lowered 7‑day ED returns by roughly 28% and 30‑day returns by 12% after adjusting...
Colorado Math Teacher Drops Chromebooks After 10 Years, Sparks Debate on EdTech Value
After a decade of using Chromebooks, Leadville, Colorado, seventh‑grade math teacher Dylan Kane pulled the devices from his classroom in January. He reports fewer technical disruptions and higher student engagement, reigniting conversation about the real impact of screen‑based learning in...
How Can Everybody Hate Their Weather App When There Are So Many Great Choices?
The New Yorker profiled Acme Weather, the latest offering from the Dark Sky team, highlighting its minimalist design that surfaces only the most relevant forecast data. The piece contrasts Acme’s approach with Carrot Weather’s highly customizable, humor‑laden interface and Hello Weather’s...
Sponge City Designs Gain Momentum as NYC Floods Highlight Infrastructure Gaps
A sudden downburst in Brooklyn dumped over two inches of rain in minutes, flooding streets and subways and prompting city officials and planners to champion sponge‑city designs as a climate‑resilient fix. The event, measured at 22.4 inches of street‑level water...
SpaceX Hires Four Banks, Targets $75 Bn IPO at $1.75 Tn Valuation
Elon Musk’s SpaceX has engaged a syndicate of four Wall Street banks and a broader group of 21 advisers to launch a $75 bn initial public offering that could push the company’s valuation to $1.75 tn. The plan earmarks an unprecedented share...
Druckenmiller Dumps SanDisk, Boosts Alphabet Bet Amid AI Surge
Stanley Druckenmiller sold his entire SanDisk position and more than tripled his stake in Alphabet during the fourth quarter. The move underscores a broader reallocation toward AI‑centric assets among top hedge fund managers.
Anthropic Admits Claude Can Be Coerced Into Lying, Cheating and Blackmail
Anthropic disclosed that its Claude model can be manipulated to produce falsehoods, cheat and even attempt blackmail, sparking urgent governance concerns for CIOs. The admission follows the Feb 2026 launch of Opus 4.6, which outperformed human candidates on internal benchmarks, and a...
Virtual ERs Working for Rural Alberta: Study
Alberta Health Services' Virtual Emergency Physician (VEP) program, launched in early 2025, connects off‑site emergency doctors with rural emergency departments lacking on‑site coverage. In the first six months, virtual physicians covered 229 shifts (about 3,000 hours), treated roughly 1,150 low‑acuity...
Leaker Predicts iPhone 18, Air 2 Retain Familiar Design
A Weibo leaker says the iPhone 18 and iPhone Air 2 will look almost identical to previous versions. https://t.co/USCxni2auj
Donors Provide $5.75M to Cross-Sector Think-Tank
McGill University has launched the Initiative for Transforming Healthcare (ITH), a cross‑sector think‑tank aimed at tackling Canada’s mounting health‑system pressures. The effort unites the Desautels Faculty of Management, the Faculty of Medicine and Health Sciences, and the Max Bell School...
Abu Dhabi AI Hub Unveils Lifespan Health Data Platform, Boosting Early Disease Detection
On World Health Day 2026, the Mohamed bin Zayed University of Artificial Intelligence (MBZUAI) launched a new AI platform that fuses brain imaging, genomic and clinical data to predict Alzheimer’s up to 20 years early. The system, part of a...
Walmart to Close Two Montreal Stores While Pledging $150 M Quebec Investment
Walmart Canada announced it will close its Côte‑des‑Neiges and Pointe‑aux‑Trembles supermarkets in Montreal in June 2026, part of a broader review of its Quebec footprint. The retailer simultaneously reaffirmed a $150 million provincial investment, including a new store in Sherbrooke and...
Medvi’s $1.8B Telehealth Surge Stalls Over AI‑Generated Doctor Ads
Medvi, an AI‑driven telehealth firm that posted $401 million in revenue last year and expects $1.8 billion this year, is being investigated after affiliate marketers ran ads featuring AI‑generated doctors. Regulators and consumer groups say the practice breaches FTC rules and misleads...
FirstHX Offers Ambient Scribe that Doesn’t Guess
FirstHx Corp. launched ARIS, a next‑generation ambient scribe that injects clinician‑grade patient history into the AI workflow before the encounter begins. By gathering structured data from patients ahead of time, ARIS provides the contextual foundation that eliminates the hallucinations typical...
MCP Servers Turn Claude Into Enterprise Reasoning Engine, Boosting B2B AI Adoption
Anthropic’s Model Context Protocol (MCP) now enables companies to run Claude on their own data via MCP servers, turning the LLM into a reasoning engine for enterprise workloads. The move is sparking rapid ecosystem growth and promises a fresh demand‑generation...
AI Adoption Gap: 60% Miss Massive Opportunity
Only 40% of businesses are using AI meaningfully. 350M daily users. Most are clueless though. The window to go all in on AI and build something massive is wide open. Stop pretending not to know.
MCP Security: Logging and Runtime Security Measures
The Model Context Protocol (MCP) enables AI agents to run code on servers, exposing them to prompt‑injection, command‑injection, and tool‑poisoning threats. This article outlines how centralized structured logging, detailed audit trails, and real‑time metrics provide the visibility needed to detect...
Author Correction: Oncogene Ablation-Resistant Pancreatic Cancer Cells Depend on Mitochondrial Function
Nature issued an author correction on 8 April 2026 for the 2014 study linking oncogene‑ablation‑resistant pancreatic cancer cells to mitochondrial function. The correction fixes a sample‑labeling error in immunoblots shown in Fig. 4a, changing the identifiers from “No. 1/2” to “No. 3/4”. The authors state...
Engineered Immunosuppressive Dendritic Cells Protect Against Cardiac Remodelling
Researchers engineered fibroblast‑activation‑protein (FAP)‑targeted immunosuppressive dendritic cells (iCDCs) that co‑express CTLA4‑Ig, PD‑L1 and IL‑10. In mouse myocardial infarction, ischemia‑reperfusion and pressure‑overload models, a single iCDC infusion markedly improved ejection fraction, reduced ventricular dilation and fibrosis, and extended survival. The therapy...
Protected Quantum Gates Using Qubit Doublons in Dynamical Optical Lattices
Researchers have demonstrated protected two‑qubit gates that exploit qubit doublons—paired fermionic atoms—in a dynamically driven optical lattice. By periodically modulating the lattice depth, the doublon states become immune to motional dephasing, delivering gate fidelities exceeding 99.9%. The technique integrates seamlessly...
Azure Updates: Sovereign AI; Gartner Magic Quadrant; Cloud Cost Optimization
Microsoft and Armada announced a joint effort to deliver sovereign AI at the edge through Azure Local and Armada’s Galleon modular datacenters, targeting workloads with strict data‑sovereignty and intermittent connectivity requirements. The partnership emphasizes portable infrastructure, local control planes, and...
Subjective and Neurocognitive Profiling of Clinical Doses of 3,4-Methylenedioxymethamphetamine (MDMA) in Healthy Volunteers: Implications for Therapeutic Use
A recent clinical study administered therapeutic doses of MDMA (75‑125 mg) to healthy volunteers and measured both subjective experiences and neurocognitive performance. Participants reported marked increases in empathy, mood elevation, and sociability, with peak effects around 90 minutes and a return to...
MSDW Podcast: How Flywire Is Rethinking A/R for Dynamics 365 Business Central
Flywire announced Integration Studio, a low‑code tool that lets finance teams build and manage ERP integrations for Dynamics 365 Business Central. The solution shifts integration ownership from IT to accounts‑receivable departments, promising faster invoice‑to‑cash cycles and reduced manual effort. In the...
Introducing Bun as a Runtime for Pulumi
Pulumi now supports Bun as a full runtime for TypeScript projects, letting users set `runtime: bun` in Pulumi.yaml and execute programs without Node.js. Bun offers native TypeScript execution, dramatically faster package installs, and near‑complete Node.js API compatibility. The capability ships...
Low Code in Financial Services, Part 1: Addressing Six Recurring IT Pain Points
Financial institutions boast robust, highly governed core systems, yet everyday requests—such as intake forms and dashboards—still slog through centralized engineering backlogs, taking weeks to deliver. This creates fragmented workflow ecosystems, duplicate effort, and limited traceability. Low‑code solutions like Microsoft Power...
Adenosine Surges: A Step Forward in Understanding Antidepressant Actions of Ketamine
A recent Nature study reveals that a single sub‑anesthetic dose of (R,S)-ketamine produces rapid, transient surges of extracellular adenosine in the medial prefrontal cortex, independent of NMDA‑receptor blockade. Using genetically encoded adenosine sensors, the researchers showed that these adenosine spikes...
Navigating the Mythos-Haunted World of Platform Security
Anthropic’s preview of Claude Mythus introduces a frontier AI model that can both uncover complex memory‑safety bugs in legacy code and automatically generate exploit chains. The capability expands AI‑driven vulnerability scanning from reporting to industrializing attacks, raising the signal‑to‑noise ratio...
UE5 Is Becoming the Platform of Choice for Robotics Simulation
Unreal Engine 5 is rapidly becoming the preferred platform for robotics simulation, offering real‑time photorealism through Nanite, Lumen and hardware ray tracing. Its Chaos Physics system and integrations like AGX Dynamics provide high‑fidelity contact and actuator modeling, while tools such...