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Researchers have uncovered that kinetochores actively regulate anaphase spindle length by promoting microtubule depolymerization. Live‑cell imaging and laser ablation experiments showed that loss of kinetochore‑mediated depolymerization reduces spindle length by roughly 15‑20 percent. The study identifies the kinesin‑13 family protein MCAK as a key effector recruited to kinetochores during anaphase. These results reshape our understanding of how mechanical forces are coordinated during chromosome segregation.
The Senate’s failure to pass the omnibus spending bill left the rare‑pediatric priority review voucher (PRV) program without reauthorization, prompting biotech CEOs to intensify lobbying. Without a renewal, about 200 rare‑disease therapies could lose eligibility, threatening up to $4 billion in...
Vetter Pharma announced a €1.5 billion expansion to build a new commercial sterile‑injectable manufacturing plant in Saarlouis, Germany, slated to create up to 2,000 jobs and begin phased construction in Q2 2026. The investment also includes a clinical production facility in Des Plaines,...
Researchers at Japan's RIKEN Center applied inverse probability weighting to data from mandarin orange orchards in 12 prefectures, revealing that cutting chemical pesticides boosts soil microbial diversity but also increases leaf‑pathogen fruit diseases. The analysis showed soil carbon improves when...
Researchers have mapped the complete set of genes responsible for withanolide biosynthesis in Ashwagandha and successfully transferred them into engineered Saccharomyces cerevisiae. The yeast platform produced withanolide A and related compounds at concentrations exceeding 150 mg per liter, a five‑fold improvement over prior...
For those worried about #Nipah virus: Yes, it's a dangerous disease. Yes, India has recently reported 2 cases. But Nipah doesn't spread as easily as Covid. "WHO assesses the risk posed by Nipah to be moderate at the sub-national level, and...
There's a fascinating fight brewing between Regeneron and, well, everybody else. But what do we call it? Dupixent, the treatment for atopic dermatitis and other autoimmine issues that $REGN sells with Sanofi, is one of the biggest selling drugs in the...
Bitterroot Bio, a specialist in CD47 immunotherapy, announced that its program has reverted to the pre‑clinical discovery stage after a brief push toward clinical development. The move coincides with the unexpected resignation of its chief executive officer, raising questions about...
Another possible data point on the challenges for new vaccine development: Moderna's chief medical officer, Jacqueline Miller, a longtime vaccine developer who rose through the ranks at GSK and Merck, is departing. David Berman, a veteran of immuno-oncology efforts at AstraZeneca...
The European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP) voted against extending Eli Lilly’s weight‑loss drug tirzepatide (Mounjaro) to treat heart failure, citing insufficient efficacy data. In the same meeting, the CHMP gave a positive opinion to...
Amgen has terminated its collaboration with Kyowa Kirin on the OX40‑targeting eczema drug rocatinlimab, returning all rights to the Japanese partner. The decision follows Phase 3 trials that met primary endpoints but failed to demonstrate superiority over established therapy Dupixent and showed...
Ultragenyx has re‑submitted its FDA approval request for UX111, an adeno‑associated virus (AAV) gene‑therapy targeting a rare neurodegenerative disease. The company previously faced a complete response letter last summer, prompting additional pre‑clinical work and safety analyses. UX111 aims to replace...
The former CytoDyn chief executive was sentenced to 30 months in prison after convictions for securities fraud, wire fraud and insider trading. Meanwhile, major pharmaceutical companies are accelerating AI adoption, signing multi‑billion‑dollar deals with platform providers such as Nvidia and...
Quince Therapeutics announced that its once‑monthly steroid‑based therapy for ataxia‑telangiectasia failed to meet the primary endpoint in a pivotal Phase 3 trial. The rare genetic disorder affects roughly 1 in 100,000 children and currently lacks disease‑modifying treatments. Following the data...
Moderna has signed a licensing agreement with Italy’s Recordati to transfer a Phase 3 rare‑disease mRNA therapeutic to the European drugmaker. The deal provides Recordati with worldwide commercialization rights, an upfront cash payment estimated at $150 million, and a series of development...
Amgen abruptly terminated its collaboration with Japan’s Kyowa Kirin on a late‑stage immunology candidate, returning all rights to the partner despite the drug’s recent Phase 3 success. The move aligns with Amgen’s broader strategic shift toward internal R&D priorities and upcoming biosimilar...
Eli Lilly has allocated $3.5 billion to build a new manufacturing complex in Pennsylvania’s Lehigh Valley that will produce its next‑generation obesity injectable retatrutide and related compounds. The plant is designed for flexible, single‑use bioreactor technology and aims to output over a...
Lanifibranor (IVA-337) is an oral pan‑PPAR agonist entering Phase 3 trials for metabolic dysfunction‑associated steatohepatitis (MASH/MASLD). The molecule was optimized from high‑throughput screening and its preclinical data were published in the Journal of Hepatology in June 2025. Inventiva Pharma is leading development,...
The FDA released draft guidance urging sponsors of multiple myeloma drugs to use minimal residual disease (MRD) negativity as the primary endpoint for accelerated approval, moving beyond traditional overall response rates. The agency defines MRD‑negative as one cancer cell per...
Evidence‑based practice (EBP) is essential for modern nursing, linking care decisions to the best research. A cross‑sectional study by Miszewska and Zarzeczna‑Baran surveyed Polish nurses across specialties, revealing a stark split in EBP competence. While a minority demonstrated solid knowledge,...
A recent multinational cohort study reveals pronounced ethnic disparities in long COVID symptom profiles. Black and Hispanic patients report fatigue and neurological complaints at rates significantly higher than White counterparts, even after adjusting for age and comorbidities. Socioeconomic deprivation and...
NASA‑backed researchers have resurrected a 3.2‑billion‑year‑old nitrogenase enzyme, demonstrating that its nitrogen‑isotope signature remains unchanged despite billions of years of molecular evolution. By reverse‑engineering modern nitrogenase, the team recreated ancestral versions and expressed them in microbes, confirming that the isotopic...
A new study by Yan, Yao, and Liu demonstrates a direct link between three‑dimensional patellar shape and the likelihood of patellar dislocation. Using automated coordinate algorithms and statistical shape modeling on a diverse cohort, the researchers identified distinct geometric features...
Opentrons Labworks has promoted James Atwood, who has led its Robotics Business Unit since April 2023, to chief executive officer. Under his guidance the company expanded its installed base to more than 10,000 robotic systems deployed worldwide across academia, biotech...
Researchers have engineered highly stable coacervate microdroplets using polyethyleneimine (PEI) and sodium thioctate (ST) that resist coalescence for over 35 days without any additives. The droplets exploit electrostatic and hydrophobic interactions, creating a charge‑repelled surface that preserves structural integrity. They...
Researchers have engineered biomimetic hematoma microspheres that combine a pH‑responsive GelMA outer layer with a NaHS‑loaded liposomal core to deliver hydrogen sulfide (H₂S) directly to bone defect sites. The microspheres release H₂S in acidic environments, simultaneously reducing chronic inflammation, stimulating...
You can not do Bioinformatics with hard cutoffs and thresholds Let me tell you something real: Biology is more about p-values. It’s messier than that. 🧵 https://t.co/iewqWMvU6D
With continued uncertainty over federal government support for biomedical research, PhD students are struggling to find labs willing to take on new students, @JonathanWosen reports. New students are the future of US science. https://t.co/1eeq2PAbCm
Researchers have engineered an alginate/polycaprolactone (PCL) composite dressing that co‑delivers silver nanoparticles and platelet‑derived growth factor‑B (PDGF‑B). The hybrid matrix provides sustained antimicrobial release while preserving the bioactivity of PDGF‑B to stimulate tissue regeneration. In vivo tests on rodent wound...
Johnson & Johnson entered 2026 aiming for $100‑$101 billion in sales after a 9.1 % Q4 revenue rise to $24.6 billion. The company is banking on its oncology portfolio—particularly Darzalex, Tecvayli, Carvykti and emerging lung‑cancer combos—to offset the imminent loss of exclusivity for...
The White House postponed the rollout of TrumpRx, the federal direct‑to‑consumer drug marketplace. Officials cite potential violations of the federal anti‑kickback statute as a key factor, prompting HHS to issue a guidance bulletin outlining required safeguards. Major manufacturers including Pfizer,...
The European Medicines Agency has opened a review into the data integrity of the pivotal ADVOCATE trial that underpinned the EU approval of Amgen’s oral complement C5 inhibitor Tavneos. The regulator’s concerns focus on how the study data were handled...
Researchers at the Indian Institute of Science examined how perchlorate, a toxic chemical in Martian regolith, influences biocementation by a robust native strain of Sporosarcina pasteurii. While perchlorate slows bacterial growth, it triggers extracellular matrix formation that creates microbridges, resulting...
Researchers in Ethiopia identified several sorghum genotypes that exhibit strong resistance to anthracnose, a fungal disease that can devastate yields. Field trials across major growing regions showed up to 20% higher grain production compared with susceptible varieties under disease pressure....
Researchers have detailed how Pinus nigra (black pine) resists infection by the fungal pathogen Diplodia sapinea, which causes tip blight and significant timber loss. The study highlights rapid resin exudation, elevated phenolic production, and a coordinated transcriptional shift toward defense...
Sanofi announced it has deprioritized its SP0237 mRNA‑based seasonal flu vaccine, removing the candidate from near‑term launch plans. The hexavalent shot was in a Phase I/II safety and immunogenicity trial for adults over 50, which remains active but is not recruiting...
The FDA’s Center for Biologics Evaluation and Research granted NanoMosaic an Advanced Manufacturing Technology (AMT) designation for its Nanoneedle platform, which multiplexes vector genome and capsid titer testing in AAV gene‑therapy production. The designation confirms the technology’s ability to streamline...
IDDI, a global clinical data science partner, launched a refreshed brand to mark its 35‑year anniversary, debuting publicly at the SCOPE Summit on February 2, 2026. The new identity underscores a patient‑centric approach, biostatistical rigor, and regulatory insight while highlighting...
The U.S. Food and Drug Administration has set a November 14 deadline to rule on Summit Therapeutics’ bispecific antibody ivonescimab, which targets PD‑1 and VEGF in EGFR‑mutant non‑small cell lung cancer. Summit’s Phase III HARMONi trial demonstrated a roughly 50% improvement in...
AgomAb Therapeutics, SpyGlass Pharma, and Veradermics have filed Nasdaq IPO pricing, each seeking $150‑200 million. AgomAb plans to sell 2.5 million shares at $15‑$17, targeting a post‑money valuation near $875 million. SpyGlass will issue 9.4 million shares at the same price range, aiming for...
Janux Therapeutics announced the appointment of William Go, M.D., Ph.D., as its new chief medical officer, replacing Zachariah McIver. The hire follows a recently disclosed partnership with Bristol Myers Squibb that provides a $50 million upfront payment for Janux’s T‑cell engager...
The FDA has undergone an unprecedented wave of politicization in the past year, marked by mass staff departures, early retirements, and a surge of political appointees across senior roles. This shift has altered advisory committees, review processes, and introduced the...
Researchers have uncovered why facial skin heals with less scarring than other body sites. They identified a signaling pathway centered on the protein ROBO2 that keeps facial fibroblasts in a low‑fibrotic state by inhibiting EP300. In mouse models, pharmacologic EP300...
Yosemite, the cancer‑research investment firm led by Reed Jobs, is seeking to raise a fund of up to $350 million. The capital target positions the firm among the largest early‑stage biotech funds currently forming. Jobs leverages his Silicon Valley connections and...
A recent study evaluated three leading AI models—GPT‑5, DeepSeek, and Claude—on multiple‑choice questions that simulate dental treatment scenarios for medically compromised patients. GPT‑5 delivered the most accurate and comprehensive answers, while DeepSeek excelled in localized problem solving but faltered on...
Multiple randomized trials and electronic‑health‑record analyses show that a 14‑day course of metformin, started during or shortly after acute SARS‑CoV‑2 infection, significantly lowers the risk of developing Long COVID. Across four studies, one Long COVID case is prevented for every...
Dr. Clare Wareing, founder and CEO of Cumulus Oncology, discussed the company’s risk‑adjusted preclinical pipeline aimed at high‑unmet‑need cancers. Cumulus employs a platform‑agnostic, precision‑medicine strategy that prioritizes patient subgroups to improve development success. The interview highlighted the supportive Scottish biotech...
Researchers have linked the circadian rhythm of soluble CD26 (sCD26) to acute graft‑versus‑host disease (aGVHD) risk in cord blood transplantation (CBT). Peak sCD26 levels suppress pathogenic T‑cell activity, creating a temporal window that lowers aGVHD incidence and severity. The team...
A recent Pediatric Research study demonstrates that the systemic immune‑inflammation index (SII) predicts mortality in critically ill children with acute kidney injury (AKI). The researchers analyzed ICU data, finding that higher SII scores—reflecting neutrophilia, lymphopenia, and thrombocytosis—correlate with increased death...
Dr. Josef Neu’s recent article argues that reliable biomarkers for necrotizing enterocolitis (NEC) remain elusive due to the disease’s heterogeneity, methodological flaws in prior studies, and the unique physiology of preterm infants. He highlights that single‑molecule indicators such as cytokines...
