
FDA approves first CIRM‑funded gene‑editing therapy for rare immune disorder
The FDA has granted approval to KRESLADI, a gene‑editing therapy from Rocket Pharmaceuticals that treats severe leukocyte adhesion deficiency‑I in children without a matching bone‑marrow donor. It is the first product directly funded by California’s Institute for Regenerative Medicine (CIRM), highlighting the agency’s impact on translational research.
Also developing:
By the numbers: Syneron Bio raises $150M Series B
New research led by Queensland University of Technology examined 12 Queensland general practitioners during the first year of the state’s voluntary assisted dying (VAD) legislation. The study found GP involvement varied widely, from none to more than 50 cases, and identified administrative complexity, lack of a dedicated Medicare rebate, and insufficient training as primary barriers. Rural and regional doctors reported especially limited access to funding and education. Researchers argue that improved remuneration, streamlined processes and consistent training are essential to expand GP participation and sustain VAD services.
Over half of all lumbar fusions fail. They’re still covered by insurance. Conservative care that actually works — exercise, PT, load management — gets denied or severely limited. We don’t have a back pain problem. We have a financial incentive problem.
Physical exercise and health-related quality of life in mid- to late-adulthood: a multi-group chain-mediation analysis https://t.co/vd6yqa45rx
The study assessed pericoronary fat attenuation index (FAI) and left main coronary artery (LMCA) angle as predictors of high‑risk plaques in left‑dominant coronary artery disease using coronary CT angiography. Among 106 patients, 45 exhibited high‑risk plaques and showed significantly higher...
Australia faces a silent chronic kidney disease (CKD) epidemic, with one in seven adults showing early markers yet remaining undiagnosed. Rising rates of diabetes, hypertension and obesity are driving an 86 % projected surge in dialysis demand by 2032, straining already...
The University of Mississippi Medical Center (UMMC) was hit by a ransomware attack that shut down phone, email and electronic medical record systems, forcing the closure of more than 30 affiliated clinics and canceling elective procedures. The outage jeopardized emergency...

At SXSW, industry leaders tackled the widening trust gap in technology and healthcare, highlighting four distinct approaches. Merck introduced its “Red Chair” campaign to keep patient perspectives front‑and‑center in drug development. City of Hope showcased Hope LLM, a generative‑AI tool...
A new meta‑analysis of nine randomized trials involving 4,754 patients demonstrates that intra‑operative indocyanine green fluorescence angiography (ICGFA) cuts anastomotic leak risk by roughly 40% in colorectal surgery, especially for rectal and left‑sided resections. The study, published in The Lancet...
A Chinese trial of an AI‑driven clinical decision support system (CDSS) involving 21,603 acute ischemic stroke patients across 77 hospitals showed significant improvements in care quality and long‑term vascular outcomes. Patients whose physicians used the CDSS experienced a 26% reduction...

I've been a dad for five days - and somehow, it's already made me question what I thought about AI and the patient experience. Lemme explain… We had an incredible experience in the hospital. Not because of any Tech… but because...
A cross‑sectional survey of 295 emergency department physicians in Türkiye found that 95.6% experienced at least one form of workplace violence in the preceding six months, with verbal aggression being the most common. Exposure to violence was linked to significantly...

On February 15, 2012, the FDA announced that Bracco Diagnostics’ CardioGen‑82 generator will re-enter the U.S. market after a voluntary recall in July 2011. The agency approved revised labeling that introduces a Boxed Warning and new “Alert Limits” for strontium‑82...

The FDA has revised the Tysabri (natalizumab) label to detail progressive multifocal leukoencephalopathy (PML) risk based on infusion count and prior immunosuppressant exposure. Data show 102 PML cases among 82,732 treated patients, with incidence rising sharply after 24 infusions. A...

MedPAC’s 2026 annual report to Congress concludes that Medicare’s statutory payment update of roughly 2.3% for FY 27 is sufficient and does not merit an extra boost. Hospital financial health is improving, with all‑payer operating margins rising from 5.2% in 2023...
Special needs plans (SNPs) are emerging as the primary growth engine for Medicare Advantage, with KFF estimating they will account for roughly half of enrollment gains between 2024 and 2025. By 2025, SNPs will cover about 21% of all MA...

The JC virus, a common polyomavirus, silently infects up to 90% of adults. While it usually remains dormant, it can mutate into a neurotropic form that causes progressive multifocal leukoencephalopathy (PML). A new case study links PML to chronic kidney...
Adam Grant warned that healthcare excels at thinking but lags at rethinking, causing organizations to fall behind disruptive forces. He urged leaders to foster psychological safety so frontline staff can surface problems without immediate solutions. The talk highlighted the need...

The post outlines how multi‑agent metabolic regimens—using repurposed drugs and nutraceuticals—initially suppress tumors but often trigger adaptive resistance after about two years. Resistance arises from metabolic plasticity, enrichment of cancer‑stem‑cell‑like subpopulations, and rewiring of stress‑signaling pathways. The author proposes press‑pulse,...

CMS announced that risk‑based surveys will be expanded to roughly 10% of U.S. skilled nursing facilities, with final criteria slated for release by late summer. Facilities receiving a risk‑based survey can still be escalated to a full recertification if inspectors...

The FDA has granted clearance for Siemens Healthineers’ Varian radiotherapy platforms—including TrueBeam, TrueBeam STx, VitalBeam and Edge—to treat medically refractory osteoarthritis in adults. Low‑dose radiation therapy offers a non‑invasive alternative to steroid injections, physical therapy, and ultimately joint replacement surgery...
Researchers at the University of Sheffield introduced the Partial Denture Experience Questionnaire (P‑DEQ), a patient‑focused tool that records both clinical performance and the emotional and social impacts of removable partial dentures. Published in Gerodontology and developed with partners from Queen’s...
North Star Health Alliance announced additional job cuts as part of its Chapter 11 restructuring, following a January reduction of more than 100 positions. The health system did not disclose the exact number of employees affected in this latest round....
Oregon Governor Tina Kotek sent a letter to PeaceHealth demanding a 180‑day delay in the system’s plan to shift emergency‑room staffing from its long‑standing local physicians to Atlanta‑based ApolloMD. The request follows concerns that the deal may breach Oregon’s strict...
A recent JAMA Health Forum viewpoint warns that upcoming federal budget changes could cripple the U.S. nursing faculty pipeline. Proposed cuts to the Nurse Faculty Loan Program and a new $200,000 cap on federal loans for professional degrees threaten to...

EyePoint Therapeutics filed a lawsuit in Massachusetts accusing rival Ocular Therapeutix of spreading false and misleading statements about EyePoint’s lead experimental eye drug, Duravyu. The complaint alleges defamation, commercial disparagement, consumer‑protection violations, and interference with business relationships. EyePoint seeks a...

Medicare does not enroll automatically for those who delay Social Security, so missing the sign‑up can leave retirees with secondary coverage and surprise bills. At age 65 Medicare becomes the primary payer, pushing other policies into a secondary role. Delaying...

A recent clinical trial found that a structured pre‑chemotherapy exercise program significantly reduced cancer‑related fatigue. Participants who completed a 12‑week supervised regimen reported fatigue scores up to 30% lower than controls. The study, involving 150 early‑stage cancer patients, also showed...
CMS finalized a rule that phases out fax machines and snail‑mail for healthcare claims documentation, establishing national standards for electronic exchange of clinical records. The Administrative Simplification Final Rule is projected to save the industry about $781 million each year, though...
Healthcare IT teams are increasingly pivotal in software assessment, purchase, and implementation, yet friction often arises when clinical and IT priorities clash. Early involvement of IT can surface technical constraints—such as data transfer protocols—before contracts are signed, avoiding costly redesigns....

Physicians are turning to translational fertility experts to rescue IVF patients with poor egg quality or recurrent embryo failures. By applying a revised ovulation paradigm, clinicians extended stimulation cycles and fine‑tuned hormone dosing, leading to viable embryos and live births...
How the new DOT ruling on food allergies threatens air travel safety http://dlvr.it/TRcKjc Conditions #AllergiesImmunology

Orthopedic surgery remains one of the most competitive specialties, with 916 residency slots across 218 programs and a 74.3% match rate for U.S. allopathic seniors in 2024. Dr. John Klibanoff emphasizes that Match Day marks the start of a broader...
Artificial intelligence is gaining traction in hospital pharmacy operations, yet many health systems remain stuck in small pilots. Dr. Bickkie Solomon argues that treating AI as a narrow IT project overlooks broader operational and governance needs, causing initiatives to stall....
The Governing Body of Jehovah’s Witnesses announced a clarification that lets members decide whether to have their own blood drawn, stored, and returned for surgery. The change stops short of lifting the ban on donor blood, sparking praise and criticism...
Fun day .. “You’re my 5th opinion.” Knee injury These are usually a problem. Previous 4… -Only one exam -All repeated X-rays -2 MRIs. - One Special NY hospital often insists their MRIs...

Louisiana lawmakers are advancing two bills aimed at tightening health‑care oversight. Senate Bill 273 would require hospice facilities to produce clearer care plans, improve provider‑family communication, and document patient‑care decisions more thoroughly. House Bill 554 seeks to double civil monetary...
Privia Health, a publicly traded physician‑management firm, has embarked on a systematic AI rollout across its revenue cycle after interviewing roughly 30 vendors. The company piloted tools for denials management, accounts‑receivable follow‑up, prior authorizations, coding and patient demographics, then began...

The American Hospital Association has opened early‑bird registration for its inaugural Healthier Together Conference, with discounted rates available until March 31. The three‑day event will take place May 12‑14 in Dallas and will concentrate on community health, care‑delivery transformation, and reducing health‑outcome...

Health Care Management Corporation (HCMC) announced the launch of the Excellence in Hospital Capacity Management Award, targeting hospitals that excel in patient flow and resource optimization. The award will assess candidates on data‑driven strategies, measurable outcomes, and innovative practices, with...

I will NEVER miss an opportunity to call out medical misinformation so people know how to protect themselves and rally for change. On this particular panel, we got into the hype and hope of stem cells in an honest and cathartic...

SightGlass Vision’s DOT (Diffusion Optics Technology) lenses were shown in two 12‑month trials—North American CYPRESS and Chinese CATHAY—not to increase astigmatism in children compared with control spectacles. The studies also confirmed that DOT lenses slow axial length growth and spherical...

A new NBER working paper finds that adding 1,000 immigrants to a U.S. metropolitan area reduces elderly mortality by roughly ten deaths. The effect is driven by an influx of 142 foreign‑born healthcare workers, especially long‑term care staff, who augment...

Cardinal Health announced a voluntary nationwide recall of its Webcol™ Large Alcohol Prep Pads after detecting microbial contamination with Paenibacillus phoenicis. The affected lots, distributed in the U.S., Puerto Rico, and Japan between September 2025 and February 2026, pose a...
Some interesting comments from Jacob Van Naarden, $LLY head of business development, at STAT's Breakthrough Summit East event yesterday: On deal volume: Jake, himself, is seeing approx 10 deals per week, ie deals that are important enough, or diligenced enough,...
Read “Bottle of Lies.” FDA needs to perform spot checks of generics - not just inspections.

A third‑year medical student describes how point‑of‑care calculators like MDCalc translate evidence‑based scores into actionable decisions during an emergency medicine clerkship. While these tools improve consistency, the author warns that they can solidify into rigid protocols, turning probabilistic aids into...

Endometriosis and Oocyte Quality: Morphological Alterations, Developmental Competence, and Modifiable Strategies for Reproductive Longevity https://t.co/I2ZrtJkguK https://t.co/LkH3LXzkcg
Automatic enrollment in Medicare Advantage plans under consideration, top Trump health official says https://t.co/Bgv6WBeo2u via @statnews

The post promotes a recent interview titled “The Vaccine Mafia & Religion” featuring Livio Sanchez of the Vaccine Safety Research Foundation. The conversation, hosted on Rumble, examines how vaccine skepticism is framed through religious language and claims of liability. Readers...
To appeal or not to appeal (yet): The potentially politically dicey situation facing HHS over a preliminary court ruling this week on #ACIP and the rewritten childhood vaccination schedule. By @ChelseaCirruzzo. https://t.co/3P1PW1lDFT