Loss of Schizophrenia Risk Gene XPO7 Disrupts Neuronal Excitability and Network Regularity via Altered Na+ Channel Dynamics in Human Neurons
Researchers used CRISPR‑edited human iPSC‑derived neurons to delete one or both copies of the schizophrenia‑risk gene XPO7. Loss‑of‑function altered voltage‑gated Na⁺ channel conductance, shifting activation and inactivation curves and increasing channel density, especially in heterozygous cells. Electrophysiology and high‑density MEA recordings showed heightened excitability, abnormal action‑potential waveforms, and disrupted network synchrony. Parallel transcriptomic and imaging analyses revealed up‑regulation of SCN sodium‑channel genes, reduced dendritic branching, and lower synapse density, linking XPO7 deficiency to cellular mechanisms of schizophrenia risk.
Postpartum Psychosis Is Associated with Elevated Neuromelanin-MRI Signal in the Midbrain
A new study published in Molecular Psychiatry reports that women with a history of postpartum psychosis (PP) exhibit significantly higher neuromelanin‑MRI (NM‑MRI) signal in the substantia nigra, ventral tegmental area, and related midbrain nuclei compared with demographically matched controls. The...
Printed MoS2 Memristive Nanosheet Networks for Spiking Neurons with Multi-Order Complexity
Researchers at Northwestern University have aerosol‑jet printed graphene/MoS₂/graphene memristive networks that exhibit snap‑back negative differential resistance and volatile threshold switching. The printed devices operate on flexible substrates, delivering oscillatory neuron circuits with tunable spiking frequencies up to 20 kHz and surviving...
Monolithic 3D Integration of Tantalum Pentoxide Nonlinear Photonics
Researchers have unveiled a monolithic three‑dimensional integration platform that embeds tantalum pentoxide (Ta₂O₅) waveguides directly on silicon substrates. The approach delivers ultra‑low propagation loss below 0.08 dB/cm and a Kerr nonlinear coefficient exceeding 1×10⁻¹⁸ m²/W, enabling on‑chip octave‑spanning frequency combs within a...
Brainwide Blood Volume Reflects Opposing Neural Populations
Researchers used functional ultrasound imaging and Neuropixels recordings in mice to map blood volume and neuronal activity across the brain. They discovered that arousal, indexed by whisking, triggers brain‑wide blood‑volume fluctuations driven by two opposing neuronal populations with distinct haemodynamic...
Genome-Wide Tandem Repeat Expansions Modify Schizophrenia Risk in the Presence of a 22q11.2 Deletion
Researchers sequenced the genomes of 438 individuals with the 22q11.2 deletion and discovered that rare tandem repeat expansions (TREs) are significantly enriched in those who develop schizophrenia. The burden of genic TREs showed odds ratios of 1.75–2.14, comparable to the...
Individual versus Group-Based Interventions: A Systematic Review and Meta-Analysis of Physical Activity, Functional, Psychosocial and Health Outcomes
A new meta‑analysis of 71 studies comparing individual and group‑based physical activity (PA) interventions found that group formats deliver a modest, statistically non‑significant advantage for overall activity, psychosocial, and health outcomes, but a significant benefit for functional measures after outlier...
Retraction Note: The Hidden Fitness of the Male Zebra Finch Courtship Song
The authors of a 2024 Nature paper on zebra finch courtship songs have retracted their study after discovering that two synthetic song pairs used in female preference tests were unreliable. One pair correctly ranked short versus long path lengths only...
Identifying the Topographic Signature of Early Martian Oceans
A new study applies Earth‑based topographic metrics to Mars, revealing a broad low‑slope, low‑curvature zone that the authors interpret as an ancient coastal shelf. The shelf spans elevations from roughly –1.8 km to –3.8 km and covers about 10.2 million km², roughly 7 % of...
This Popular, Short Colorado Trail Isn't For The Faint Of Heart
Colorado’s Pete‑E‑Kes to Lemon Squeezer trail, a 3.5‑mile route near Grand Junction, offers a rugged high‑desert experience without steep climbs. The hike’s challenge lies in narrow rock passages that can feel claustrophobic and a rocky, uneven surface. The trail doubles...
Linear RAG Scanning Mediates Editing of Igκ Variable Region Repertoires
The study reveals that linear scanning by the RAG1‑RAG2 complex, rather than loop‑extrusion‑driven diffusion, drives secondary Igκ V(D)J recombination. Deleting the Cer/Sis CTCF‑binding elements converts primary Vκ‑Jκ1 joining into a linear‑scanning mechanism, mirroring the process used for secondary rearrangements. High‑throughput...
Carbonyl Swapping Converts Cyclic Ketones to Saturated Heterocycles
Researchers at Peking University have unveiled a modular carbonyl‑swapping strategy that converts readily available cyclic ketones into a wide array of saturated heterocycles. The approach hinges on a bis(aroylperoxy) ketal intermediate that undergoes electronically guided peroxy cleavage, effecting double C–C...
Giant Room-Temperature Third-Order Electrical Transport in a Thin-Film Altermagnet Candidate
Researchers report a giant third‑order electrical transport response at room temperature in (101)‑oriented RuO₂ thin films 5–9 nm thick. The third‑order Hall signal surpasses that of previously studied materials such as FeSn, MnBi₂Te₄, and Cd₃As₂, even without high magnetic fields. X‑ray...
Feature Selection Leads to Divergent Neurobiological Interpretations of Brain-Based Machine Learning Biomarkers
A new study in Nature Human Behaviour shows that the common practice of univariate feature selection in brain‑based machine‑learning models discards many informative connections. By partitioning connectome edges into ten non‑overlapping deciles, the researchers demonstrated that mid‑ranked and lower‑ranked feature...
Don't Feel Like Exercising? Maybe It's the Wrong Time of Day for You
A new Open Heart study of 134 Pakistani adults in their 40s and 50s with heart‑risk factors found that aligning exercise with an individual’s chronotype—morning for larks, evening for owls—produces larger gains in blood pressure, aerobic capacity, metabolic markers and...
Study Finds when Parents Are Depressed May Shape Children’s Mental Health for Decades
A new 30‑year longitudinal study of 5,329 British individuals published in JAMA Network Open shows that the timing of parental depression critically shapes adult mental‑health outcomes. Exposure to maternal depression during late pregnancy increased the odds of psychotic symptoms by...
American Express Global Lounge Collection: Lounges You Can Access and Cards That Get You In
American Express’s Global Lounge Collection gives Platinum, Business Platinum, Centurion and Business Centurion cardholders entry to more than 1,550 lounges in 140 countries, including flagship Centurion lounges, Escape, Plaza Premium, Priority Pass Select, Delta Sky Club and select Lufthansa locations. The...
Washington's Unsung Island Is A San Juan Alternative Filled With Scenic Beaches And A Thriving Art Scene
Camano Island, a 40‑square‑mile landmass east of Whidbey Island, offers a quieter alternative to the San Juan archipelago. Accessible via a bridge, it lies just an hour from downtown Seattle, making day trips easy. The island boasts scenic state parks—including a...
Beef Prices Are Soaring In 2026 (And It Might Just Get Worse)
U.S. beef prices surged about 16% in 2026, with ground beef averaging $6.70 per pound and steaks $12.73 per pound—roughly double the 2021 cost. Federal Reserve Bank of St. Louis data shows a sharp jump after a decade of modest...
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The Hubble Space Telescope captured a detailed view of NGC 602, a 5‑million‑year‑old star cluster on the outskirts of the Small Magellanic Cloud, located about 200,000 light‑years from Earth. The image spans roughly 200 light‑years and shows massive young stars eroding...
Spotify Rolls Out Government Vaping Education Campaign
Spotify has teamed with the Australian Government to launch the third phase of its anti‑vaping initiative, titled “Buddy Up – Make a Pact to Quit Together.” The new phase shifts focus from education to a community‑driven model that encourages peers...
Godzilla Minus Zero: First Trailer Sees the Statue of Liberty in Danger
*Godzilla Minus Zero*, the sequel to the Oscar‑winning *Godzilla Minus One*, drops its first trailer showing the monster heading for New York’s Statue of Liberty. Set in 1949, the film follows the Shikishima family as they confront a new calamity, with Ryunosuke Kamiki and...
Astronauts as Influencers
Artemis II marked the first moon‑orbit mission to be broadcast across a dozen streaming services and traditional TV networks, generating fragmented but massive viewership. Nielsen reported 18.1 million tuned in for the launch and 27.3 million watched the splashdown on legacy news channels,...
The Only 2 Ingredients Slow-Cooker Ribs Need For Rich Sticky-Sweet Flavor
The article presents a minimalist slow‑cooker short rib recipe that relies on just Coca‑Cola and barbecue sauce to achieve a rich, sticky‑sweet flavor. The soda’s acidity breaks down tough meat while the sauce adds caramelized depth, and a final broil...
SharkNinja's New $499 Vacuum Flexes Under Furniture and Can Auto-Empty
SharkNinja introduced the PowerDetect Speed Clean and Empty System, a $499 cordless stick vacuum that can bend under furniture using its MultiFlex Technology and automatically empty its dustbin into a dock. The vacuum adjusts suction based on floor type and...
Young Stars Dim Quickly in Their X-Ray Output, Potentially Benefiting Orbiting Planets
Scientists using NASA’s Chandra X‑ray Observatory discovered that Sun‑like stars dim their X‑ray emission far more rapidly than previously modeled. By examining eight star clusters aged 45‑750 million years, they found X‑ray output drops to roughly a quarter‑third of expected levels...
A Garmin Trademark Filing Hints at a New Whoop-Like Wearable
Garmin has filed a U.S. trademark for a new screen‑free wearable named Cirqa, positioning it as a recovery‑focused health band that streams data to a companion app. The filing describes the device as a non‑medical sensor that monitors bio‑signals, stress...
Butterfly Numbers Are Dropping but Here Are Five Species You May See More Of
The UK Butterfly Monitoring Scheme, with 44 million records from 782 000 surveys since 1976, shows a mixed picture for British butterflies. While 33 of the 59 native species have declined, five adaptable species—including the Red admiral and Large Blue—are thriving as...
Dua Lipa Calls This Britney Spears Hit ‘One of the Greatest Pop Songs Ever Made’: ‘She’s Such an Icon’
Dua Lipa praised Britney Spears’ 2003 hit “Toxic” as one of the greatest pop songs ever made during Vogue’s Toast to Cinema series, where she crafted a Basil Smash cocktail inspired by the track. Lipa highlighted the song’s timeless appeal,...
You Only Need 3 Ingredients To Recreate Dunkin's Dunkalatte At Home
Dunkin' introduced the Dunkalatte in late 2024, a latte made with espresso and a homemade coffee‑milk blend. The drink’s popularity caused a temporary shortage of coffee milk, prompting a brief discontinuation before sporadic returns. Home enthusiasts can replicate the beverage...
Sperm Whales May Make Their Own Vowel Sounds, Similar to Human Language
A new study in Proceedings of the Royal Society B shows sperm whales produce two distinct click types, dubbed a‑coda and i‑coda, that function like vowel sounds in human speech. Researchers used spectrogram analysis to reveal that whales manipulate a...
Faherty’s Cofounder on Turning a Childhood Goal Into a Global Brand
Faherty, the surf‑inspired apparel label founded by twins Alex and Mike Faherty in 2013, has grown into a nine‑figure business in just over a decade. The family‑run operation now employs about 130 corporate staff and more than 600 retail workers,...
The New V&A East Museum Has Culinary as Well as Cultural Clout. Café Jikoni Is a Fresh Idea for Feeding...
Café Jikoni, the acclaimed Marylebone eatery, has opened inside the new V&A East museum in Stratford, offering a menu that fuses South Asian, Kenyan, Persian and British flavors. Chef Ravinder Bhogal and co‑founder Nadeem Nanjuwany emphasize house‑made dishes, traceable Ugandan...
Triassic Croc Relative From Ghost Ranch, New Mexico Finally Identified After Nearly 80 Years in Museum Basement
A fossil unearthed in 1948 at Ghost Ranch, New Mexico, has been re‑examined and named Eosphorosuchus lacrimosa, a short‑snouted crocodylomorph distinct from the previously assumed Hesperosuchus agilis. The specimen, hidden in Yale's Peabody Museum basement for 75 years, features a...
Ranking Every Line From the Hershey Biopic Trailer
A trailer for the upcoming Hershey biopic, produced by Angel Studios, has surfaced and been dissected line‑by‑line. The short clip mixes a nostalgic, Christian‑work‑ethic aesthetic with a low‑budget, almost AI‑generated script. Angel Studios, known for faith‑based hits like *The Sound...
Women Who Have Made History at the Rock & Roll Hall of Fame
The Rock & Roll Hall of Fame’s 2026 class features six women—Sade, Gillian Gilbert, Celia Cruz, Queen Latifah, MC Lyte and Linda Creed—continuing a five‑year streak of gender‑diverse inductees. The list highlights historic firsts, from Celia Cruz as the inaugural Latin American...
Missouri's Vibrant Suburb Outside St. Louis Has An Artsy Downtown, Local Eats, And Scenic Parks
University City, a vibrant suburb just northwest of St. Louis, anchors its appeal around the historic Delmar Loop—a pedestrian‑friendly strip of cafés, boutiques, and live‑music venues highlighted by the Chuck Berry statue. The neighborhood blends cultural attractions with a diverse dining scene,...
Plasma P-Tau217 Tracks Alzheimer’s Biomarkers Over Time
A multi‑center longitudinal study shows that plasma p‑tau217 reliably tracks core Alzheimer’s disease biomarkers over time. Researchers measured p‑tau217 in blood samples from 1,200 participants and compared the results with amyloid PET scans and cerebrospinal fluid tau levels across a...
A New York Bagel Fest Rolls Into L.A. to Show the Best of West Coast Innovation
BagelFest founder Sam Silverman expanded his New York‑originated bagel celebration to Los Angeles, drawing over 1,000 attendees to a sold‑out event at the Wilshire Boulevard Temple. The inaugural BagelFest West showcased innovative, culturally‑infused bagel creations from West Coast bakers, with only 16% of...
Koa Smith and Friends Got Their Fill of Tubes at a Private Oaxacan Sand Bar
Koa Smith hired a local guide service to unlock a private, gated point break on Oaxaca’s coast, joining fellow surfers Nathan Zoller and Max Beach for a rare session. The team navigated a rough, branch‑laden road that even blew out...
Space Force Selects Blue Origin as Possible Lessor of “Sudden Flats” Site at Vandenberg for Future Heavy Lift Rocket Launches
The U.S. Space Force has chosen Blue Origin to develop and potentially lease the Sudden Flats site, also known as Space Launch Complex‑14, at Vandenberg Space Force Base for future heavy‑lift commercial rockets. The decision follows a December 2025 request...
Vans' Supple Leather Skate-Loafer Is Part Punk, All Stud
Vans has introduced the Loafer 53, a leather slip‑on that merges its iconic skate‑culture aesthetic with business‑casual styling. The shoe features a smooth brown leather upper, alternating rustic studs and plum‑toned jewels, and retains the brand’s signature waffle outsole. Priced...
Luther Vandross Estate Reacts to Rock & Roll Hall of Fame Inclusion: ‘People Reawakened to What Luther Had to Offer’
Luther Vandross, posthumously honored, has been selected for the Rock & Roll Hall of Fame’s Class of 2026, marking his first induction after years of Grammy and industry accolades. The Vandross estate’s manager, David Gottlieb, says the family is “over...
Catching Distant Gamma-Ray Explosions with Precisely Aligned X-Ray Optics
Researchers at Kanazawa University have demonstrated a practical alignment technique for the Micro Pore Optics (MPO) used in the EAGLE wide‑field X‑ray monitor, a key instrument on JAXA’s upcoming HiZ‑GUNDAM satellite. By fine‑tuning the tilt of individual lobster‑eye segments with...
Scientists: First Data From Europe’s Proba-3 Satellites Suggest the Sun’s Slow Solar Wind Is Faster and More Chaotic than Expected
Europe’s Proba‑3 twin‑satellite mission has delivered its first measurements of the Sun’s slow solar wind, revealing that plasma blobs can travel at 250‑500 km/s—far faster than the 100 km/s speeds predicted near the solar surface. The data also show that these blobs...
Neon Bows Horror Movie ‘Alpha’ on Digital Retail Platforms, on Disc June 23
Neon Bows began offering the indie horror film Alpha for rental and purchase on digital platforms on April 14, 2026. The movie will arrive on Blu‑ray on June 23, distributed by Alliance Home Entertainment, and will feature an interview with...
Osgood Perkins Moves to Paramount with New ‘Longlegs’ Movie Starring Nicolas Cage
Indie horror auteur Osgood Perkins is leaving Neon for a new multi‑picture deal with Paramount, beginning with a follow‑up to his breakout film Longlegs starring Nicolas Cage. Cage will reprise his role as the titular killer and join Perkins as a...
Virtual Sunspots Help AI Find Rare Magnetic Matches in Vast Solar Archives
SwRI scientists combined three machine‑learning models to generate realistic solar magnetic patches and used them as queries to retrieve matching real observations, turning generative AI into a data‑interrogation tool for heliophysics. The method links hidden generative space to physical parameters...
Exploring Giraffe-Human Conflict in Kenya
Reticulated giraffes, with fewer than 20,000 individuals left, have suffered a 56% population drop over three decades. In Kenya’s Bour‑Algy Giraffe Sanctuary, researchers surveyed 400 households to gauge human‑giraffe conflict (HGC). The majority of residents view the animals as low‑risk,...
Interstellar A&E: The Scottish Doctor of Space Medicine
Dr Christina Mackaill, a Glasgow A&E physician, has become a leading figure in space medicine, partnering with NASA and the European Space Agency. She co‑developed the Mackaill‑Russomano method, a gravity‑defying CPR technique designed for lunar and Martian environments. Mackaill is also helping...