The Bride Flops with $225K Opening, $11.5M Total
#TheBride hits new low of $225K Monday for $11.5M domestic total against $90M budget Good thing WB did so well Sunday night to mask this DISASTER 💀💀💀 https://t.co/jO9ZQ0PIWZ
Microplastics Detected in Every Tested Placenta, Threatening Newborns
It is honestly scary that microplastics are now being found in human placentas, amniotic fluid, breast milk, and even testicular tissue. A 2024 study found microplastics in every single one of the 62 placentas they tested. The plastics in your...
Embrace “Good Enough” Speed, Focus, and Delegation
"What would an incompetent CEO do that would still outpace me?" I added this one question to my morning planning/journal sesh and it's had an impact. It spurs thoughts that I probably wouldn't have otherwise: - They'd say good enough, ship it, improve...
Defensive Mindset: Realistic, Proactive Business Fortification
Building a Fortress Is a Mindset Shift. Thinking defensively doesn’t mean being negative—it means being realistic, proactive, and prepared. The Business Fortress: https://t.co/cgIOurdGHq https://t.co/6Xo8EFoHQK
Navigating Climate Science Amid Growing Uncertainty
Horizons Podcast: Climate Science in an Age of Uncertainty | My recent conversation with @PennSAS Dean Mark Trodden https://t.co/8Ocy4Bk1Tg
Believing You’re on Steroids Increases Strength Significantly
You should placebo yourself into thinking you’re on steroids. Athletes given a placebo they thought was Dianabol added ~8.5 kg to their bench, ~7 kg to their military press, and ~16 kg to their squat in 4 weeks compared to when...
Single-Cell Analysis Advances Neurodegenerative Disease Understanding
Neurodegenerative diseases at the single-cell level, a powerful tool to differentiate and better understand https://t.co/Pkz4qW0ELM @jclinicalinvest https://t.co/LiJ4FojRYZ
Stop Apologizing for Your Time, Own Your Priorities
“The moment you begin apologizing for how you manage your time, you are essentially apologizing for your priorities, which means apologizing for your life.” — Maria Popova (@themarginalian) Listen to this special episode on how to simplify your life in...
Physician Burnout Stems From Lost Authority and Opacity
This week on Lifers, Graham Walker is “sounding the alarm” for physicians. * 50% of medical students already plan to quit before they finish school. * Doctors are becoming "factory employees," losing their authority to care for patients. * Tech focuses on the...
Living Is Rare; Most People Merely Exist
To live is the rarest thing in the world. Most people exist, that is all. — Oscar Wilde https://t.co/caQtIwYE1U
Comfort Is a Self‑Made Prison; Courage Is True Freedom
Most people are living in a prison they built themselves. • The safe job. • The predictable income. • The comfortable routine. Then they call people who escaped "lucky." "Luck" is just what comfortable people call "courage"
Shift From Rigid Focus to Values‑aligned Agility
Emotionally rigid: Keep your head down, one eye on the prize, the other on the bottom line, no matter the cost. Emotionally agile: Realize your circumstances have evolved, and make a values-aligned choice to change course. These questions can help you reevaluate...
Know What You Want, Act; Overthinking Hinders
Re introspection After I graduated from college and did not get offered a full-time job at the NYT where I was an intern, I decided to spend a month hiking on the Appalachian Trail to do some reflecting on what...
Genre Guides, Not Governs: Use It to Elevate Writing
I recently wrote about the downfalls of obsessing too much over your genre. That has sparked author Andromeda Romano-Lax to argue for how genre can inspire and instruct rather than limit. Her take: https://janefriedman.com/genre-as-delight-not-dictator-how-learning-about-genres-helps-you-write-better/
Brendan Canty Rings Cantybell at Minute One
when brendan canty hits the cantybell™ almost exactly one minute into the new messthetics https://t.co/Cfx1nfVIi8
Co‑varying Residues in MSAs Predict Protein Contact Points
A great read: What we can learn from evolving proteins "A signal hidden in Mulitple Sequence Alignments (MSAs): amino acid positions that tend to co-vary in the MSA tend to interact with each other in the folded structure, often via direct...
Meteorite Crash in NE Ohio Leaves Everyone Unharmed
NE Ohio just got hit with a meteorite, heard it from all over .. I think it was a truck unloading by our house. Looks like everyone's OK
Speed Work Beats Long Runs for Aging Athletes
“A lot of people tend to drift up in distance as they age, thinking, “well, if I can’t go faster, I’ll just go longer.” I believe dropping down is underrated and probably provides more bang for your buck as you...
Indispensability, Not Workload, Drives Burnout
You don’t have a workload problem. You have an “I must be indispensable” problem. If your value is tied to being the one who holds everything together… your burnout IS guaranteed.
Celebrate Each Child's Uniqueness, Avoid Labels and Rivalry
• Labels shape identity. • Comparison fuels rivalry. • Celebrate uniqueness. • Avoid side-taking. Reflect. #SiblingRivalry #HealthyFamilies #ParentingAdvice #ConsciousParenting #FamilyDynamics
Hidden Mistakes, Not Bad Data, Threaten Genomics
1/ You think the biggest danger in genomics is bad data. More than that. It's the mistakes you make—without knowing. Here are the ones I learned the hard way. 🧵 https://t.co/3oj9cseVq7
Biology Leaders Tackle Alzheimer Research Reproducibility Crisis
For decades, they’ve set the record straight in biology. Next up: science’s reproducibility crisis A new coalition of biology grand challenge organizers will assess Alzheimer’s literature https://t.co/nLX1g0EEcB
Ann Wilson Launches “In My Voice” Documentary Tour
Heart’s Ann Wilson to Premiere New Documentary, ‘In My Voice,’ With 10-City Screening/Q&A Tour (EXCLUSIVE) https://t.co/gkdLEPEQz1 via @variety
Elastic Tissues Store and Release Energy Within the Body
Elastic tissues aren't isolated; they're part of a messy, damped, energy-leaking body. What they do is store a chunk of it temporarily as stretch, twist, or shear then dump it back out as recoil.
Teach Kids Movement, Not Just Conditioning, for Real Speed
Most youth athletes don’t need more conditioning… They need to learn how to move. We’ve got 8-year-olds doing ladders and suicides...who can’t balance, skip, or control their body. That’s the problem. Speed Demons program gives45 athletic activities and games you can use: 🏡 Backyard 🏋️ Gym 🏈...
FreezOpt Controls Ice Nucleation, Preserves Cells in Cryopreservation
I've always been fascinated by animals that can survive being frozen—cell walls are delicate and can be destroyed by ice crystals. HOHCells just launched FreezOpt, which is designed to keep cells intact during cryopreservation. It enables controlled initiation of ice...
Consistent Daily Effort Turns Dreams Into SRE Reality
Few years ago, I dreamt of becoming a DevOps Engineer. Today, I’m an SRE/DevOps Engineer. Not by luck. Not overnight. But by showing up daily — even on days I felt stuck. What are you doing today that your future self will thank you for?
Dirty Bulking Harms Metabolism; Choose Whole‑food Fueling
I require routine labs for my athletes every 6–12 months and the trend is clear: “Dirty bulking” is damaging metabolic health. I am seeing: • Elevated triglycerides • Increased cholesterol • Poor blood glucose control Mass without strategy ≠ performance. Course correct with: ✔️ Fiber-rich carbs ✔️ Lean protein ✔️...
One Solid Win Kickstarts Lasting Improvement
If you want to get better at anything, it starts with 1 success. If you want to be a better trader, you make 1 good trade with solid rules including risk/sizing/exit management. If you want to get healthier, you eat real food,...
Disney Appoints Ex‑Google Product Chief to Lead Streaming
🔥 The most interesting/exciting part of Disney's leadership reorg that is not getting talked about is that former Google/YouTube chief product officer Adam Smith has been elevated to co-head of Disney's DTC businesses. Placing a tech/product person, without legacy...
Real Leaders Confront Challenges, Don't Disappear
Tired of bosses who vanish when things get tough? True leadership means facing challenges head-on, not hiding from them. Stream now: 🔗 https://t.co/JgtHAvt0Jg 📽️ https://t.co/ZUgNnzEnoz 🔗 https://t.co/DmYp21NDA3 https://t.co/RQhrS6W64N
Putting Baby to Sleep Shouldn't Feel Like a Spy Mission
Placing a sleeping baby in the crib shouldn’t feel like a covert mission… and yet here we are. You’ve rocked, bounced, paced the hallway like it’s your job. Th
Elite Athletes Fuel Success with Disciplined Nutrition and Mindset
Elite athletes don’t… ❌ Skip meals especially breakfast ❌ Gossip about teammates or blame others for their own failures ❌ Stay up late scrolling or partying all summer ❌ Miss training or ignore chances to sharpen their skills ❌ Avoid hard nutrition changes or cling...
Teen Rebellion Targets Autonomy‑Driven Areas Like Homework, Screens
Teen resistance is rarely random. It usually shows up in predictable places: Homework Screens Sleep Chores Social life These areas all involve autonomy.
Treat Writing Like a Sport: 9 Mental Fitness Habits
I'm not a "genius" writer. But over the last 10 years, I have: • Published 11 books • Written thousands of articles • Built multiple 7-figure writing businesses The secret? I treat my writing like a mental sport. I use these 9 habits to stay...
Quick Decision-Making: 8 Mental Models to Cut Mental Tax
Every unmade decision sitting in your head is a tax: • It drains your focus • It consumes mental energy • It sabotages your conversations The longer it festers, the more it infects your life. Here are 8 mental models I use to make any...
One Decision Can Change Life, Comfort Fuels Misery
Most people are one decision away from a completely different life But they keep choosing comfort And comfort keeps choosing misery
Essential Winter Art Books Curated with Quick Reviews
I've picked my Top Art Books to Read this Winter for @worldofFAD - each with a concise review so you can see if it's for you >> https://t.co/b53RyZCsDR #LondonArtCritic #ArtBooks https://t.co/Si1gbPEwTb
John Galliano Returns with Unexpected New Look
John Galliano is coming back to fashion - and with an unexpected new look: https://t.co/yRCt9q7UYL via @NYTimes
Mechanical Forces: Emerging Tools for Diagnosis and Therapy
Mechanical forces play essential roles in biology. Measuring and controlling these forces represent emerging strategies for disease diagnosis and therapeutic intervention, to complement more traditional approaches. This review article, published today in Nature Reviews Bioengineering (https://t.co/byKGFuVFLH), summarizes the status of...
Seeking Life‑Changing Quotes for My Next Book
I'm getting an urge to write a second book. One thing I've done for years is try to collect wisdom. From books. From people. From my own mistakes. I hear them. I remember them. I try to live them. What sentence or insight...
Open‑Source AI Agent Automates Physics Research End‑to‑End
Physical Superintelligence dropped Get Physics Done, an open-source AI agent that can scope research problems, run experiments, verify results, and draft papers https://t.co/0gDAIMmxe7 #ArtificialIntelligence #Innovation #Technology #Tech #TechNews https://t.co/nudT0C4wXm
Complex Health Needs Multidisciplinary Team, Not Solo Fix
If a trainer, nutritionist, coach, or naturopath tells you they can get to the “root cause” of your health issues on their own… 🚩 Health is complex. Most conditions—especially anything involving hormones, mental health, GI issues, or chronic disease—don’t have a single...
One Small Step Starts Life‑Changing Momentum
One small step That is all it takes for us to begin making changes in our lives. What will your small step be?
Reading Climbs: Women Lead, Adults Average 15 Books
Here are the most recent stats on reading: • The average adult reads 14.6 books per year • Women on average read 20 books a year • Men on average read 13 books a year • 48% of adults read 6+ books in 2025 Overall, it...
Fatherhood Turns Life’s Draft Into a Fresh Start
everyone told me having a kid would slow me down but my son is 9 months old now and i feel like my life just started this is my first time reflecting on it publicly. here's everything i've learned so far: 1. everything...
Pro Footballers Burn ~3,200 Kcal Daily in Preseason
Pre-season energy expenditure of professional football players ⚽️🔥 This new study investigated energy expenditure of pro football players across a 14-day preseason period using doubly labelled water 🔍 Which encompassed a… 🥅 Training only week 🏆 Training + match week Here is what they...
Graceful Parenting Meets Teenage Kitchen Catastrophes
I constantly try to remind myself that my teenager is still just a kid, doing his best to navigate a world grown adults struggle with, and that I need to give him some grace as he grows into the person...
You Control Your Morning Attitude, Be Remarkable
Morning ☀️ everyone :) hope you’re remarkable this morning 🌞… and more importantly.. hope you realize you’re in control of how you are ❤️
What Fugazi Taught Me: Ongoing Lessons
Between the recent Vitiello/Rowe/Canty show in Barcelona and the Albini sessions of In On the Kill Taker, I’ve been thinking a lot about Fugazi lately. In today’s newsletter, I went long on what they meant to me, and what I’m...