Hollywood Stars Rally Against Paramount‑Warner Merger
Joaquin Phoenix, Ben Stiller, Kristen Stewart and 1,000-Plus Hollywood Names Oppose Paramount-Warner Deal in Open Letter: ‘Block the Merger’ https://t.co/1uGZPIVoSq
Peptides Are Potent Therapeutics, yet only a Few Qualify.
“The big picture is that peptides are a legitimate, powerful class of therapeutics, but the legitimacy is confined to a relatively narrow subset of them.” —Peter Attia 👨🏻⚕️
When Work Becomes Yours, Effort Feels Effortless
Effortless effort isn’t the absence of work. It’s what work looks like when it finally belongs to you.
Integrate scRNA‑seq PBMCs only After Evaluating Batch Effects
🧵 Should you integrate single-cell RNA-seq datasets or not? You've got PBMCs from multiple donors. Merge them—or keep them separate? Let's break it down.
Embrace Uncertainty: Mid‑Journey Isn’t Failure
You are allowed to be in the middle of figuring it out without calling it failure.
Talking Enhances Attention, Memory, Mood and Brain Health
Brand new TPH episode with Dr. Maryellen Macdonald about how talking sharpens attention, boosts memory, regulates emotions, and even protects against cognitive decline. https://t.co/f39rfYufQO
7 Running Don’ts for Consistent Progress
7 Running DON’Ts to Keep You on Track: 1. Don’t try anything new on race week—stick to your routine. 2. Don’t run too hard, too often; balance is key. 3. Don’t be afraid to walk; it’s part of the journey. 4. Don’t neglect your...
Your Circle Determines Your Growth—Choose Upward Company
A reminder to start the week: If the people around you aren’t leveling up, they’re holding you down. Your environment shapes your outcome. Success is never built alone, you can always tell who has the right people behind them. Surround...
Efficiency Means Trimming Nonessential Tasks, Not Passion Projects
Often we act as if “efficiency” means minimizing all types of work. It is, for work that needs to be done but isn’t key to your winning, or fun for you. Like paying taxes. But don’t minimize work you love, or that...
Tour Skipping Midwest Sparks Personal Offense
This "Gillian Welch/David Rawlings play the Dead's RECKONING" tour skipping the midwest is a personal affront.
Change Comes When Excuses Exhaust, Not Fearlessness
The women who change their lives are not always the most fearless. They are usually the ones who got tired enough of their own excuses.
Light Monday and Friday Schedules Boost Admin Time
A light schedule on Mondays & Fridays is the cheat code. More admin time than back to back meetings 👌🏾
Artemis–Chinese Space Station Distance Might Exceed Estimates
Oh, but wait.... A preliminary check suggests the Artemis- Chinese Space Station max distance may be even larger. I'll have to do a more careful analysis
Motivate a Dreamer: Share This Monday Inspiration
Keep dreaming on this Monday morning .. send this to someone you know “can make it” ❤️❤️❤️ 😴 💭 https://t.co/iLUmpXuZZy
Free Weekly Guide to Raising Tweens and Teens
Every Monday I send out an “Untangling Family Life” newsletter full of practical guidance on raising tweens and teens. Click here to read today’s newsletter and, if you like what you see, subscribe for free: https://t.co/Zn6McyVilu https://t.co/UBay9dcUED
Affordable London Housing Embraces Arts & Crafts Aesthetics
"Textured brickwork, arch motifs and large mansard roofs nod to the Arts and Crafts style surroundings of Farmstead Road, an affordable housing development in London by local studio Metropolitan Workshop." #passivhaus #passivehouse https://t.co/XgA8QmCTpA https://t.co/twVWdeQXFH
Eat Big to Cut Weight and Keep Power
This is how a 57kg MMA fighter ate in camp to make weight 2,500kcals 350g carbs 150g protein 46g fats When you train like a beast, you need to eat like one too Funny thing is he’s eating more now...
Same DEXA Score, Different Fracture Risks Explained
Your DEXA scan gives you a number, your doctor gives you a category, but the conversation often ends there... there's so much more nuance. Two people with the exact same T-score can have completely different fracture risk, and DEXA...
Amazon Slashes The Growth Equation Price 26% in UK
Wow. So Amazon are offering my book, The Growth Equation at a whopping 26% discount in the UK. This is the best price I've ever seen it, so worth grabbing a few copies for your founder freinds 😇 https://t.co/Xzg0WBUY5a
Vietnamese Animator Debuts ‘In Waves’ at Cannes
Beautiful first look at the animated film titled In Waves - premiering in the Critics Week sidebar at #Cannes2026 this May. Directed by Vietnamese animation filmmaker Phuong Mai Nguyen (who graduated from Les Gobelins in France). A love story /...
Bold Choices Outlive Safety; They Define Your Legacy
36 years on Earth taught me that nobody remembers the version of you that played it safe Not your kids. Not your future self. Bold moves compound. Safe ones just pass time Here are 7 more cheat codes I wish I knew...
Pancreatic Cancer Trials Yield Only 1‑2 Month Gains
I remember years ago in pancreatic cancer trials you were realistically looking for 1 to 2 months improvement in survival (at best) in pancreatic cancer trials. Bravo $RVMD.👏
Caffeine Boosts Performance, Disrupts Sleep—Timing Is Key
Caffeine can enhance performance and impair sleep. Learn how dose and timing matter in sport. Sign up: https://t.co/0PJC4DLDwV https://t.co/PHd1LGS0UD
Ask, Listen, and Build Deeper, Meaningful Connections
Asking questions and listening attentively to the response with the intent to learn more about the person is the key to cultivating high-quality connections. Working to better understand the other person by asking questions about what's important to them,...
Second‑line RVMD Improves Pancreatic Cancer Survival over First
As noted by others, the $RVMD dara mOS in 2nd line PDAC is better than mOS for current first-line regimens.
Straw Passivhaus in NZ Proves Low‑Carbon, Recyclable Living
Straw built Passivhaus coming to Grand Designs NZ: "You can have a passive house, which is very low energy & low carbon - the owners have the view that the material should be ultimately recyclable. This build breaks stereotypes.” #passivhaus #lowcarbon https://t.co/aHdNY7cl28
Trust Yourself, Rely on Close Allies, Dismiss the Noise
Trust yourself & your own experience first, And then a small group of close & proven confidants. Assume everything else is noise or willful misdirection. This is the age we live in.
Turning Stress Into Recovery With One Unexpected Purchase
March got away from me. I let the habits slip, the stress stack, and the nervous system pay the price. April has been different. I wrote about what I'm doing to come back to myself — including the most annoying purchase...
Artemis 2 Set Record: 413,145 Km From Earth
Artemis 2 was the furthest human voyage from Earth. Per the final JPL Horizons trajectory I estimate the max distance from the geocenter was 413145 km at 2304 UTC Apr 6 (about 4 km less and 1...
Low‑Cost Vaccine Creator Outshines Rogan’s Diet Critique
I make low cost vaccines for global health, including a Covid vaccine technology for $2-3 per dose reached 100 million people, bypassed big pharma, didn’t make money, and all these Rogan types can talk about is a joke I made...
Future‑Focused Hard Work Means Building What’s Missing
Paul Graham’s essay on hard work is full of gems, but this one really stuck: 'To do hard work, live in the future, then build what's missing.' What comes next shifts your whole perspective. Here’s what he had to say:
Existing Home Upgraded to Meet Passivhaus Standards
"...the project involved updating the existing home to meet rigorous Passivhaus standards while introducing a new..." #passivhaus #passivehouse #retrofit #EnerPHit https://t.co/RkuqBv28Rr https://t.co/8bYeC3LV22
Angara-5M to Launch PTK Prototype by 2028
Upgraded Angara-5M rocket is now promised to fly with a development prototype of the PTK crew vehicle during a 2027-2028 period (a delay from 2025). Context and full story: https://t.co/ithnEIbQfV https://t.co/g9fUBxzoNz
STATION MODEL VIOLENCE's New Album Inspires Punk Reflection
New album from STATION MODEL VIOLENCE is straight-up inspiring and so was this correspondence with the great punk mind Daniel Stewart https://open.substack.com/pub/thefutureisourstomake/p/sometimes-you-need-to-keep-a-wound
Admired Leaders Excel Through Feedback, Behavior, Followership
Leadership is shaped by behavior, feedback, and followership. A conversation with Randall Stutman, founder of @AdmiredLeaders, on what admired leaders do differently, giving feedback, and the behaviors that drive results. https://t.co/UAyXtb5Nqq With thanks to @AlphaSenseInc, Canoe, and Ridgeline.
Flight Attendant Pours Flawless Tea Stream at 35,000 Feet
Flight Attendant Pours Tea In One Long Perfect Stream At 35,000 Feet [Roundup] - View from the Wing https://t.co/OMCvbN0CSW
Keep Moving: Rest Worsens Knee Osteoarthritis
Knee Osteoarthritis... Thread #2 ! Your knee hurts. Your instinct is to rest it. Please don't. That instinct is very often wrong — and following it makes osteoarthritis worse, not better. Movement is one of the best evidence-based primary treatments for...
Simple Health Upgrades Offer Massive Returns
Health stuff I spend money on that’s 100% worth it: - High-quality mattress - Blackout shades - Sauna - Quarterly blood panels - Wild Roman skincare - Food sensitivity test - Non-toxic cookwear - White noise machine - Bright desk lamp Simple investments with asymmetric returns.
Daraxonrasib Halves Pancreatic Cancer Mortality, Doubles Survival
Finally, best news of the morning (and something you didn't expect so soon)... Revolution Medicines $RVMD daraxonrasib Ph3 results in second-line pancreatic cancer. Median overall survival in ITT patients (KRAS mutants + wild type combined) Dara 13.2 months vs chemo 6.7...
5 Affordable Passivhaus Retrofit Tips From the Trust
"The Passivhaus Trust's top 5 tips for affordable Passivhaus retrofits" #passivhaus #passivehouse #enerPHit #retrofit https://t.co/YgBB8AhdAT https://t.co/d2y476l7jb
Your First Anxiety Spot Reveals Where Relief Begins
When you feel anxious, where do you feel it first in your body? Chest. Throat. Jaw. Stomach. Shoulders. I am asking because most people know the answer instantly. They have just never been asked. And the place where you feel it first is often where the release begins.
Teen Clinginess Often Signals Underlying Anxiety, Not Rebellion
Your teen's clinginess might be anxiety. They might be feeling... Insecure Unsure Self-conscious Judged They might need your proximity to feel safe.
Truthful Humility Fuels Grounded Confidence on the Court
Don’t lie to yourself. Grounded confidence begins with truth-telling. Grounded confidence requires courage to act and humility to learn. “When I stepped on the court, I wasn’t out there hoping I could win.” Larry Bird https://t.co/JDFyAiGggc
330kg RDL Shows Hinge Pattern Near Conventional Deadlift
Heres a 330kg RDL for 5. An extreme example of the capacity of the hinge pattern. The Gap between it and conventional deadlift is smaller than you think. https://t.co/jCl8GMoN9q
Social Connections Shape Immune Health Under Stress
Stress and the social self – the fascinating science of how relationships affect our immune system https://t.co/WD4JqfGF3U
Parents Underestimate Deadly Risk of Vaccine‑preventable Diseases
https://youtu.be/sLyGdEtRPyQ?si=HhO95z45Mz20D6kp We never imagine that our children could suffer or die from a vaccine-preventable disease.
Allogeneic CAR‑T Achieves 42% MRD Boost, Safe Profile
Allogene $ALLO cema-cel interim ALPHA3 results just reported: B-cell lymphoma MRD negativity: cema-cel 58% vs observation 16% A 42% absolute difference in MRD clearance is better than expected. Clean safety profile, too. Allogeneic CAR-T may have found its role. Nice...
Self‑Talk Boosts Focus, Memory, Mood, and Brain Health
Do you talk to yourself and feel a little embarrassed about it? For the full 10percenthappier podcast episode with Maryellen MacDonald — cognitive scientist, professor emerita of psychology and language sciences at UW-Madison, and author of More Than Words — head...
Tight 10‑Day Constraints Drive Our Best Work
Before heading out to Lisbon, @vitaliidodonov told me that the greatest work gets done when there's a tight constraint. That's why we've decided on 10 days. From "idea/vision" to finished product in that short time span forces us to do our best...
Revelation Space: A Wild Ride for Hardcore Sci‑Fi Fans
Just finished Alastair Reynold's Revelation Space, what a wild ride. Will review soon on the blog. Definitely recommend, but for hardcore sci-fi fans only.