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Science Spotlight: New Ways to Attack Β-Amyloid Plaques in Alzheimer’s

Two pre‑clinical studies propose active clearance of β‑amyloid as a new Alzheimer’s strategy. Researchers at Washington University engineered astrocytes with chimeric antigen receptors (CARs) that engulf plaques, while another team designed bispecific peptides that ferry amyloid into cells for lysosomal degradation. Both approaches demonstrated reduced plaque load and cognitive benefits in animal models, challenging the reliance on passive anti‑β‑amyloid antibodies.