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‘An AlphaFold 4’ – Scientists Marvel at DeepMind Drug Spin-Off’s Exclusive New AI

Isomorphic Labs unveiled IsoDDE, a proprietary AI engine touted as an “AlphaFold 4”‑level breakthrough in drug discovery. The 27‑page technical report claims the model outperforms AlphaFold 3, the open‑source Boltz‑2, and traditional physics‑based methods in predicting binding affinity and antibody‑protein interactions. Researchers highlighted its ability to generalise to out‑of‑distribution compounds, a problem that has long limited AI‑driven chemistry. Unlike DeepMind’s earlier AlphaFold releases, IsoDDE’s architecture and training data remain undisclosed, sparking both excitement and concern in the scientific community.