New Study Says I Was Wrong About NMN and NR?
Recent human trials have shown that nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) raise circulating NAD levels to a similar extent, contradicting a small Bergen study that suggested NR was superior. Both compounds appear to be metabolized largely by gut microbes into nicotinic acid before entering the NAD biosynthetic pathway. Despite consistent NAD elevation, meta‑analyses reveal little to no improvement in muscle strength, metabolic markers, or long‑COVID symptoms. Consequently, the long‑standing NR‑vs‑NMN rivalry may be a marketing distraction rather than a scientific breakthrough.
New Study Says I Was Wrong About NMN and NR?
Recent human trials have reignited the NR‑vs‑NMN debate, with a small six‑person crossover study suggesting NR raises blood NAD 2.3‑fold more than NMN, while a larger 65‑participant Nature Metabolism trial found no meaningful difference between the two. Both studies, however,...
GLP-1: The Risks They're Hiding From You + My Protocol to Start Producing It Naturally
GLP-1, a naturally produced hormone that regulates blood sugar and satiety, is the same mechanism targeted by weight‑loss drugs such as Ozempic and Wegovy. The article explains that endogenous GLP‑1 is rapidly broken down by the enzyme DPP‑4, whereas pharmaceutical...
Academic Clinical Trials for Rapamycin to Answer Questions on Dosing for Anti-Aging Use
Researchers at UT Health San Antonio have launched a multi‑phase academic clinical trial to evaluate rapamycin’s biological effects in older adults. The program begins with a younger‑cohort benchmark study, then seeks the optimal dose that restores immune and metabolic markers...
A Review Focused on Exerkines in Extracellular Vesicles Generated by Muscle Tissue
A new review examines how muscle‑derived extracellular vesicles (EVs) act as carriers of exercise‑induced exerkines, linking physical activity to systemic health benefits. It details the molecular cargo—proteins, lipids, and non‑coding RNAs—that modulates muscle stem‑cell activation, combats sarcopenia, and influences distant...
Physical Activity Correlates With a Sizable Difference to Late Life Mortality
A 15‑year emulated trial of 11,169 Australian women found that consistently meeting WHO guidelines of at least 150 minutes of moderate‑to‑vigorous activity per week cut all‑cause mortality risk by half, equating to a 5.2‑percentage‑point absolute reduction. The study also observed...
Why Rest Is Essential for Performance
Julia Samuel’s latest Longer Monday Top Tips episode, featuring regenerative performance coach Dr. Pippa Grange, argues that modern work culture’s obsession with nonstop productivity is eroding mental and physical health. The discussion frames burnout as chronic stress that worsens when...
#386 – Aging Clocks—What They Measure, How They Work, and Their Clinical and Real-World Relevance
Aging clocks, built on DNA‑methylation patterns, aim to quantify biological age as a shortcut for long‑term health outcomes. Researchers view them as surrogate endpoints that could compress 20‑year anti‑aging trials into months, helping evaluate drugs or lifestyle interventions. However, the...
What If Ten Habits Could Slow Every Way Your Body Ages?
In 2023 researchers refined the twelve hallmarks of aging, creating a framework that links daily actions to measurable biological processes. A recent article ranks ten simple habits by how many hallmarks they influence, asserting that the top four—waist‑line monitoring, fermented...
Breathing Retraining: What It Is, Why It Works and How to Do It
Breathing retraining targets dysfunctional breathing patterns—over‑breathing, shallow or mouth breathing—by teaching diaphragmatic, slow nasal, and CO₂‑tolerance exercises. Clinical tools like the Nijmegen Questionnaire identify at‑risk individuals, while studies link retraining to higher heart‑rate variability, reduced anxiety, and fewer ER visits....
13 Essential Vitamins Good for the Brain
The article outlines 13 vitamins essential for optimal brain function and explains how deficiencies can blunt the effects of popular nootropic supplements like racetams and tryptophan. It cites NHANES data showing over 40% of U.S. adults lack adequate vitamin intake,...
Signal Reprogramming as an Approach to the Challenge of cGAS-STING Overactivation
A new open‑access review highlights the cGAS‑STING pathway as a central driver of ovarian aging, linking DNA and mitochondrial leaks to chronic inflammation and follicle loss. The authors propose three therapeutic angles: small‑molecule inhibitors that silence cGAS or STING, upstream...
Only Sleep & Sex: How to Engineer Perfect Sleep
The article argues that chronic insomnia stems from trying to force sleep, which raises cognitive arousal, and proposes a permissive approach that treats sleep as an allowed state. It outlines a five‑point framework—circadian alignment, sleep pressure, environmental setup, stimulus control,...
The Future of Joint Regeneration Is Here — And It's Not Coming From Where You Think
A quiet revolution is reshaping joint medicine as researchers demonstrate that cartilage—once deemed irreparable—can be regenerated using a three‑pronged biological protocol. The approach blends stem cells, growth‑factor cocktails, and bio‑engineered scaffolds to stimulate cellular repair at the joint surface. Early...
How To Optimize Exec Performance | Kevin Bailey, CEO @ Dreamfuel
Kevin Bailey, CEO of Dreamfuel, teaches executives to boost performance by managing their nervous system rather than merely coaching behavior. He outlines a "performance chain" where physiology influences emotions, cognition, and ultimately results, and introduces a four‑state model—flight, freeze, fight,...
Proposing Atrial Fibrillation and Heart Failure to Be Manifestations of the Same Condition
Researchers propose that atrial fibrillation and heart failure share a common molecular origin: reduced expression of the transcription factor TBX5. Mouse models lacking TBX5 in the atria develop arrhythmias and gene‑expression patterns that closely resemble heart‑failure signatures. Human atrial tissue...
On MAHA Action's Media Hub, Dr. Cate Shanahan Slams ‘Hateful Eight’ Seed Oils
On April 1, 2026 the MAHA Action Media Hub featured Dr. Cate Shanahan, who denounced eight common seed oils as the most harmful component of ultra‑processed foods. She labeled corn, canola, cottonseed, soy, sunflower, safflower, rice bran and grape seed...
NR0B2 Is Protective of Cartilage, But Expression Decreases as Osteoarthritis Progresses
Researchers identified the orphan nuclear receptor NR0B2 (also known as SHP) as a protective factor in cartilage, with its expression markedly reduced in osteoarthritic tissue. In male mice, global or chondrocyte‑specific deletion of Nr0b2 worsened pain and joint damage after...
What Are Postbiotic Supplements — and Do You Really Need Them?
Postbiotic supplements contain isolated bacterial metabolites such as short‑chain fatty acids, enzymes, and cell‑wall fragments, but they do not replicate the continuous production achieved by a healthy gut microbiome. Research shows these compounds can reinforce gut barrier integrity, lower inflammation,...
Smart Drugs Are Here
A recent proof‑of‑concept study introduces DNA‑drug conjugates (DDCs) that turn “smart drugs” into programmable therapies. DDCs use split DNA strands as logic gates to release payloads only when specific biomarker combinations are present, offering higher specificity than antibody‑drug conjugates (ADCs)....
An Overlooked Aspect of Memory: Gut Microbes
The post spotlights emerging research that links the gut microbiome to memory performance, noting that the gut‑brain axis can directly affect cognitive function. It references a study where transplanting healthy mouse gut microbes into older mice restored their memory abilities....
Remaining Challenges in the Development of Partial Reprogramming Therapies
Partial reprogramming—brief exposure to Yamanaka factors OCT4, SOX2, KLF4 and MYC—has demonstrated modest rejuvenation in mouse studies but carries a substantial cancer risk if cells slip into full pluripotency. Funding is concentrated in a few well‑capitalized firms, notably Altos Labs,...
Beyond Cheap Fish Oil: How A 5:1 DHA Ratio Powers Brain Health & Vision
The article promotes IQ Ultimate Omega‑3, a supplement that delivers a 5:1 DHA‑to‑EPA ratio and is fortified with lutein and zeaxanthin. It explains that DHA is the primary omega‑3 in brain cell membranes and retinal photoreceptors, making a DHA‑dominant formula...
Want a Simple Health Upgrade? Start With Your Air
The post highlights that indoor air is often laden with dust, mold spores, and chemical pollutants, which add to the body’s inflammatory load. It urges readers to improve ventilation by opening windows daily and to introduce indoor plants as a...
March 2026: Dave’s Favorite Products
Dave Asprey’s monthly "Dave’s Favorite Products" series spotlights biohacking tools that reinforce four core health pillars—circulation, cellular strength, mitochondrial energy, and nervous‑system resilience. The February 2026 post continues the trend, linking to January and December roundups that curate supplements, wearables,...
Avoid These 12 Myths & Build More Muscle
A recent scientific review debunked 12 pervasive muscle‑building myths, from elaborate periodization models to the so‑called “anabolic window” and spot‑reduction claims. The authors found that progressive overload, sufficient protein and energy balance, and consistent training volume are the true drivers...
A Gut Microbiome Response to Low Protein Intake Drives Beneficial Browning of Fat Tissue
Researchers have shown that low‑protein diets (LPDs) stimulate the conversion of white adipose tissue into thermogenic beige fat, mirroring effects seen with cold exposure or β‑adrenergic activation. The browning response depends on specific gut microbes; germ‑free mice fail to brown,...
Efforts to Treat Neurodegenerative Disease by Altering the Gut Microbiome
Research increasingly shows that gut microbiome composition influences brain health, with age‑related dysbiosis linked to Alzheimer’s and Parkinson’s disease. Animal studies demonstrate that probiotic strains such as Lactobacillus and Bifidobacterium can reduce neuroinflammation and improve cognitive markers, while fecal microbiota...
Piperine
Piperine, the alkaloid extracted from black pepper, markedly improves the bioavailability of nootropic compounds by inhibiting the drug‑transporter P‑glycoprotein and the liver enzyme CYP3A4. It also acts as a monoamine oxidase inhibitor, raising serotonin, dopamine and norepinephrine levels, which can...
Myth Busting Monday: Do You Need IV Vitamin Drips?
IV vitamin drip clinics have surged across U.S. cities, offering premium‑styled lounges and menu‑driven infusions like “Immunity Boost” and “Glow Up.” Sessions cost roughly $150–$300 and promise quick health benefits, capitalizing on the broader wellness spending boom. However, scientific evidence...
Iodine Requirements During Pregnancy: Timing, Thyroid Hormones, and Fetal Brain Development
The article highlights that only about 20% of UK women know iodine needs rise during pregnancy, despite recommendations increasing from 150 µg to 200‑250 µg daily. Early‑gestation iodine deficiency is linked to measurable drops in child IQ and thyroid hormone deficits, while...
Appetite Regulation, Hunger & Satiety: Mechanisms and Implications for Weight Loss
The article outlines how appetite is governed by both homeostatic energy‑balance mechanisms and hedonic reward pathways, distinguishing hunger, satiation and satiety. It highlights research identifying low‑ and high‑satiety phenotypes, showing high‑satiety individuals lose roughly twice as much weight over 12...
Proven Steps for a Long, Healthy Life
The Formula author has released a two‑page reference called "Proven Steps for a Long, Healthy Life," offered as a free download to paid subscribers. The guide aims to cut through profit‑driven, hype‑filled health advice that dominates social media and news...
A Novel G9a Inhibitor Reduces Symptoms in Mouse Models of Alzheimer's Disease
Researchers have unveiled FLAV-27, a novel G9a histone methyltransferase inhibitor that readily crosses the blood‑brain barrier and exhibits subnanomolar potency. The compound demonstrates high selectivity for G9a over related enzymes and a favorable safety profile, addressing the limitations of earlier...
Reviewing the Aging of Heart Muscle
Researchers review the biological mechanisms behind cardiac aging, highlighting molecular changes such as mitochondrial dysfunction, non‑coding RNA activity, and cellular senescence that impair myocardial energetics and regeneration. The article links these alterations to clinical outcomes like fibrosis, hypertrophy, valve calcification,...
13 BEST Magnesium Supplements Review 2026: Ultimate Guide
A comprehensive 2026 guide reviews 13 magnesium supplements, ranking them by bioavailability, purity, synergistic cofactors, and real‑world results. The methodology, based on four years of personal testing and biometric tracking, disqualifies low‑absorption oxide products. Top picks include RnA ReSet ReMag...
13+ Amazing Magnesium Benefits You Must Know For Optimal Health
Magnesium, an essential mineral involved in over 300 enzymatic processes, is increasingly recognized for its broad health benefits ranging from neuroplasticity to cardiovascular support. Recent analyses highlight that modern diets and lifestyle factors leave the majority of adults deficient, despite...
Protect the Eyes, Protect the Brain—A Potentially Simple Lever for Dementia Risk
Neurodegeneration leading to dementia could affect up to 152 million people worldwide by 2050. A recent meta‑analysis of more than 540,000 older adults found cataract surgery reduces the risk of cognitive impairment or dementia by roughly 25 % compared with untreated cataracts,...
How To Master Hydration with the Water Cures Protocol
The Water Cures protocol proposes that true hydration requires an osmotic pull created by a precise salt‑to‑water ratio rather than sheer water volume. It recommends 1/8 tsp of unrefined sea salt per 16 oz of water and a “10 % rule” –...
Night Shift Weight Loss: A Practical Fasting Guide for Physicians
Physician Aaron Grubner tested a simple fasting rule—no eating from 8 p.m. to 1 a.m.—while working night shifts. Over eight weeks, his weight fell from an average of 207.2 lb to 202.3 lb, a loss of about 4.9 lb (0.8 lb per week). Daily weigh‑ins showed...
1389A. I Injected Stem Cells Into My Penis (Here’s What Happened)
Dave Asprey visited Costa Rica’s RMI Clinic to undergo a neurocognitive protocol that blends functional MRI mapping, neuronavigation, transcranial magnetic stimulation, focused ultrasound and mesenchymal stem‑cell infusion. The treatment targets hypofunctioning brain regions with millimeter precision and is followed by...
Cellular Senescence and Senotherapeutics: The Expert Roundup
Cellular senescence has become a focal point for longevity medicine, prompting a surge of senolytic and senomorphic drug development. Pioneering studies showed that clearing senescent cells can extend healthspan, leading biotech firms like Rubedo, SENISCA, Deciduous Therapeutics, and Arda Therapeutics...
The Latest on Ketone Supplementation
A recent Belgian study published in the Journal of Physiology examined exogenous ketone supplementation around training. Researchers found that consuming ketones during exercise did not improve performance metrics. However, taking ketone esters after a workout appeared to accelerate metabolic recovery...
10-Second Habit That Changes Your Entire Day
Jen Smiley introduces the "Wake Up Shot," a two‑minute, ten‑second morning drink that blends fresh ginger, lemon juice, turmeric with black pepper, and water. The recipe claims to improve digestion, lower inflammation, boost energy, and support immunity when taken first...
The Mice Had Unlimited Food, No Predators, and No Disease. They All Died Anyway.
The post recounts John Calhoun’s 1968 “Universe 25” mouse experiment, where abundant food, water and shelter failed to stop a colony’s collapse once social roles became saturated. Mice entered a “beautiful” phase, losing reproductive drive and social behavior, leading to extinction...
Move Like a Man: Exercise as a Natural Testosterone Booster
Exercise, especially resistance training and high‑intensity interval work, has been shown to raise testosterone levels in men both acutely and over the long term. Declining hormone levels are linked to obesity, stress, and sedentary lifestyles, prompting a shift toward natural,...
How to Future-Proof Your Brain in a World That Makes It Easier Not to Think
The conversation between Gabrielle Lyon and Dr. Tommy Wood reframes brain health as a dynamic process driven by stress management, cognitive demand, and social engagement rather than a static disease‑prevention checklist. Research shows that interpreting stress as a challenge, maintaining...