I Wear a Continuous Glucose Monitor. Here's What MOTS-C Did to My Numbers.
The author, a biohacker who monitors glucose continuously, reports that weekly injections of the mitochondrial peptide MOTS‑c consistently drop post‑meal blood sugar by about 20 mg/dL compared with baseline. The effect appears reproducible across multiple CGM recordings while keeping food intake identical. In addition to lower glucose, the author notes a reduction in visceral fat, positioning MOTS‑c as a promising tool for metabolic health. Despite these personal results, the peptide remains largely absent from mainstream endocrinology discussions.
The Gut Microbe in INDY Related Longevity in Flies
Researchers investigated how the longevity‑associated Indy gene influences the gut microbiome in Drosophila. Indy heterozygous flies displayed lower bacterial load and greater microbial diversity as they aged, while still achieving lifespan extension even in germ‑free conditions. The study linked Indy...
Things I Looked Into While Trying to Fix Chronic Pain
A chronic‑pain sufferer with Hashimoto’s and psoriatic arthritis created a self‑curated guide of over 50 interventions, ranging from low‑dose naltrexone (LDN) to supplements, sauna and creatine. Frustrated by conventional clinicians who dismissed his symptoms, he graded each option by evidence...
Prostate Cancer - I’m Asking for some Specific Advice/Thoughts to Determine My Physical (Cell-Level Age) versus Chronological Age
The large TRAVERSE trial of about 5,200 hypogonadal men found no increase in prostate‑cancer incidence with testosterone replacement therapy—12 cases on treatment versus 11 on placebo—though the study’s 33‑month follow‑up and 60% dropout limit statistical power. Mechanistically, androgen‑receptor saturation occurs...
Peptides / Bioregulators
The invite‑only California Peptide Club convened over 100 tech‑savvy attendees in San Francisco to discuss self‑optimization peptides, a trend now outpacing even pickleball in Google searches. Participants, ranging from clinicians to DIY biohackers, shared personal stacks and demonstrated injection techniques...
Melatonin — the Missing Link Between Sleep Deprivation and Immune Dysregulation
A 2025 narrative review of 50 studies found that sleep deprivation consistently suppresses melatonin, which in turn elevates pro‑inflammatory cytokines, oxidative stress, and impairs natural‑killer and lymphocyte activity. The hormonal drop also triggers cortisol spikes, gut‑barrier damage, and microbiome disruption,...
Dr. Kaeberlein's Optispan Podcast Series - Rapamycin and More
The Optispan podcast hosted by Dr. Kaeberlein outlines a translational protocol for 3‑hydroxyanthranilic acid (3HAA), a mouse‑tested longevity molecule. Using FDA BSA scaling, the human equivalent dose (HED) is calculated at roughly 1.1 g per day for a 70‑kg adult. Safety...
ATF5 as a Point of Tradeoff in Muscle Mass versus Muscle Quality
Researchers discovered that deleting the transcription factor ATF5 in mice prevents the typical age‑related loss of skeletal muscle mass, but this comes at the cost of reduced muscle quality and endurance. ATF5‑deficient mice showed lower activation of mitochondrial quality‑control proteins,...
Why Do Falls Rise with Age? Cerebellar Neuron Firing Problems (and Potential Therapeutics)
A new McGill University study published in PNAS shows that age‑related motor decline is not due to loss of cerebellar Purkinje neurons but to a drop in their intrinsic firing frequency. The researchers demonstrated that suppressing Purkinje firing in young...
Dasatinib and Quercetin as Senolytic May Cause Brain Damage
A March 2026 PNAS study shows that the senolytic combo dasatinib and quercetin (D+Q) triggers demyelination in the corpus callosum of aged mice. The researchers used intermittent oral doses of 5 mg/kg dasatinib and 50 mg/kg quercetin, identical to regimens linked to...
The Longevity Effects of Reduced IGF-1 Signaling Depend on the Stability of the Mitochondrial Genome (Paper April 2026)
The study shows that reducing IGF‑1 signaling via Pappa loss does not extend lifespan in Polg D257A mutator mice, which harbor unstable mitochondrial DNA. While Pappa deletion improves several health metrics—splenomegaly, anemia, inflammation, muscle and cardiac function—the longevity benefit seen in...
Is VC6TF the OSK Reversal Cocktail?
Researchers at the Sinclair Lab have identified a five‑molecule mix called VC6TF that chemically mimics the OSK (Oct4, Sox2, Klf4) gene‑therapy cocktail used to reset cellular age. The core of the “three‑chemical” version discussed by Dr. Sinclair includes CHIR‑99021, RepSox...
Your Spine Shrinks 2cm Every Workday
People lose up to 2 cm of height each workday as spinal discs compress from prolonged sitting. A Dublin product manager measured a 1.8 cm drop by 6 pm, confirming research that the average daily loss is about 19 mm. Traditional stretches like cobra...
Prostate Cancer: A PSA on PSA
Prostate cancer mortality is stalling as advanced‑stage diagnoses climb in the United States and Canada, a trend linked to the 2008‑2012 USPSTF move away from routine PSA screening. New evidence shows that refined PSA strategies—tracking PSA velocity and PSA density—combined...
The Bathroom Habit That May Be Raising Your Blood Pressure
Recent research reveals that antiseptic mouthwash can disrupt oral bacteria that convert dietary nitrate into nitrite, a key step in the body’s nitric oxide production pathway. Reduced nitric oxide leads to modest but measurable rises in blood pressure within days...
Longevity: What 2 or 3 Other Supplemental Medications Would You Use Along with Rapacan/Sirolimus?
An anonymous forum user seeks supplemental drugs to pair with rapamycin (sirolimus) for longevity, already taking resveratrol. Community responses recommend metformin, acarbose, and SGLT2 inhibitors such as dapagliflozin to counter rapamycin‑induced glucose spikes, plus statins or ezetimibe for lipid control...
Exercise Triggers More Brain-Boosting Protein in Fit People
A 2026 Brain Research study found that only after a 12‑week fitness program do sedentary adults show a marked increase in brain‑derived neurotrophic factor (BDNF) during exercise. The rise in BDNF correlated with higher VO2 max scores and translated into faster...
Piracetam
Piracetam, the first racetam‑class nootropic developed by Dr. Corneliu Giurgea at UCB Pharma in 1964, remains a cornerstone of cognitive‑enhancement supplements. It modulates AMPA and NMDA glutamate receptors, boosts acetylcholine activity, and increases cerebral blood flow, supporting memory, learning, and...
The Interventions Testing Program Shows that Another Eleven Compounds Do Not Slow Aging in Mice
The National Institute on Aging’s Interventions Testing Program evaluated eleven small‑molecule and supplement candidates—including astaxanthin, meclizine, mitoglitazone, pioglitazone, α‑ketoglutarate, mifepristone, methotrexate, and an atorvastatin‑telmisartan combo—in genetically heterogeneous UM‑HET3 mice and found none extended lifespan. Earlier studies that suggested modest benefits...
6 Simple Steps To Reset Your Lungs’ Natural Cleaning System
The post explains how everyday pollutants—traffic exhaust, VOC‑laden cleaners, secondhand smoke, and wildfire smoke—overwhelm the lungs’ ciliary cleaning system, leading to mucus buildup, congestion, and reduced endurance. It details the biological limits of cilia and the warning signs of impaired...
Oxygen Sensing as a Component of Differences in Regenerative Capacity Between Species
Researchers investigated how oxygen sensing influences tissue regeneration by comparing amphibian and mammalian models. They cultured frog tadpole limbs and mouse embryos under varied oxygen levels, focusing on the HIF1A protein that stabilizes under low oxygen. Reduced oxygen accelerated wound...
Part I:When the Body Stops Finishing What It Starts
Dr. Benjamin Caplan explains that many middle‑aged professionals experience lingering fatigue not because they lack discipline, but because their bodies' recovery processes no longer finish completely. As physiological margins narrow with age and cumulative stress, minor disruptions linger, producing a...
In Search of Novel Means to Provoke Mild Mitochondrial Stress to Slow Aging
Researchers screened 770 FDA‑approved drugs to find compounds that safely trigger a mild mitochondrial stress response, a process known as mitohormesis that can improve cellular resilience. The screen highlighted terbinafine and miglustat, which extended lifespan and healthspan in C. elegans...
Eat More Salt for Metabolic Health.
Recent analysis challenges the long‑standing advice to limit dietary salt, citing Dr. Ray Peat’s review of roughly 100 studies. Large cohort research shows that lower sodium intake correlates with higher mortality and fewer coronary events, while modest increases in daily sodium...
Dietary Interventions for Healthy Aging: An Epigenetic Perspective
A new review from Nanjing University of Chinese Medicine argues that diet functions as epigenetic software, supplying metabolites such as SAM, NAD+, α‑ketoglutarate and acetyl‑CoA that directly shape DNA methylation and histone modifications. It dissects three evidence‑backed interventions—Caloric Restriction, the...
Fix Your Sleep in 7 Days (Neuroscience-Based Protocol)
The article outlines a 7‑day neuroscience‑based reset designed to retrain the brain’s sleep system. It explains how hyperarousal, misaligned cortisol, dopamine spikes, and circadian disruption keep the mind awake despite physical fatigue. The protocol hinges on three core rules—light exposure,...
How Aging Reshapes the Mammalian Body: Atlas of 7 Million Cells Reveals All
Researchers at The Rockefeller University have created the most comprehensive single‑cell atlas of aging, profiling nearly 7 million cells from 21 mouse organs at 1, 5 and 21 months. The study identified over 1,800 cell subtypes, revealing that about a quarter...
IGF-1 Signaling Suppression Fails to Slow Aging in Mitochondrial Mutator Mice
Researchers examined whether suppressing insulin-like growth factor‑1 (IGF‑1) signaling could extend the lifespan of mitochondrial mutator mice, which carry a high rate of mitochondrial DNA mutations. Contrary to expectations, reduced IGF‑1 signaling did not increase longevity; most downstream pro‑longevity pathways...
Applying Mendelian Randomization to the Correlation Between Fitness and Health
Researchers applied a phenome‑wide Mendelian randomization approach to test whether genetically predicted aerobic fitness causally influences health. Screening 712 European‑ancestry phenotypes, they identified 108 discovery associations, with 34 confirming in independent validation. Higher genetically determined fitness correlated with lower risks...
How Your Gut Signals Fullness — and What Happens When That System Breaks Down
The post explains that the gut hormone GLP‑1, which curbs appetite and stabilizes blood sugar, depends on the short‑chain fatty acid butyrate produced by fermentable fiber. Modern diets high in seed oils and low in resistant starch starve butyrate‑producing bacteria,...
What Your Wearable Knows That Your Doctor Ignores: Weekly Livestream W/ Brooks Leitner
The Food is Health newsletter is hosting a live stream on April 17 at 2 p.m. ET with Dr. Brooks Leitner, a Yale‑trained physician‑scientist and co‑founder of VO Health. The discussion will focus on VO2 max, a fitness metric that research shows...
Vitamin D: The Prohormone Your Doctor Is Under-Dosing
The post argues that vitamin D is a prohormone most physicians under‑dose, often recommending only the minimal 400‑800 IU despite widespread deficiency. It cites research supporting daily intakes of 2,000‑5,000 IU, especially in winter, and highlights the superior bioavailability of vitamin D3 over D2....
Blue Zone BS
The post dismantles the popular Blue Zones narrative, arguing that its longevity claims rest on shaky demographic data and an oversimplified focus on plant‑based diets. It points out inconsistent birth records in regions like Okinawa, Sardinia and Nicoya, which can...
Cellular Senescence and Mitochondrial Dysfunction and the Aging of the Vascular Endothelium
The review links cellular senescence and mitochondrial dysfunction to the aging of the vascular endothelium, showing how reduced nitric‑oxide, oxidative stress, and chronic inflammation drive atherosclerosis, hypertension, and blood‑brain barrier leakage. It details a feedback loop where mitochondrial bioenergetic decline...
Homoharringtonine as a Senotherapeutic Drug
Researchers used a large‑scale drug‑repositioning screen to identify homoharringtonine (HHT), an FDA‑approved anti‑leukemic agent, as a potent senotherapeutic. In vitro, HHT selectively eliminated senescent pre‑adipocytes while sparing healthy cells. In male mice, HHT cleared senescent adipocytes, restored white‑adipose tissue function,...
The Optimal Rep Range for Muscle Growth Isn’t What You Think
Two recent studies challenge the long‑standing belief that 6‑12 reps are optimal for hypertrophy. One intra‑subject trial found no difference in muscle size or protein synthesis between 8‑12‑rep and 20‑25‑rep sets when both were taken to failure, suggesting load is...
Lipoprotein (Lipid) - A Deep Dive Into Genetic Pathways for Actionable Insights
A comprehensive genetic analysis of lipoprotein pathways reveals a PCSK9 gain‑of‑function homozygous variant, a MYLIP loss‑of‑function hit, and a protective NPC1L1 loss‑of‑function allele. The profile also shows an APOA5 risk genotype that is currently offset by high‑dose omega‑3, tirzepatide and...
GHK-Cu Peptide Rescues Aging Cognition but Splits Molecular Pathways in the Brain
Researchers examined the copper‑binding peptide GHK‑Cu, noting its molecular weight of about 402 g/mol and a 15.8% copper composition. Translating the mouse dose of 15 mg/kg to humans yields an 85 mg daily intake, delivering roughly 13.4 mg elemental copper—well above the 10 mg tolerable...
Hair Loss and Graying - A Deep Dive Into Genetic Pathways for Actionable Insights
A detailed personal genomics report links specific DNA variants to hair loss and premature graying, highlighting a homozygous NRF2 impairment, a four‑gene glutathione bottleneck, and a quadruple SRD5A1/2 genotype that perfectly matches dutasteride therapy. The analysis recommends high‑priority sulforaphane supplementation,...
Reversing Some Age-Related Changes via Creation of DNA Gaps with the Box A Domain of HMGB1
Researchers delivered a plasmid encoding the Box A domain of HMGB1 to perimenopausal cynomolgus macaques, inducing DNA gap formation. The intervention reversed age‑related alterations in the plasma proteome, bringing key markers such as APOE and SHBG back to levels observed...
A Single Sauna Session Causes White Blood Cell Mobilization
A study from the University of Eastern Finland found that a single 30‑minute Finnish sauna at 73 °C triggers a rapid, transient increase in circulating white blood cells in middle‑aged adults. Neutrophils, lymphocytes and mixed cell types rose immediately after exposure,...
The Senescence Associated Secretory Phenotype as a Basis for an Aging Clock
Researchers have created a composite Senescence‑Associated Secretory Phenotype (SASP) Score using large‑scale proteomics and a guided autoencoder transformer model. The score, built on curated SASP proteins from the UK Biobank Pharma Proteomics Project, independently predicts mortality and major chronic diseases...
An Approach to Reduce Harmful Inflammation without Greatly Compromising the Normal Immune Response
Scientists at Scripps have discovered a novel way to curb chronic inflammation by targeting the Munc13-4‑syntaxin 7 interaction that activates Toll‑like receptors inside endosomes. After screening roughly 32,000 compounds, they isolated ENDO12, which selectively blocks this molecular handshake without disrupting other...
Your Body Isn't Losing Muscle First. It's Losing Something Far More Important.
Recent research shows that muscle power, not muscle mass or strength, is the first and fastest declining attribute with age, a condition now termed powerpenia. Large fast‑twitch motor neurons begin to die around age 60, causing a shift toward slower...
Study Finds Coffee Tied to ‘Younger’ Biological Age in People with Mental Illness
A November 2025 observational study of 436 Norwegian adults with schizophrenia or affective disorders found that drinking three to four cups of coffee daily was associated with longer telomeres, a cellular marker of biological aging. In adjusted models, these participants...
Evidence for Retrotransposon Suppression to Reduce Biological Age in Humans
Researchers evaluated two FDA‑approved nucleoside reverse transcriptase inhibitor (NRTI) regimens in healthy adults to see if they could blunt age‑related epigenetic drift. Over 12 weeks, the emtricitabine/tenofovir‑alafenamide (FTC/TAF) combo lowered multiple DNA‑methylation clocks, including DunedinPACE and PhenoAge, and reduced inflammatory...
The Cellular Incinerator: How Interventions Like Rapamycin Hijack Autophagy to Hack Aging
A recent review by Ebata and Hansen (2026) synthesizes evidence that dietary restriction, intermittent fasting, spermidine‑rich foods, exercise, sleep hygiene, and hormetic temperature stress all stimulate autophagy—a cellular recycling process linked to longer healthspan. In model organisms, these interventions require...
Industry-Funded Study of the Week: Taurine Supplements
Nestlé’s research unit conducted a double‑blind, crossover trial with 44 healthy adults aged 25‑40, testing a blend of taurine and vitamins B6, B9, and B12. After 14 days of daily supplementation, participants reported significant gains in motivation, attention, mental energy...
An Attempt to Obtain Data on Longevity Effects of Human Psilocybin Use
A small observational analysis compared the longevity of documented psilocybin users—referred to as psychedelic personalities—with cancer and aging researchers. The study identified 11 psychedelic users, 12 cancer researchers and 5 aging researchers who died between 2010 and 2025, excluding deaths...
Reviewing What Is Known of Sex Differences in Response to Established Longevity Interventions
Recent research highlights that male and female mammals, especially mice, respond differently to interventions that aim to slow aging. While women outlive men in most populations, they also endure more disease, a pattern echoed in laboratory rodents where sex‑specific outcomes...