FDA Approves Veppanu, First PROTAC Therapy for ESR1‑Mutant Breast Cancer
The U.S. Food and Drug Administration has approved Veppanu (vepdegestrant), the first PROTAC drug for estrogen‑receptor‑mutant breast cancer. The decision follows the VERITAC‑2 trial, where Veppanu extended median progression‑free survival to five months in the ESR1‑mutant subgroup, compared with 2.1 months on standard fulvestrant.
Documentary Shows Mining-Funded Conservation Shaping Liberia's Nimba Mountains
The documentary "Overburden," produced by historian Gregg Mitman, examines how mining giants like ArcelorMittal are funding conservation in Liberia's Nimba Mountains. The film highlights a recent agreement between ArcelorMittal and the Liberian government to co‑manage the East Nimba Nature Reserve,...
Samsung Galaxy Watch 6 Predicts Fainting Episodes with 84% Accuracy in Clinical Study
Samsung announced that its Galaxy Watch 6 can predict vasovagal syncope up to five minutes before onset, achieving 84.6% accuracy, 90% sensitivity and 64% specificity in a study of 132 patients. The result could reshape wearable health monitoring, but experts...
Yvonne Rogers – ‘The Button Jar’
New York pianist Yvonne Rogers releases her solo piano album "The Button Jar" on Kris Davis’s Pyroclastic Records. The record features eleven composed pieces and three free improvisations, presented as concise miniatures that balance clarity with adventurous exploration. Recorded with...
Low Snowfall Has Silver Lining for Las Vegas Ski Area
Lee Canyon’s 2025/26 ski season began with a robust snowpack but warm March temperatures forced an early winter closure. The resort quickly pivoted, launching its downhill mountain‑bike park on May 1—its earliest opening on record. The bike park features two lifts...
‘Hrithik Roshan Said Kick Me if Needed; He Was in Wet Mud’: Amit Behl Recalls Lakshya Shoot
Amit Behl recalled his experience shooting the 2004 film *Lakshya*, highlighting a memorable scene where Hrithik Roshan allowed himself to be kicked while covered in mud. Director Farhan Akhtar kept every take of Behl’s performance, refusing to edit him out—a contrast to earlier...
Terrestrial Energy to Power Riot Platforms' Data Centers with Four 390 MW Molten‑Salt Reactors
Terrestrial Energy signed a deal to install four 390 MW Generation IV molten‑salt reactors at Riot Platforms' upcoming data‑center sites, providing a total of 4 GW of low‑carbon power. The partnership aims to meet soaring AI compute demand while reducing reliance on fossil‑fuel...
Discover My Top Recommended Investing Book
This week I wrote about one of the best investing books I've ever read. https://t.co/80gBuYmXRm
Gut Metabolites Shape Immunity in Aging and Disease
Gut microbiota-derived metabolites as immune modulators in aging and age-related chronic inflammatory diseases https://t.co/iVUKH7ONVa https://t.co/8M3LmurbCa
Five Pavilions to See at the Venice Biennale
The 2024 Venice Biennale showcases five standout national pavilions. Japan invites visitors to hold 5.5‑kg baby dolls that hide QR‑code poems, creating an intimate, comforting ritual. Britain’s Lubaina Himid pairs bright, multi‑canvas paintings with a pastoral soundscape to interrogate migration...
South Florida Hotels Battle Record Sargassum Invasions, $5B Losses
South Florida beachfront hotels are confronting unprecedented sargassum seaweed invasions that have driven tourism revenue losses of roughly $5 billion. Taxpayers are footing nearly $4 million a year for removal, while scientists explore turning the algae into a food‑grade ingredient.
A Quiet Storm (2025) by Benjamin Nicholas Documentary Short Review
“A Quiet Storm,” Benjamin Nicolas’s 2025 documentary short, returns him to nonfiction after a varied career in photography, advertising and narrative film. The film follows 14‑year‑old Maïto, a Tokyo teenager who channels his yearning for maternal attention into Krump dance,...
Ema Onigah Wants To Sing In Rhythm
Nigerian singer‑songwriter Ema Onigah has dropped his new seven‑track EP “ITEM VII” on Gamma Records, positioning it as a bridge between Afrobeats and rap. The project showcases collaborations with heavyweight producers Ozedikus and Tekno and revisits his earlier work with...
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I’ve Lived in Florida for 25 Years and This Is Its Most Charming Beach Town—And It Has Few Crowds and...
Atlantic Beach, the northernmost of Jacksonville’s beach towns, offers a laid‑back, residential vibe with pristine white‑sand shores and few crowds. The town’s walkable, bike‑friendly layout centers around Beaches Town Center, where indie eateries, boutique shops, and a monthly art walk...
Nanoparticle Platform Achieves 100% Survival in Drug‑Resistant Cancer Mice
Researchers led by Prof. Eijiro Miyako at Tohoku University unveiled a multifunctional nanoparticle that first blocks P‑glycoprotein pumps, then releases doxorubicin, and adds near‑infrared photothermal heating. In mouse models of multidrug‑resistant tumors the treatment caused full tumor regression and 100%...
Blxst Announces New Self-Produced Album ‘Labor of Love’
Grammy‑nominated rapper Blxst announced his next album, Labor of Love, slated for June 12 2026 via EMPIRE. Unlike his 2024 narrative‑driven project, the new record is fully self‑produced and draws on his experiences as a father balancing fame and family. A trailer...
Isomorphic Labs Nears $2 Billion Funding Round Led by Thrive Capital
Isomorphic Labs, the DeepMind‑spun AI drug‑discovery startup, is negotiating a financing round of more than $2 billion. Thrive Capital will lead the round, with Alphabet also participating, positioning the company for global expansion and a next‑generation drug‑design platform.
SpaceX Secures EchoStar’s $17 B Spectrum to Power Next‑Gen Starlink Direct‑to‑Cell
SpaceX has agreed to purchase EchoStar’s AWS‑4 and H‑block spectrum licenses for $17 billion—half cash, half stock—to expand its Starlink Direct‑to‑Cell service. The deal adds 50 MHz of exclusive S‑band and global mobile satellite service rights, positioning SpaceX to deliver broadband to...
5.9.26 | 💛 How I Prepared For A Second (HG) Pregnancy
The author, a Los Angeles entrepreneur, recounts conceiving her first daughter during the COVID‑19 lockdown and now preparing for a second pregnancy despite a family history of Hyperemesis Gravidarum (HG). She describes how remote work and her husband's reduced travel gave...
“The Fierce Urgency of Now”
On April 4, On Being recorded a special podcast episode at New York’s Riverside Church to mark the 59th anniversary of Dr. Martin Luther King Jr.’s “Beyond Vietnam” speech. Hosted by Krista, the conversation featured civil‑rights scholar Michelle Alexander and activist Lucas Johnson, both...
What’s Your Heart’s GPA?
The American Heart Association’s Life’s Essential 8 (LE8) provides a 0‑to‑100 composite score that aggregates four health‑behavior and four health‑factor metrics into a single cardiovascular health grade. The average U.S. adult scores 65, roughly a D+ on traditional grading scales,...
Astronomers Discover A Giant Galaxy That Isn’t Spinning
Astronomers using the James Webb Space Telescope and Keck Observatory identified XMM‑VID1‑2075, a massive galaxy only two billion years old, that exhibits no net rotation. The galaxy’s stars move randomly, and an excess of peripheral light suggests an external object is...
China's NMPA Grants Breakthrough Therapy Designation to NHWD-870 for Rare NUT Carcinoma
Zhejiang Wenda Pharmaceutical's oral BET inhibitor NHWD-870 has earned breakthrough therapy designation from China's NMPA for advanced thoracic NUT carcinoma, after Phase II data showed a 45% response rate and median survival of 9.33 months. The designation accelerates review and...
These 1960s Photos Reveal Jamaica's Lost Paradise
Marine scientist Eileen Graham’s 1960s dive archive captured Jamaica’s reefs at 80‑90% live‑coral cover, showcasing dense coral forests and abundant fish. Decades of hurricanes, invasive species, pollution, overfishing and warming have driven cover down to roughly 10‑20% today. The rediscovered...
Plot Twist Newsletter: Art or Propaganda? The Furore at the Venice Biennale
The Economist's Plot Twist newsletter examines the heated debate surrounding the 2026 Venice Biennale, where several high‑profile installations were accused of serving as state‑backed propaganda. Critics and artists clash over whether the works represent legitimate artistic expression or political messaging,...
Lonely Jupiter-Like Planet 900 Light Years Away Tells Us More About Gas Giants
University of Cincinnati researchers used the James Webb Space Telescope to obtain the first near‑infrared spectroscopic data of exoplanet TOI‑2031Ab, a Jupiter‑sized gas giant located 901 light‑years away. The planet, discovered last year, orbits its star in just six Earth...
Booking.com Makes It Easier Than Ever to Star in Your Own Movie-Inspired Route 66 Road Trip
Booking.com, the Official Travel Partner of the Route 66 Centennial, is launching a limited‑time, movie‑inspired road‑trip package from June 25‑28, 2026. For a symbolic $1 fee, travelers receive a three‑night stay for two, $10,000 in Booking.com Wallet Credits, and a choice of three...
Josephine De Smet Reclaims The Power On ‘Butterflies’
Belgian singer‑songwriter Josephine De Smet has released “Butterflies,” a pop anthem that confronts online hate and reclaims personal confidence. Co‑produced with Pascal Oorts, the track pairs ceremonial layered vocals with rhythmic beats, allowing De Smet’s voice to dominate both delicate and...
Exploring Science-Driven Wellness and Longevity in the Philippines
The Philippines is positioning itself as a premier wellness‑travel destination by leveraging its diverse natural landscapes—from surf‑rich Siargao to cool highlands like Baguio—and integrating indigenous healing traditions such as hilot and kawa baths with modern longevity programs. The Department of...
Day 76 - The Morning Wins: Why the First Hour Determines Everything
The post argues that the first hour after waking determines the rest of the day’s performance. It outlines a three‑block routine—movement, mental prep, and nutrition—while banning phone use. By controlling this hour, readers can boost energy, focus, momentum, and confidence....
Wolf Worm by T Kingfisher💙📚
T Kingfisher’s novella *Wolf Worm* follows 1899 scientific illustrator Sonia Wilson as she takes a job with the eerie Dr. Halder in rural North Carolina. While sketching his collection of grotesque insects, she encounters bizarre animal threats—a watching squirrel and a door‑opening possum—that...
How to Avoid Shin Pain When You Run
Shin pain affects roughly one in five runners and accounts for over half of lower‑leg injuries, disrupting training cycles and overall wellbeing. The article outlines three primary sources—medial tibial stress syndrome (shin splints), tibial stress fractures, and chronic exertional compartment...
Patience Outpaces Shortcuts for Long-Term Success
Most people are chasing shortcuts. This is why patience is the rare skill that will propel you further than most.
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Amazon Is Quietly Clearing Out Inventory Ahead of Summer—Shop the 50 Best Travel Deals Up to 75% Off
Amazon is quietly clearing out travel‑related inventory ahead of the summer season, offering discounts up to 75% across clothing, shoes, luggage and accessories. Deals include $50 earbuds (originally $199), Delsey Paris luggage for $294 (down from $450), and a range...
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The 1-Ingredient Secret to Exceptionally Creamy Scrambled Eggs
A simple cornstarch slurry added to beaten eggs creates ultra‑creamy scrambled eggs that stay soft even after minutes on the plate. The method, first documented by blogger Mandy Lee and later popularized by chef J. Kenji López‑Alt, involves whisking 1½ teaspoons of...
Vibrant Bird Baths Transform Your Backyard Oasis
From classic pedestals to colorful glass hangers, these bird baths are sure to bring a little more life to your backyard. https://t.co/462WtPYWuN https://t.co/Y2dMo9yHoF
Eckotrigger Embrace The Pleasure & Pain
London‑based duo Eckotrigger has dropped "Pleasure & Pain," an 80s‑inspired synth‑pop single that channels the spirit of Depeche Mode, The Cure and David Bowie. The track blends nostalgic electronic textures with contemporary production reminiscent of Hot Chip and Metronomy. Founders...
5 of the Best Hotels in Tokyo for Architecture and Design
Tokyo’s boutique hotel scene is gaining global attention, with the Michelin Guide naming five design‑focused properties that span from budget‑friendly to luxury. BnA_WALL turns each room into a living artwork, while K5 swaps televisions for vinyl players to encourage slower...
Cut Toxic, Unreliable People Out of Your Life Fast
"The toxic people who are trying to fool you or lie to you — who aren't reliable in meeting their commitments — the great lesson is [to] get them the hell out of your life. And do it fast". —...
The Narrow Window of Redemption
The article repurposes the childhood five‑second rule as a metaphor for rapid error correction in innovation. It argues that small, fixable mistakes should be addressed immediately rather than ignored, because lingering errors stall progress. By treating brief windows of redemption...
Rocky Has Entered the Building
The Philadelphia Museum of Art’s new exhibition “Rising Up: Rocky and the Making of Monuments” examines the iconic Rocky Balboa statue, a 1980 commission that has become a global tourist magnet. An estimated four million visitors flock to the statue each...
Poetry Review: ‘Wellwater,’ by Karen Solie
Canadian poet Karen Solie’s seventh collection, *Wellwater*, blends deadpan humor with stark ecological observation. The poems navigate prairie and northern cityscapes, exposing glyphosate drift, fracking, and water scarcity while probing personal memory and collective responsibility. Solie’s anticapitalist undertones surface through...
Israel: What Went Wrong? By Omer Bartov Review – the Long View
Omer Bartov’s new book examines Israel’s trajectory from a liberal, democratic promise in 1948 to what he describes as a morally and politically degenerated state. Drawing on his personal background as a kibbutz‑born former IDF officer and a Holocaust‑genocide scholar, Bartov...
Shoulder Pain Exercises: 7 Moves to Improve Mobility
Shoulder pain is among the most common musculoskeletal complaints, driven by the joint’s shallow socket and reliance on soft‑tissue support. Experts from Hospital for Special Surgery and the University of Indianapolis explain that an imbalance between the powerful deltoids and...
Book Review: ‘Selling Opportunity,’ by Mary Lisa Gavenas
Mary Lisa Gavenas’s new book *Selling Opportunity* offers a dual biography of Mary Kay Ash and the cosmetics empire she built. The narrative traces Ash’s rise from a modest Houston upbringing to founding a multilevel‑marketing powerhouse that rewarded top sellers...
What Angels Fear by CS Harris
C.S. Harris’s “What Angels Fear”, the 19th entry in a long‑running Regency mystery series, blends a tightly plotted murder case with richly described London scents and a brooding aristocratic hero. Protagonist Sebastian St Cyr, a former army intelligence officer, navigates post‑war...
When Will Mortal Kombat 2 Come to Streaming, HBO Max, Blu-Ray, and DVD?
Warner Bros. is expected to roll out the sequel Mortal Kombat II on digital platforms in early June 2026, followed by a Blu‑ray/DVD launch in July. The film will likely debut on HBO Max in late July, mirroring the studio’s recent 30‑day...
The Best Books to Read on American Empire
Alexis Coe’s column examines the uneasy marriage of American power and liberty, tracing the idea of an "empire for liberty" from Jefferson through the Mexican‑American War to modern debates. She highlights key titles that unpack this paradox, especially Amy S....
Taj Mahal’s New Album, ‘Time,’ Keeps the Blues Looking Ahead
Legendary blues artist Taj Mahal, turning 84 on May 17, has released his latest album “Time.” The record continues his decades‑long practice of fusing traditional blues with sounds from India, Mali, Jamaica, and other world musics. Recorded with a roster of diaspora...
Charli XCX, Rolling Stones: 8 Songs We’re Talking About This Week
This week’s music roundup highlights Charli XCX’s genre‑bending single “Rock Music,” Paul McCartney’s new album *The Boys of Dungeon Lane* featuring Ringo Starr on “Home to Us,” and the Rolling Stones’ fresh track “In the Stars” from their upcoming July 10 album *Foreign...