AI-Powered Longevity Science — One Gene to Reverse Aging? | Daniel Ives PhD
In this episode, Dr. Robert Lovekin talks with Dr. Daniel Ives, founder of Shift Bioscience, about moving from hypothesis‑driven aging research to data‑driven, AI‑powered approaches. Ives explains how his early focus on mitochondrial DNA mutations as the primary cause of aging was disproven by epigenetic clock data, prompting a pivot to using single‑cell aging clocks and virtual cell models to run thousands of in‑silico experiments. The discussion highlights the discovery of single genes that can rejuvenate cells without inducing pluripotency and the translation of these findings into targets for conditions like fibrosis and age‑related hearing loss.
The Longevity Economy Is Built for the Rich
The episode examines the $6 trillion "longevity economy"—the booming market built around anti‑aging and wellness innovations—and highlights how its benefits are disproportionately accessible to the wealthy. It outlines macro trends driving investment in longevity, critiques the uneven distribution of cutting‑edge therapies,...
How I Fixed My Blood Sugar in 4 Simple Steps -Revolutionize How Your Body Absorbs Glucose
In this episode the host explains how conventional fasting blood‑sugar tests miss the daily spikes and crashes that cause fatigue, brain fog, cravings, skin breakouts, and mood swings. Drawing on recent research, they describe the hidden "blood‑sugar roller coaster" that...
Dr. Ryan Cole on Defending His Medical License and Improving Health
In this episode, Dr. Ryan Cole discusses his recent battle defending his medical license, his new role leading medical and scientific affairs at the Independent Medical Alliance, and his advocacy for free‑speech rights in medicine following a landmark Supreme Court...
Keto Saved My Life — The Future of Metabolic Medicine | Nick Norwitz PhD MD
In this episode, Dr. Nick Norwitz, a PhD in human metabolism and new Harvard MD, shares how a ketogenic diet rescued him from severe ulcerative colitis, leading to complete remission and allowing him to finish his PhD and medical training....
Medical Doctor Shares Life Changing Ibogaine Treatment Stories
In this episode, Dr. Fernando Vega, a family physician with 45+ years of practice, discusses his extensive work using psychedelic medicines—especially ibogaine—to treat PTSD, depression, anxiety, and opioid addiction. He shares compelling case stories, including a former alcoholic who regained...
Why the Rich Want to Live Forever — with Kara Swisher
In this episode, Kara Swisher explores the burgeoning obsession among tech billionaires with longevity and body optimization, tracing how figures like Jeff Bezos, Mark Zuckerberg, and Larry Ellison are funding anti‑aging research, hormone therapies, and cutting‑edge biotech. Swisher critiques the...
Episode 194: Tommy Wood Discusses How to Future-Proof the Adult Brain
In this episode, neuroscientist Dr. Tommy Wood expands on his new book, The Stimulated Mind, outlining science‑backed strategies to future‑proof the adult brain against dementia. He emphasizes that neuroplasticity persists throughout life and that diet, exercise, and continual mental challenge...
Running: Will It Wreck Your Body?
In this episode of Science Versus, hosts Akedi Foster-Keys and senior producer Meryl Horn examine the science of running, focusing on injury risk, optimal training progression, and the physiological benefits of the activity. They cite research showing that about half...
Can a Transplant Cure Aging? | Catherine Baucom MD PhD
In this episode, Dr. Robert Lovekin talks with Dr. Catherine Baucom, chief medical officer of MitoSense, and veteran health expert Van about mitochondrial organelle transplantation—a novel therapy that injects healthy mitochondria from young donors into patients to repair damaged cells....
EXPLAINER: Walking Won't Burn Fat (Here's What It Actually Does)
In this episode, Dr. Robert Lufkin debunks the myth that walking burns fat primarily through calorie expenditure, explaining that the body compensates for most exercise calories. He highlights how walking triggers GLUT4-mediated glucose uptake, activates AMPK, and lowers insulin and...
Stronger Culture - The Mental Side of Bodybuilding Nobody Talks About
In this episode of Stronger Culture, hosts Eric and his guest dive into the often‑overlooked mental side of bodybuilding, focusing on supplement safety, third‑party testing, and the psychological pressures that drive athletes to chase every new product. They compare testing...
The Longevity Nerve: The Missing Link in Stress, Aging & Brain Health | Elisabetta Burchi MD
In this episode, Dr. Elisabetta Burchi explains how the vagus nerve serves as a central hub linking the brain to the heart, gut, immune system, and overall longevity. She outlines the anatomy and function of the vagus within the parasympathetic...
RHR: Mouth Taping: Beyond the Hype—What the Science Really Says
The episode examines mouth taping, a social‑media sleep hack, against scientific evidence. A May 2025 systematic review of 10 studies (213 participants) found limited, inconsistent benefits and notable safety concerns, especially for those with nasal obstruction or moderate‑to‑severe OSA. Benefits were...
My Video Chat with the Mighty Kara Swisher
In this episode, host Dan Carlin sits down with tech journalist Kara Swisher to discuss her new CNN series on longevity, "Kara Swisher Wants to Live Forever." They explore why ultra‑wealthy tech entrepreneurs are obsessed with hacking death, the mix...
260: Dr. Michelle Jorgensen, Pioneer in Holistic Dentistry: Your Dentist Might Know Your Sleep Problem
In this episode, Dr. Michelle Jorgensen, a holistic dentist, explains how oral health—particularly mercury‑containing fillings, hidden infections, and airway obstruction—can drive inflammation and compromise sleep quality, leading to issues like bruxism and sleep apnea. She shares her personal journey from...
Broadcasting Pedal to the Metal: How John Fredericks Turned His Studio Van Into a Test Lab for Vitality
In this episode, host John Fredericks and Dr. Peter McCullough discuss the growing market for anti‑inflammatory drugs and introduce the Wellness Company’s peptide‑based “Regenerate” drops, which aim to repair musculoskeletal tissue rather than merely mask pain. They also cover natural testosterone‑boosting...
Perform with Dr. Andy Galpin
In this introductory episode, Dr. Andy Galpin, a kinesiology professor and veteran performance coach for elite athletes, outlines the mission of his new show: translating cutting‑edge, peer‑reviewed research on maximal human performance into practical, actionable advice for everyday listeners. He...
RHR: Erythritol: The ‘Safe’ Sweetener That’s Anything But
Recent studies from the Cleveland Clinic and the University of Colorado Boulder have identified erythritol, a widely used sugar‑alcohol, as a potent risk factor for cardiovascular disease. Elevated blood erythritol levels were associated with roughly a two‑fold increase in heart...
Thinking in Trade-Offs: A Necessary Antidote to Diet Tribalism
The episode examines the pervasive diet‑tribalism that claims any single eating plan is a flawless solution, arguing instead that all diets are trade‑off‑driven optimizations against the typical American diet, which is high in excess calories, refined carbs, and ultra‑processed foods....
Do Longevity Supplements Really Work?
In this episode of Longevity by Design, Dr. Andrea Mayer discusses the scientific evidence behind multivitamin and mineral supplements, highlighting that they may modestly improve cognition, mood, and blood pressure in at-risk or nutritionally deficient individuals, but show little benefit...
536 2 Inch Parasites Out Of Her Eyes - Dry Fasting With Theo Lucier
In this episode, host Sean McCormick and bio‑hacker Theo Lucier discuss the rising popularity of dry fasting—a five‑day abstention from both food and water—highlighting its purported benefits such as stem‑cell activation, gut reset, muscle preservation, and profound mental clarity. They...
10 Silent Killers of Youth: What's Aging You Without You Knowing
The episode outlines the top ten hidden factors that speed up aging, ranging from smoking and UV exposure to sugar, chronic stress, poor sleep, chronic inflammation, sedentary behavior, excessive alcohol, ultra‑processed foods, and social isolation. Each factor is explained in...
What Houses, Garbage, and Trucks Teach Us About Aging with Dr. Uri Alon
In this episode, Dr. Uri Alon explains his systems‑biology view of aging using a vivid village metaphor: houses (cells) generate garbage (damage) while a fixed fleet of trucks (the immune system) removes it, leading to overload and a robustness threshold...
259: Dr. Matt Bernstein, Metabolic Psychiatrist: Your Sleep & Mental Health Problems Might Start With Food
In this episode, host Molly Eastman talks with Dr. Matt Bernstein, a psychiatrist and CEO of Accord, about metabolic psychiatry and how diet—particularly ketogenic nutrition—affects mental health, anxiety, and sleep. Dr. Bernstein explains the science behind ketosis, its impact on...
Born to Live Longer? Inside the Genetics and Biology of Centenarians
In this episode, Dr. Paola Sebastiani explains how the genetics of extreme longevity are far more complex than a single "longevity gene," highlighting the growing list of genetic variants—such as APOE, chromosome 9 loci, and inflammation‑related regions on chromosome 6—that...
339. Summary: Nutrients That Help Fight Chronic Fatigue - Life Extension
The Live Foreverish episode hosted by Dr. Mike and Dr. Crystal tackles chronic fatigue syndrome, highlighting how nutrient‑based strategies can alleviate persistent exhaustion. They discuss established supplements such as CoQ10, B‑complex vitamins, and vitamin C, explaining their roles in cellular...
339. Nutrients That Help Fight Chronic Fatigue - Life Extension
In this episode, Dr. Mike and Dr. Crystal Gossard discuss chronic fatigue syndrome (CFS), outlining its diagnostic criteria, common symptoms like post‑exertional malaise and orthostatic intolerance, and the challenges patients face in getting an accurate diagnosis. They explore potential causes—including...
Episode 193: Tommy Wood and His New Book Bust the Belief that the Adult Brain Is Fixed
In Episode 193 of STEM Talk, neuroscientist Dr. Tommy Wood discusses his new book, *The Simulated Mind*, which challenges the long‑standing belief that adult brains are fixed and inevitably decline. He explains how modern research shows the brain remains plastic...
#385 – AMA #82: Applying the Tools of Longevity in the Real World: Disease Prevention, DEXA Scans, Artificial Sweeteners, Injury...
In this AMA episode, Dr. Peter Atiyah tackles a wide array of practical health questions, covering how health priorities shift across the decades, the hierarchy of chronic disease risk, and the most useful consumer health metrics. He discusses the role...
#385 - AMA #82: Applying the Tools of Longevity in the Real World: Disease Prevention, DEXA Scans, Artificial Sweeteners, Injury...
In this AMA sneak‑peek, Dr. Peter Atiyah fielded listener questions on practical longevity strategies, covering how health priorities shift across the 20s, 40s, and 60s+, the hierarchy of chronic disease risk (cardiovascular, cancer, neurodegeneration, metabolic), and the most useful consumer...
Age Faster or Slower? The Surprising Role of Mental Health and Self-Control
In this episode, Dr. Gil Blander talks with Dr. Terry Moffitt, a leading psychologist behind the 50‑year Dunedin Multidisciplinary Health and Development Study, about how early‑life mental health influences the biological pace of aging. Dr. Moffitt explains the study’s unique...
How To Reverse Alzheimer's | Heather Sandison ND
In this episode, Dr. Heather Sandison, a naturopathic physician, challenges the conventional view that Alzheimer's is irreversible by presenting evidence that cognitive decline can be slowed, halted, or even reversed through a comprehensive, personalized lifestyle program. She discusses the shortcomings...
RHR: New Study Challenges the Plant-Based Longevity Myth
In this episode Chris Kresser reviews a new American Journal of Clinical Nutrition study of over 5,000 Chinese adults aged 80+, which found vegetarians and especially vegans were 19‑29% less likely to become centenarians than omnivores, with the effect driven...
Ten Minute Tips #74: FTP Training Mistakes (And Solutions)
In this episode of the Empirical Cycling Podcast, hosts Coley Moore, Erica, and Fabiano dissect common mistakes cyclists make when trying to improve their Functional Threshold Power (FTP) and offer practical solutions. They discuss flawed testing protocols, the danger of...
Chris Bradley: Better Science for Longevity
In this episode, host Rizim Tom chats with Chris Bradley of MatterBio about the science of longevity, focusing on how genomic damage drives the hallmarks of aging. Bradley explains that while cells constantly renew, DNA damage from internal sources like...
Inside The Race To Reboot Human Cells - EP 60 Nabiha Saklayen
In this episode, host Ashley Vance talks with Nabiha Saklayen, co‑founder and CEO of Celino, about induced pluripotent stem cells (iPSCs) and their rapid evolution from a Nobel‑winning discovery to emerging therapies. They discuss how iPSCs can be reprogrammed from...
The Sugar Addiction Lie | Christine Trimpe
In this episode, Christine Trimpe shares her decade‑long transformation from morbid obesity, pre‑diabetes, and chronic fatigue to a sugar‑free, metabolically healthy life. She recounts a pivotal mountain‑hike moment that sparked her resolve, the step‑by‑step quitting‑sugar plan, and how Dr. Jason...
257: Dr. Melissa Sonners, Chiropractor, Author/Podcaster The Connection Code: 2 Minutes to Better Sleep
In this episode, host Molly Eastman talks with Dr. Melissa Sauners, a chiropractor and nervous‑system alignment specialist, about how women (and anyone) can quickly downshift their nervous system to achieve deeper, more restorative sleep. Dr. Sauners explains that chronic over‑stimulation...
Chris Masterjohn: COVID-19 to Mitochondrial Health, Communicating and Applying "the Science"
Chris Masterjohn, a nutritional scientist and mitochondrial biologist, launched Mitome, a consumer‑focused platform for mitochondrial health testing. In a conversation with Razib Khan, he critiqued the COVID‑19 response, alleging authorities overstated certainty and faced attempts at censorship. Masterjohn also argued...
Episode 192: Ken and Dawn Weigh in on ChatGPT, Ketamine, Urolithin-A, Rapamycin, and More in Wide-Ranging AMA
In this AMA episode, host Dawn Cornegas and IHMC CEO Dr. Ken Ford field listener questions on a wide array of topics, from astronaut training in NASA's Neutral Buoyancy Lab to the latest research on supplements like urolithin‑A and anti‑aging...
The Gut-Fatigue Connection: Is Your Digestion Making You Tired?
In this episode the host explores the emerging link between chronic fatigue—including Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)—and gut health, emphasizing how gut dysbiosis may drive persistent exhaustion. They explain the gut microbiome as a complex ecosystem, using a garden metaphor...
We’re Not Sick. We’re Being Sold | David Etheridge
In this episode, Dr. Robert Lovekin interviews author David Etheridge about his book *We’re Not Sick, We’re Being Sold*, which argues that the food and pharmaceutical industries have distorted nutrition advice, leading to widespread chronic disease. Etheridge shares his personal...
#382 ‒ AMA #80: Longevity Optimization Through Strength Benchmarks, VO₂ Max Targets, Nutrition Principles, Brain Health, Supplements, GLP-1 RAs, Wearables,...
In this AMA episode, host Peter Atiyah answers listener questions on practical longevity strategies, covering strength metrics (relative strength, grip, lower‑body power), starter exercise routines for time‑pressed beginners, and the role of complex movement for brain health. He emphasizes normalized...
255: Rob Sweetman, Former Navy SEAL, MBA, Sleep Scientist: Sleep Isn’t a Luxury: A Former Navy SEAL on Sleep,...
In this episode, former Navy SEAL and sleep scientist Rob Sweetman discusses how chronic sleep deprivation undermines military readiness, first‑responder health, and overall resilience. He shares his personal journey from a SEAL who was taught to ignore sleep to a...
Watts Doc #62: Setting Up Your N=1 Training Experiment
In Watts Doc #62, hosts dive into how cyclists can design and run their own n=1 training experiments, covering the fundamentals of hypothesis formulation, data collection, and analysis. They walk listeners through selecting variables, establishing baselines, and using tools like...
Why Am I Always Hungy? | Jason Fung MD
In this episode, Dr. Jason Fung, a nephrologist and author of *The Obesity Code* and the upcoming *The Hunger Code*, explains why the simplistic "calories in vs. calories out" model fails to address weight gain. He introduces the body‑fat thermostat...