Know What's Happening in Healthcare
Know What's Happening in Healthcare
FDA approves KRESLADI, first CIRM‑backed gene‑editing therapy
The FDA cleared KRESLADI, a gene‑editing treatment from Rocket Pharmaceuticals for severe leukocyte adhesion deficiency‑I in children, eliminating the need for a bone‑marrow donor. It is the first product directly funded by California’s Institute for Regenerative Medicine to receive approval.
Also developing:
By the numbers: Syneron Bio raises $150M Series B
A peer‑reviewed study from Icahn School of Medicine evaluated ChatGPT Health across 60 clinical scenarios and 960 interactions. The model delivered correct advice for just 35.2% of non‑urgent cases and 48.4% of true emergencies, often down‑triaging serious conditions like asthma attacks and diabetic ketoacidosis. It also over‑recommended medical visits for 64.8% of low‑risk situations and failed to trigger suicide‑crisis alerts in most relevant prompts. Accuracy was highest for semi‑urgent cases but remained below physician performance.
Reminder that it’s costing us about $450 BILLION more every year to have this shitty healthcare system https://pubmed.ncbi.nlm.nih.gov/32061298/
The article highlights the ongoing exodus of Filipino nurses, driven by low domestic pay, heavy workloads, and better overseas opportunities. While the Philippines supplies 300‑350 k nurses abroad and earns a record $38 billion in remittances, the home health system faces severe...
Americans are increasingly relocating to Italy, drawn first by the low‑cost, universal health system that eliminates the fear of massive medical bills. Once settled, many discover a healthier lifestyle driven by the Mediterranean diet, walkable neighborhoods, and a slower daily...
Sweden’s archipelagos and severe winter weather make helicopter emergency medical services (HEMS) exceptionally challenging, requiring pilots to navigate low clouds, ice, and sudden wind shifts. Avincis Sweden operates 13 H145 helicopters from ten bases, handling 124 missions over a three‑day...
Hospital systems have accelerated acquisitions of physician practices, claiming cost savings and better coordination, yet evidence shows the opposite. Ownership reclassifies office visits as hospital outpatient services, adding facility fees that raise patient costs without improving outcomes. It also erodes...
The article argues that many therapists either dismiss neuroscience or weaponize it, creating a "brain denial" that hampers effective treatment. Recent advances in neuromodulation—such as TMS, tDCS, and focused ultrasound—demonstrate that directly altering brain networks can produce rapid, measurable improvements...
Former Prime Minister Boris Johnson promised 40 new NHS hospitals by 2030, a flagship pledge of the 2019 Conservative manifesto. The ambition stalled as the COVID‑19 pandemic, successive ministerial reshuffles, and fiscal pressures halted the construction pipeline, leaving none of...
Clover Health announced it is the first payer to go live on a CMS‑aligned health information exchange network, marking a tangible step toward nationwide interoperability. The rollout enables Medicare Advantage members to retrieve claims and clinical data through FHIR‑based APIs,...
The FDA has issued a final guidance titled “Scientific Considerations in Demonstrating Biosimilarity to a Reference Product.” The document outlines the agency’s scientific framework for establishing biosimilarity of therapeutic proteins submitted via the abbreviated licensure pathway. It details expectations for...
Dr. John Pandolfino at Northwestern Medicine has created a digital twin of the esophagus to guide myotomy surgery for achalasia patients. The virtual model reproduces pressure and motion, runs millions of simulations, and recommends the optimal surgical cut. A 400‑patient...
A ten‑year longitudinal study of 1,371 Dutch adults found that consuming ultra‑processed foods, which made up about 20% of daily diet weight, did not accelerate cognitive decline. Researchers used the NOVA classification to quantify processing levels and applied multiple cognitive...
New South Wales Health continues to use the LeadCare II point‑of‑care device to screen children’s blood lead levels in Broken Hill despite known accuracy issues and a 2020 TGA removal from the national register. The machine can produce errors of +/- 6 µg/dL,...
Michael Dalton argues that virtual‑first care has moved beyond a novelty, yet many health‑system leaders still react with surprise when they see fully integrated models. He highlights that true virtual‑first requires deep EHR integration, clinical governance, and seamless handoffs, not...
The healthcare data landscape is finally moving from three‑decades of batch ETL to event‑driven pipelines powered by Kafka, Flink and modern cloud services. Legacy systems were built around billing cycles, leaving clinicians without real‑time data for urgent decisions. Recent API...
Amanda King ND’s recent post highlights the growing interest in repurposing ivermectin and fenbendazole as adjuncts in naturopathic oncology. She outlines pre‑clinical evidence suggesting anti‑cancer properties for both agents and discusses how they fit into an integrative treatment protocol. The...
New CDC data shows over one‑in‑five U.S. children were obese between 2021‑2023, a record high and a sharp rise from 5.2% in the 1970s. The surge coincided with pandemic‑related school meal disruptions and cuts to nutrition programs, prompting the Make...
The newsletter urges donations to support a lab studying lethal childhood glioma, noting NIH grant success rates of only 4‑5%. It reports FDA biologics chief Vinay Prasad’s second departure, a rare leadership turnover that could affect approval stability. Additional highlights...
HCA Healthcare posted a strong Q4 2025 earnings beat, with EPS rising 29% to $8.01 and adjusted EBITDA up 11% YoY, despite revenue missing estimates by $158 million. The company logged its 19th straight quarter of volume growth and reported roughly 47 million...
The Power of Zero - Why CAC Scoring Changes Everything for Heart Disease Risk https://youtu.be/XVNLubDAE-M https://www.innerscopic.com/
As a medical school professor, I've watched patients take vitamin D for years with zero improvement in their blood levels. Now a Vanderbilt clinical trial explains why: they're missing magnesium. Key findings: > Magnesium RAISED vitamin D in people who were deficient > But...
![Unregulated Botanical Products Pose Hidden Risks in Convenience Stores [PODCAST]](/cdn-cgi/image/width=1200,quality=75,format=auto,fit=cover/https://kevinmd.com/wp-content/uploads/Design-4-scaled.jpg)
Convenience stores, gas stations and vape shops are flooding the market with unregulated botanical supplements such as kratom, 7‑OH, kava, gummies, shots and powders. Physicians report patients using these products for energy, focus or pain relief, often trusting store clerks...
Too funny. @emilyakopp (below) outs Vinay Prasad as the host of Thursday’s HHS/FDA media call to discuss $QURE.
A single Covid infection can permanently destroy your immune system, (yes even if you’re fully vaxxed). That’s why it’s so crucial to actually prevent infection by wearing a respirator mask and ventilating the air
A study by Ma and Kim in Nature Communications unveils the dilution‑and‑delay (DnD) susceptibility assay, a high‑resolution, high‑throughput method that combines antibiotic dilution gradients with timed incubation delays. Leveraging microfluidic chips and real‑time imaging, the assay can screen thousands of...
Learn what CGM sensors measure, how accurate they are and get clear guidance on how to use them. Register to the webinar: https://t.co/ZfMJ6h3ak0 https://t.co/0YCTKzK85x
Potentially modifiable risk factors for dementia in Norway (HUNT4 70+): a retrospective cohort study https://t.co/8DUSdzlf4e
The article argues that traditional electronic fetal monitoring (EFM) relies on outdated pattern‑recognition, contributing to high C‑section rates without reducing cerebral palsy. It highlights that 35 % of cerebral palsy cases are genetic, underscoring the limits of current monitoring. Advances in...
Direct implications for Health IT licensing -- as HTI-5 proposes AI/RPA as a first-class means of "access"/"use" of health information.
As a medical school professor, I tell my students: muscle isn't vanity. It's a longevity organ. A new JAMA Network Open study of 5,000+ women ages 63-99 just proved it: > Every 7kg increase in grip strength = 12% lower mortality > Faster...
A Bayesian adaptive trial with 99 trauma‑exposed healthcare workers showed that a brief, guided Tetris‑based imagery‑competing task significantly reduced intrusive memories at four weeks and maintained benefits over follow‑up. The authors stress that the intervention targets a specific PTSD symptom...
Dr. Selene Castrejon runs a medical practice. She doesn’t have time for AI experiments that don’t work. Every hour matters. Inside the AI Business Lab® Mastermind, she built trained AI bots that now provide CFO-level insights and marketing strategy—saving hundreds of...
GLP-1s already have market cap close to 1/3 of the top 10 biopharma companies combined. Consumer health biotech products will dwarf disease-focused biotech products.
AI voice assistants are increasingly used to combat senior loneliness, but they can create an illusion of care that misleads older adults into believing they are interacting with a compassionate human. The article highlights research linking isolation to mortality comparable...
Impact of creatine supplementation on menopausal women’s body composition, cognition, estrogen, strength, and sleep https://t.co/8ZqpAr94uG
I've known @dmgorenstein for 2 decades and have always found him to be extraordinarily thoughtful – not afraid to ask tough questions and to grapple with nuance and, yes, tradeoffs. It was great to chat with him on his @tradeoffspod...
Researchers led by Dr. James Murrough and Dr. Emma Guttman‑Yassky identified the Th2 immune pathway as a contributor to major depressive disorder. Using proteomic profiling and computer modeling, they repurposed dupilumab—an IL‑4 receptor antibody approved for eczema—to target this pathway....
Patent Fights, GLP-1 Turf Wars, and the FDA Tightens the Screws | Ep. 952 https://t.co/v0fulR3NfB https://t.co/9gGdkAVvlv
A revenue-cycle nurse cut denials by 60% in 1 month using agentic AI. See how in the new article from Anshar AI 👉 https://t.co/mKAaugRe28 Meet them at #HIMSS26 or book a private workflow session. #AnsharAI #HITSM
The article reveals how power, data, and sensing networks act as the hidden nervous system of modern surgical robots. Advances in interconnect density, force‑sensing modules, and integrated electronic architectures are enabling higher precision and reliability. Michael Klitze of TE Connectivity...
There's a lot you can learn about sleep. Like 83% hadn't heard of DORAs. https://t.co/2lV3Fw6cwg https://t.co/IWRTdPTMOL
One of the most impressive advances we've ever seen for some autoimmune diseases: cures https://t.co/OZDuq4Iooy
Researchers Forster, Novelli, and Welch applied four frequentist and two Bayesian sequential designs to the COVID‑disrupted UK DISC clinical trial. All six approaches confirmed the trial’s original finding of treatment superiority but suggested different optimal points for restarting patient recruitment....
Fragmentomic liquid biopsy enables early breast cancer detection, molecular subtyping and lymph node assessment https://t.co/RC5rTrFO4l https://t.co/s0Z6lc7Jeb
A team at Gladstone Institutes and the San Francisco VA has launched HIV‑seq, a virus‑specific single‑cell RNA‑sequencing platform that isolates active HIV reservoir cells from patients on antiretroviral therapy (ART). The method captured 25 treated‑patient cells and over 1,000 cells from...
Researchers combined network toxicology, machine‑learning models and SHAP interpretability to show that exposure to the plasticizer Di(2‑ethylhexyl) phthalate (DEHP) generates immune signatures overlapping with Sjögren’s syndrome. By mapping thousands of DEHP‑associated genes, proteins and metabolites, they identified shared pathways involving...
Governments in the UK, US and EU are committing to phase out animal testing, starting with skin‑irritation assays and targeting broader reductions by 2030. Rapid advances in new‑approach methodologies—organs‑on‑chips, organoids and AI‑driven computational models—have driven a fourfold rise in NAM‑only...
Researchers have identified lysophosphatidylcholine acyltransferase 1 (LPCAT1) as a driver of head and neck squamous cell carcinoma (HNSCC) by amplifying mitochondrial oxidative phosphorylation through the COX17 chaperone. Overexpression of LPCAT1 reshapes mitochondrial membrane lipids, stabilizing COX17 and boosting cytochrome c oxidase activity,...
Eli Lilly used an AI‑driven digital twin to dramatically increase manufacturing capacity for its high‑demand GLP‑1 drugs Zepbound and Mounjaro. The virtual factory model allowed real‑time optimization of equipment, process parameters, and defect detection, delivering production volumes the company says would...
A recent preclinical study shows that inhibiting interleukin‑2‑inducible T‑cell kinase (ITK) markedly improves the efficacy of anti‑CD19 CAR‑T cells. Researchers combined an ITK‑selective inhibitor with a second‑generation CD19‑CAR construct, observing enhanced cytotoxicity, reduced exhaustion markers, and prolonged persistence in mouse...
