Leukemia Drug HHT Delays Aging, Extends Mouse Lifespan
Homoharringtonine exhibits senotherapeutic activity that mitigates diet- and age-associated obesity and insulin resistance and extends lifespan in mice [an FDA-approved anti-leukemic drug; authors found that "HHT treatment delays aging and extends the lifespan in progeroid and aged mice"] https://t.co/LEegM8XUtR
Grateful for All the Book Talk Opportunities
One more quick roundup of me talking my book. Thx again to everyone who gave me a chance riff on the book on your platform. 1/
Crawling Builds Core Strength and Lifelong Coordination
Don't rush your baby out of the crawling phase. Crawling makes your baby hold their whole body up on their hands and shoulders. That builds the kind of upper body and core strength they'll need later to grip a pencil, use...
Explore America’s Iconic Land Art From 1960s Origins
For @TimeOutUSA, I wrote about where to see the most iconic Land Art pieces across the country. The modality dates back to the '60s when artists ditched the traditional gallery settings to place their work in nature, often in vast...
Therapeutic Plasma Exchange Cuts High Blood Microplastic Levels
New research at the intersection of environmental medicine and therapeutic apheresis: https://t.co/i3zVSyYePU A paper just published in the Journal of Clinical Apheresis (Weinstein et al., 2026) reports the first deliberate attempt to remove circulating microplastics from human blood using therapeutic plasma exchange...
Comedy Launch Nets $430k, Targets $4M Weekend
$430k pre-show launch for new comedy #ILoveBoosters incl $70k from before THU. Will try to get to $4M area for its 4-day holiday opening wknd #boxoffice.
Miley Cyrus Walk of Fame Interview Highlights Revealed
In honor of her Walk of Fame star, some leftovers from my sit-down with Miley Cyrus (link below) https://t.co/SaJPxLQBfE
Meaningful Work Starts When You Choose and Stay Focused
Going deeper requires something most of us avoid. It asks us to choose what matters and stay with it, instead of moving on to the next thing. That’s where meaningful work begins to take shape. Read on my blog ➜ https://t.co/EF06moqklF #clarity #focus...
U.S. Streamlines Review Process for Fusion Energy
Fusion energy poised for simpler U.S. review https://t.co/DlwoCqRGP4 via @axios with reporting from @WebSummit Vancouver. https://t.co/zg6hM8eYOv
Clitoral Anatomy Mis‑taught Until 1998, Widening Orgasm Gap
The clitoris was not correctly mapped in a peer-reviewed medical journal until 1998. Every gynecologist who graduated before 2000 trained on an incomplete anatomy and passed their lack of knowledge onto you. Most of their patients never knew. It led to not...
Moderate Sex Frequency Minimizes Heart Risk, Extremes Harmful
Americans who had sex 1-3x/week (52–103x/year) had the lowest risk of cardiovascular disease and death. Both very low frequency (<12x/year) and extremely high frequency (≥365x/year) were linked to a higher risk. Low sexual activity might suggest cardiovascular problems (ED), hormonal dysfunction, or...
GLP‑1 Cancer Link Unclear, Dedicated Trials Needed
Whether there is a real impact of GLP-1 drugs on cancer is unresolved. If confirmed, it could simply reflect weight loss or, as seen for other conditions (e.g. heart, kidney), weight loss independent effects. We need dedicated trials to resolve...
Mandalorian & Grogu Open $12M, Matching Forecasts
#TheMandalorianAndGrogu lifts off with $12M THU night Identical preview cash haul as CAPTAIN AMERICA: BRAVE NEW WORLD which debuted with $88.8M so this is right around where forecasts had it WOM should not be stellar here so will be one to watch...
Your Willingness to Risk Shapes Life's Size
life shrinks and expands on the proportion of your willingness to take risks and try new things
Dreamlike Road Trip Explores Sleep’s Transformative Power
High Winds by Sylvan Oswald and Jessica Fleischmann. How does sleep—or its absence—change us? At the end of another wakeful night, High Winds tears off on a hallucinatory road trip in search of his estranged half brother, led by cryptic signs...
Higher Cardiorespiratory Fitness Cuts Depression, Dementia Risk
Cardiorespiratory fitness and risk of mental disorders and dementia: a systematic review and meta-analysis High CRF was associated with a reduced risk of depression (HR = 0.64); all-cause dementia (HR = 0.61) and psychotic disorders (HR = 0.71) in adults. https://t.co/5dNZ0WfU8H
Olivia Rodrigo’s ‘The Cure’ Boosts Album Anticipation
Why the new @oliviarodrigo song is heightening anticipation for the new album... Olivia Rodrigo Is Heartsick Again With ‘The Cure’ and, Well, That’s a Little More Like It: Single Review https://t.co/3skhNwCXJR via @variety
Environment Trumps Willpower: Change Surroundings, Change Behavior
An Army Ranger captain who ran psychedelic retreats for veterans told me the #1 lesson he learned at war AND at McKinsey: Willpower will lose to your environment. Every. Single. Time. We frame metabolic disease, addiction, even burnout as failures of discipline....
Exercise‑released Myokines Boost Brain, Inactivity Harms Cognition
Muscle talks to the brain. 💪🧠 Exercise triggers myokines & myometabolites that boost cognition, while inactivity sends harmful signals that impair brain function. This muscle–brain crosstalk shapes behavior and resilience to aging and neurodegeneration. @WuTsaiAlliance https://t.co/63skqJToIa
Natural Killer Cells: The Cleanest Senescent Cell Eraser
As a medical school professor, I have watched senolytics shift from drug discovery to immune engineering. A new review in Immunity & Ageing argues your own natural killer cells may be the cleanest eraser of senescent cells we have. (1/4)
SpaceX Reschedules Starship IFT‑12 Launch for Tonight
SpaceX's website says they are "preparing to launch" Starship IFT-12 today, Friday, May 22, after yesterday's scrub. Same launch window (6:30-8:00 pm ET). https://t.co/WmDymzCeJd
Insight Alone Won’t Move the Part That Holds You
There’s a particular frustration that comes from understanding yourself deeply and still finding yourself back in the same place. It’s not because you haven’t tried. But because the part of you that keeps pulling back isn’t responding to insight. It never...
Eccentric Squat Speed Shapes Jump, Strength, and Growth
Effects of Isolated Eccentric Squat Training at Different Velocities on Countermovement Jump Performance, Quadriceps Function, and Hypertrophy https://t.co/AMlcqWJxyX
Trap Bar Dead Pull Boosts Strength, Forgives Form Flaws
Most athletes need more trap bar work than they think. It’s the ‘Dead’ pull that forgives a few technical sins while still delivering serious strength and athletic transfer. https://t.co/Bq8JFT0xKL
Bridging Four Key Gaps Toward Quantum Advantage
Mind the gaps: The fraught road to quantum advantage Quantum computing is advancing rapidly, yet substantial gaps separate today's noisy intermediate-scale quantum (#NISQ) devices from tomorrow's fault-tolerant application-scale quantum (#FASQ) machines. https://t.co/aSWIa4Z6CA In this perspectives article, @preskill and I identify four related hurdles...
Measure Growth Against Yesterday, Not Strangers Online
Stop comparing yourself to strangers on X. Stop comparing yourself to strangers on IG. Stop comparing yourself to strangers on FB. Compare yourself to the person you were last year. And ask: Are you improving? Are you staying the same? Or are you going backwards?
Heavy Squats Trigger Heat‑Shock Proteins Like Hot Cardio
Guess what simulates the massive heat shock protein release that you would normally get from hard aerobic exercise in the heat? The answer: intense resistance training (such as 6 x 10 heavy back squat at 85+ %), even if it’s not...
20 Phase‑3 Trials Poised to Redefine Cancer Care
In the wake of the #ASCO26 data drop, we reflect on 20 key phase 3 trials which could make a significant impact. Some of these may make their competitors irrelevant if they change the standard of care: https://t.co/EGtw35EsSk https://t.co/CG0Oe4QxDg
Genomics Predict Venetoclax Response in T(
Genomic Determinants of Clinical Outcomes in Multiple Myeloma with t(11;14)(CCND1;IGH) Treated with Venetoclax [Dec 7, 2024] @MKaddouraMD et al. @lbaughn #ASH24 Abst 249 https://t.co/TLon5bCQ3i #mmsm #PrecisionMedicine
Phase 3 Trial Tests Daratumumab Regimens For
.@SWOG S2213 Ph3 RCT Dara-VC Induction Followed by ASCT or Dara-VCD Consolidation & Daratumumab Maintenance in Pts w/ Newly Diagnosed AL Amyloidosis [Activated: 12/1/23] https://t.co/OizUfJCc2c #mmsm #bmtsm
First Look: Maika Monroe Leads New Horror Victorian Psycho
First Look Teaser for Horror 'Victorian Psycho' Starring Maika Monroe https://t.co/dCLZ9n3CyU #Cannes2026 #horror #VictorianPsycho #MaikaMonroe #ThomasinMcKenzie #RuthWilson https://t.co/1VeDwJOi69
Simple Mantras Transform Decisions Into Opportunities
Three helpful mantras: 1. “I’m good either way” 2. “This is not that hard” 3. “What an opportunity” I’ve recently been saying these to myself throughout the day as I encounter decisions & challenges. Borrow if useful.
Omega-3 Intake May Lower Alzheimer’s and Cognitive Decline Risk
The Relationship of Omega-3 Fatty Acids with Dementia and Cognitive Decline: Evidence from Prospective Cohort Studies of Supplementation, Dietary Intake, and Blood Markers "Dietary intake or long-term supplementation of omega-3 fatty acids may help reduce risk of AD or cognitive decline." https://t.co/YQNC2Uljmz
Omega‑3 Supplements May Speed Cognitive Decline in Seniors
The association between omega-3 supplementation and cognitive decline in older adults Controversial paper of the day. It concluded🤔 "Omega-3 supplementation may be associated with accelerated cognitive decline in older adults, potentially through adverse effects on cerebral synaptic function rather than classical AD...
Omics and AI Build Precise Biological Age Clocks
Predicting healthspan and disease risks through biological age "...Advances in omics technologies and machine learning enable the development of sophisticated aging clocks that can track aging at the molecular, cellular, and organ levels...." https://t.co/irxSfuy6qJ https://t.co/AJf53HWR3O
Take Risks, Embrace New Experiences, I’ll Support You
I need you to take that “chance” .. That girl, that guy, that job, that company, that idea, that friend, that meeting, that moment. I want to be your shield, so you can go out and actually try. If you want...
Eat Your Biggest Meal at Lunch, Not Dinner
The timing of your largest meal matters more than most nutrition advice suggests. People who eat their biggest meal at lunch have better metabolic markers than people who eat the same calories at dinner — even with identical food. Your digestive system...
Calling Your Son an Old Friend Is Hilarious
There’s nothing funnier than referring to your son as someone you’ve known for a long time. https://t.co/qVn0KRAd9l
Longevity Expert Dr. Charlop Joins FOX Business Roundtable
Dr. Gregory Charlop here. I’m excited to announce I’m a featured longevity expert on FOX Business. I’ll be appearing on the Barron’s Roundtable to discuss common-sense health solutions for executives and family offices.
Sleep's Complex Physiology Links Directly to Dementia Risk
Sleep physiology and dementia, a new 5★ review @ScienceMagazine, gets into glymphatics, blood volume, heart rate variability, vasoactive amines, and neuromodulators. by @MaiNedergaard https://t.co/zBMc1XQZcX https://t.co/eORVYPWmNM
Spotting Trendy Therapists Lacking Real Knowledge
Signs of a therapist who is trendy but not knowledgeable: - Being opposed to behaviorism, then saying they use ERP, ACT, or DBT in clinical practice 👀 - Assuming that the idea of "parts" came from IFS - Thinking that therapy inherently neglected...
Belated Galapagos Highlight: Friend’s Top‑of‑the‑day Snapshot
A belated “top of the day” from a friend in the Galapagos a couple of weeks ago #Galapagos https://t.co/jQPvUtiott
Self‑Awareness Beats Resume Polish in Top Sales Hires
The best sales hire I ever made had a resume that wasn't particularly impressive. Average company. Modest numbers. What changed my mind was a question I asked at the end of the second interview: "Walk me through a deal where you made a...
Gracie Abrams Drops Lead Single “Hit the Wall”
Gracie Abrams' "Hit the Wall" is out now, the lead single from her third album 'Daughter from Hell,' written and produced with Aaron Dessner and arriving July 17th. https://t.co/OoJN7OpHol
Scientists Fear New Methane Rules Won’t Cut Emissions
“Why are scientists worried about the new global methane rules and emission goals?” | Article by Basudha Das for @business_today: https://www.businesstoday.in/science/story/why-are-scientists-worried-about-the-new-global-methane-rules-and-emission-goals-532537-2026-05-21
Bon Jovi Cards Feature Real Stage Artifacts and Guitar Pieces
Bon Jovi's new Keepsake Trading Cards contain real stage-used artifacts, on-card autographs, and pieces of Jon Bon Jovi's personal guitar. Once they're made, that's it. https://t.co/xTvlcAiRJh
Radiohead Extends Brooklyn Show, Adds Student Discount, Announces New Cities
Radiohead's Motion Picture House: Kid A Mnesia has expanded its Brooklyn run through June 28th, added Wednesdays with a 30% student discount, and confirmed stops in Chicago, Mexico City, and San Francisco.
First FDA‑approved Longevity Drug Targets Dogs First
NEW Exclusive Interview: This miracle pill could make dogs live longer, with Celine Halioua, Founder & CEO of Loyal @celinehalioua is building the first drug ever FDA-approved for lifespan extension itself — starting with dogs. We sat down on Onward to...
Choose Methylfolate: Ready-to-Use Folate for Prenatal Health
There are two forms of folate in prenatals. One requires your body to convert it. The other is ready to use. Folic acid is the synthetic form of folate in most prenatals. Before your body can use it, it has to...
AI‑Designed PE8 Editors Boost Prime Editing Efficiency
Today in @NatureBiotech we report a new suit of PE8 prime editor proteins. PE8 variants were developed from laboratory-evolved PE6 proteins using AI-guided protein redesign. This approach combines recent advances in computational protein design and directed evolution to increase prime...