Nanotech News and Headlines

Bacterial Armory: Engineering Dual Photosensitized Bacteria for a Triple‐Modal Therapy on Tumors

Researchers engineered a probiotic E. coli strain by coating it with polydopamine and a cationic BODIPY photosensitizer, creating the E@PB platform that combines photothermal, photodynamic, and immune therapies. The dual‑laser system (808 nm and 660 nm) induces localized hyperthermia and reactive oxygen species, while the coating improves tumor colonization and enables fluorescence imaging. In mouse models the approach cut tumor volume by nearly 90 % and demonstrated enhanced biosafety through regulated bacterial growth. This triple‑modal strategy showcases a scalable route to synergistic, image‑guided cancer treatment.