Nanotech News and Headlines

Biomimetic Bimetallic‐Polyphenol Network as a Novel siRNA Carrier for the Treatment of Rheumatoid Arthritis via Macrophage Repolarization

Researchers have engineered a biomimetic nanocarrier—TSSC@M1—by integrating a metal‑polyphenol network loaded with TNF‑α siRNA, Sr²⁺, and Cu²⁺, and cloaking it with M1 macrophage membranes for inflammatory targeting. The carrier exploits a proton‑sponge mechanism to escape lysosomes, releasing its cargo to scavenge reactive oxygen species, silence TNF‑α, and promote macrophage repolarization from pro‑inflammatory M1 to anti‑inflammatory M2 phenotypes. In collagen‑induced arthritis mice, TSSC@M1 accumulates in inflamed joints, reduces cytokine levels, and supports cartilage repair, demonstrating a synergistic therapeutic effect. The study highlights a multifunctional, safe nanomedicine platform for rheumatoid arthritis treatment.