Antigen Orientation Boosts HPV Cancer SNA Vaccine, Slows Tumors in Models
Northwestern researchers engineered a spherical nucleic acid (SNA) vaccine in which the HPV16 E7 peptide is displayed at the nanoparticle surface via its N‑terminus. This N‑terminal orientation (N‑HSNA) generated up to eight‑fold higher interferon‑γ secretion and 2.5‑fold greater cytotoxicity than alternative configurations. In HPV‑positive mouse models, N‑HSNA reduced tumor burden more than threefold and extended survival, while patient‑derived spheroids showed a 2.5‑fold increase in tumor‑cell killing. The work demonstrates that precise antigen placement can dictate therapeutic potency in cancer vaccines.
A New Inhalable Treatment for Tuberculosis: Once-Weekly Nanoparticles Match Daily Oral Rifampin in Mice
Researchers at the University at Buffalo have created an inhalable nanoparticle that encapsulates rifampin and can be administered once weekly, matching the efficacy of daily oral dosing in mouse models of tuberculosis. The biodegradable particles target lung macrophages, sustain drug...
Novel Nanosheets Boost Clot Clearing While Limiting Systemic Bleeding
Researchers in China have unveiled a silicon‑based nanothrombolytic platform that couples urokinase with hydrogenated silicene (SiH) nanosheets and fibrinogen to clear arterial clots. The SiH sheets temporarily inhibit urokinase during circulation, then self‑degrade at the thrombus, reactivating the drug and...
How a New Terahertz Antenna Could Unlock One-Terabit 6G Speeds
Researchers from Singapore, France, and the United States unveiled a compact terahertz antenna that leverages topological photonics. The silicon‑based chip, patterned with two sizes of triangular holes, creates a conical beam and achieves roughly 75 % spatial coverage—about 30 times better...
![Single-Molecule SERS Gets Steadier as CB[7] Traps a 'Dancing' Molecule](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/render/image/public/images/thumbnails/a218bb91a3d27332f4ed8f925f30842c.webp?width=1200&resize=contain&quality=75)
Single-Molecule SERS Gets Steadier as CB[7] Traps a 'Dancing' Molecule
Researchers at the Institute of Physical Chemistry, Polish Academy of Sciences have demonstrated that encapsulating a single molecule within cucurbit[7]uril (CB[7]) stabilizes its surface‑enhanced Raman spectroscopy (SERS) signal. By forming a supramolecular complex with thionine dye, the CB[7] cage suppresses...
Nanodevice Tugs Single Proteins to Reveal How Cells Sense Force
Yale researchers have created a DNA‑based nanodevice that can tug on individual proteins with piconewton precision. The U‑shaped frame clamps a protein via DNA handles that fold to apply controlled tension. Using talin as a test case, the device reproduced...
![Record‐Low Compressibility in [N(C2H5)3CH3]FeCl4 Expands Phase Engineering Horizons in Hybrid Molecular Ferroelectrics](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/render/image/public/images/thumbnails/107965387dfea3a80d86633fe165031c.webp?width=1200&resize=contain&quality=75)
Record‐Low Compressibility in [N(C2H5)3CH3]FeCl4 Expands Phase Engineering Horizons in Hybrid Molecular Ferroelectrics
Researchers report that the lead‑free hybrid ferroelectric [N(C2H5)3CH3]FeCl4 (EMAFC) exhibits a bulk modulus of 42 GPa, the lowest compressibility recorded for any molecular ferroelectric. The material remains structurally stable and mechano‑chromic up to 51.5 GPa, undergoing a reversible P63mc‑to‑P1 phase transition at...
A Perspective on Commercializing Perovskite Solar Cells: Unlocking Opportunities in Niche Applications
Perovskite solar cells have reached certified efficiencies above 25 percent, rivaling silicon panels, but commercialization remains constrained by scaling, stability, and cost challenges. The article outlines strategies such as tandem architectures and targeting niche markets—like building‑integrated photovoltaics and aerospace—to leverage perovskite’s...
Incoherent‐Light‐Excitable Lanthanide Upconversion Enabled by Highly Hydrophilic and Photostable Dye Sensitization
Researchers introduced a one‑step coating method that transforms dye‑sensitized lanthanide upconversion nanoparticles (dsUCNPs) from hydrophobic, photolabile probes into highly hydrophilic, photostable agents. By applying unsaturated fatty acid salts—particularly sodium linolenate—the particles gain superior water dispersibility and a photobleaching half‑life 87...
Spontaneously Formed Orientation Polarization Thin Films for Engineering Organic‐Organic Interfaces
Researchers have demonstrated that vacuum‑deposited thin films of specially designed polar molecules can spontaneously develop orientation polarization (SOP) by tilting their permanent dipoles against the substrate. By incorporating multiple fluoroalkyl substituents, the molecules achieve extreme structural asymmetry, producing a record‑high...
Structure‐Property‐Application Correlations of Early Transition Metal Chalcogenides: A Dichalcogenide‐Centered Perspective
Early transition metal (ETM) chalcogenides display a broad structural palette, from disulfides to polychalcogenides, enabling tunable electronic, catalytic, and memory functionalities. The review adopts a dichalcogenide‑centered lens to link crystal polymorphism with performance in 2‑D devices, phase‑change memory, and energy...
Hierarchically Structured Artificial SEI with Interlayer Electronic Coupling for High‐Performance Aqueous Zinc Batteries
Researchers introduced a hierarchically structured artificial solid‑electrolyte interphase (SEI) called ZnO@MX‑DE for aqueous zinc‑ion batteries. The engineered petalosphere heterostructure creates interlayer electron coupling that directs Zn²⁺ transport while repelling SO₄²⁻, dramatically improving ionic conductivity and Zn²⁺ transference. Laboratory tests showed...
Colloidal Quasi‐2D Cs2AgBiBr6 Double Perovskite Nanosheets: Synthesis and Application as High‐Performance Photodetectors
Researchers have developed a colloidal synthesis route for quasi‑2D Cs2AgBiBr6 double‑perovskite nanosheets, achieving lateral dimensions up to 1.4 µm and thickness of only a few nanometers. By fine‑tuning ligand chemistry and reaction temperature, they obtained high‑purity nanosheets suitable for optoelectronic integration....
Orbital‐Hybridization‐Driven N‐Fe‐Mo Interatomic Charge Bridges at Amorphous FeMoOx/Porous Carbon Nitride Interface Boosting Peroxymonosulfate Activation in Fenton‐like Reaction
Researchers engineered an amorphous FeMoOx/porous carbon nitride interface featuring N‑Fe‑Mo interatomic charge bridges via orbital hybridization. This design accelerates electron transfer to peroxymonosulfate, dramatically lowering the Fe(III)→Fe(II) reduction barrier and favoring singlet oxygen generation. In a continuous‑flow test, the catalyst...
Separation of Magnetic Microparticles With Different Molecular Surface Functionalizations by Close‐to‐Surface Traveling‐Wave Magnetophoresis
Researchers demonstrated that magnetic microparticles (MPs) driven by traveling‑wave magnetophoresis exhibit velocity differences when transported close to a substrate. The velocity disparity arises from surface‑functionalization‑dependent drag forces, as distinct polymer coatings (COOH vs COOH/NH2) change the average particle‑wall separation. Experiments...
High‐Density Co and N Dual‐Doping in Self‐Supporting 3D Graphene Aerogel for Synergistically Enhanced Supercapacitor Performance
Researchers introduced a one‑step hydrothermal method to co‑dope cobalt and nitrogen into a three‑dimensional graphene aerogel, creating a self‑supporting Co‑NGA electrode. The dual‑doping and porous architecture deliver a record specific capacitance of 2092 F/g at 1 A/g, far surpassing undoped graphene aerogels....
Hybrid Cryomicroneedles Enhance DC Vaccine Efficacy and Function as Non‐Typical Artificial Tertiary Lymphoid Structures to Provide Neuroprotective Immunity in Spinal...
Researchers have engineered hybrid cryomicroneedle patches (pG/DL@npDC‑cryoMNs) that embed a neuroprotective dendritic cell vaccine within a methacrylated decellularized lymph‑node matrix and porous GelMA hydrogel. The device rapidly releases viable npDCs, triggers a strong CD4⁺ T‑cell response, and forms a non‑typical...
Designing a Silicon/Iron Selenide Heterojunction as Liquid and All‐Solid‐State Lithium‐Ion Battery Anodes Displaying Excellent Performances
Researchers have engineered a silicon‑iron selenide heterojunction anode (Si@FeSe@C) featuring a robust Fe–Se–Si interfacial bond and an external carbon coating. The material delivers 1,092.8 mAh g⁻¹ after 100 cycles at 0.2 A g⁻¹ and sustains Coulombic efficiencies above 99.6% for 500 cycles at 1.0 A g⁻¹....
Ionic Polyimine Nanocomposite Membranes with Bidirectionally Tunable Mechanics for Flexible Electronics
Researchers have created ionic polyimine nanocomposite membranes reinforced with inorganic conductive nanofillers (iCONs) via in‑situ polymerization. By varying iCONs loading, the membranes’ mechanics can be tuned bidirectionally—from highly flexible (76 % elongation) to rigid (8.56 MPa tensile strength). A wearable sensor built...
Inverse High‐Entropy Design Enables Superior Energy Storage in Moderate and High Electric Fields
Researchers introduced an inverse high‑entropy design by embedding ferroelectric BaTiO3 into the quasi‑linear ceramic Bi1/6Na1/6Sr1/6Ca1/6Li1/6La1/6TiO3 matrix. This approach creates a weakly polar tetragonal phase that boosts polarization while maintaining breakdown strength. The resulting composites achieve recoverable energy densities up to...
Atomically Dispersed Co Anchored Into Highly Nitrogen‐Doped One‐Dimensional Mesoporous Carbon with Large Pore Size for Ultra‐Stable Potassium‐Ion Storage
Researchers introduced a cobalt single‑atom‑doped, nitrogen‑rich mesoporous carbon anchored on carbon nanotubes (Co‑NMC@CNTs) using a tetraethyl orthosilicate‑mediated co‑assembly route. The composite exhibits a large 23.7 nm mesopore size, robust one‑dimensional structure, and 13.6 at% nitrogen doping, which together lower potassium‑ion diffusion barriers....
Supercapacitor Developer Skeleton Opens First US Engineering Facility in Houston, Texas
Estonian supercapacitor maker Skeleton Technologies opened its first U.S. engineering facility in Houston, Texas, to support AI data‑center customers. The graphene‑based devices can smooth power spikes and claim up to 45% energy savings for high‑performance computing workloads. Skeleton already has...
Graphene‑BC₂N Heterostructures Could Enable High‑capacity Anodes for Next‑generation Lithium‑ion Batteries
Researchers from several Chinese institutions have designed BC₂N/graphene heterostructures as high‑capacity anodes for lithium‑ion batteries. Six interface configurations were modeled, with the III‑HN and III‑HH variants delivering a theoretical capacity of 414 mAh g⁻¹, surpassing graphite and many competing 2D materials. The...
New Devices Might Scale the Memory Wall
Researchers at UC San Diego unveiled a new bulk resistive RAM (RRAM) that switches an entire material layer instead of forming filaments, enabling 3D stacking and selector‑free operation. The devices are 40 nm wide, can be stacked in up to eight layers,...
Scientists Finally Solve a 100-Year-Old Mystery in the Air We Breathe
University of Warwick researchers have introduced a simple, predictive method to calculate the motion of irregularly shaped nanoparticles in air, reviving a century‑old Cunningham correction factor. The new framework replaces spherical assumptions with a shape‑agnostic correction tensor, eliminating the need...
Graphene-Engineered Interfaces Enable Stable, High-Efficiency Flexible Perovskite Solar Cells
Researchers at India’s CSIR‑Central Scientific Instruments Organization demonstrated that incorporating reduced graphene oxide into SnO₂ and TiO₂ electron‑transport layers creates graphene‑engineered interfaces for flexible all‑inorganic perovskite solar cells. The graphene‑modified contacts boost interfacial conductivity, suppress trap‑assisted recombination and reduce hysteresis,...
Dutch Tech Giant ASML Posts Bumper Profits, Eyes Bright AI Future
ASML reported a 2025 after‑tax profit of €9.6 billion, up €2 billion from the prior year, and record net sales of €32.7 billion. CEO Christophe Fouquet highlighted robust AI‑related demand as the primary growth driver and forecast 2026 sales between €34 billion and €39 billion....
US Contract Vehicle to Speed US Made Defense Semiconductors Into Military Systems
Northrop Grumman has secured a $25 billion, ten‑year award under the Defense Microelectronics Activity’s Advanced Technology Support Program V (ATSP‑5). The indefinite‑delivery, indefinite‑quantity contract lets the company respond to proposals within 30 days and move from award to delivery in roughly 80‑90 days, dramatically shortening...
Encapsulated PbS Quantum Dots Boost Solar Water Splitting without Sacrificial Agents
UNIST researchers have engineered a metal‑encapsulated PbS quantum‑dot photoelectrode that resists corrosion during photoelectrochemical water splitting. The device delivers a record photocurrent density of 18.6 mA cm⁻² in 1 M NaOH and retains roughly 90 % of its initial output after 24 hours of continuous...
Exposure to Grilled Lamb‐Borne Carbon Quantum Dots Induces Intrahepatic Cholestasis by Activating the Intestinal Microbial‐Derived Lipopolysaccharide‐TLR4 Pathway
Researchers discovered that carbon quantum dots (CQDs) released from grilled lamb accumulate in mice after nine weeks of oral exposure at 25 mg kg⁻¹, damaging liver and intestinal barriers. The CQDs elevate gut‑derived lipopolysaccharide, triggering the intestinal LPS‑TLR4‑MyD88 signaling cascade and hepatic...
Advanced Photoporation: Micro‐Nanostructures for Size‐Specific Highly Efficient Biomolecular Delivery
Photoporation is emerging as a versatile, non‑viral platform for intracellular delivery, and a new review proposes a size‑centric framework that categorises strategies by cargo dimensions rather than by laser or material type. The authors analyse how micro‑ and nanostructured substrates...
Biocompatible Glue‐Enabled Drug Localization and Mechanical Reinforcement of Lyophilized Microneedle Systems
The Lyophilized Microneedle System with Biocompatible Glue (LMS‑BG) integrates a porous, drug‑loaded microneedle tip with a biodegradable ethanol‑based glue to create a mechanically robust, ultra‑fast dissolving transdermal platform. In tests using lidocaine, the system dissolved 11‑times faster than conventional dissolving...
Cu–O–In Bridge Engineering in Cu2O/In2O3 Nanowires for Efficient CO2‐to‐CO Electroreduction
Researchers have engineered a Cu2O/In2O3 heterointerface within three‑dimensional copper foam nanowires, creating Cu–O–In bridges that precisely tune the d‑band centers of Cu and In sites. This electronic modulation boosts CO2‑to‑CO electroreduction, achieving over 90% Faradaic efficiency across a wide potential...
Microstructure‐Interface Modulation Boosts Sodium Storage Capacity and Stability of Hard Carbon
The researchers applied a synergistic microstructure‑interface modulation to resin‑derived hard carbon, introducing carbonyl groups for reversible Na⁺ adsorption and using carboxyl/phenolic hydroxyl groups to anchor Zn²⁺ ions that template a hierarchical pore network. Expanded interlayer spacing further speeds Na⁺ intercalation,...
Bioinspired and Engineered Ion‐Selective Membranes Toward High‐Flux and High‐Selectivity Energy Devices
The review examines recent advances in ion‑selective membranes that aim to break the longstanding permeability‑selectivity trade‑off. By drawing inspiration from biological ion channels, researchers are engineering nanofluidic architectures, hybrid polymer‑nanomaterial composites, and AI‑assisted design tools to boost both ion flux...
Optimizing HostGuest Interaction Sites in Metal‐Organic Frameworks for Benchmark One‐Step Ethylene Purification
Researchers introduced three conformational isomeric Fe3‑based metal‑organic frameworks (SNNU‑705‑α/β/γ) that strategically combine open metal sites, aromatic rings, and amino Lewis basic sites to preferentially adsorb acetylene and ethane while weakly binding ethylene. This host‑guest interaction design enables a benchmark one‑step...
Synthesis of Zirconium Boron‐Oxo Clusters With Tunable Third‐Order Nonlinear Optical Response
Researchers have developed a modular synthesis route for zirconium boron‑oxo clusters (Zr‑BOCs) using in‑situ condensation of boron sources with dioxime ligands under pyrazole‑thermal conditions. The resulting planar Zr₂B₈O₁₀ cores feature d‑p‑π delocalization, and systematic ligand exchange with aromatic acids tunes...
Self‐Lubricating Nanofiber/Hollow Microsphere All‐Ceramic Architecture for Robust Flexible Thermal Insulation
Researchers have created an all‑inorganic SiO2 composite membrane by electrospinning nanofibers embedded with hollow silica microspheres. The resulting self‑lubricating 3D architecture delivers an ultralow thermal conductivity of 31.39 mW m⁻¹ K⁻¹ while maintaining exceptional flexibility, surviving over 100 000 bending cycles at 99 % strain....
Dynamically Reprograms Mitochondrial Respiration to Augment Cuproptosis in Cancer Therapy
Researchers engineered a copper‑coordinated polymer that transports lactate oxidase into cancer cells, converting intracellular lactate to pyruvate. This metabolic shift elevates mitochondrial respiration, sensitizing tumors to copper‑driven cuproptosis. Simultaneously, copper triggers DLAT oligomerization and a Fenton‑like reaction, inducing ferroptosis. In...
Biomimetic, Hierarchical‐Porous Composite Aerogel Fiber with Spectral Selectivity and Water Microchannels for Synergistic Radiative‐Evaporative Passive Cooling Textile
Researchers have created structure‑engineered aerogel fibers (SAFs) that replicate desert animal hair, using a double‑diffusion wet‑spinning process and hollow glass microspheres. The fibers exhibit 96.1% emissivity in the atmospheric window and 92.3% solar reflectivity, while their 93.9% internal porosity enables...
A Metal‐Free Phthalocyanine Additive for Defect Passivation and Processing Tolerance in High‐Efficiency Perovskite Solar Cells
Researchers have introduced CG-0, a fully substituted, metal‑free phthalocyanine, as a highly soluble additive for wide‑bandgap perovskite solar cells. The additive simultaneously promotes defect passivation, controlled crystallization, and remarkable processing tolerance, allowing ultra‑high doping levels up to 1.75 mM. Devices incorporating...
Asymmetric Metal Oxide Electrodes for High‐Efficiency Evaporation‐Induced Energy Harvesting
Researchers have built an evaporation‑driven energy generator using a montmorillonite clay membrane and surface‑modified graphitic carbon electrodes coated with TiO₂ and Co₃O₄ nanowires. Replacing traditional copper contacts with these metal‑oxide electrodes boosted power output by roughly 8,000 times. The device...
NBD Integrated and Vitamin B6‐Driven Charge‐Reversible Peptide‐Based Nanocarriers for Targeted Therapeutic Delivery
Researchers have engineered a phenylalanine‑tryptophan dipeptide nanocarrier functionalized with the fluorescent probe NBD and a vitamin B6‑derived pH‑responsive unit. The self‑assembled nanospheres load doxorubicin with high efficiency and undergo charge reversal at mildly acidic pH, triggering rapid drug release and nuclear...
Dual Therapeutic Effects of Ultra‐Small Platinum‐Selenium Nanoparticles on Oxalate‐Induced Acute Kidney Injury
Researchers synthesized ultra‑small platinum‑selenium (Pt‑Se) nanoparticles that effectively halt calcium oxalate (CaOx) crystal nucleation and growth, reducing crystal‑cell interactions and oxidative damage. In vitro assays demonstrated strong inhibition of CaOx crystallization, while a hyperoxaluria mouse model showed markedly lower renal...
Fluorescently Labeled Gradient Hydrogels Reveal Matrix‐Dependent Cell Responses to Substrate Stiffness
Researchers introduced a thermophoresis-based method to fabricate fluorescently labeled stiffness gradient hydrogels, enabling contactless stiffness mapping via standard microscopy. The technique leverages fluorescein isothiocyanate labeling, where fluorescence intensity reflects polymer concentration and thus stiffness. Experiments with gelatin methacryloyl (GelMA) and...