Dasatinib and Quercetin as Senolytic May Cause Brain Damage
A March 2026 PNAS study shows that the senolytic combo dasatinib and quercetin (D+Q) triggers demyelination in the corpus callosum of aged mice. The researchers used intermittent oral doses of 5 mg/kg dasatinib and 50 mg/kg quercetin, identical to regimens linked to increased survival in prior mouse work. Despite preserving oligodendrocyte numbers, D+Q caused oligodendrocyte dysfunction and white‑matter injury, suggesting a neurotoxic side effect independent of dosage magnitude. These results raise safety questions for ongoing human trials and the broader anti‑aging supplement market.
The Longevity Effects of Reduced IGF-1 Signaling Depend on the Stability of the Mitochondrial Genome (Paper April 2026)
The study shows that reducing IGF‑1 signaling via Pappa loss does not extend lifespan in Polg D257A mutator mice, which harbor unstable mitochondrial DNA. While Pappa deletion improves several health metrics—splenomegaly, anemia, inflammation, muscle and cardiac function—the longevity benefit seen in...
Robust Mouse Rejuvenation (RMR1) Study Update
The Robust Mouse Rejuvenation (RMR) program, led by Dr. Aubrey de Grey and the LEV Foundation, is testing multi‑intervention stacks to extend mouse lifespan far beyond the ~4‑month gains seen with single agents. RMR1 combined rapamycin, telomerase gene therapy, heterochronic bone‑marrow...
Did Your Brain Accidentally Train Itself to Be Anxious?
Neuroscientist Dr. Jud Brewer reveals that anxiety functions as a reward‑based habit loop, mirroring everyday habits like nail‑biting. He argues that willpower‑driven suppression intensifies the loop, while cultivating open curiosity quiets the brain’s rumination centers. Brewer’s RAIN‑based "Curiosity Pause" technique...
A Closer Look at Body Composition in Obesity Drug Trials
A new systematic review of 36 randomized controlled trials, published in Annals of Internal Medicine, reveals that obesity medications often cause a sizable loss of lean mass. In 65% of drug trials, more than a quarter of total weight loss...
Is VC6TF the OSK Reversal Cocktail?
Researchers at the Sinclair Lab have identified a five‑molecule mix called VC6TF that chemically mimics the OSK (Oct4, Sox2, Klf4) gene‑therapy cocktail used to reset cellular age. The core of the “three‑chemical” version discussed by Dr. Sinclair includes CHIR‑99021, RepSox...
Your Brain Is Wired for Threat, Not Safety
Human nervous systems are hardwired to prioritize threat detection over safety, a trait honed by evolutionary pressures where missing danger was costly. Modern life replaces acute dangers with persistent stressors, causing the sympathetic response to stay active and preventing natural...
CDC: Antibiotic Resistant Shigella Becoming Higher Risk in US
The CDC’s latest analysis shows a sharp rise in extensively drug‑resistant (XDR) Shigella infections in the United States, climbing from 0% of isolates in 2011‑2015 to 8.5% in 2023. Of the 510 XDR isolates identified, two‑thirds were Shigella sonnei and...
HSS Studies Contribute Early Evidence to Help Guide Emerging Perioperative Considerations for Patients Using GLP‑1 Medications
At the ASRA annual meeting, Hospital for Special Surgery researchers presented two studies on peri‑operative management of patients taking GLP‑1 agonists. A multicenter ultrasound assessment of 354 elective surgery patients found no statistically significant difference in full‑stomach incidence between GLP‑1...
Compass Pathways Commends White House Executive Order to Accelerate Research and Access for Psychedelic Treatments
Compass Pathways welcomed the White House Executive Order aimed at speeding up research and access to psychedelic therapies for serious mental illness. The biotech highlighted its COMP360 synthetic psilocybin, which has delivered statistically significant results in two Phase 3 trials for...
Fauci And CDC Proven Wrong As Massive Denmark Study Shows Masks And Vaccines Failed To Stop COVID
The blog post argues that masks and COVID‑19 vaccines failed to curb the pandemic, citing a large Danish study as evidence. It quotes Anthony Fauci and former CDC chief Rochelle Walensky asserting that vaccines, masks, tests and antivirals were the "tools"...
Dynamic Liquid Crystal Elastomers Drive Adaptive Soft Robotics at Liquid Interfaces
Researchers at Chengdu and Sichuan Universities, together with the Université de Sherbrooke, have created a 3D‑printed soft robot that operates at the air‑water interface and can switch among three distinct propulsion modes using only a near‑infrared light beam. The robot’s...
Prostate Cancer: A PSA on PSA
Prostate cancer mortality is stalling as advanced‑stage diagnoses climb in the United States and Canada, a trend linked to the 2008‑2012 USPSTF move away from routine PSA screening. New evidence shows that refined PSA strategies—tracking PSA velocity and PSA density—combined...
Hazel Szeto, SS-31 Peptide, the World's First FDA-Approved Mitochondria-Targeted Drug (Longevity Summit, 2025)
SS‑31 (elamipretide), the first FDA‑approved mitochondria‑targeted drug, is being promoted on TikTok as a vision enhancer, despite its approval only for a rare mitochondrial disease. Clinical data for age‑related macular degeneration (AMD) show the drug failed to meet endpoints, with...
Exercise Triggers More Brain-Boosting Protein in Fit People
A 2026 Brain Research study found that only after a 12‑week fitness program do sedentary adults show a marked increase in brain‑derived neurotrophic factor (BDNF) during exercise. The rise in BDNF correlated with higher VO2 max scores and translated into faster...
Agenus Reports Phase II Data Demonstrating Immune Reprogramming and Durable Survival with Botensilimab, Balstilimab and agenT-797 in PD-1 Refractory Gastroesophageal...
Agenus presented Phase II data showing that a combination of botensilimab, balstilimab and the allo‑iNKT cell therapy agenT‑797 achieved a 77% disease‑control rate in PD‑1‑refractory gastroesophageal adenocarcinoma. Patients who received an induction cycle of agenT‑797 before the full regimen experienced median...
Phytomining Rare Earths (Mining with Plants)
Researchers have demonstrated that the fern Blechnum orientale can biosynthesize nanoscale monazite crystals, marking the first observation of rare‑earth mineral formation inside a living plant. A separate team at North Carolina State University developed a non‑destructive fluorescence method to detect...
SAGA Diagnostics to Present New Pathlight™ MRD Data for Ovarian and Metastatic Breast Cancer at AACR 2026
SAGA Diagnostics will present two abstracts at AACR 2026 showcasing its Pathlight™ structural‑variant‑based circulating tumor DNA (ctDNA) assay. In metastatic breast cancer, the test achieved a 77% detection rate, with ultrasensitive reads predicting therapeutic response and preceding radiologic progression. In...
Humid Air Makes This 3D-Printed Nanogenerator Work Better, Not Worse
Researchers have created a 3D‑printable hygroscopic polymer that captures water molecules, turning high humidity into a performance boost for triboelectric nanogenerators (TENGs). The amide‑based resin, enhanced with 5 wt % sulfobetaine methacrylate, delivers 45.6 µA, 802 V and a peak power density of 48.4 W m⁻²...
Mice that Ate Artificial Sweeteners Passed Metabolic Changes to Their Grandchildren
A recent animal study found that mice fed artificial sweeteners produced grandchildren with impaired glucose tolerance and altered gut microbiome, despite the descendants never consuming the sweeteners themselves. The transgenerational metabolic changes suggest that zero‑calorie sweeteners can leave a lasting...
Turning Plant Waste Into Nanocellulose and Biocomposites for Sustainable Space Missions
The European Space Agency‑funded BioSTEP project demonstrated that plant biomass and discarded packaging can be transformed into nanocellulose and high‑performance biocomposites suitable for Moon and Mars missions. Conducted by NTNU’s CIRiS and RISE PFI during 2024‑25, the study identified crops with...
Mining Companies Are Using Cosmic Rays to Find Critical Minerals – by Adam Bluestein (Scientific American – April 14, 2026)
Mining firms are turning to cosmic‑ray muon tomography to map deep‑rock mineralization, a technique that can locate copper, gold and other critical ores without invasive drilling. Rising prices and record‑high demand for copper and other key minerals have exposed a...
Flexible Capacitive Pressure Sensor Gains Sensitivity Under Increasing Load
Researchers at Zhejiang University unveiled a flexible capacitive pressure sensor whose sensitivity increases with pressure, a reversal of the typical decline seen in conventional designs. The 3‑D cage‑like architecture, created via buckling‑guided assembly and laser cutting, delivers a peak sensitivity...
Piracetam
Piracetam, the first racetam‑class nootropic developed by Dr. Corneliu Giurgea at UCB Pharma in 1964, remains a cornerstone of cognitive‑enhancement supplements. It modulates AMPA and NMDA glutamate receptors, boosts acetylcholine activity, and increases cerebral blood flow, supporting memory, learning, and...
Why, if After 7 to 21 Years of Follow-Up Data, Disc Arthroplasty Has a Mere 0.67% Index Level Revision Rate,...
A new long-term study of 1,187 lumbar total disc arthroplasty patients, followed for 7 to 21 years, shows durable pain relief and functional improvement. Index‑level revision occurred in only 0.67% of cases, while adjacent‑level surgery was 1.85%. Outcomes were comparable...
Bringing AI-Driven Protein-Design Tools to Biologists Everywhere
OpenProtein.AI has launched a no‑code, web‑based platform that gives biologists instant access to powerful protein‑language models and design tools. The suite includes the PoET transformer and its newer PoET‑2 version, which delivers higher accuracy while using a fraction of the...
Bio-Based Foam Replaces Petroleum-Based Materials - without Changing Production Processes
A Fraunhofer‑led consortium has created xPBS, a bio‑based extrusion foam made from polybutylene succinate that matches the density and performance of conventional polyethylene foams. The material can be processed on existing extrusion lines, eliminating the need for costly equipment upgrades....
Anti-Amyloid Alzheimer’s Drugs Show Limited Benefit in Cochrane Review
A Cochrane review of 17 randomized trials involving 20,342 participants found that anti‑amyloid antibodies deliver little to no clinically meaningful improvement in memory, cognition, or dementia severity after roughly 18 months of treatment. The analysis also identified a markedly higher...
The Interventions Testing Program Shows that Another Eleven Compounds Do Not Slow Aging in Mice
The National Institute on Aging’s Interventions Testing Program evaluated eleven small‑molecule and supplement candidates—including astaxanthin, meclizine, mitoglitazone, pioglitazone, α‑ketoglutarate, mifepristone, methotrexate, and an atorvastatin‑telmisartan combo—in genetically heterogeneous UM‑HET3 mice and found none extended lifespan. Earlier studies that suggested modest benefits...
Funding Friday: Stretching the Limits of Climate Tech
This week’s climate‑tech funding roundup featured a $139 million Series A for quantum‑AI startup Sygaldry, a $29 million raise by NanoTech Materials to scale heat‑resistant, reflective coatings, and a $26 million round for Critical Loop’s modular microgrid systems. The U.S. Department of Energy added...
MGHPCC Powers Breakthroughs in Biomedical Research with High-Performance Computing
The Massachusetts Green High Performance Computing Center (MGHPCC) is powering data‑intensive biomedical research across the state. Harvard’s Huttenhower Group leverages its massive compute capacity to parse terabytes of gut microbiome sequences, while Yale’s O’Hern Group runs high‑resolution simulations of breast‑cancer...
Wick Rotating Spinors and Twistors
The talk in Marseille examined the longstanding difficulty of Wick rotating spinor fields between Minkowski and Euclidean spacetimes, highlighting that complex spacetime geometry simplifies spinor and twistor representations while real spacetimes introduce incompatibilities. The speaker proposed redefining the Minkowski Lorentz...
Lattice Surgery Optimises Quantum Computation, Reducing Failure Rates by 16 Percent
Researchers at the University of Warwick introduced O3LS, a framework that simultaneously optimises space and time for lattice‑surgery‑based fault‑tolerant quantum computation. Numerical tests show O3LS can shrink qubit‑space overhead by up to 46.7% and cut logical error rates by as...
A Window on Absolutely Everything
Quantum field theory uses the path‑integral formalism, summing every possible particle trajectory, but most contributions cancel, leaving straight‑line paths dominant. Physicists capture the remaining effects with Feynman diagrams, organizing interactions by decreasing impact. Anomalies—situations where diagram sums break required symmetries—force...
Experts Needed To Confirm/Affirm NASA Goddard Expertise
The National Academies have launched a congressionally mandated study to evaluate the technical and scientific capabilities at NASA's Goddard Space Flight Center. The effort will assemble a committee of roughly ten volunteer experts to assess advanced technologies, testing, systems development,...
Quantum Data Cleaning Now Obeys the Laws of Physics
Researchers Guo and colleagues at HKUST and the University of Hong Kong unveiled a universal quantum state purification framework that respects energy‑conservation constraints for depolarizing noise. The protocol reaches an average fidelity of 0.867, surpassing the previous unconstrained ceiling of...
SEALSQ Plans 100-Satellite Constellation for Quantum Services in Space
SEALSQ and its subsidiary WISeSat unveiled the Quantum Spatial Orbital Cloud (QSOC), a 100‑satellite constellation designed to deliver quantum‑secured communications, quantum randomness and post‑quantum security as a subscription‑based cloud service. The first phase of 15 fully funded satellites will be...
Pasqal’s 1024 Atoms Show Less Than 0.5% Defects, 5000-Second Lifetimes
Pasqal has demonstrated a neutral‑atom quantum register containing 1,024 qubits with a defect rate below 0.5%, doubling its previous record. The array maintains coherence times of up to 5,000 seconds (about 80 minutes), a forty‑fold increase over earlier cryogenic setups....
QTREX Ltd. Targets $72B Quantum Market With 3D Architecture
Inspira Technologies is seeking shareholder approval to rename itself QTREX Ltd., marking a strategic shift toward solving quantum‑computing connectivity bottlenecks inside dilution cryostats. The company will leverage its additive manufactured electronics (AME) platform, backed by more than $200 million of prior...
An Ultrathin Solid Electrolyte Keeps Lithium Metal Batteries From Catching Fire
Researchers have created a 20‑µm composite solid electrolyte that embeds trimethyl phosphate inside a copper‑based MOF cage, releasing the flame‑retardant only above 120 °C. The ultrathin electrolyte delivers ionic conductance 880‑times higher than conventional PEO membranes while raising the lithium‑ion transference...
Google Quantum AI Achieves Tunable Asymmetric Potential for Reactions
Researchers at Google Quantum AI and Yale University have built a tunable asymmetric double‑well quantum simulator using a Kerr parametric oscillator and a tunnel Josephson junction. The platform lets them independently adjust barrier height and well depth, revealing that slight...
Mixed States Approximate Matrix Integrals Using Quantinuum’s New Method
Quantinuum unveiled a probabilistic quantum algorithm that encodes functions into mixed states, bypassing traditional block‑encoding techniques. The method can approximate the normalized inverse of positive‑definite matrices and compute weighted sums or integrals, enabling efficient solutions to Lyapunov equations and matrix...
The World's Most Neglected Disease
A new meta‑analysis of 6.1 million people across 119 countries shows hypertension prevalence has nearly doubled since 2000, with the surge concentrated in low‑ and middle‑income nations. While high‑income regions saw modest declines and control rates rise to 40%, only one...
Friday Hope: Palmitoylethanolamide (PEA): Inhibits Spike Entry, Reduces Proinflammatory Markers in COVID and Improves Symptomology in Long COVID
Recent peer‑reviewed studies demonstrate that palmitoylethanolamide (PEA), a naturally occurring lipid, can block SARS‑CoV‑2 spike protein entry, cut viral replication by roughly 70%, and lower key inflammatory biomarkers in acute COVID‑19 patients. A separate real‑world cohort shows PEA supplementation markedly...
Revolution Medicines' Daraxonrasib Cuts Pancreatic Cancer Death Risk by 60% – This Week in Biotech #96
Revolution Medicines announced Phase 3 RASolute 302 results for its oral RAS‑ON inhibitor daraxonrasib in second‑line metastatic pancreatic ductal adenocarcinoma. The trial reported a median overall survival of 13.2 months versus 6.7 months with standard chemotherapy, a hazard ratio of 0.40 and a 60%...
FDA Commissioner Makary: Miracle Cancer Cures Are in the Pipeline
FDA Commissioner Marty Makary has announced that "miracle" cancer cures are on the horizon, promising faster FDA approvals and unprecedented transparency in clinical data. He suggests that trials could be completed within months using thousands of volunteers, dramatically shortening the...
Oxygen Sensing as a Component of Differences in Regenerative Capacity Between Species
Researchers investigated how oxygen sensing influences tissue regeneration by comparing amphibian and mammalian models. They cultured frog tadpole limbs and mouse embryos under varied oxygen levels, focusing on the HIF1A protein that stabilizes under low oxygen. Reduced oxygen accelerated wound...
Weekly Neuroscience Update
Researchers unveiled a fully implantable brain‑computer interface that lets paraplegic patients control a robotic exoskeleton with their thoughts, aiming to restore both walking and its sensation. Parallel advances include an AI pruning framework that mimics infant brain development to slash...
Hybrid Filler Composites Boost 3D Print Heat Flow
A recent research paper demonstrates that hybrid‑filler polymer composites can significantly raise thermal conductivity while staying printable on standard FFF and resin 3D printers. By mixing ceramic and carbon‑based fillers, the composites create efficient heat pathways at lower filler loadings,...
Climate Knowledge Linked to Student Stress
A Quinnipiac University study of 305 undergraduates found that while 95% recognize climate change as real, greater climate knowledge is linked to heightened stress, anxiety, and depression. Students reporting higher stress are more likely to adjust daily habits and reconsider...