Metformin Raises Exercise‑Mimetic Metabolite in Prostate Cancer Patients
Researchers at the Sylvester Comprehensive Cancer Center reported that metformin elevates N‑lactoyl‑phenylalanine (Lac‑Phe), a molecule that spikes after intense exercise, in men undergoing hormone therapy for prostate cancer. The finding, published in EMBO Molecular Medicine, suggests a drug‑based route to replicate exercise’s metabolic benefits when physical activity is limited.
Pfizer, BioNTech Drop Updated COVID‑19 Vaccine Study After Low Enrollment
Pfizer and BioNTech have scrapped a late‑stage trial of an updated COVID‑19 vaccine for adults aged 50‑64 because enrollment fell short of FDA‑required numbers. The move highlights the difficulty of conducting large‑scale studies in a post‑pandemic market and comes as...
UPAR Targeting to Enable CAR T Cell Therapies to Treat Solid Cancers
Researchers at Memorial Sloan Kettering demonstrated that CAR T cells engineered to target the urokinase plasminogen activator receptor (uPAR) can eradicate solid‑tumor cells and metastases in multiple preclinical models. uPAR was found elevated in 12 of 14 examined cancer types,...
AI‑Written Code Beats Human Teams in Predicting Preterm Birth, Shaking Up Biomedical Big Data
Researchers at UCSF used large language models to generate code that predicted gestational age and preterm‑birth risk from massive biomedical datasets, matching or surpassing expert‑written analyses. The finding highlights how AI can democratize big‑data analytics in health research.
Generare Bags $21.6m for Nature-Derived Drug Leads
Paris‑based biotech Generare closed a €20 million Series A to expand its nature‑derived compound library. The company claims it uncovered more than 200 previously unknown microbial small molecules in 2025, outpacing the rest of the field combined. Generare’s platform scans microbial genomes,...
How Many GLP-1 Users Must Seek Medical Care for Side Effects?
Recent Phenomix and Mayo Clinic data reveal that 50‑60% of GLP‑1 users experience significant side effects, far higher than earlier estimates. About 10% of patients incur $5,000 in out‑of‑pocket expenses, while many spend roughly $1,000 managing symptoms. The high cost...
The Longevity Nerve: The Missing Link in Stress, Aging & Brain Health | Elisabetta Burchi MD
In this episode, Dr. Elisabetta Burchi explains how the vagus nerve serves as a central hub linking the brain to the heart, gut, immune system, and overall longevity. She outlines the anatomy and function of the vagus within the parasympathetic...
STAT+: Merck’s Experimental HIV Prevention Pill Could Be Made for Less than $5 a Year, Researchers Say
Merck’s experimental HIV‑prevention pill MK 8527 could be manufactured for less than $5 per patient annually, according to a recent cost‑analysis. The drug is in two late‑stage clinical trials that will report efficacy data in the second half of 2027. Earlier...
Gut-Brain Health Effects of PREbiotics in Older Adults with Suspected COgnitive DEcline: Design of the PRECODE Randomised Placebo-Controlled Trial
The PRECODE trial is a four‑arm, double‑blind, placebo‑controlled study enrolling 164 adults aged 60‑79 with subjective cognitive decline (SCD+) and additional lifestyle risk factors. Over 26 weeks participants receive chicory inulin, resistant dextrin, seaweed polysaccharide, or maltodextrin placebo to test whether...
Selective Anticancer Activity of Vachellia Nilotica Fruit Extract: Integrated Phytochemistry with Antioxidant, Antimicrobial, and Cancer Cell Targeting
Researchers evaluated methanolic fruit extract of Vachellia nilotica, revealing high phenolic (419 mg GAE g⁻¹) and flavonoid (245 mg QE g⁻¹) contents that confer strong antioxidant activity (IC₅₀ ≈ 31.8 µg mL⁻¹). The extract inhibited a range of bacteria, producing up to 23 mm inhibition zones, and suppressed growth of several...
Bootstrapped Cryo‑AI: LLMs Power Life‑Saving Freeze Tech
Meet Dr. Mark Woodward, undergrad and grad from Stanford, PhD from Harvard, Many years at Google as part of Google brain. One day he realizes that we need the enabling technology to pause biological time for patients that are about...
Amgen Scores with New Thyroid Eye Disease Formulation
Amgen’s Tepezza, the only FDA‑approved therapy for thyroid eye disease, generated about $1.9 billion in 2023 but its IV dosing schedule has limited broader adoption. The company has developed a subcutaneous formulation delivered twice weekly via a wearable injector, aiming to...
New CAR-T Approach May Extend Osteosarcoma Survival
Researchers at Case Western Reserve University and University Hospitals have engineered a novel CAR‑T cell therapy, OSM CAR‑T, that targets oncostatin M receptors on osteosarcoma cells. Preclinical experiments demonstrated potent in‑vitro killing and significant tumor burden reduction in multiple mouse...
Uncovering the Cellular Origins of Cancer and Neurodevelopmental Disease
Jasmine Plummer, founding director of St. Jude’s Center for Spatial Omics, outlines how her lab merges single‑cell transcriptomics, epigenomics and cutting‑edge imaging to map cellular origins of cancer and neurodevelopmental disease. The team created STAMP, a method that turns standard microscopes...
Why Silo Pharma Shares Are Trading Higher By Around 52%; Here Are 20 Stocks Moving Premarket
Silo Pharma’s shares surged 51.8% to $0.54 in pre‑market trading after the European Patent Office issued a Rule 71(3) communication indicating a likely grant of a patent for its novel 5‑HT4 receptor preventative therapy. The announcement sparked a broader pre‑market rally...
Biotalys Achieves First Research Milestone in Syngenta Partnership for Novel Bioinsecticide Development
Biotalys announced the first research milestone in its Syngenta partnership, confirming promising in‑vitro results for a novel bioinsecticide built on its AGROBODY™ platform. The achievement moves the collaboration into the next phase of in‑vivo testing on living organisms. The milestone...
4D Atlas of Thousands of Genes Offers Unparalleled Insight Into Embryogenesis
A University of Basel team introduced weMERFISH, an imaging technique that captures activity of nearly 500 genes with subcellular resolution across an entire zebrafish embryo. Using this method they built a 4D atlas linking gene expression to cell migration, tissue...
Clean Food Group Unveils Eco Cosmetics Oil Made From Yeasts Fed on Surplus Bread
UK biotech startup Clean Food Group has launched CleanOil 25, a yeast‑derived oil produced from surplus bread that aims to replace palm and other tropical oils in cosmetics. The ingredient delivers premium skin‑friendly textures, matches performance expectations, and cuts greenhouse‑gas...
Allergan Aesthetics Finds Its Next Growth Engine in GLP-1s
Allergan Aesthetics presented new data at the 2026 AAD meeting linking the surge in GLP‑1 weight‑loss drug use to a growing demand for facial aesthetic treatments. A survey of U.S. clinicians showed that 52% of patients on GLP‑1 agonists express...
The Evolving Landscape of Subcutaneous Drug Administration
The pharmaceutical sector is rapidly moving toward subcutaneous (SC) delivery as biologic approvals outpace small‑molecule drugs. While SC administration cuts clinical‑site costs and boosts patient comfort, it suffers from 60‑80% lower bioavailability, demanding higher doses and larger volumes. Innovators are...
The Hollow Promise of Protection
A Singapore study led by Wee et al. examined thousands of cancer patients who were fully vaccinated with mRNA COVID‑19 shots. Despite high vaccination rates, most participants contracted COVID‑19 and developed long‑COVID symptoms such as fatigue, dyspnea, and cognitive impairment....
Stereotaxis Launches Synchrony System for Cath Labs
Stereotaxis has received FDA 510(k) clearance to launch Synchrony, a digital platform for cardiac catheterization labs. The system features a 55‑inch 4K ultra‑high‑definition display that unifies control of disparate equipment and delivers full‑fidelity video with ultra‑low latency. Accompanying the hardware,...
CGT’s Next Obstacle: Securing the Leukapheresis Supply Chain
Leukapheresis is emerging as a structural bottleneck as CAR‑T and other cell‑gene therapies expand beyond oncology into autoimmune, cardiovascular and respiratory diseases. The current model relies on a handful of academic centers, creating capacity constraints, geographic inequities, and variability in...
CuraTeQ Reports P-III Trial Data on BP11 (Biosimilar, Xolair) in Chronic Spontaneous Urticaria
CuraTeQ Biologics announced topline Phase‑III data showing its biosimilar BP11 matches Xolair in treating chronic spontaneous urticaria. The trial involved 608 patients at about 80 sites and met the primary endpoint of ISS7 score change at week 12 within predefined...
Digital Twins Simulate Psychedelic Effects for Consciousness Disorders
Digital twins allow virtual clinical trials of psychedelics for disorders of consciousness 🧠↔🧠 | Innovation | Tech for Good. 💬 Using magnetic resonance imaging (MRI), scientists have developed personalized, whole-brain computational models of patients with disorders of consciousness. Using these...
Probability of Success Integrates Development Risk Into Biotech Valuations
Incorporating Probability of Success (PoS) is a unique aspect of #biotech valuation investors must be aware of. It tries to factor development risk into revenue and cost assumptions. Here is a table of PoS values: #learnbiotechinvesting #investing #BiotechPrometheus https://t.co/GA3LVSmWFZ
Amgen Reports Topline P-III Trial Data for Tepezza (Teprotumumab-Trbw) in Active Thyroid Eye Disease
Amgen announced topline results from a phase‑3 trial of subcutaneous Tepezza (teprotumumab‑trbw) administered every two weeks for 12 doses in patients with moderate to severe active thyroid eye disease. The study met its primary endpoint, showing a 76.7% proptosis response...
Canagliflozin - Another Top Longevity Drug
Canagliflozin and other SGLT‑2 inhibitors are gaining attention as potential longevity agents due to their ability to cut cardiovascular events, renal decline, and COPD exacerbations in patients with type‑2 diabetes. Recent meta‑analyses show reduced emergency‑room visits and lower mortality among...
Self‐Assembled Carrier‐Free Nanomedicines Potentiate Chemo‐Photothermal Immunotherapy by Overcoming Prostaglandin E2‐Mediated Immunosuppression
Researchers have created a carrier‑free nanomedicine that self‑assembles indocyanine green, paclitaxel and celecoxib to treat triple‑negative breast cancer (TNBC). The formulation delivers combined chemo‑photothermal therapy while inhibiting the COX‑2/PGE2 inflammatory axis that fuels immunosuppression. In preclinical models, the nanomedicine markedly...
Programmable Biohybrid Probiotics with Long‐Term Storage Stability for Enhanced Intestinal Microbiota Regulation and Ulcerative Colitis Treatment
Researchers unveiled a multilayer encapsulation platform that merges a metal‑polyphenol network, silica shell, and iron‑based metal‑organic framework to shield the anaerobic probiotic Bifidobacterium longum. The system achieved a 41‑fold boost in aerobic storage stability and an 871‑fold increase in gastric...
Sanofi Reports P-II Trial Results on Lunsekimig Across Multiple Immunology & Inflammatory Indications
Sanofi announced phase‑IIb results for its subcutaneous antibody lunsekimig across three inflammatory diseases. In the AIRCULES asthma study, the drug reduced exacerbations and improved pre‑bronchodilator FEV1 versus placebo, meeting both primary and key secondary endpoints. The DUET trial in chronic...
VML Just Created the World’s First T-Rex Leather
Creative agency VML, The Organoid Company, and Lab‑Grown Leather have engineered the world’s first T‑Rex leather from reconstructed dinosaur collagen and turned it into a one‑of‑a‑kind luxury handbag. The piece debuted beside a massive T‑Rex statue at Amsterdam’s Art Zoo...
Decentralized Trials That Scale Globally Without Compliance Risks - with Emma Vitalini of Amgen
In this episode, Emma Vitalini, Head of Global Digital Health Technology Innovation at Amgen, discusses how AI and decentralized trial technologies are transforming patient recruitment, screening, and global trial accessibility. She explains that AI can rapidly parse unstructured genomic and...
Press Release: Sanofi’s Lunsekimig Met Primary and Key Secondary Endpoints in Phase 2 Respiratory Studies in Asthma and CRSwNP
Sanofi announced that its bispecific Nanobody lunsekimig achieved both primary and key secondary endpoints in the phase 2b AIRCULES asthma trial and the phase 2a DUET study for chronic rhinosinusitis with nasal polyps (CRSwNP). The asthma study showed a statistically...
Biotalys Achieves First Milestone in Bioinsecticide Partnership with Syngenta
Biotalys announced it reached the first research milestone in its partnership with Syngenta to develop a novel protein‑based bioinsecticide using the AGROBODY™ platform. Laboratory tests showed promising in‑vitro activity against a key insect molecular target. The collaboration will now move...
‘Tech Bro Hype’ Vs. Serious Science: The Inside Story on Colossal’s Attempt to Create a Real-Life Jurassic Park
Colossal Biosciences announced that it has produced three gene‑edited pups it calls dire wolves, marking its first high‑profile claim of de‑extinction. The Dallas‑based firm says a woolly mammoth will follow within two years, with a dodo later on, using ancient...
GMO Pictures May Reinforce Existing Views, Deepening the Divide of Attitudes Towards Them
A new study in the Journal of Science Communication examined how different images affect U.S. public attitudes toward genetically modified organisms. Researchers presented participants with either no image, a plain apple, or an apple paired with a syringe to suggest...
Brown Fat Protein SLIT3 Unlocked as Key to Metabolism, Weight‑Loss Potential
Researchers published in Nature Communications have identified a dual‑fragment protein system, SLIT3‑N and SLIT3‑C, that constructs the vascular and neural scaffolding essential for brown adipose tissue to burn calories. The discovery, based on analysis of more than 1,500 human samples,...
EU‑Funded PsyPal Project Starts Psychedelic Trials for Palliative Care Distress
The European Union‑funded PsyPal project kicked off its first psychedelic‑assisted therapy trials for psychological distress in palliative care on 13 April 2026 in Brussels. The launch, hosted by the Directorate‑General for Health and Food Safety, signals a coordinated effort to...
New Diagnostic Platform Measures Biological Age with Year‑Level Precision
A molecular diagnostic platform unveiled in 2026 can quantify an individual’s biological age to within a year, offering clinicians a concrete metric to tailor preventive interventions. Backed by NIH funding and epigenetic‑clock research, the tool promises to shift how doctors...
Interventional Radiologist 1st in World to Deliver Newly Approved Cancer Treatment
Interventional radiologists at Mount Sinai performed the world’s first TheraSphere Y‑90 Any Day Dosing procedure for hepatocellular carcinoma, following the FDA’s March 2026 clearance. The treatment uses microspheres to deliver targeted radiation directly to liver tumors while sparing healthy tissue. The...
Self‑Administered Peptide Clinics Surge After Huberman Podcast, Raising Safety Concerns
After a 2024 appearance on Andrew Huberman’s podcast, Dr. Koniver’s peptide‑focused clinic added 800 new patients in a month, now serving about 1,000 and maintaining a 6,000‑person waitlist. Memberships cost $15,000 a year, generating tens of millions in revenue, while...
AI Meets Drug Discovery at NYC Meetup Tuesday
AI x Drug Discovery meetup next Tues (14) in NYC ! @ginkgo excited to host with @AAlphaBio — sign up here : https://t.co/GG5c7F4ogO
What Would Robert Louis Stevenson Say About Ozempic?
The article warns that GLP‑1 drugs such as Ozempic, Wegovy and Mounjaro, while effective for weight loss, may blunt dopamine‑driven pleasure centers, leading to apathy and altered behavior. It draws a parallel between these modern injectables and the historic side...
Study Shows 88% Accuracy for OTC Medication Abortion Kit Self‑Assessment
A new JAMA Internal Medicine study reports that 88% of participants accurately judged their eligibility for an over‑the‑counter medication abortion kit, suggesting self‑assessment could be safe. The findings arrive amid state bans and a lack of FDA applications, intensifying calls...
Polyunsaturated Lipids Kill Senescent Cells by Ferroptosis
Researchers led by Zhang published in Cell Press Blue identified two polyunsaturated lipids that selectively trigger ferroptosis in senescent cells. The study demonstrates that senescent cells are uniquely vulnerable to iron‑dependent lipid peroxidation, and that these lipids can clear them...
Towards Scalable Biomarker Discovery in Posttraumatic Stress Disorder: Triangulating Genomic and Phenotypic Evidence From a Health System Biobank
Researchers leveraged a large health‑system biobank to combine genomic polygenic risk scores with electronic health‑record phenotypes, creating a scalable pipeline for PTSD biomarker discovery. The analysis identified immune‑related and metabolic signatures that correlate with PTSD risk, and highlighted sex‑specific genetic...
Characterization of the Chromosome 7 Locus Associated with Suicidal Behavior
Researchers have pinpointed a chromosome 7 locus that shows a genome‑wide significant association with suicidal behavior. The discovery stems from a large meta‑analysis of suicide‑attempt GWAS, combined with expression quantitative trait loci (eQTL) mapping and single‑cell transcriptomic profiling of brain...
An Opinionated Take on NEJM Highlights for Q1 of 2026
The first quarter of 2026 NEJM featured several disruptive studies, including a Canadian‑Australian dialysis trial where fish‑oil supplementation halved myocardial infarctions and cut strokes by two‑thirds. Merck’s oral PCSK9 inhibitor enlicitide achieved a 57% LDL reduction, positioning it for a...
Why ImmunityBio Stock Slumped on Monday
ImmunityBio (NASDAQ: IBRX) saw its stock dip after the FDA sent a warning letter accusing the company of false or misleading promotion of its bladder‑cancer drug Anktiva. The regulator flagged a TV advertisement and a provocative podcast episode, prompting ImmunityBio...