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India has overhauled its startup framework, extending deep‑tech status to 20 years and raising the revenue eligibility threshold to ₹3 billion. The change dovetails with a ₹1 trillion Research, Development and Innovation fund and the $1 billion‑plus India Deep Tech Alliance, aimed at easing financing for capital‑intensive sectors like semiconductors, biotech, and space. Officials say the longer runway reduces premature loss of startup benefits and aligns policy with the long development cycles of science‑led ventures. Investors remain cautious, noting that deep‑tech funding depth beyond early stages is still a major hurdle.
Oh and it’s been a while since this topic has come up, but, to the $HIMS-employed doctors/nurse practitioners etc who have been writing millions of “personalized” doses of semaglutide nonstop in order to help the company skirt intellectual property rights: Do...
NASA’s Crew‑12 mission will launch aboard SpaceX’s Crew Dragon on Feb. 11, carrying two NASA astronauts, an ESA specialist, and a Russian cosmonaut. While aboard the ISS, the crew will conduct the Venous Flow study to assess blood‑clot risk and a...
Sanofi disclosed results from its Phase 3 trial of the BTK inhibitor tolebrutinib in primary progressive multiple sclerosis (PPMS). The study failed to meet its primary endpoint of slowing disability progression, and secondary outcomes showed no meaningful benefit. Safety data...
Researchers discovered that carbon quantum dots (CQDs) released from grilled lamb accumulate in mice after nine weeks of oral exposure at 25 mg kg⁻¹, damaging liver and intestinal barriers. The CQDs elevate gut‑derived lipopolysaccharide, triggering the intestinal LPS‑TLR4‑MyD88 signaling cascade and hepatic...
Photoporation is emerging as a versatile, non‑viral platform for intracellular delivery, and a new review proposes a size‑centric framework that categorises strategies by cargo dimensions rather than by laser or material type. The authors analyse how micro‑ and nanostructured substrates...
The Lyophilized Microneedle System with Biocompatible Glue (LMS‑BG) integrates a porous, drug‑loaded microneedle tip with a biodegradable ethanol‑based glue to create a mechanically robust, ultra‑fast dissolving transdermal platform. In tests using lidocaine, the system dissolved 11‑times faster than conventional dissolving...
Researchers engineered a copper‑coordinated polymer that transports lactate oxidase into cancer cells, converting intracellular lactate to pyruvate. This metabolic shift elevates mitochondrial respiration, sensitizing tumors to copper‑driven cuproptosis. Simultaneously, copper triggers DLAT oligomerization and a Fenton‑like reaction, inducing ferroptosis. In...
Researchers have engineered a phenylalanine‑tryptophan dipeptide nanocarrier functionalized with the fluorescent probe NBD and a vitamin B6‑derived pH‑responsive unit. The self‑assembled nanospheres load doxorubicin with high efficiency and undergo charge reversal at mildly acidic pH, triggering rapid drug release and nuclear...
Researchers synthesized ultra‑small platinum‑selenium (Pt‑Se) nanoparticles that effectively halt calcium oxalate (CaOx) crystal nucleation and growth, reducing crystal‑cell interactions and oxidative damage. In vitro assays demonstrated strong inhibition of CaOx crystallization, while a hyperoxaluria mouse model showed markedly lower renal...
Researchers introduced a thermophoresis-based method to fabricate fluorescently labeled stiffness gradient hydrogels, enabling contactless stiffness mapping via standard microscopy. The technique leverages fluorescein isothiocyanate labeling, where fluorescence intensity reflects polymer concentration and thus stiffness. Experiments with gelatin methacryloyl (GelMA) and...
A prospective, population‑based MASAI trial in Sweden screened over 100,000 women using a commercially available AI system alongside radiologists. The AI‑assisted workflow identified more clinically relevant breast cancers and cut interval‑cancer rates without raising false‑positive alerts. Radiologists read AI‑flagged cases...
Scientists have identified two small‑molecule inhibitors—SHY1643 targeting the SARS‑CoV‑2 papain‑like protease (PLpro) and QY1892 targeting the host kinase RIPK1—that together produce a potent antiviral effect in a mouse COVID‑19 model. Individually, each compound modestly reduced viral loads and inflammation, but...
Former McKinsey senior partner emeritus Franck Le Deu has joined Aulis Capital as a venture partner. Aulis, the Hong Kong‑based fund launched by veteran Chinese VC Nisa Le Ung, will back emerging biotech and health‑tech companies across Asia and the West. Le Deu, who...
A new multidisciplinary, evidence‑based guideline set recommends therapeutic drug monitoring (TDM) for biologic therapies in inflammatory bowel disease (IBD). The recommendations integrate pharmacokinetic data, disease activity metrics, and patient‑specific factors to optimize dosing of anti‑TNF, anti‑integrin, and anti‑IL agents. The...
After four years of falling series A activity, biotech start‑up financing stabilized in 2025. The number of companies raising series A remained flat versus 2024, while total dollars raised increased. BioCentury’s analysis shows a broader revival, with round sizes, investor profiles, and...
Fascinating interview with Chief Scientist Sharon Rosenzweig-Lipson about working with the FDA, prepping for clinical trials, and what's next lifespan.io/news/first-human-cellular-reprogramming-trial-cleared-by-the-fda/
How is your p-value histogram look like? chatomics blog post: Downstream of bulk RNAseq: read in salmon output using tximport and then DESeq2 https://t.co/zGjobde9TO https://t.co/aCJaxto5tS
Scientists have created a new class of macrocyclic inhibitors that target the TRPC5 ion channel with picomolar potency. The lead compound JDIC‑127 achieves an IC₅₀ of 374 pM, roughly 200‑fold more potent than the previous benchmark HC‑070, and demonstrates high selectivity...
A recent Molecular Psychiatry study measured circulating mitochondrial DNA and other cellular damage markers in individuals with long COVID and found them significantly elevated compared with recovered controls. The analysis revealed strong correlations between higher mtDNA levels and reduced performance...
Researchers have created a food‑safe gelatin microneedle sensor that pierces sealed packaging and changes color as protein‑rich foods spoil. The device embeds red‑cabbage anthocyanin, shifting from purple to blue when pH rises, providing a visual spoilage cue. Mechanical tests show...
The U.S. government has referred tele‑health firm Hims & Hers to the Department of Justice for a formal investigation into its GLP‑1 weight‑loss program. Hims, which recently launched a compounded version of GLP‑1 drugs to compete with Novo Nordisk’s market‑leading injectables, is...
Sanofi announced that its glucosylceramide synthase (GCS) inhibitor for Fabry disease failed to meet the primary efficacy endpoint in a late‑stage trial. The double‑blind study enrolled roughly 280 patients and showed no statistically significant improvement in key renal or cardiac...
Coincidence that $HIMS has suddenly taken down all ads touting “the same active ingredient as Wegovy”? $HIMS may have finally called enough attention to their bullshit antics to get regulators to finally crack down on them. This could...
A recent study demonstrates that applying modulated UV‑C light to harvested guavas can significantly prolong their shelf life. The researchers found that pulsed UV‑C treatment suppresses microbial growth while using roughly 30% less energy than continuous exposure. Shelf life extensions...
1. Some news about #flu & #measles in the US: 8 more kids have died from flu this winter. That brings the pediatric death toll to 60 & flu season isn't over. Flu B activity seems to be increasing & flu...
President Donald Trump unveiled TrumpRx, a direct‑to‑consumer drug platform promising to let Americans purchase prescription medicines without traditional insurance intermediaries. The rollout was framed as a fulfillment of broken political promises to lower drug costs. However, early feedback highlights that...
Recent research highlights AI‑driven discovery of tetrahydrocarbazoles as click‑activated, broad‑spectrum antitumor agents, while a plant‑derived limonoid, DHL‑11, targets IMPDH2 to inhibit triple‑negative breast cancer. A U.S. survey shows patients still favor in‑clinic cervical cancer screening over home tests, and a...
Researchers at National Jewish Health published a study showing that particulate matter from military burn pits provokes markedly stronger inflammatory and oxidative responses in lung macrophages than ordinary desert dust. The work identifies Toll‑like Receptor 2 (TLR2) as the primary sensor...
A new open‑access study re‑examines human longevity heritability, arguing that previous estimates were biased low because they ignored extrinsic mortality and arbitrary age cutoffs. By modeling and correcting for these factors, the authors find intrinsic lifespan heritability rises to roughly...
The U.S. Department of Health and Human Services has abandoned its legal challenge to a federal court’s injunction that halted a proposed 340B drug‑price rebate pilot. The pilot, designed by the Trump administration to test new rebate mechanisms for hospitals...
President Donald Trump signed the federal spending bill preserving the FDA’s ability to grant a seven‑year exclusivity period for orphan drugs that receive new indications. The provision reverses earlier suggestions to shorten the exclusivity term, embedding the policy in the...
A doctoral thesis from the University of Borås demonstrates that mycoprotein is digested as efficiently as chicken and fish, with amino acid profiles meeting human nutritional needs. Simulated INFOGEST digestion revealed iron is more bioavailable because mycoprotein lacks phytate. The...
Insilico Medicine has appointed Dr. Halle Zhang as Vice President of Clinical Development for Oncology, bringing over two decades of oncology experience from BMS and other biotech firms. Zhang will lead global clinical strategy for Insilico’s AI‑driven oncology portfolio, spanning...
The FDA granted priority review for Pfizer’s marstacimab, marketed as HYMPAVZI, to broaden its label to patients aged six and older with inhibitors and to children 6‑11 without inhibitors. Marstacimab is a weekly subcutaneous anti‑TFPI antibody, the first of its...
Recent research highlights formic acid as a pivotal microbial metabolite that shapes gut ecosystem dynamics and host physiology. The study shows that specific bacterial strains generate formic acid, which modulates intestinal pH, nutrient absorption, and immune signaling. In murine models,...
Researchers from the phase‑2 BIONIKK trial published an exposure‑response analysis of ipilimumab and nivolumab in metastatic clear‑cell renal cell carcinoma. By correlating drug concentrations with patient outcomes, the study identified optimal dosing windows that balance efficacy with toxicity. The findings...
A 2026 study by Modi published in Pediatric Research demonstrates that neonatal body composition, measured with advanced techniques such as air‑displacement plethysmography, is a more informative health metric than weight alone. The research shows that specific macronutrient and human‑milk‑based feeding...
Researchers led by Wu, C. demonstrated that acetylshikonin, a plant‑derived molecule, markedly increases SIRT1 expression in gouty arthritis models. The up‑regulation of SIRT1 coincided with significant drops in IL‑1β and TNF‑α levels, curbing joint inflammation. In parallel, the compound boosted...
$IMMX looks like it wants to move higher. Enrollment completion in Feb ’26 is the next key catalyst, setting up the path toward a filing-grade dataset in AL amyloidosis. Market starting to sniff it out. Check out the AL Amyloidosis success story here: https://t.co/1ei6kat25y
Four biotech firms—Agomab Therapeutics, Eikon Therapeutics, Spyglass Pharma, and Veradermics—went public this week, collectively raising close to $1 billion. A fifth company, Generate Biomedicines, filed IPO paperwork, signaling renewed confidence in public markets. The wave follows a prolonged downturn where only...
Researchers have identified cardiopulmonary phase synchronization as a robust biomarker for autonomic nervous system maturation in preterm infants. By applying Hilbert‑transform‑based signal processing to continuous ECG and respiratory waveforms, the study mapped a clear maturational trajectory that correlates with gestational...
The White House launched TrumpRx, an online portal selling about 40 prescription drugs from manufacturers such as Pfizer, Eli Lilly, and Novo Nordisk at discounted rates. The platform targets cash‑pay consumers, offering "most‑favored‑nation" pricing that mirrors low overseas prices. While the service...
A Penn State-led simulation of the Grass2Gas system—combining year‑round cover crops with anaerobic digestion of manure and biomass—shows an average reduction of more than 20% in the carbon footprint of milk from a typical Pennsylvania dairy. Life‑cycle assessment reveals that...
Integrated CDMO networks are reshaping drug development by offering end‑to‑end expertise, especially for complex modalities such as antibody‑drug conjugates (ADCs). Partnerships between specialist CDMOs allow small and mid‑size biopharma firms to access high‑potency handling, bioconjugation, and lyophilization capabilities without building...
Researchers led by Jun Pang at Sun Yat‑Sen University identified a CDK12‑FOXA1 signaling axis that drives prostate cancer progression. CDK12 phosphorylates FOXA1 at serine 234, enhancing its transcriptional potency and up‑regulating MDM2, which in turn degrades the tumor‑suppressor p53. Inhibiting CDK12 with...
The article outlines modern methods for identifying drug repurposing opportunities, focusing on neurodegenerative diseases such as Alzheimer’s and Parkinson’s. It highlights computational screening, network pharmacology, and real‑world evidence as core techniques, and presents case studies where existing drugs showed disease‑modifying...
Researchers identified intrinsic unbalanced group‑velocity dispersion in nonlinear interferometers as a major source of axial resolution loss for undetected‑photon optical coherence tomography (OCT). The dispersion stems from non‑degenerate optical parametric down‑conversion, making physical compensation difficult. By extracting phase from high‑precision...
Marcio Temtem, Hovione’s VP of Strategic Business Management, highlighted three industry shifts: growing small‑molecule complexity, faster development cycles driven by AI, and the regionalization of supply chains. Hovione counters these pressures with its amorphous solid dispersion platform, continuous flow and...
The danger of adopting a Danish-style vax schedule: "When we remove a vaccine like the meningococcal shot from the routine schedule, we aren’t just changing a line on a chart. We are inviting previously well-controlled diseases back into our high...
