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HIV-Seq Tool Finds Active Reservoir Cells During Therapy

A team at Gladstone Institutes and the San Francisco VA has launched HIV‑seq, a virus‑specific single‑cell RNA‑sequencing platform that isolates active HIV reservoir cells from patients on antiretroviral therapy (ART). The method captured 25 treated‑patient cells and over 1,000 cells from untreated donors, far exceeding standard scRNA‑seq yields. Profiling revealed that ART‑suppressed cells adopt anti‑inflammatory, pro‑survival phenotypes, while pre‑therapy cells are cytotoxic and inflammatory. Published in Nature Communications, the work suggests new avenues for targeting the persistent reservoir.