Today's Longevity Pulse
Retro Biosciences valued at $1.8B after latest fundraising round
Longevity startup Retro Biosciences announced a new fundraising round that places its valuation at $1.8 billion. The round is backed by OpenAI CEO Sam Altman and supports the company’s goal to add ten healthy years to human life through gene and cell‑replacement therapies. Retro is also launching its first clinical trial of a pill designed to clear protein aggregates in Alzheimer’s patients.
My Secret Homemade Electrolyte Recipe
Valérie Orsoni argues that staying hydrated isn’t just about drinking water; it requires a balance of electrolytes—sodium, potassium, and magnesium. She explains how excessive plain water can dilute these minerals, stressing the nervous system and impairing performance. Commercial electrolyte drinks are criticized for added sugars, artificial sweeteners, and fillers, prompting her to share a simple, clean, homemade recipe. The post positions DIY electrolytes as a healthier, cost‑effective alternative for athletes, keto‑followers, and anyone seeking optimal recovery.
Train Sideways Now to Prevent Falls Later
Most gym training happens in a straight line. Squats, deadlifts, rows, presses. Forward and backward, up and down, all in the sagittal plane. But… life doesn't stress you in a straight line. You step off a curb at an angle, shuffle...
Three Key Nutrients for Brain Longevity, Plus Polyphenols
As a bioscientist studying aging, my top 3 nutrients for brain longevity are: → Omega-3s (fatty fish 2–3x/week) → Vitamin B12 (beef, dairy) → Choline (2 eggs daily) Plus plenty of polyphenol-rich foods: berries, extra virgin olive oil, cocoa, nuts, and coffee.
Loyal's Canine Longevity Pill Nears Market After FDA Deems Likely Effective
Loyal, the biotech startup founded by Celine Halioua, has moved its canine longevity pill closer to market after the FDA deemed it likely effective in February 2025. The drug, which could add a year to a dog’s healthy lifespan, arrives amid...
GLP Success Sparked Unstoppable Peptide Boom
The (hard for some to accept) reality is that the popularity of GLPs, which of course have lots of RCTs to support them, are actually what opened the doors for the immense interest in all the other peptides. People are...
Small Daily Habits Compound Into Lifelong Longevity
As a scientist studying aging, I can’t stress this enough: You don’t need to optimise everything. What really moves the needle is the compounding effect of small habits repeated over years. The 20-minute daily walks. The nutrient-dense, fibre-rich breakfast bowl...
Long‑Term Health Score Outperforms Diet and Exercise in Longevity Prediction
Researchers from the Framingham Heart Study reported that a cumulative health score measured over 25 years predicts lifespan more accurately than any single health snapshot. Participants in the top quartile of the score lived, on average, 7.4 years longer without...
Family Offices Add Wellness Services for Next‑Gen Principals
Folks constantly ask me, what do I do? What is a family office chief wellness officer (CWO)? I help family offices add health, wellness, longevity, and lifestyle design services into their offerings. Modern principals, particularly the next-gen, want their family offices...
Curing Disease Doesn't Change Its Classification,
cool. as soon as you show me a worm or mouse you modify so that it doesn’t degrade or end life, i’ll accept your premise your position is it’s a disease if it’s curable now i want to know if you told...
Wearable AI Tools Target Chronic Disease in New Longevity Series
Journalist Kara Swisher premiered a new episode of her series “Kara Swisher Wants to Live Forever,” highlighting emerging wearable and AI technologies designed to reduce chronic disease. The episode underscores a shift in the longevity market toward tools that improve...
Five Hidden Lab Numbers Reveal Your True Health
Your labs are "normal." But you haven't felt normal in years. There are 5 numbers your doctor probably isn't checking — and they tell a very different story. Free live webinar: May 5, 5 PM PT → 30dayhealth.co/webinar
This Overlooked Mineral May Play A Role In Protecting Against Alzheimer’s
Physician‑scientist David Fajgenbaum highlights emerging evidence that lithium, a long‑used mood stabilizer, may protect against Alzheimer’s disease. Human post‑mortem studies show lower lithium in the prefrontal cortex of patients with mild cognitive impairment, while mouse experiments demonstrate that dietary lithium...
The Body’s Most Mysterious Organ May Play a Key Role in Longevity and Cancer
Recent studies have revived interest in the thymus, showing that a healthy gland predicts lower risk of lung cancer, heart disease and all‑cause mortality. Researchers at Mass General used AI to create a thymic health score from CT scans and...
Your Lifespan Mirrors Your Same‑sex Parent’s Longevity
How long you live is influenced by how long your same-sex parent lives♀️♂️ Men whose fathers lived to 90 were 42% more likely to reach 90 as well. If their fathers lived to 100, their odds were 1.5–2× higher. Women whose mothers...
Consider Renaming Senescent Cells as “Aged” Cells
Good point, we may soon be talking of "aged" senescent cells. Maybe it's time to rename senescent cells?
Out of 400 Drugs, Only These Might Help You Live Longer - Dr. Kevin Perez and Siim Land
A UK Biobank study of 500,000 participants tracked medication use for up to 20 years and compared users of 400+ drugs with matched controls. After adjusting for demographics, health status and socioeconomic factors, only fourteen drugs showed a statistically significant...
Glucagon Signaling Required for Caloric Restriction Benefits
Glucagon receptor signaling is indispensable for the healthspan effects of caloric restriction in aging male mice https://t.co/xZYiHWkw5s @GeroScienceAGE https://t.co/WcZgdHgsG2
Nature Study Turns Into Immediate
I wrote about this 6 weeks ago at Ground Truths when the 2 @Nature papers by @HugoAerts and colleagues came out. Today it's a "Health Alert"! https://t.co/CgxBU7IAk1 https://t.co/24PijmLhzR
The Plasticization of Human Longevity: Are Microplastics the New Gerontogens?
A new review in the Journal of Xenobiotics argues that micro‑ and nanoplastics (MNPs) accumulate in human tissues and act as systemic gerontogens, accelerating biological aging. By age 70, an average person could carry over 50,000 plastic particles, a load...
Higher‑intensity Aerobic Exercise Cuts Loneliness in Older Adults
Effects of aerobic exercise of different intensities on the social, emotional, and financial functioning of healthy older adults: results from a 16-week exercise randomized control trial https://t.co/SePImekLGY Interaction plot depicting change across time in loneliness by condition:
Vaccines, Not Geroscience, Drove Lifespan Gains; GLP‑1s Now Hype
fun facts: class of medicines that have most greatly extended human lifespan: vaccines class of medicines longevity docs are most excited by now: GLP1s did these come from geroscience? they did not by the way, NR didn't come from geroscience either
After Heart Attack, Therapeutic Plasma Exchange (TPE) Rescues the Aging Heart
Researchers at UC Berkeley demonstrated that therapeutic plasma exchange (TPE) performed 24 hours after a heart attack can nearly reverse damage in aged mice, the equivalent of humans in their 60s. By replacing half of the plasma with saline‑albumin solution, the...
Longevity Genes Trade Growth for Extended Lifespan
if there were no aging, you would not have matured as a man in fact, the most powerful monogenic life-extending mutations in mice impair growth and maturation
Tadpoles, Dolly, and Salamanders Prove Age Reversal Possible
That’s what I used to think, too, but tadpoles, Dolly, and salamanders changed my mind about age reversal
High-Dose Vitamin D Cuts Diabetes Risk in Genetically Susceptible, Lowers Alzheimer Biomarkers
Two peer‑reviewed studies published in April 2026 reveal that high‑dose vitamin D supplementation can slash type‑2 diabetes risk by 19% in people with specific vitamin‑D‑receptor gene variants and is associated with lower tau protein, a key Alzheimer’s biomarker. The findings...
Hope for Recursive Boost and Human Longevity Progress
Let's hope there is another level of recursion where Craig will wake up to a great deal of bonus points. And we will work hard on human longevity https://t.co/NriaobLBMS
Blood Test May Forecast Alzheimer’s Years Before Symptoms
A new study by researchers at Harvard-affiliated Mass General Brigham has found that a blood test has the potential to predict progression of Alzheimer’s disease ***years before*** symptoms or brain scan changes. https://t.co/WtghaB12r2
Neuroscientist Names Five Brain Threats That Boost Dementia Risk
Neuroscientist Anaïs Roux identified five major threats to brain health—chronic stress, social isolation, poor sleep, unhealthy diet, and lack of mental stimulation—arguing they significantly raise dementia risk. She stresses that up to one‑third of Alzheimer’s cases might be preventable through...
Sinclair Explains GLP‑1’s Role in Longevity Protocols
David Sinclair just did a 25-minute live Q&A on aging, longevity and AI. Here are the top 9 questions the audience asked him and his answers to each one: 1) How can GLP-1 drugs be used in longevity protocols? https://t.co/q5V2fyfFnq
Glial Senescence Drives Neuroinflammation and Brain Degeneration
Disentangling causality in brain aging: The complex interplay between glial senescence, neuroinflammation, and neurodegeneration https://t.co/kiLXyxFUL0 https://t.co/XmyARd1bst
Vitamin D Study Split: 2,000 IU Boosts Aging Cells, While D2 May Undermine Immunity
A recent study found that daily 2,000 IU vitamin D supplementation helps preserve telomere length in older adults, suggesting a potential anti‑aging benefit. At the same time, researchers in the UK reported that vitamin D2 supplements can suppress vitamin D3...
Depression Reduces Chances of Exceptional Longevity in Older Women
Prospective association of depression symptoms with exceptional longevity among older women "...Depression symptoms associated with lower odds of healthy longevity..." https://t.co/RnVcQs7XG4
One Hour Screen‑free Before Bed Restores Sanity
For real, turn screens off 60 min before bed. I know it feels like death at first. Do it for a few days, and you’ll realize that it was slowly chipping away your sanity.
Meta‑Analysis Shows GLP‑1 Drugs Cut Cardiovascular Events by 13% Over Three Years
Researchers at Anglia Ruskin University analyzed data from more than 90,000 patients and found GLP‑1 receptor agonists lower major adverse cardiovascular events by roughly 13% over an average three‑year follow‑up. The benefit appears across diabetic and non‑diabetic high‑risk groups, reinforcing...
Epigenetic Reprogramming Enters Human Trials for Vision
Aging biotech has made TIME's "New Frontiers" list. @lifebiosciences is using Yamanaka factors, and the FDA just cleared their first-in-human trial for optic neuropathies. Partial epigenetic reprogramming is no longer theoretical. It's in human trials. https://t.co/ZtVT5PxbHZ https://t.co/OhqLtNfqGT
Low Leukocyte mtDNA and High Inflammation Predict Elderly
Association of leukocyte mitochondrial DNA copy number and inflammation with mortality among older adults https://t.co/AeqAZIv3er
‘The Happiest Time of Life Is as You Get Older’: Can Positive Thinking Help You Age Better?
A new longitudinal study of more than 11,000 adults aged 50‑99 found that a positive attitude toward aging is linked to measurable gains in physical and cognitive function. Over a 12‑year follow‑up, 44% of participants improved walking speed and cognition,...
Blood Factors Drive Aging or Rejuvenation; Therapies Emerging
Aging is increasingly understood as a system-wide process shaped by factors in the blood, which can actively drive either decline or rejuvenation rather than just reflect it. Emerging therapies that modify the circulatory environment show promise in reversing aspects of...
Fever‑level Sauna Spikes Heat‑shock Proteins, May Boost Longevity
3x this week I sat in 200°F (93°C) dry sauna for 55 min to get my core body temp to 102.4°F (39°C) That temp, at that duration, triggers primal panic. Took blood samples before and after each session to measure heat shock protein...
Could Ozempic Help With Alzheimer’s Disease? Scientists Are Taking a Closer Look
A new Anglia Ruskin University review of 30 preclinical studies suggests GLP‑1 drugs such as Ozempic and Wegovy can lower amyloid‑beta and tau, the hallmark proteins of Alzheimer’s disease. Twenty‑two studies reported reduced amyloid‑beta and nineteen showed decreased tau, with liraglutide...
Basics Beat Gadgets: Sleep, Food, Relationships, Movement
I hate to break it to you - but no supplement stack or wellness gadget will save you if the foundations aren’t there. Consistent sleep. Home-cooked meals. A couple of close relationships. Daily movement. These will do more for your...
It's Never Too Late to Transform Your Health
If you’re in your 50s or 60s and feel like it’s too late to start prioritising your health, take it from a bioscientist who studies aging: it’s not. Start the resistance training. Fix up your diet. Limit the harmful habits....
Warwick Review Finds Plant‑Based Diets Cut Inflammation by 1.13 Mg/L
Researchers at the University of Warwick analyzed seven randomized trials involving 541 participants and found plant‑based diets lowered C‑reactive protein by an average of 1.13 mg/L versus omnivorous diets. The finding, published in Nutrition, Metabolism and Cardiovascular Diseases, adds rigorous evidence...
Daily Brain Boost: Exercise, Hydration, Sleep, Supplements
3 things I’ve started to do for my brain health daily: Trying to incorporate more walking (and working out) Drinking enough water Less alcohol Sleep Creatine Lion’s Mane Methyl B-12
NMN Curbs Antibody Attacks, Eases Bleeding Disorder
NEW CLINICAL TRIAL RESULT: NMN suppresses harmful antibody-driven immune attacks to alleviate a common bleeding disorder. Authors suggest it may help other autoimmune diseases like lupus and rheumatoid arthritis 🙏🧵 https://t.co/eMvefTFxZo
Mimio’s Fasting Supplement Shows Measurable Metabolic and Cardioprotective Gains
Mimio announced that its fasting‑mimetic supplement delivered significant improvements in metabolic health, hunger regulation and cardioprotective markers in a decentralized clinical trial published in Nature. The study, run with People Science, underscores the potential of supplement‑based biohacking to replicate fasting...
Longevity Pill May Redefine Human‑dog Bonds
YOUR NEXT DOG A new pill could soon extend dogs’ lives. How will that change our relationship with our pets? By @andersen 🔗https://t.co/u2cuBfKGuU https://t.co/Iaw4uoZfZe
Morning Coffee Shown to Protect Brain Health
Your morning coffee is protecting your brain. JAMA just confirmed it with 131,821 people and 43 years of data...
7 Smart Habits to Extend Your Life, From a Massive Harvard Study of More Than 100,000 Women Over 50 Years
Harvard’s Nurses’ Health Study, tracking over 121,000 women since 1976, has become one of public health’s most extensive longitudinal projects. Researchers have identified a set of evidence‑based habits—regular exercise, plant‑forward diet, non‑smoking, adequate sleep, and strong social connections—that consistently correlate...
Melatonin Shields Mitochondria From Radiation Damage
Melatonin as a radioprotectant against mitochondrial damage 🤔"Melatonin can protect against irradiation-induced mitochondrial damage, suggesting utility for mitigating the health effects of accidental radiation exposure." https://t.co/XHZYDE916a