Longevity Blogs and Articles
Longevity Blogs and Articles
Longevity Pulse
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Every morning
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Recent peer‑reviewed studies reveal that lactoferrin, especially when paired with human milk oligosaccharides, enhances lipid mobilization, antioxidant capacity and neurodevelopment in animal models, while a 2026 randomized trial shows it improves weight, liver enzymes and insulin resistance in obese children. The author’s two‑month self‑experiment with 200 mg native bovine lactoferrin doubled serum iron and transferrin saturation without raising ferritin, suggesting altered iron handling. Variations in lactoferrin form (apolactoferrin, native, hololactoferrin) affect iron content and capsule color, and EU regulations now demand precise source labeling for such supplements.
Investigative videos reveal that wellness influencers Mark Hyman and Jordan Peterson suffered severe sepsis after undergoing experimental stem‑cell and regenerative‑medicine procedures at Dr. Adil Khan’s unregulated clinics. The series links spinal injections and intravenous therapies to bacterial infections, highlighting the...
The University of Arizona’s R. Ken Coit College of Pharmacy is launching a double‑blind, randomized Phase 3 clinical trial to test low‑dose rapamycin’s ability to boost resilience and immune function in adults aged 65 and older. The six‑year study, funded by a $12 million...
University of Arizona’s R. Ken Coit College of Pharmacy is launching a double‑blind, randomized Phase 3 clinical trial to test low‑dose rapamycin’s ability to improve resilience and immune function in adults 65 and older. The $12 million study is fully funded by...
AI modeling compares 6 mg rapamycin taken with grapefruit juice versus berberine 1000 mg daily. Grapefruit juice irreversibly destroys intestinal CYP3A4 and P‑gp, boosting rapamycin AUC 3‑4× and Cmax 2.5‑3.5×, effectively tripling the dose for up to three days. Berberine provides reversible...
A recent small crossover study suggested nicotinamide riboside (NR) raised blood NAD 2.3‑fold more than nicotinamide mononucleotide (NMN), but a larger Nature Metabolism trial with 65 participants found both precursors increased NAD similarly. Mechanistic work shows oral NR and NMN...
Recent human trials have shown that nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) raise circulating NAD levels to a similar extent, contradicting a small Bergen study that suggested NR was superior. Both compounds appear to be metabolized largely by gut...
Recent human trials have reignited the NR‑vs‑NMN debate, with a small six‑person crossover study suggesting NR raises blood NAD 2.3‑fold more than NMN, while a larger 65‑participant Nature Metabolism trial found no meaningful difference between the two. Both studies, however,...
Aging clocks, built on DNA‑methylation patterns, aim to quantify biological age as a shortcut for long‑term health outcomes. Researchers view them as surrogate endpoints that could compress 20‑year anti‑aging trials into months, helping evaluate drugs or lifestyle interventions. However, the...
The article outlines 13 vitamins essential for optimal brain function and explains how deficiencies can blunt the effects of popular nootropic supplements like racetams and tryptophan. It cites NHANES data showing over 40% of U.S. adults lack adequate vitamin intake,...
A new open‑access review highlights the cGAS‑STING pathway as a central driver of ovarian aging, linking DNA and mitochondrial leaks to chronic inflammation and follicle loss. The authors propose three therapeutic angles: small‑molecule inhibitors that silence cGAS or STING, upstream...
Researchers identified the orphan nuclear receptor NR0B2 (also known as SHP) as a protective factor in cartilage, with its expression markedly reduced in osteoarthritic tissue. In male mice, global or chondrocyte‑specific deletion of Nr0b2 worsened pain and joint damage after...
Recent animal research shows that high-dose nanoplastic accumulation can trigger cellular dysfunction, including oxidative stress and senescence. While these harmful exposure levels exceed current environmental concentrations, older adults may experience greater cumulative burden due to lifelong exposure and age‑related physiological...
Partial reprogramming—brief exposure to Yamanaka factors OCT4, SOX2, KLF4 and MYC—has demonstrated modest rejuvenation in mouse studies but carries a substantial cancer risk if cells slip into full pluripotency. Funding is concentrated in a few well‑capitalized firms, notably Altos Labs,...
Dave Asprey’s monthly "Dave’s Favorite Products" series spotlights biohacking tools that reinforce four core health pillars—circulation, cellular strength, mitochondrial energy, and nervous‑system resilience. The February 2026 post continues the trend, linking to January and December roundups that curate supplements, wearables,...
Dave Asprey and PUORI CEO Oliver Amdrup‑Chamby reveal widespread contamination in the supplement market, showing that plant‑based and organic protein powders can contain up to ten times more heavy metals than whey. They explain that the organic label offers no...
Tai chi, a slow‑movement exercise that blends posture, breath control, and meditation, is emerging as a leading preventive tool for older adults. Recent clinical trials and meta‑analyses show it markedly improves balance, proprioception, and lower‑limb strength, which reduces both fall...
Dave Asprey visited Costa Rica’s RMI Clinic to undergo a neurocognitive protocol that blends functional MRI mapping, neuronavigation, transcranial magnetic stimulation, focused ultrasound and mesenchymal stem‑cell infusion. The treatment targets hypofunctioning brain regions with millimeter precision and is followed by...
Norn Group has released a free, detailed spreadsheet that maps 47 age‑related disease indications, providing mechanisms, incidence, market size, clinical endpoints, animal models, and trial cost estimates. The guide is designed to help longevity‑focused startups choose FDA‑approved disease targets rather...
