Effects of Glucagon-Like Peptide-1 Receptor Agonists on Perioperative Outcomes in Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis
Researchers performed a systematic review and meta‑analysis of six retrospective cohort studies covering over 48,000 hip and knee arthroplasty patients to assess the impact of pre‑operative glucagon‑like‑peptide‑1 receptor agonist (GLP‑1 RA) therapy. The analysis found a 20 % reduction in revision surgery odds (OR 0.8) and a 45 % decrease in blood‑transfusion odds (OR 0.55) within 90 days post‑operatively for patients receiving GLP‑1 RAs. Other complications—including respiratory events, acute kidney injury, deep‑vein thrombosis, and infection—showed no statistically significant differences. The authors conclude GLP‑1 RAs appear safe for pre‑operative use but emphasize that the evidence is of low certainty and call for prospective randomized trials.
AI Can Screen 15 Million Molecules in a Day. It Still Can’t Cure Alzheimer’s.
Novartis used generative AI to design 15 million molecular‑glue candidates for Huntington’s disease and synthesized about 60, yielding a promising scaffold. While AI can trim early‑stage drug discovery timelines by 30‑40 percent and lower costs, no AI‑discovered compound has secured FDA approval...
New Yellow Fever Vaccine Matches Safety and Effectiveness of Current Shot
Sanofi's new live‑attenuated yellow fever vaccine, vYF, demonstrated safety and efficacy comparable to the licensed YF‑VAX in a phase 2 trial of 485 healthy adults. Protective antibodies appeared in 99.7% of vYF recipients versus 99.4% for YF‑VAX within 28 days, with...
Green Growth Solutions for Climate Change Adaptation in the Mangrove Forest Area of Tien Hai Wetland Nature Reserve, Vietnam
A mixed‑methods study of 143 households in Vietnam's Tien Hai Wetland Nature Reserve shows that ecological aquaculture, mangrove restoration, waste recycling and community‑based eco‑tourism can boost incomes—averaging about $105 per month per household—while raising climate awareness to 81% and green‑growth...
National Prevalence of Diarrhea and Associated Factors Among Children Under Five in Afghanistan
A 2022‑23 survey of 32,989 Afghan children under five found that 38.2% had experienced diarrhea in the past two weeks. The risk was highest for children aged 6‑35 months, while maternal age over 20, higher household wealth, and maternal education...
Energy Storage Breakthrough Traps Sunlight in a Molecule
Researchers at UC Santa Barbara have engineered an organic molecule, pyrimidone, that captures sunlight and stores the energy directly in its chemical bonds. The molecular solar thermal storage (MOST) system achieves an energy density of 1.6 MJ kg⁻¹ (≈ 444 Wh kg⁻¹), roughly double that...
Artemis II Splashdown Gives NASA Momentum in Renewed Moon Race
NASA’s Artemis II mission splashed down safely in the Pacific on April 11, 2026, concluding the first crewed deep‑space flight since 1972. The four‑person crew—three Americans and a Canadian—completed a lunar‑orbit trajectory that demonstrated the Space Launch System’s performance and re‑entry capabilities....
Joi Scientific’s Long Hydrogen Illusion
Joi Scientific has resurfaced with a refreshed website, new press releases and a 2024 patent family, but it is essentially a continuation of an 18‑year‑old hydrogen over‑unity narrative. The company’s earlier claims of 200‑300% energy return have been replaced with...
New Research Leads to Increased Understanding of Longevity Gains in the United States
A new BMJ Open study by University of Wisconsin–Madison scholars finds that every U.S. state experienced life‑expectancy gains for cohorts born between 1941 and 2000, overturning earlier research that suggested stagnation or declines in parts of the South. Using the...
Ideas Podcast: How to Change a Memory
Steve Ramirez, a Boston University neuroscientist and former MIT graduate student, details how his lab created false memories and argues that future technologies could edit, erase, or fabricate recollections. His new book, *How to Change a Memory*, blends memoir with...
The Artemis II Mission Has Ended. Where Does NASA Go From Here?
NASA’s Artemis II mission successfully completed a 700,000‑mile lunar flyby and splash‑down, marking humanity’s first deep‑space crewed flight in over 50 years. The Space Launch System delivered a near‑perfect orbit insertion, while Orion returned safely, providing valuable data on heat‑shield performance and...
EV-RNAs Show Promise for IBD Diagnosis and Treatment
A review in *ExRNA* led by Professor Xiyang Wei outlines how extracellular vesicle‑associated RNAs (EV‑RNAs) influence inflammatory bowel disease (IBD) pathogenesis and progression. By synthesizing multi‑omics and animal data, the authors show EV‑RNAs can serve as highly accurate, non‑invasive biomarkers...
Nanomedicine Offers Targeted Solutions for Breast Cancer Treatment
Nanomedicine is reshaping breast cancer therapy by using nanoscale carriers to improve drug solubility, targeting, and controlled release. Recent preclinical studies show lipid‑polymer hybrids boosting oral bioavailability over threefold and photothermal nanoparticles halving tumor growth when combined with chemotherapy. Metallic...
NASA’s Artemis II Mission Was a Historic Success
NASA’s Artemis II mission returned safely on 10 April after a historic crewed flyby of the Moon, the first human trip beyond low Earth orbit since Apollo 17 in 1972. The Orion capsule traveled to a record‑breaking 406,771 km from Earth, surpassing Apollo 13’s distance...
How Recovery Personnel Will Secure Artemis II Capsule at Sea After Splashdown
NASA’s Artemis II Orion capsule splashed down in the Pacific off San Diego, leaving four astronauts afloat in a vessel that survived re‑entry temperatures near 5,000 °F. Five airbags on the capsule’s top automatically inflated, righting the spacecraft and stabilizing it against waves...
IFIT3 Knockdown Attenuates Pressure-Overload-Induced Cardiac Inflammation and Remodeling Through a JNK/H3K9 Lactylation-Associated Mechanism
The study identified interferon‑induced protein IFIT3 as a macrophage‑enriched hub gene in failing human hearts. Using AAV‑mediated knockdown in a transverse aortic constriction mouse model, researchers showed that reducing IFIT3 expression improves cardiac function, lowers inflammatory cytokine release, and attenuates...
Elon Musk's Next Big Bet: Inside the Rise of SpaceX
Fox Business aired a panel titled “Elon Musk's next big bet: Inside the rise of SpaceX,” where analysts examined the company’s rapid growth and its pivotal role in NASA’s Artemis II mission. The discussion highlighted SpaceX’s Starship development, expanding Starlink broadband...
A Multifunctional Terahertz Metadevice Enabled by Single-Layer VO2 : From Ultra-Broadband to Dual-Narrowband Perfect Absorption
Researchers have demonstrated a terahertz metamaterial absorber that switches between ultra‑broadband and dual‑narrowband perfect absorption using a single vanadium dioxide (VO₂) layer. In its metallic phase, the device delivers over 90% absorption from 4.10 to 12.58 THz, covering an absolute bandwidth...
NASA Artemis II Splashes Down in Pacific Ocean in ‘Perfect’ Landing for Moon Mission
NASA’s Artemis II mission successfully returned the four‑person crew to Earth after a ten‑day lunar flyby. The Orion capsule, named Integrity, splashed down in the Pacific off San Diego at 5:07 p.m. PT, with all astronauts in good health. The flight marked the first...
Back to Earth: What Happens to the Artemis II Astronauts Now?
The Artemis II crew safely splashed down off California after re‑entering at 25,000 mph, completing the first crewed flight to travel farther than any human before – roughly 4,000 miles beyond Apollo 13’s record. Upon landing, the astronauts were examined on a U.S. warship,...
Orion Survives Re-Entry, Crew Splashes Down Safe
Orion’s Orion capsule survived a high‑energy re‑entry and splashed down off California, with all four astronauts remaining inside the capsule as recovery crews arrived. The Artemis‑2 mission, a three‑day lunar fly‑by, is now complete, though analysis of the heat‑shield performance...
Protecting Flowering Plants Is Crucial to Our Future
Ecologist David George Haskell argues that flowering plants ignited a massive biodiversity surge and now underpin modern ecosystems. In his new book How Flowers Made Our World, he explains how floral genetics enabled angiosperms to colonize new habitats for over 130 million...
Early Permian Multi-Ovulate Fruit Rewrites Angiosperm History
Researchers have described a new fossil genus, Shuozhoufructella, from the Lower Permian of Shanxi, China. The plant bears a multi‑ovulate fruit in which ovules are attached by funiculi along the fruit rim, a configuration previously unknown in gymnosperms but typical...
‘It’s 13 Minutes of Things that Have to Go Right’: Artemis II Splashes Down Despite Faulty Heat Shield
NASA’s Artemis II mission returned safely to the Pacific after a historic 10‑day lunar flyby, despite a known flaw in the Orion heat shield. Engineers discovered the shield’s internal layers could trap gas during reentry, risking chunk loss. To mitigate, NASA...
Different People Attract Different Mosquito Species
Researchers tested three mosquito species against 119 people using a Uniport olfactometer, finding distinct preferences. Aedes aegypti showed an 89% attraction rate and uniquely favored male participants, while Aedes albopictus responded to specific skin ketones and Culex quinquefasciatus preferred a...
Longitudinal Study Links Associative Learning Gains to Later Improvements in Fluid Intelligence
A three‑year longitudinal study of 160 Chinese elementary students found that improvements in associative learning and fluid intelligence reinforce each other over time. Children who exceeded their baseline in forming associations showed greater gains in reasoning the following year, and...
Pyrazole-Derived TRPC3 Antagonist Ameliorates Synaptic Dysfunctions and Memory Deficits in Alzheimer’s Disease Models
Researchers have engineered a pyrazole‑derived, metabolically stable TRPC3 antagonist that readily penetrates the CNS. In cultured neurons, amyloid‑beta oligomers up‑regulate TRPC3, leading to calcium overload and toxicity. Administration of the compound to 5xFAD and APPKI mouse models reversed synaptic deficits...
Multi-Omics and Electrophysiological Examination of GABAA Receptors in the Dorsolateral Prefrontal Cortex of Humans with Alcohol Use Disorder
Researchers recorded electrophysiological activity of reactivated GABA_A receptors from the dorsolateral prefrontal cortex of postmortem brains of individuals with alcohol use disorder (AUD). Multi‑omics analysis revealed significantly lower mRNA levels for several GABA_A subunits, yet protein abundance and synaptic function...
Chance Encounter in Space: JANUS Camera Captures Interstellar Comet 3I/ATLAS
The European Space Agency’s JANUS camera captured high‑resolution images of interstellar comet 3I/ATLAS during a close flyby in early 2026. The observations were made when the comet passed within 0.3 AU of Earth, revealing an elongated nucleus and active gas jets....
The Local Universe’s Expansion Rate Is Clearer Than Ever, but Still Doesn’t Add Up
New observations from the Nearby Supernova Factory and Gaia‑based distance ladders have sharpened the local measurement of the Hubble constant to 73.2 ± 0.8 km s⁻¹ Mpc⁻¹, the most precise to date. Despite the reduced uncertainties, this value remains 5‑6 km s⁻¹ Mpc⁻¹ higher than the value inferred...
Flavored Tobacco Bans Linked to Lower Youth Vaping in California
Researchers at UC San Diego examined data from over 2.8 million California students and found that local bans on flavored tobacco products lowered youth vaping rates from 7.7% to 6.2% without increasing cigarette smoking. Using a dynamic difference‑in‑differences design covering 2017‑2022,...
Mysterious Flashes in 1950s Skies Linked to Nuclear Tests and UAP Sightings: Study
A statistical review of Palomar Observatory sky plates from 1949‑1957 uncovered over 100,000 brief, star‑like flashes that vanished within a single 50‑minute exposure. The researchers found these transients occurred on 310 of 2,718 days and were 45% more likely within...
Australia: Ingestible Smart Sensor Boosts Non-Invasive Diagnostics
A world‑first ingestible gas‑sensing capsule, developed from RMIT University research, has been commercialised in Victoria, offering clinicians a radiation‑free, real‑time view of the gastrointestinal tract. The device moves beyond invasive procedures, targeting the roughly 40% of people who suffer from...
Reprogramming Regulatory T Cells Could Help Immunotherapy Work in Pancreatic Cancer
Researchers at Oregon Health & Science University discovered that pancreatic tumors suppress immunotherapy by recruiting large numbers of regulatory T cells (Tregs). In mouse models, an agonistic CD40 therapy not only activated tumor‑killing immune cells but also reprogrammed Tregs into...
Under One Moon
NASA’s Artemis II crew completed a historic lunar flyby, capturing striking images of Earth rising behind the Moon and collecting data on previously unseen craters, a solar eclipse and meteor impacts. The mission demonstrated Orion’s deep‑space capabilities and reinforced the United...
Chang'e Mission Samples Reveal How Exogenous Organic Matter Evolves on the Moon
China’s Chang’e‑5 and Chang’e‑6 lunar sample returns have, for the first time, revealed nitrogen‑bearing organic compounds embedded in moon soil grains. The study shows these organics exist as particles, surface‑adhered films, and mineral inclusions, and bear isotopic signatures that point...
Is a Super El Niño Coming in 2026? Here’s What Scientists Are Saying
Scientists warn that a rare "Super El Niño" could develop by late 2025, raising the odds of a strong El Niño in 2026. NOAA’s April advisory assigns a 61% chance of any El Niño and a one‑in‑four probability it will be unusually intense....
Universal Surface-Growth Law Confirmed in Two Dimensions After 40 Years
A Würzburg research team has delivered the first experimental verification of the Kardar‑Parisi‑Zhang (KPZ) universality class on two‑dimensional surfaces. By cooling a gallium‑arsenide semiconductor to –269.15 °C and injecting polaritons with a precision laser, they tracked spatial‑temporal growth that matches KPZ...
Mayo Clinic Enhances Imaging Test with AI
Mayo Clinic researchers applied artificial intelligence to standard coronary artery CT scans, extracting measurements of pericardial fat that markedly improve long‑term cardiovascular disease risk prediction. The findings, published March 24 in the American Journal of Preventive Cardiology, demonstrate that a metric...
How Do Fish Know How to Build Nests?
Researchers at the Max Planck Institute for Biological Intelligence examined African cichlid Neolamprologus ocellatus to determine whether nest building is purely instinctive or can be learned. Fish raised from birth without shells eventually constructed nests using 3‑D‑printed shells, though their...
New Fundamental Physics Measurement Deepens Quantum Mystery
Physicists at CERN's CMS experiment have released a new measurement of the W boson mass, 80,360.2 ± 9.9 MeV, which aligns with Standard Model predictions. The result matches the precision of the 2022 CDF measurement that had suggested a significant deviation, but it...
After More than 9 Days in Flight, NASA's Artemis II Is Set to Return to Earth
NASA’s Artemis II crew completed a nine‑day lunar flyby and splashed down in the Pacific off San Diego. The Orion capsule re‑entered at over 24,000 mph, enduring temperatures near 5,000 °F before deploying three parachutes. Four astronauts—including the first woman and the first person...
Maternal Prepregnancy BMI, Birth Length Linked to Offspring Atopic Dermatitis
A new study of 2,107 Scandinavian mother‑child pairs links higher maternal prepregnancy body mass index (ppBMI) and longer newborn length to an increased risk of atopic dermatitis by age three. By the third birthday, 525 children (25%) had been diagnosed,...
Scientists Successfully Made Advanced, Lab-Grown Brains—Could They Become Conscious?
Scientists have advanced brain organoid technology by connecting miniature brain tissue to prototype spinal cords, creating a four‑part assembloid that mimics the human pain‑sensory pathway. Despite this complexity, the structures contain just 0.002% of the neurons found in a full...
The Bad Seed and the Problem of Blame
Behavioral geneticist Kathryn Paige Harden’s new book *Original Sin* explores how genetics influences vice, weaving together science, philosophy, and Christian theology. The work argues that ignoring genetic factors perpetuates social inequality, yet warns against deterministic narratives that could fuel eugenic...
Finerenone Reduces Clinical Events in Patients With Heart Failure Regardless of CHD History
A prespecified analysis of the FINEARTS‑HF trial evaluated finerenone in 6,001 patients with heart‑failure with mildly reduced or preserved ejection fraction, 54% of whom had a history of coronary heart disease. Finerenone reduced the composite of cardiovascular death and heart‑failure...
Predictors of Rapid, Complete Skin Clearance With Psoriasis Biologics
A real‑world analysis of 299 moderate‑to‑severe psoriasis patients treated with biologics found that 76.3% achieved an early super‑response (PASI 100 by week 4 and maintained PASI < 1 through week 48). The strongest positive predictors were biologic‑naïve status and higher baseline neutrophil counts, while palmoplantar...
Subaru Telescope Sheds Light on Jupiter Trojan Asteroids' Color Mystery
Using the Subaru Telescope’s Suprime‑Cam, researchers observed 120 small Jupiter Trojan asteroids and found that, unlike larger Trojans, the smaller bodies lack a clear red/less‑red color bimodality and share identical size distributions across color groups. The study, published in *The...
How Will NASA Get the Artemis II Crew Safely Back on Earth? Here's the Science Behind Splashdown
NASA will bring the Artemis II crew back to Earth on 10 April 2026 with a splashdown in the Atlantic Ocean. The Orion capsule’s heat shield, redesigned after unexpected damage on the uncrewed Artemis I flight, will endure re‑entry temperatures near 1,500 °C before a...
New Paper Argues History, Not Mantle Plume, Powers Yellowstone
A new Science paper argues that the extinct Farallon plate, not a deep mantle plume, drives the Yellowstone hotspot. The authors model a translithospheric magma plumbing system (TLMPS) where stresses from the sinking Farallon slab open conduits for mantle material....