Know What's Happening in Science
Know What's Happening in Science
High‑altitude hypoxia curbs blood‑sugar spikes in mice
A mouse study found that low‑oxygen (hypoxic) conditions cause red blood cells to absorb far more glucose and convert it into a molecule that eases oxygen release, acting as a glucose sink. Mice exposed to 8% oxygen showed markedly smaller blood‑sugar spikes after glucose injections, and the effect persisted after they returned to normal air.
A 12‑year‑old girl presented with recurrent fever of unknown origin, later developing intermittent joint pain. Extensive infectious, rheumatologic and oncologic testing, including cultures, metagenomic sequencing and bone‑marrow analysis, were negative. MRI and PET‑CT revealed multifocal hypermetabolic bone lesions, prompting concern for malignancy, but femoral bone biopsy showed lymphoplasmacytic infiltration without infection or cancer, confirming chronic non‑bacterial osteomyelitis (CNO). The case underscores CNO’s atypical fever‑dominant presentation and the risk of diagnostic delay.
Erbium nanoparticles produced by pulse laser ablation in liquid were thermally annealed from 200 °C to 1000 °C. At 600 °C the mixed cubic‑monoclinic structure fully converts to a pure cubic Er₂O₃ phase, eliminating surface hydroxyl groups and compacting the particles. This structural...
UW‑Madison researchers released eight GPS‑collared red foxes in Madison suburbs to test urban translocation. The animals quickly dispersed up to 53 miles, and only one was confirmed alive weeks later. Three were killed on roads, one was shot at an...
Mushroom mycologist Paul Stamets presented data indicating that Agarikon (Fomitopsis officinalis) mycelium possesses broad antiviral properties. In two placebo‑controlled trials, a combined Agarikon‑turkey‑tail extract reduced COVID‑19 vaccine side effects, sustained antibody titers, and accelerated recovery in hospitalized patients. The research,...
Bestselling novelist and winner of the Climate Fiction Prize Abi Daré joins Bloomberg Green's Zero podcast to discuss why she couldn’t ignore climate change as she told the story of girls in Nigeria https://t.co/gyYuRstCge
A newly described crocodile species, Crocodylus lucivenator, lived in Ethiopia between 3.4 and 3 million years ago and featured a distinctive snout hump. Fossil evidence suggests it grew up to 15 feet long and weighed around 1,300 pounds, making it the top...
Researchers evaluated three‑day meal plans generated by five leading AI chatbots for fictional overweight and obese 15‑year‑olds. The AI‑created menus were on average 695 calories lower per day than dietitian‑designed plans and featured insufficient carbohydrates with excess protein and fat....
Glymphatic dysfunction links vascular pathology to Alzheimer’s biomarkers and cognitive decline "These findings highlight glymphatic dysfunction as a key mechanism linking vascular pathology with tau, inflammation and neurodegeneration, independent of Aβ uptakes." 🧠 https://t.co/YUCjeay0kr
Gut Microbiota Manipulation by Probiotic Lacticaseibacillus paracasei DG I1572 as New Therapeutical Strategy to Counteract Vascular Inflammaging https://t.co/91dumlTNgU https://t.co/tkL0m8P6nd
Matteo Paz, a high‑school student at Caltech’s Planet Finder Academy, built an AI system to scan NASA’s NEOWISE infrared archive. The algorithm, dubbed VARnet, processed over 200 billion detections and uncovered roughly 1.5 million previously unidentified celestial objects, ranging from binary stars...
New tissue models could help researchers develop drugs for liver disease by Anne Trafton @MIT Learn more: https://t.co/hkeRZ0W47B #HealthTech #EmergingTech #TechForGood #Innovation https://t.co/LNvft8iX9M
Researchers have demonstrated that graphene oxide (GO) selectively kills bacteria by forming hydrogen bonds with a phospholipid, POPG, found only in bacterial membranes. The study shows that GO’s oxygen‑rich surface is essential for this activity, achieving over 99% suppression of...
What birds dream about and how evolution invented REM in the avian brain so we may practice the possible in our sleep https://t.co/N8KS6IV92p
RIKEN and IBM have executed a closed‑loop hybrid workflow that couples the full capacity of Japan’s Fugaku supercomputer with an on‑premises IBM Quantum Heron processor. The integration enabled the largest and most accurate quantum chemistry simulation to date, targeting a...
Researchers develop dirt-repelling solar panel coating that doesn’t affect light absorption #energysky -- via Solar Power World: https://t.co/BJgSBTxln9
China’s 2025 R&D outlay surged to 3.9 trillion yuan, with basic research surpassing 7% of total spending for the first time. The new five‑year plan prioritises self‑sufficiency, funneling billions into frontier chemistry, biotech, and advanced materials. State‑backed agencies and tech giants...
Researchers tracked 81 African turquoise killifish from adolescence to death, using continuous video and machine‑learning analysis to create a behavioural clock. The study found that fish that were more active and confined sleep to nighttime during early adulthood lived significantly...
Genomic analysis of 48 chondrichthyan species reveals that most animals labeled as sharks are more closely related to rays and skates than to hexanchiform sharks, making the traditional shark group paraphyletic. Researchers examined 840 protein‑coding genes and roughly 350 ultra‑conserved...
BioRxiv has posted over 310,000 preprints since its 2013 launch, attracting roughly ten million monthly views and four million downloads. Monthly submissions surged to more than 4,000 by 2025, with neuroscience emerging as the dominant discipline. About 80% of preprints...
Recent nutrition research highlights that drinking coffee only before noon lowers all‑cause mortality by 16% and cardiovascular death by 31% compared with non‑drinkers, while consuming coffee throughout the day erases these benefits. A large metagenomic study shows vegans and vegetarians...
A new review surveys a decade of post‑mortem research seeking biological signatures of suicide, highlighting consistent alterations in stress‑related systems, inflammation, neuroplasticity, and especially serotonergic pathways. The authors compiled 129 studies, emphasizing shifts from hypothesis‑driven to data‑driven multi‑omic analyses, yet...
Researchers have engineered Aedes aegypti mosquitoes to carry vaccine antigens in their saliva, successfully inoculating bats against rabies and Nipah viruses in laboratory experiments. The mosquitoes were fed vaccine‑laden blood, then transmitted the immunogen when they fed on or were...
Researchers at Harvard’s Wyss Institute and Dana‑Farber unveiled DoriVac, a DNA origami‑based vaccine platform that delivers antigens and adjuvants on a self‑folding nanostructure. In pre‑clinical mouse studies and a human lymph‑node‑on‑a‑chip model, DoriVac generated antibody and T‑cell responses comparable to...
Researchers at TU Darmstadt have engineered the first RNA‑based synthetic NAND gate by linking two riboswitches that respond to distinct ligands. Using high‑throughput screening combined with a deep‑learning‑driven Bayesian optimization loop, they evaluated only 82 variants to isolate sequences that exhibit...
Scientists at Yale have uncovered how the vitamin B5‑derived molecule coenzyme A (CoA) is shuttled into mitochondria, identifying dedicated transport proteins that move the cofactor across the organelle membrane. Using a novel mass‑spectrometry workflow, the team catalogued 33 cellular CoA conjugates and...
The FDA placed a clinical hold on Regenxbio’s RGX‑111 and RGX‑121 gene‑therapy trials after a pediatric MPS I patient developed a tumor four years post‑treatment. The case marks the first documented long‑latency cancer linked to an adeno‑associated virus (AAV) vector in...
Researchers at Chalmers University have demonstrated precise control of electron spin by stacking a perpendicular magnetic layer with a topological van der Waals material. The heterostructure switches magnetization using very small electrical currents and operates at room temperature without external magnetic fields....
Two pre‑clinical studies propose active clearance of β‑amyloid as a new Alzheimer’s strategy. Researchers at Washington University engineered astrocytes with chimeric antigen receptors (CARs) that engulf plaques, while another team designed bispecific peptides that ferry amyloid into cells for lysosomal...
It's NationalProposalDay 💍 There's more to diamonds than meets the eye; this graphic highlights the hidden chemistry: https://www.compoundchem.com/2015/12/15/diamonds/
The 2023 “Sparks of Artificial General Intelligence” paper by Sébastien Bubeck @SebastienBubeck is aging very well.
Researchers at RIKEN have engineered protein‑based artificial kinetochores that compete with natural chromosome kinetochores for microtubule attachment during meiosis. By lowering the overall pulling force, these constructs keep weakened chromosome pairs together in aged mouse oocytes, restoring accurate DNA segregation....
Ok. Since you asked so nicely, here’s a few from the NG factory. Can’t beat a rocket factory… And the folks taking me around are awesome. Anything else? https://t.co/XW4SA1PBpD
EAA241 - Ph 2 RCT Dara-Bor-Dex vs Cy-Bor-Dex in the treatment of Newly Diagnosed Multiple Myeloma with Light Chain Cast Nephropathy (LCCN) [Study activated 8/11/25] @keruakous https://t.co/1NgvVZ3fTA #NCT07085728 #mmsm @eaonc https://t.co/IvK3UNeem9
Physicist Colin R. McInnes has shown that Dyson Bubbles and flat‑disk Stellar Engines can be engineered for passive stability, countering long‑standing claims of inherent gravitational instability. By concentrating mass at the rim of a reflective disc, radiation pressure and gravity can...
#EAonc EAA173 - Daratumumab to Enhance Therapeutic Effectiveness of Revlimid in Smoldering Myeloma (DETER-SMM) - PI: @nsc_natalie https://t.co/VtBMJUjI5X Activated: Apr 30, 2019 #mmsm @eaonc #NCT03937635 @VincentRK @mweissmdphd https://t.co/ikQKjHjscU
.@SWOG S2213 Ph3 RCT Dara-VC Induction Followed by ASCT or Dara-VCD Consolidation & Daratumumab Maintenance in Pts w/ Newly Diagnosed AL Amyloidosis [Activated: 12/1/23] https://t.co/OizUfJCc2c #mmsm #bmtsm https://t.co/FoT3i0xGcL
The Met Office marked one year of its Microsoft‑powered "supercomputing as a service" platform, delivering roughly 1.8 million cores and 60 petaflops of compute in Azure. The cloud‑based system achieved 100 % uptime for critical workloads and 99.77 % availability for the supercomputing tier....
Population differences in the associations between chromosomal abnormalities and overall survival of multiple myeloma [Jan 31, 2025] Bei Wang et al. @Bloodneoplasia https://t.co/IFPgCwpGo6 #mmsm #PrecisionMedicine #cancerdisparities https://t.co/1eBp98ZNOg
Genomic landscape of multiple myeloma and its precursor conditions [May 21, 2025] Jean-Baptiste Alberge et al. @IrenemGhobrial @NatureGenet https://t.co/DDWGRrpI4Y #mmsm #PrecisionMedicine #cagenome https://t.co/LY1MzFXSBN
Two independent studies examined the motions of the nearby Centaurus A/M83 and M81/M82 galaxy groups to infer the local expansion rate. By balancing gravitational attraction against cosmic expansion, the researchers derived a Hubble constant of roughly 64 km s⁻¹ Mpc⁻¹, slower than the 73 km s⁻¹ Mpc⁻¹...
Multimodal antigenic escape to GPRC5D-targeted T cell engagers in multiple myeloma [Jan 15, 2026] @hollyleeYJ et al. @NBahlis @NatureMedicine https://t.co/mz393mPMAq #mmsm #PrecisionMedicine #tcellrx THREAD: https://t.co/lNX9b7LsnR HT @AuclairDan https://t.co/2qih7LwP1c
Astronomers analyzing archival data identified a dramatic, multi‑year flickering of the Sun‑like star Gaia20ehk, 11,000 light‑years away, and linked it to a catastrophic collision between two planets. The event produced a dense cloud of hot dust that dimmed visible light...
Researchers at Kyushu University used atomic force microscopy to directly visualize the motion of individual polymer chain segments on solid surfaces. They identified three distinct dynamic states—thermally activated, thermally suppressed, and a switching state that alternates between the two—revealing non‑equilibrium...
A new study published in *The Anatomical Record* reveals that cats’ upper thoracic spines can rotate up to 360 degrees, enabling rapid mid‑air reorientation. Researchers examined cadaver spines and performed controlled drop tests on live cats, finding the upper spine...
Identifying potential germline variants from sequencing hematopoietic malignancies [Dec 4, 2020] Ira L. Kraft, Lucy A. Godley @ASH_hematology Education Book https://t.co/L09eJ55sNW #geneticcounselors #PrecisionMedicine #hemeonc https://t.co/Ggq8IEzQEa
This is apparently the week that climate skeptics in X discovered that CO2 has a logarithmic relationship with radiative forcing. We've actually known this since Arrhenius' work in 1896, and its embedded in all our models. But congratulations on getting caught...
The European Space Agency partnered with Russia’s Institute of Biomedical Problems to run MARS500, a ground‑based simulation of a 520‑day crewed Mars mission from 2010‑2011. Six international participants lived in sealed modules, experienced realistic communication delays, and followed a scripted...
Earth scientist Kate Marvel’s new book, *Human Nature: Nine Ways to Feel about Our Changing Planet*, blends climate science with personal emotion, arguing that scientists need not hide their feelings. Each chapter explores a different emotion—wonder, anger, hope, fear—to make...
Researchers at the University of Helsinki have unveiled a new theoretical model that sets a universal upper limit on the intensity of planetary radiation belts. The framework combines magnetic field strength, plasma density, and wave‑particle interaction physics to calculate a...
Astronomers observed an unprecedented burst of high‑energy radiation emanating from two colliding galaxies, offering direct evidence of rapid heavy‑element synthesis during galactic mergers. The event, captured by space‑based X‑ray and gamma‑ray observatories, displayed spectral signatures of r‑process nucleosynthesis, traditionally associated...
