Know What's Happening in Science
Know What's Happening in Science
High‑altitude hypoxia curbs blood‑sugar spikes in mice
A mouse study found that low‑oxygen (hypoxic) conditions cause red blood cells to absorb far more glucose and convert it into a molecule that eases oxygen release, acting as a glucose sink. Mice exposed to 8% oxygen showed markedly smaller blood‑sugar spikes after glucose injections, and the effect persisted after they returned to normal air.
NASA’s Artemis II crew—Commander Reid Wiseman, Mission Specialist Christina Koch, Pilot Victor Glover and Canadian astronaut Jeremy Hansen—are slated to launch on April 1 aboard the Space Launch System, beginning a 10‑day, 685,000‑mile journey around the Moon, the first crewed lunar flyby in more than half a century. The mission tests Orion’s deep‑space habitat and clears the way for a permanent lunar base.
Researchers at the University of Pennsylvania and collaborators have developed a preclinical gene therapy that selectively silences pain‑processing circuits in the brain, mimicking morphine’s analgesic effect without activating reward pathways. Using an AI‑driven system to map morphine‑responsive neurons in mice,...
A population‑based analysis of U.S. death certificates from 2020‑2022 examined Alzheimer’s disease mortality across 443 occupations. Taxi drivers (1.03% of deaths) and ambulance drivers (0.91%) showed the lowest adjusted proportions of Alzheimer‑related deaths, well below the overall adjusted rate of...
Scientists analyzing pristine material from asteroid Ryugu have identified adenine, guanine, cytosine, thymine and uracil—the complete set of canonical nucleobases used in DNA and RNA. The findings, based on 5.4 g of contamination‑controlled samples, provide direct evidence that these biomolecules can...
Psychologists Denise de Ridder and Johanna Peetz highlighted recent research indicating that self‑control can be built through small, repeatable habits rather than taxing willpower. Experiments show participants who kept modest daily goals for three months reported stronger habits and less...
In a recent interview, former two‑time NFL Pro Bowler Julius Thomas, Psy.D., outlined a new framework that ties mental‑training techniques to longer, healthier lives. He argues that chronic stress at the cellular level and low‑grade inflammation are the hidden culprits...
Biohackers World announced a two‑day conference in Los Angeles on March 28‑29, 2026, slated to draw about 1,500 researchers, founders and enthusiasts. The event will shift the biohacking conversation toward everyday habits, supportive technology and environmental design. Organizers say the...
Eli Lilly’s experimental injectable retatrutide has reported substantial weight‑loss outcomes in a 2023 trial, positioning it as a potential challenger to existing GLP‑1 drugs. The triple‑agonist targets three metabolic receptors, and large Phase 3 studies are now under way, drawing attention...
NASA announced a $20 billion acceleration of a permanent lunar base, abandoning the Gateway orbital station in favor of surface infrastructure. The move, framed as a leadership response to China’s fast‑moving lunar program, aims for a foothold on the Moon within...
TotalEnergies announced a 65% reduction in operated methane emissions since 2020, surpassing its 60% cut target for 2025. The progress, detailed in its 2026 Sustainability Report, comes alongside a 38% fall in overall greenhouse‑gas output and a rapid expansion of...
Chinese AI companies XtalPi and Blacklake have moved from loss‑making research to sustainable profitability by targeting specialized data‑driven markets. XtalPi reported a 134.6 million‑yuan ($19.5 million) profit in 2025, while Blacklake achieved its first profit in late 2024, underscoring a shift in...
Researchers at Chiba University have created a redesigned porous carbon nanomaterial called viciazites that captures CO₂ and releases it at temperatures under 60 °C, dramatically lowering energy input. The breakthrough hinges on precisely positioned nitrogen groups, achieving up to 82% selectivity...
AST SpaceMobile’s launch of Bluebird 6, the largest LEO communications‑array antenna, has propelled its shares up 196% over the past year. The rally comes as the company raises $3.9 bn in new financing while posting a $340 m net loss, highlighting both investor...
Researchers at Northwestern University introduced "metamachines," modular robots that keep crawling even after a limb is severed. The breakthrough showcases a new class of shape‑shifting machines that could redefine robotics in unstructured environments.
Nektar Therapeutics presented Phase 2b data for its regulatory T‑cell agonist rezpegaldesleukin at the 2026 American Academy of Dermatology meeting, showing statistically significant EASI improvements in 393 atopic dermatitis patients and a 28.2% mean SALT reduction in severe alopecia areata....
The Hib vaccine protects against Haemophilus influenzae type b (Hib) bacteria, which can cause severe illnesses like meningitis, pneumonia, and epiglottitis. Th
The results of this first phase 2a clinical trial of intranasal 5-MeO-DMT administered adjunctively to SSRIs demonstrated acceptable safety and tolerability with promising improvements in depressive symptoms. https://t.co/m15DkPP4qX
CERN has integrated ultra‑compact AI models directly into silicon chips, enabling the Level‑1 Trigger to discard 99.98% of LHC collision data in under 50 nanoseconds. The move replaces conventional GPUs with custom FPGA/ASIC implementations, addressing a data stream of up...
Senescent immune cells protect against damage, inflammation and disease 🤯 In mice, p16-expressing immune cells delay age-related organ deterioration and preserve tissue homeostasis. More evidence of the physiological roles of senescent cells? https://t.co/UtBKDF00P1
This paper took us 13 years and is one of the longest papers ever in Cell. Check it out & judge for yourself https://t.co/Ra0CX1i5zt https://t.co/LbGXx2u4cq
Earth observation (EO) data are now widely accessible through open archives, cloud platforms and shared tools, yet true public use remains limited. The article argues that openness is more than data availability; it requires institutional capacity, sustained funding, and clear...
New randomized data from the Ez‑PAVE trial in South Korea show that lowering LDL cholesterol to below 55 mg/dL in patients with established atherosclerotic cardiovascular disease reduces major cardiovascular events by 33% compared with a target of less than 70 mg/dL. The...
Supercomputer simulations of a two-million-atom human cell model have mapped the dynamic motions of the spliceosome, offering detailed insights into gene splicing mechanisms and informing future drug development. computationalbiology
University College London and electric marine propulsion firm RAD have released a peer‑reviewed study demonstrating that RAD’s 40 kW electric outboard reduces underwater noise by up to 43 dB compared with a comparable internal combustion engine. Tests on the River Hamble and...
Biogen announced positive Phase 2 results for litifilimab, its anti‑BDCA2 antibody targeting systemic lupus erythematosus. After 24 weeks, 14.7% of patients achieved complete clearance of skin lesions, meeting the trial’s primary endpoint. The data suggest the drug could become a...
A new study from the Gladstone Institutes explains why living at high altitude reduces diabetes risk. Researchers discovered that under hypoxic conditions red blood cells dramatically increase glucose uptake, using it to produce 2,3‑DPG and release more oxygen. The team...
The phase II KARDINAL trial evaluated monthly versus single‑dose tonlamarsen, an angiotensinogen‑targeted nucleic‑acid therapy, in patients with resistant hypertension on multiple drugs. While monthly injections achieved a 67% reduction in plasma AGT compared with 23% after a single dose, both regimens...
Ancient DNA analysis shows that domesticated dogs lived alongside humans in Western Eurasia over 14,000 years ago, sharing diets and forming close bonds long before the advent of agriculture. archaeology
An empirical study by LSU examined 394 confirmed bugs across twelve open‑source quantum simulators, revealing a far higher defect rate than previously assumed. The research shows that 60 % of failures stem from classical infrastructure such as memory management, while only...
Starfish Space announced that its Otter Pup 2 docking demonstration will target a new, still‑undisclosed partner after D‑Orbit withdrew in late 2025. The spacecraft, launched in June 2025, uses an electrostatic capture system to attach to flat surfaces on satellites lacking a...
An international team of astronomers has identified an ultra‑metal‑poor star in a nearby dwarf galaxy, providing a direct window into the chemical makeup of the early universe. The star’s iron abundance is less than one ten‑thousandth that of the Sun,...
Researchers at Shenzhen International Quantum Academy have built a silicon quantum processor that executes a complete set of error‑detecting logical operations using four physical qubits. The chip ran a Variational Quantum Eigensolver algorithm on a water molecule, delivering results within...
New research published in Sleep shows that pink noise, often marketed as a sleep aid, actually reduces REM sleep by about 19 minutes, worsening overall sleep quality. In a controlled seven‑night lab study with 25 healthy adults, intermittent traffic noise...
Merck announced a cash deal to acquire TERN, while CORT secured FDA clearance for its cancer therapy. In parallel, INSM reported positive trial data, VALN fell short of expectations, and Anavex withdrew its EU filing for an Alzheimer’s candidate.
Psilocybin therapy is rapidly expanding across U.S. states, with Oregon reporting 5,935 patients in 2025 and Colorado opening its first regulated healing center. New Mexico is developing its own medical program while the federal government maintains prohibition. Scientific evidence shows...
Takeda announced that its oral TYK2 inhibitor zasocitinib delivered rapid and durable skin clearance in two global Phase 3 LATITUDE trials involving 693 and 1,108 moderate‑to‑severe plaque psoriasis patients. The drug met both co‑primary endpoints—sPGA 0/1 and PASI 75 at week 16—showing statistically significant...
An 88‑year‑old civil‑rights veteran used an AI‑powered dyslexia program and saw his reading accuracy jump from 50 % to 80 % in phonemic awareness. Clinical evidence shows that neuroplasticity remains viable in seniors, allowing language‑based cognitive training to improve reading and memory...
Priovant Therapeutics announced that its TYK2/JAK1 inhibitor brepocitinib met the primary endpoint in the Phase 3 VALOR trial for dermatomyositis, showing a 15.3‑point improvement in Total Improvement Score at week 52 versus placebo. The 30 mg dose also delivered significant steroid‑sparing effects, with...
Climate change is increasingly linked to mental‑health outcomes, yet no global indicator reliably captures this relationship. Researchers highlight the difficulty of attributing specific weather events—such as stronger hurricanes or unprecedented heat‑humidity—to depression, anxiety, or suicide. Data gaps, inconsistent diagnoses, and...
![[Story] Human Alignment Isn't Enough](/cdn-cgi/image/width=1200,quality=75,format=auto,fit=cover/https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/40a8a166ea5b07f07401f100e02df602.webp)
A speculative story describes a Martian organism discovered in cave expeditions that rapidly self‑assembles and emits molecules enabling synthetic computation, boosting human cognition and cooperation by about 20%. The material’s side effects led to a 2‑percentage‑point solar‑cell efficiency breakthrough and...
Adam, I used to think this way. Then gene therapy & IO worked. IL2 has consumed a lot of hope; but new variations make it hard to quit. Abeta worked. And synergy: combine modest drugs, unlock big benefits. Invest or...
"Ten Unsolved Mysteries of the Brain" in Discover Magazine. I wrote this article 19 years ago. Amazingly, these are still the mysteries we face. https://t.co/SIfEB8VkUv
The researchers I know are far more likely to love this than hate it. You really think people enjoy the process of writing papers vs the actual hypothesis generation and designing & steering the research? Automate everything that can...
When I started Don't Die in 2021, we evaluated all the scientific evidence for the most powerful anti-aging therapies. Psychedelics were no where to be found. A wild turn of events that they're now front and center for us....
Cholesterol-lowering effects of oats induced by microbially produced phenolic metabolites in metabolic syndrome: a randomized controlled trial "Here we show that microbial phenolic metabolites are driving factors for the cholesterol-lowering effect of oats.." https://t.co/Y6fmNYStmZ
In a randomized trial of a PCSK9 inhibitor [for LDL cholesterol lowering] vs placebo for patients with diabetes and no known heart disease, there was significant reduction of major cardiovascular events including deaths #ACC26 @JAMA_current https://t.co/mzuI79c4IN https://t.co/16Cpxf7IBx
A new Science #Robotics study highlights Saranga, a deep neural network that can denoise ultrasound echolocation signals to improve aerial navigation even in dense fog, snow, or darkness. @nitinjsanket https://t.co/utyw7UGfJ9 https://t.co/ElinoMN830
Validation of aggressive LDL lowering to reduce major adverse cardiovascular events, a randomized trial targeting LDL < 55 mg/dl. In participants with atherosclerotic cardiovascular disease (secondary prevention) @NEJM #ACC26 https://t.co/oLnkqhawOd
Now @NASA Unveils Its $20 Billion Moon Base Plan—and a Nuclear Spacecraft for Mars by @EddyTheGent https://t.co/2xGqkZeZyd https://t.co/N24jKsM0AN
AI needs data. And biology is finally generating it at scale. I spoke with @10xGenomics CEO Serge Saxonov about the single-cell and spatial biology revolution — and why the convergence of AI + biological measurement could transform medicine. Read the full profile...
